Macromolecular Materials and Engineering最新文献

{"title":"Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications","authors":"Aslı Eldem,&nbsp;Yamaç Tekintaş,&nbsp;Muhammed Ucuncu,&nbsp;Nesrin Horzum","doi":"10.1002/mame.202500014","DOIUrl":"https://doi.org/10.1002/mame.202500014","url":null,"abstract":"<p>Electrospinning offers a versatile platform for developing nanofibrous scaffolds capable of enhancing the therapeutic potential of photodynamic therapy (PDT). Photosensitizer (PS) loaded fibers exhibit a high surface area-to-volume ratio, promoting efficient drug delivery, prolonged retention at the target site, and controlled release profiles. Inducing reactive oxygen species (ROS) generation through light activation offers a targeted therapeutic approach, selectively generating cytotoxic effects in cancerous or pathogenic cells while minimizing damage to healthy tissue. This selective cytotoxicity arises because the ROS are produced only in illuminated areas where PS releases and accumulates, limiting their harmful effects to desired regions. Additionally, PS-loaded fibers are highly effective in wound healing applications, promoting cell proliferation and tissue regeneration while providing a barrier against microbial infections. This review highlights recent advances in the design and biomedical application of PS-loaded nanofibers, emphasizing their influence on cell viability and effectiveness in microbial inhibition, thereby setting the stage for future innovations in cancer therapy, wound healing, and infection control.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202500014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information: Macromol. Mater. Eng. 2/2025","authors":"","doi":"10.1002/mame.202570005","DOIUrl":"https://doi.org/10.1002/mame.202570005","url":null,"abstract":"","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202570005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Encapsulation of Ferritin-Like Nanoparticles Within Polymeric Nanofibers Using a New Electrospinning Set-Up and Its Effect Upon Iron Release Properties","authors":"Lewis R. Anderson,&nbsp;Charlotte C. Hancox,&nbsp;Simon R. Collinson,&nbsp;Katja Rietdorf,&nbsp;Peter G. Taylor,&nbsp;Nicholas P. Chatterton","doi":"10.1002/mame.202400400","DOIUrl":"https://doi.org/10.1002/mame.202400400","url":null,"abstract":"<p>Encapsulation of nanoparticles (NPs) in polymeric nanofibers is an effective way of controlling physicochemical properties such as stability and integrity. In this study, bioavailable ferritin-like NPs, previously demonstrated to be an effective treatment for iron deficiency anemia (IDA), are encapsulated successfully in the pH-sensitive polymer Eudragit L100 through modification of the electrospinning configuration and reversal of the conventional input voltage. Transmission electron microscopy (TEM) of these nanofibers show IHAT NPs are enveloped more effectively than in equivalent materials produced by conventional electrospinning. These modifications lead to a significant reduction in the burst release of iron during the first 30 min of dissolution testing at pH 1.0 due to the enhanced encapsulation, potentially reducing the degradation of these NPs in gastric fluids and thereby increasing bioavailability. The materials are also characterized by scanning electron microscopy (SEM), simultaneous thermogravimetric analysis (STA) and Fourier transform infrared spectroscopy (FTIR). Kinetic analysis of the dissolution data showed that the better encapsulated NP formulations reduced burst release of iron. Dynamic light scattering (DLS) and TEM measurements of the NPs released from the materials suggest that they are unmodified during the formulation process. The modified electrospinning configuration requires significantly lower energy input than conventional electrospinning.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144299945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Stab Resistance of Bombyx Mori Silk Cocoons","authors":"Ateeq Ur Rehman,&nbsp;Vasileios Koutsos,&nbsp;Parvez Alam","doi":"10.1002/mame.202400418","DOIUrl":"https://doi.org/10.1002/mame.202400418","url":null,"abstract":"<p>This study considers the mechanical response of <i>Bombyx mori</i> silk cocoons to knife stabbing, a simple but controlled way of simulating predaceous penetration. Here, we stab test both entire cocoons (EC) and cocoon wall segments (CWS) statically and dynamically, and note that the process can be broken down in three stages. The first stage involves material deflection, the second is knife penetration, and the third is knife perforation. It is found that ca. 95 % of the kinetic energy is lost during the penetration stage. There are noticeable differences in strain between the equatorial (<span></span><math>\u0000 <semantics>\u0000 <mover>\u0000 <mi>ε</mi>\u0000 <mo>¯</mo>\u0000 </mover>\u0000 <annotation>$bar{varepsilon }$</annotation>\u0000 </semantics></math> = 13 %) and meridional (<span></span><math>\u0000 <semantics>\u0000 <mover>\u0000 <mi>ε</mi>\u0000 <mo>¯</mo>\u0000 </mover>\u0000 <annotation>$bar{varepsilon }$</annotation>\u0000 </semantics></math> = 1.5 %) directions before and after the stabbing of EC specimens (p &lt;0.001). The apparent area of the cocoon is noted to be on average 7 % lower after stabbing than it is prior to being stabbed (p &lt;0.01). It is found that while compression of the cocoon from stabbing results in equatorial expansion (with a Poisson's ratio, ν = 0.25), in the meridional direction the cocoon contracts (ν = -0.05) thus displaying auxetic behavior. Force-deflection curves are different in CWS specimens as compared to EC specimens, and this is attributable to natural curvatures in CWS specimens remaining even after a being flattened for mounting and testing. Differences between EC and CWS specimens are also noticeable in the sizes of the stab footprints, with EC samples exhibiting 33 % smaller footprints than CWS samples (p &lt; 0.001). It is concluded that testing whole cocoon structures provides a more accurate understanding of their properties as compared to cut and flattened structures. This is because flattening cocoon wall specimens induces delamination and multiple failure zones, reducing the natural stab resistance of the material.