Macromolecular Materials and Engineering最新文献_第4页

Detailed Compositional and Structure–Property Analysis of Ethylene Oxide-Propylene Oxide Triblock Copolymers 环氧乙烷-环氧丙烷三嵌段共聚物的组成及结构性能分析

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-01-13 DOI: 10.1002/mame.202570001

Gergő Róth, Tibor Nagy, Ákos Kuki, Levente Novák, Dávid Nyul, Miklós Zsuga, Sándor Kéki

引用次数: 0

An Injectable IPN Nanocomposite Hydrogel Embedding Nano Silica for Tissue Engineering Application 一种可注射的IPN纳米复合水凝胶包埋纳米二氧化硅用于组织工程

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-01-13 DOI: 10.1002/mame.202570003

Ali Kakapour, Saied Nouri Khorasani, Shahla Khalili, Mahshid Hafezi, Mehdi Sattari-Najafabadi, Mahsa Najarzadegan, Samin Saleki, Shadab Bagheri-Khoulenjani

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Issue Information: Macromol. Mater. Eng. 1/2025 发布信息：Macromol。板牙。Eng。1/2025

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-01-13 DOI: 10.1002/mame.202570002

引用次数: 0

Targeting MDA-MB-231 Cancer Stem Cells With Temsirolimus in 3D Collagen/PGA/Na2SiO3-Based Bone Model 替西莫司靶向MDA-MB-231肿瘤干细胞在3D胶原/PGA/ na2sio3骨模型中的应用

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-01-08 DOI: 10.1002/mame.202400360

Özlem Altundag-Erdogan, Hayrullah Çetinkaya, Mustafa Özgür Öteyaka, Betül Çelebi-Saltik

{"title":"Targeting MDA-MB-231 Cancer Stem Cells With Temsirolimus in 3D Collagen/PGA/Na2SiO3-Based Bone Model","authors":"Özlem Altundag-Erdogan, Hayrullah Çetinkaya, Mustafa Özgür Öteyaka, Betül Çelebi-Saltik","doi":"10.1002/mame.202400360","DOIUrl":"https://doi.org/10.1002/mame.202400360","url":null,"abstract":"This study evaluated the efficacy of temsirolimus in a 3D model mimicking breast cancer stem cell (CSC) metastasis to bone. A composite material (collagen/PGA/Na₂SiO₃) is used to create a scaffold with bone marrow mesenchymal stem cells (BM-MSCs) and human umbilical vein endothelial cells (HUVECs). MSCs maintained over 80% viability for 21 days on the scaffold. Calcium analysis shows increased calcium release in both control (3-fold, 2.7-fold) and osteogenic (2.3-fold, 2.5-fold) mediums on days 14 and 21. Gene expression analysis reveals higher levels of Osteopontin (OPN) (6-fold), Osteocalcin (OCN) (12-fold), and RUNX Family transcription factor 2 (RUNX2) (1.8-fold) in the osteogenic medium (p < 0.05). The impact of 5 µM temsirolimus treatment for 6 hours is assessed under control and dynamic culture conditions, reducing mammalian target of rapamycin (mTOR)-related protein levels (phospho (p)-mTOR and p-AKT) in CSCs. The composite material is characterized through viscosity and compression testing, confirming its suitability for supporting osteogenic differentiation and cell viability (WST-1, Alizarin Red Staining, Calcium Assay, RT-qPCR). Gene expression of CSCs, selected based on CD133 expression, shows elevated stemness-associated genes (OCT4, NANOG), EMT (MMP2, CXCR4, CDH1, CDH2), and drug resistance (ABCG1, ABCG2) in the CD133⁺ group in dynamic condition. Temsirolimus treatment reduces the expression of these genes by 21-fold to 7.52-fold (p < 0.05). These findings suggest temsirolimus as a promising therapeutic for CSC metastasis to bone.[Correction added on April 8, 2025, after first online publication: the word CHD is updated to CDH in this version.]","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of CuO/Al2O3 and NiO Loaded Form-Stabilized Composite Phase Change Materials with Improved Thermal Properties and Comparison of their Thermal Energy Storage Characteristics CuO/Al2O3与NiO负载形式稳定复合相变材料的制备及储热特性比较

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-01-02 DOI: 10.1002/mame.202400379

