Macromolecular Materials and Engineering最新文献

Carboxymethyl Xanthan Gum/Pullulan Hydrogel Loaded With Ranunculus Laetus Extract for Enhanced Antibacterial Activity and Inflammatory Modulation 含毛茛提取物的羧甲基黄原胶/普鲁兰水凝胶增强抗菌活性和炎症调节作用

IF 5.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2026-11-06 DOI: 10.1002/mame.70384

Aima Ghouri, Muhammad Haseeb Nawaz, Akbar Niaz, Muhammad Iftikhar Faraz, Syed Quadir Moinuddin, Muhammad Atiq Ur Rehman

{"title":"Carboxymethyl Xanthan Gum/Pullulan Hydrogel Loaded With Ranunculus Laetus Extract for Enhanced Antibacterial Activity and Inflammatory Modulation","authors":"Aima Ghouri, Muhammad Haseeb Nawaz, Akbar Niaz, Muhammad Iftikhar Faraz, Syed Quadir Moinuddin, Muhammad Atiq Ur Rehman","doi":"10.1002/mame.70384","DOIUrl":"https://doi.org/10.1002/mame.70384","url":null,"abstract":"This study proposes novel combination of carboxymethyl xanthan gum (CMXG), pullulan (PL), and Ranunculus laetus extract (RL)- based hydrogel for potential wound-healing applications. Scanning electron microscopy demonstrated development of intra-porous structure, while Fourier transform infrared spectroscopy revealed spectral changes consistent with interactions among the components. The CMXG/RL/PL hydrogel exhibited hydrophilic behavior and optimal swelling, with contact angle of 50° ± 4° and swelling ratio of ∼76% ± 3%. The CMXG/RL/PL hydrogel also degraded in a sustained manner (∼76%) and contributed to controlled release of RL (∼79%), which resulted in bactericidal potency (as it revealed zones of ∼13.6 and ∼18.7 mm against E. coli and S. aureus, respectively) and antioxidant efficacy, with 2,2-diphenyl-1-picrylhydrazyl and hydroxyl scavenging assays reaching ∼60% and ∼67%. Cytocompatibility studies demonstrated excellent cytocompatibility after prolonged incubation. Biomarker studies revealed a decline in the release of pro-inflammatory cytokines, including IL-1α, IL-6, and TNF-α, while enhancing the expression levels of anti-inflammatory cytokines such as IL-4 and IL-10. Molecular docking further predicted potential binding of phytocomponents present in RL (centaurein and jacein) to pro-inflammatory and anti-inflammatory cytokines. The CMXG/RL/PL hydrogel exhibited promising initial results as potential wound dressing, with controlled drug release, enhanced antibacterial activity, antioxidant potential, and inflammatory regulation.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70384","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Enabling Strategy for Developing Triple Shape Memory Polymers with a Broad Glass Transition Temperature Range via Melt Blending of Miscible Hard-Soft Polymers 硬-软混相聚合物熔融共混制备具有宽玻璃化转变温度范围的三形状记忆聚合物的有利策略

IF 5.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2026-11-05 DOI: 10.1002/mame.70385