Beyza Nur KÜÇÜKER, Hatice Hande MERT

{"title":"Preparation of CuO/Al2O3 and NiO Loaded Form-Stabilized Composite Phase Change Materials with Improved Thermal Properties and Comparison of their Thermal Energy Storage Characteristics","authors":"Beyza Nur KÜÇÜKER, Hatice Hande MERT","doi":"10.1002/mame.202400379","DOIUrl":"https://doi.org/10.1002/mame.202400379","url":null,"abstract":"Alumina supported copper oxide (CuO/Al2O3) and Nickel Oxide (NiO) loaded polymer composite matrices supported n-hexadecane (HD) based composite phase change materials (PCMs) are prepared and characterized. The polymer composites assigned as supporting matrices for shape-stabilization of PCM are synthesized by emulsion-templating approach, and the composite PCMs are prepared by impregnation of HD into polymer composite matrices. The effect of CuO/Al2O3 and NiO particles of different sizes used as heat transfer promoters in the supporting matrices, on the morphological properties, thermal stabilities, and latent heat storage characteristics (LHS) of the composite PCMs are evaluated using different characterization methods. The melting temperature of the obtained composite PCMs is found to be ≈18 °C and the latent heat of melting values varied in the range of 95.0−114.5 J g−1. The heat transfer properties of the composite PCMs are investigated by performing a T-History test for obtaining heat storage and release curves. The composite PCMs with NiO loaded supporting matrices are exhibited higher thermal stability and heat storage capacity in addition to enhanced thermal conduction properties than the CuO/Al2O3 included composite PCMs. According to the results, it is revealed that shape-stabilized, thermally enhanced composite PCMs are remarkable energy storage materials with the potential for use in low-temperature thermal energy storage systems.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanofibrous Biomaterial Containing Raw-Propolis Particles Encapsulated by PLA/PBS for Wound Dressing Application 由聚乳酸/PBS包封的含有原蜂胶颗粒的纳米纤维生物材料用于伤口敷料

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-01-02 DOI: 10.1002/mame.202400321

Ecem Özdilek, Sema Samatya Yilmaz, Hüseyin Uzuner, Ayse Aytac

{"title":"Nanofibrous Biomaterial Containing Raw-Propolis Particles Encapsulated by PLA/PBS for Wound Dressing Application","authors":"Ecem Özdilek, Sema Samatya Yilmaz, Hüseyin Uzuner, Ayse Aytac","doi":"10.1002/mame.202400321","DOIUrl":"https://doi.org/10.1002/mame.202400321","url":null,"abstract":"The hollow nanofibrous materials were obtained by successfully encapsulating different rate raw-propolis particles (5%, 10%, and 15%) with hydrophobic polylactic acid/polybutylene succinate (PLA/PBS, 93/7, w/w) blend. No purification process such as extraction was applied to raw propolis and propolis was used as raw. High liquid absorbing capacity values between 400 and 600% were observed owing to the hollow core of the nanofiber. Scanning electron microscopy (SEM) surface images of hollow nanofibers became transparent, and it was seen that the fiber diameters were thickened. The tensile stress of 5% propolis-encapsulated biomaterial exhibited the highest value of 1.25 MPa. High antibacterial activity was observed especially against Staphylococcus aureus (S. aureus) at the end of the 24th and 48th h with the dispersion of raw-propolis particles in the core of propolis-encapsulated all fibrous materials. However, it was seen that the use of propolis in its raw form caused the emergence of toxic effects. It was reported that hollow biomaterials containing raw-propolis particles encapsulated by PLA/PBS could not be used as wound dressings due to insufficient fibroblast cell viability. So, it was suggested that pure hollow PLA/PBS fibrous mats could be used as skin tissue scaffolds.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design Optimization of Pressurized Gyration Technology: Orifice Height Level Effects on Production Rate and Fiber Morphology 加压回转工艺的优化设计：孔口高度对生产率和纤维形态的影响

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-01-02 DOI: 10.1002/mame.202400317

Ahmed Alneyadi, Angelo Delbusso, Anthony Harker, Mohan Edirisinghe

{"title":"Design Optimization of Pressurized Gyration Technology: Orifice Height Level Effects on Production Rate and Fiber Morphology","authors":"Ahmed Alneyadi, Angelo Delbusso, Anthony Harker, Mohan Edirisinghe","doi":"10.1002/mame.202400317","DOIUrl":"https://doi.org/10.1002/mame.202400317","url":null,"abstract":"Electrospinning and pressurized gyration are two widely adopted methods for polymeric fiber production, valued for their simplicity, versatility, and relatively low environmental impact. Despite its advantages, electrospinning has notable limitations, including low production efficiency and significant safety concerns. Pressurized gyration, however, offers greater productivity and a safer, more sustainable process, making it an excellent candidate for industrial scaling. To fully realize this potential, optimizing the pressurized gyration process is essential for enhancing efficiency and achieving sustainable large-scale fiber production. In this study, the effects of vessel orifice height on the production rate and fiber morphology in pressurized gyration are explored. A series of experiments is conducted using a 15 wt.% polycaprolactone (PCL) solution, with vessels of identical diameter but differing orifice heights 7.5, 15, and 22.5 mm tested under pressures of 0, 0.1, 0.2, and 0.3 MPa, all at a constant rotational speed of 13 000 rpm. The 7.5 mm orifice height demonstrates the highest production rate under pressure while increasing orifice height led to finer fiber diameters, better alignment, and smaller beads. These findings underscore the importance of optimizing vessel design, along with process and solution parameters, for scaling up pressurized gyration fiber manufacturing to meet industrial demands.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Cross-Link Density and Additive Effects on Mechanical and Morphological Behaviors of Cross-Linked Polymers 探讨交联密度和加性对交联聚合物力学和形态行为的影响

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-12-27 DOI: 10.1002/mame.202400383

Kamrun N. Keya, Zhaofan Li, Lan Xu, Wenjie Xia

{"title":"Exploring Cross-Link Density and Additive Effects on Mechanical and Morphological Behaviors of Cross-Linked Polymers","authors":"Kamrun N. Keya, Zhaofan Li, Lan Xu, Wenjie Xia","doi":"10.1002/mame.202400383","DOIUrl":"https://doi.org/10.1002/mame.202400383","url":null,"abstract":"Cross-linked thermoset polymeric materials are widely used in various engineering applications due to their excellent mechanical properties, thermal stability, and chemical resistance. Recent research highlights the role of cross-link density and additives in influencing segmental dynamics and thermomechanical behavior of polymers. This study employs coarse-grained molecular dynamics (CG-MD) simulations to explore the thermomechanical and morphologic behaviors of cross-linked polymers with molecular additives. Specifically, it is systematically investigated how cross-link density (c) and different additive concentrations (m) affect key glass-forming characteristics, along with the resulting changes in mechanical and morphologic properties of network materials as they approach their glass transition temperatures (Tg). Relatively weaker interaction between the polymer network and additives can lead to additive aggregation, significantly affecting the morphology and Tg as the m increases. Increasing c leads to an increase in both Tg and fragility while increasing m decreases them. The simulation reveals that both c and m moderately influence the mechanical properties (i.e., shear and tensile modulus) of cross-linked polymers with additives. This study provides valuable insights into how cross-link density and additive concentrations influence glass-forming and morphological behaviors, offering a molecular design strategy for developing advanced cross-linked thermosets.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polycondensation-Derived High-Molecular Weight Lignin as Nonblended Precursor for Carbon Fibers 缩聚衍生的高分子量木质素作为碳纤维的非共混前驱体

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-12-23 DOI: 10.1002/mame.202400388

Manuel M. Clauss, Erik Frank, Volker Bauch, Lisa Kuske, Michael R. Buchmeiser

引用次数: 0

Femtosecond Laser Transmission Joining of Fused Silica and Polymethyl Methacrylate 熔融二氧化硅与聚甲基丙烯酸甲酯的飞秒激光传输连接

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-12-23 DOI: 10.1002/mame.202400354

Felice Alberto Sfregola, Raffaele De Palo, Caterina Gaudiuso, Pietro Patimisco, Antonio Ancona, Annalisa Volpe

{"title":"Femtosecond Laser Transmission Joining of Fused Silica and Polymethyl Methacrylate","authors":"Felice Alberto Sfregola, Raffaele De Palo, Caterina Gaudiuso, Pietro Patimisco, Antonio Ancona, Annalisa Volpe","doi":"10.1002/mame.202400354","DOIUrl":"https://doi.org/10.1002/mame.202400354","url":null,"abstract":"In this study, polymethyl methacrylate (PMMA) is joined with fused silica using pulsed femtosecond laser transmission micro-welding. This technique enables the welding of transparent materials to each other without the need for intermediate opaque layers, through localized energy deposition. The laser parameters – peak fluence, scanning speed, and hatch distance – are systematically optimized to maximize joint shear strength. The ATR-FTIR spectroscopic analysis has proven that mechanical interlocking is the primary mechanism of joint formation between the two materials. An analytical model based on heat accumulation is developed to describe the joining process, with a good predictive quality confirmed by comparison with the experimental results. This joining approach is applied to seal a hybrid PMMA-fused silica microfluidic chip. The device has successfully passed a static leakage test by withstanding pressures up to the full-scale value of the employed microfluidic pump at 2 bar, demonstrating the effectiveness of femtosecond laser transmission welding for fabricating robust and reliable joints in hybrid microfluidic devices.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0