Mohammad Aberoumand, Najmeh Taala, Mahdi Bodaghi, Uttandaraman Sundararaj

{"title":"An Enabling Strategy for Developing Triple Shape Memory Polymers with a Broad Glass Transition Temperature Range via Melt Blending of Miscible Hard-Soft Polymers","authors":"Mohammad Aberoumand, Najmeh Taala, Mahdi Bodaghi, Uttandaraman Sundararaj","doi":"10.1002/mame.70385","DOIUrl":"https://doi.org/10.1002/mame.70385","url":null,"abstract":"Triple shape memory polymers (TSMPs) enable sequential shape transformations for deployable and biomedical devices, yet their development often requires complex synthesis/chemical crosslinking and/or processing. Here, the scalable melt-blending strategy of commercially available hard-soft polymers enables thermoplastic TSMPs, exhibiting microscale miscibility and molecular relaxation induced by self-concentration at the segmental-scale. Binary PMMA/PVDF and PC/PCL blends, together with ternary PMMA/PVDF/PEO systems, demonstrate miscibility, evidenced by a single glass transition, broad molecular relaxation spectra, and the absence of distinct amorphous polymer-rich phases. Dynamic mechanical thermal analysis reveals substantial glass transition broadening, reaching ≈45 °C in PMMA/PVDF/PEO and ≈70 °C in PC/PCL blends, thereby providing thermal actuation windows for programmable triple shape memory behavior. All systems demonstrate high shape fixity and shape recovery ratios, while PC/PCL blends generate actuation stresses up to 8.04 MPa. The best-performing compositions maintain stable shape and stress recovery over three successive cycles. Their broad thermal working windows, strong actuation capability, and thermoplastic processability enable versatile multi-stage actuation. Stress recovery analysis indicates that self-tightening TSMP staples may potentially provide staged wound closure to reduce tissue stress concentrations associated with conventional single-step closure. This work establishes a practical route toward high-performance thermoplastic TSMPs for engineering and biomedical applications.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149311487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regolith Simulant Adhesion to Polycarbonate and PDMS: Deposition Methods, Coverage, and Removal Resistance 模拟风化层粘附到聚碳酸酯和PDMS：沉积方法，覆盖和去除阻力

IF 5.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2026-11-05 DOI: 10.1002/mame.70357

Emma Nolan, Emily Power, Dylan Doherty, Susan M. Kelleher

{"title":"Regolith Simulant Adhesion to Polycarbonate and PDMS: Deposition Methods, Coverage, and Removal Resistance","authors":"Emma Nolan, Emily Power, Dylan Doherty, Susan M. Kelleher","doi":"10.1002/mame.70357","DOIUrl":"https://doi.org/10.1002/mame.70357","url":null,"abstract":"Dust adhesion is a critical challenge for lunar and Martian surface operations, causing equipment degradation, and reduced operational lifetimes. This study investigated the adhesion of three regolith simulants, Lunar Highlands Dust Simulant (LHS1D), Lunar Mare Simulant (LMS1), and Mars Global Simulant (MGS1), to polydimethylsiloxane (PDMS) and polycarbonate using two deposition methods: air deposition and rolling contact. Polycarbonate showed significantly lower area coverage than PDMS across all simulants and deposition methods (p < 0.001). This was unexpected, as PDMS has lower surface energy, higher hydrophobicity, and higher roughness – properties typically associated with reduced adhesion. However, PDMS has a lower Young's modulus (3.2 MPa vs. 2.9 GPa), which may allow greater surface deformation and increased contact area. Experiments with a stiffer PDMS formulation (4.2 MPa) supported this, showing reduced adhesion with increased modulus. Rolling contact generally produced higher coverage than air deposition, and the finest simulant (LHS1D) showed the highest adhesion, consistent with increased van der Waals interactions for fine particles. Drying significantly increased adhesion on both materials. These findings suggest that substrate stiffness may play a more significant role than surface energy in controlling regolith adhesion, and that rigid, high-modulus materials warrant further investigation for dust-exposed surfaces in space environments.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149311488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Macromol. Mater. Eng. 11/2026 发布信息：Macromol。板牙。Eng。11/2026

IF 5.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2026-11-04 DOI: 10.1002/mame.70381

引用次数: 0

Optimization of Fully Screen-Printed Electrostrictive Multilayer Actuators 全丝网印刷电致伸缩多层执行器的优化

IF 5.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2026-11-04 DOI: 10.1002/mame.70331

Sara Beauquis, Sara Zanchi, Eva Héripré, Valentin Reynaud, Joel Agnus, Cedric Ayela, Sébastien Roland, Damien Thuau

{"title":"Optimization of Fully Screen-Printed Electrostrictive Multilayer Actuators","authors":"Sara Beauquis, Sara Zanchi, Eva Héripré, Valentin Reynaud, Joel Agnus, Cedric Ayela, Sébastien Roland, Damien Thuau","doi":"10.1002/mame.70331","DOIUrl":"https://doi.org/10.1002/mame.70331","url":null,"abstract":"Electroactive polymers (EAP) are commonly used as actuating materials in soft robotic systems. Among EAPs, the relaxor ferroelectric poly(vinylidene fluoride-ter-trifluoroethylene-ter-chlorotrifluoroethylene) (P(VDF-ter-TrFE-ter-CTFE)) stands out for its large reversible strain (4%–5 %), however requiring high voltage for actuation. To limit the applied voltage, a fully screen-printed multilayer architecture consisting of alternating thin electrostrictive layers (<math>\u0000 <semantics>\u0000 <mo>∼</mo>\u0000 <annotation>$sim $</annotation>\u0000 </semantics></math>5 µm) and PEDOT:PSS electrodes on a flexible substrate is proposed. The electroactive ink consists in a (P(VDF-ter-TrFE-ter-CTFE)) terpolymer with 4.7 mol% of CTFE selected for its higher crystallinity compared to the frequently used 8 mol% CTFE composition. In this study, a multi-parametric design (aspect ratio, surface of actuation, thickness of the EAP layer, thickness of the substrate) optimization to enhance actuator performance is presented. The results reveal that increasing the aspect ratio leads to a larger bending angle but a lower blocking force, whereas increasing the surface of actuation increases both the bending angle and the blocking force. Additionally, the guidelines for successful screen-printing of reliable multilayer actuators are presented. These findings underline the potential of multilayered electrostrictive actuators for soft robotics.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149311467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dry-Develop Positive-Tone Poly(aldehyde) Resists Activated by Low-Voltage Electron-Beam Exposure 干显影低压电子束曝光激活的正色调聚醛抗蚀剂

IF 5.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2026-10-28 DOI: 10.1002/mame.70380

Youngsu Shin, Paul A. Kohl

{"title":"Dry-Develop Positive-Tone Poly(aldehyde) Resists Activated by Low-Voltage Electron-Beam Exposure","authors":"Youngsu Shin, Paul A. Kohl","doi":"10.1002/mame.70380","DOIUrl":"https://doi.org/10.1002/mame.70380","url":null,"abstract":"Dry-develop positive-tone resists are attractive for advanced lithographic applications because they eliminate the need for liquid development. Poly(phthalaldehyde) (PPA) is a promising dry-developable resist platform because acid-triggered depolymerization converts the polymer to volatile o-phthalaldehyde (oPA), enabling spontaneous or vacuum-assisted material removal. Here, low-voltage electron-beam activation of photoacid-generator/poly(aldehyde) films was investigated for positive-tone dry development. PPA films containing diaryliodonium photoacid generators (PAGs) were exposed using a 2 keV scanning electron microscope, and showed exceptionally high sensitivity with the volatile depolymerization products removed under vacuum. Among the PAGs investigated, diphenyliodonium hexafluoroarsenate (DIHA) produced greater mass loss at lower electron-beam doses than bis(4-tert-butylphenyl)iodonium triflate (BIT) or Rhodorsil FABA under the same molar loading conditions. DIHA loading studies showed that the remaining residue thickness, which is primarily due to non-volatile DIHA products, was reduced by lowering the DIHA concentration. Electron-beam depolymerization of cyclic poly(propanal-co-phthalaldehyde) (PPCP) was investigated to evaluate the effect of depolymerization product volatility. DIHA/PPCP films showed greater thickness loss and cleaner exposed regions than DIHA/PPA films under the same exposure and vacuum-hold conditions.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70380","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Filtration Performance of Real Polymeric Fiber Media for Non-Spherical Particles Based on CFD-DEM Simulations 基于CFD-DEM模拟的真实聚合物纤维介质对非球形颗粒的过滤性能

IF 5.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2026-10-26 DOI: 10.1002/mame.70379

Qingyang Xu, Xin Wang, Xiangqin Wang, Jianhua Fan, Yanhe Chen, Li Ding, Hai Xu

{"title":"Filtration Performance of Real Polymeric Fiber Media for Non-Spherical Particles Based on CFD-DEM Simulations","authors":"Qingyang Xu, Xin Wang, Xiangqin Wang, Jianhua Fan, Yanhe Chen, Li Ding, Hai Xu","doi":"10.1002/mame.70379","DOIUrl":"https://doi.org/10.1002/mame.70379","url":null,"abstract":"To elucidate the influence of particle morphology on filtration in real polymeric fibrous media, the present study employs Computational Fluid Dynamics–Discrete Element Method to investigate the capture dynamics of spherical, cubic, and regular tetrahedral particles. Results indicate that the pressure drop remains nearly identical across particle types. The capture efficiency of particles rises rapidly with Stokes number (0 < St < 0.8). Under the inertial-impaction-dominated conditions characterized bySt, regular tetrahedral particles achieve the highest capture efficiency, followed by cubic and then spherical. For Reynolds numbers in the range of 0 < Re < 1, where the shape-dependent flow-field structure plays the primary role, the cubic particles are more readily captured by the fibers compared to the other two particle shapes. Regular tetrahedral particles are less susceptible to capture by the fibers than spherical particles. It is found that the polymeric fibrous filter exhibits a higher quality factor for capturing cubic particles when varying the flow velocity. However, regular tetrahedral particles show a higher quality factor with decreasing viscosity. This study reveals the capture mechanism of irregular particles in real polymeric fibrous media, providing insight into the effects of non-spherical particle morphology on filtration performance.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149258915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electron-Beam Irradiation of Ground Tire Rubber in Water for Surface Activation and Improved Recycling in Natural Rubber Compounds 电子束辐照轮胎地面橡胶在水中的表面活化及改善天然胶料的回收

IF 5.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2026-10-22 DOI: 10.1002/mame.70376

László Mészáros, Ákos Szakács, Renáta Homlok, Anna Tegze, Lóránt Kiss

{"title":"Electron-Beam Irradiation of Ground Tire Rubber in Water for Surface Activation and Improved Recycling in Natural Rubber Compounds","authors":"László Mészáros, Ákos Szakács, Renáta Homlok, Anna Tegze, Lóránt Kiss","doi":"10.1002/mame.70376","DOIUrl":"https://doi.org/10.1002/mame.70376","url":null,"abstract":"In this study, we treated ground tire rubber (GTR) with electron-beam irradiation in an aqueous medium and investigated its application in natural rubber (NR)-based compounds. We characterized the changes in the internal chemical structure using Soxhlet extraction and swelling tests. Based on the results, it can be stated that both the sol content and the crosslink density changed only slightly (1%–2%), indicating that the energy imparted during electron irradiation was primarily consumed by the radiolysis of water. We used the irradiated GTR in NR-based compounds and then examined their properties. The tensile strength of the vulcanizates increased by 30%, while their elongation at break increased by 28% compared to the reference, even at an absorbed dose of 10 kGy. The tear strength reached its maximum at 40 kGy, where it increased by 42% compared to the reference. Based on the dynamic mechanical properties, it can be concluded that radiation treatment resulted in stronger adhesion between the phases, as evidenced by a decrease in the Payne effect. The results demonstrate that the water-radiolysis-assisted surface activation concept previously developed using gamma irradiation can be successfully transferred to electron-beam processing, providing a faster and more economically attractive route for industrial GTR recycling.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149258430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysine-Functionalized Boehmite/Polysulfone Nanofiltration Membranes with Enhanced Dye Rejection and Salt Separation Performance 赖氨酸功能化薄水铝石/聚砜纳滤膜对染料和盐分离性能的增强

IF 5.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2026-10-22 DOI: 10.1002/mame.70373

Behnaz Mousavipoor, Kazem Javan, Ahmad Moheb, Mariam Darestani, Morteza Sadeghi

{"title":"Lysine-Functionalized Boehmite/Polysulfone Nanofiltration Membranes with Enhanced Dye Rejection and Salt Separation Performance","authors":"Behnaz Mousavipoor, Kazem Javan, Ahmad Moheb, Mariam Darestani, Morteza Sadeghi","doi":"10.1002/mame.70373","DOIUrl":"https://doi.org/10.1002/mame.70373","url":null,"abstract":"Polysulfone (PSF) nanofiltration membranes incorporating L-lysine-functionalized boehmite nanoparticles (Lys-BM) were developed to improve dye and salt removal from water. Lysine functionalization enhanced nanoparticle dispersion and compatibility within the PSF matrix. Membranes containing 0–1 wt.% Lys-BM were fabricated by phase inversion and characterized using XRD, FT-IR, TGA, and SEM. The membranes exhibited an asymmetric structure with a dense skin layer, porous sublayer, and finger-like pores. The 0.5 wt.% Lys-BM membrane showed the best overall performance, while higher loading (1 wt.%) caused minor agglomeration and reduced efficiency. Lys-BM incorporation significantly enhanced membrane hydrophilicity, reducing the contact angle from 65.06° to 50.31°, while increasing porosity and approximately doubling pure water flux. Antifouling properties also improved substantially, with flux recovery ratio increasing from 52.85% for pristine PSF to 92.32%. The modified membranes achieved >95% Methylene Blue rejection and >90% MgSO4 and MgCl2 rejection. Zeta-potential analysis confirmed surface charge reversal following Lys-BM incorporation, supporting improved separation performance. Moreover, long-term cross-flow filtration showed that the optimized membrane retained 88–90% of its initial flux, compared with approximately 60% for pristine PSF. Overall, Lys-BM modification provides an effective strategy for producing high-performance and operationally stable nanofiltration membranes for advanced water treatment.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70373","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149258440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microgels of Levan Polysaccharide and Their Use for the Controlled Release of CBD Levan多糖微凝胶及其在CBD控释中的应用

IF 5.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2026-10-22 DOI: 10.1002/mame.70363

Ece Özyağcı, Selay Tornacı, Dana Galkina, Elina Kelle, Girts Salms, Arita Dubnika, Ebru Toksoy Öner

{"title":"Microgels of Levan Polysaccharide and Their Use for the Controlled Release of CBD","authors":"Ece Özyağcı, Selay Tornacı, Dana Galkina, Elina Kelle, Girts Salms, Arita Dubnika, Ebru Toksoy Öner","doi":"10.1002/mame.70363","DOIUrl":"https://doi.org/10.1002/mame.70363","url":null,"abstract":"Hydrogels are widely investigated as tissue engineering scaffolds due to their structural similarity to the extracellular matrix and their ability to support cell growth and controlled drug delivery. In this study, levan-based microgels were developed as injectable scaffolds capable of filling amorphous and hard-to-reach soft tissue defects while enabling controlled release of cannabidiol (CBD). A cytocompatible and immuno-neutral levan hydrogel with a porous architecture and high water uptake was successfully synthesized. The physicochemical, rheological, and biological properties of the hydrogel were systematically evaluated in different physical forms (oven-dried, lyophilized, bulk, ground, and injectable). The hydrogel exhibited a high swelling capacity (approximately 15–18 g g−1) and a well-developed porous structure throughout both surface and cross-sectional regions. Cytocompatibility was confirmed with adipocytes, gingival mesenchymal stem cells (GMSC), human osteoblasts (HOB), and human fibroblasts (PCS-201-012). ELISA results demonstrated stable interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secretion levels in GMSC cultures, indicating an immuno-neutral response. Furthermore, the hydrogel enabled a low and sustained release of CBD. Collectively, these findings highlight the potential of levan-based hydrogels as injectable, wound-healing-oriented drug delivery systems for soft tissue engineering applications.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 10","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70363","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149258443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0