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144299601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene Applications in Composites, Energy, and Water Treatment","authors":"Maryam A. Saeed,&nbsp;Amor Abdelkader,&nbsp;Yousef Alshammari,&nbsp;Cristina Valles,&nbsp;Abdullah Alkandary","doi":"10.1002/mame.202400316","DOIUrl":"https://doi.org/10.1002/mame.202400316","url":null,"abstract":"<p>Graphene, the 2D material and the basic building block of the sp₂ carbon family has received enormous attention from research and industrial communities due to its remarkable properties. Graphene's potential to be implemented is limitless and it varies from medical, water, energy, composites sectors, etc. In this paper, graphene potential in composites, energy storage, and water purification are highlighted. Reviewing, in particular, the crucial role of graphene/polymer interface in improving the mechanical properties of polymer nanocomposites and the effect of constitutive parameters such as graphene lateral size and surface chemistry. Moreover, the latest contributions of graphene and graphene derivatives in functional composites, such as sensors, actuators, hydrogels, and aerogels, are reviewed. This is followed by reviewing graphene and its derivatives for energy storage such as in lithium-ion batteries, metal–air batteries, and graphene-based supercapacitors. Finally, reporting the latest advances in graphene for water treatment, reviewing the different filtration/treatment methods, and the importance of graphene selective permeability properties.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400316","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Raster Angle on 3D Printing of Poly(Lactic Acid)/Thermoplastic Polyurethane Blends: Effects on Mechanical and Shape Memory Properties","authors":"Águeda Sonseca Olalla,&nbsp;Joaquín Lluch Cerezo,&nbsp;Vicente Ruedas Abarca,&nbsp;Lucas Rovira Soriano,&nbsp;Guido Mazzinari,&nbsp;Enrique Giménez Torres","doi":"10.1002/mame.202400427","DOIUrl":"https://doi.org/10.1002/mame.202400427","url":null,"abstract":"<p>In this study, a 60:40 blend of poly(lactic acid) and thermoplastic polyurethane (PLA/TPU) is fabricated using fused material extrusion. The morphological, thermal, mechanical and thermoresponsive cyclic shape memory effect (SME) characteristics of 3D-printed specimens at various raster angles are investigated. This work introduces the innovative utilization of TPU's fibrillar alignment within a PLA matrix to achieve enhanced mechanical anisotropy and consistent shape memory performance. Morphological analysis reveals excellent printability, with the immiscible TPU phase forming submicron-diameter fibrils (≈0.78 ± µm) within the PLA matrix, leading to significant improvements in toughness and elongation at break when aligned with the printing direction and the load. Tensile test demonstrates anisotropy, with 0° raster specimens achieving a UTS of 16.1 ± 0.2 MPa and elongation at 305.5 ± 71.9%, compared to 4.5 ± 0.6 MPa and 10.8 ± 1.5% at 90°. Notably, despite the mechanical anisotropy, shape fixity ratios exceeded 95% and recovery ratios between 91 and 95% were achieved across all raster angles, demonstrating robustness in thermomechanical properties. These findings offer valuable insights into the relationship between morphology, mechanical characteristics, and shape memory behavior of PLA/TPU blends fabricated using fused material extrusion, positioning the material as a strong candidate for biomedical applications requiring precise shape recovery performance.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Longitudinal and Transverse Piezoelectric Effects of the Ferroelectric Polymer P(VDF-TrFE)","authors":"Christine Revenant,&nbsp;Simon Toinet,&nbsp;Eleanor Lawrence Bright,&nbsp;Mohammed Benwadih","doi":"10.1002/mame.202400420","DOIUrl":"https://doi.org/10.1002/mame.202400420","url":null,"abstract":"<p>Polyvinylidene fluoride-trifluoroethylene (P(VDF-TrFE)) exhibits outstanding electromechanical properties and is a material of choice for non-volatile memories, energy-harvesting systems, multifunctional actuators, and sensors. However, this polymer remains one of the least understood materials among ferroelectric materials due to its semi-crystalline structure with chains folding in elongated grains through the lamellae and amorphous regions. Here, operando high-resolution X-ray diffraction is exploited to unravel the P(VDF-TrFE) structural evolution upon the first electric field application, called poling. This X-ray technique allows revealing drastic changes in the lamellae with the ordered amorphous (OA) emergence between crystalline nanodomains. The discovery of this OA emergence is critical because it significantly affects the structure, as well as the mechanical, ferroelectric, and piezoelectric properties of the polymer. After poling, even small nanostructural changes lead to measurable effects yielding the piezoelectric coefficients. The longitudinal and transverse piezoelectric effects can be explained by the complex P(VDF-TrFE) structure. The elongated grains consist of lamellae separated by isotropic amorphous (IA) regions. This study not only sheds light on the fundamental mechanisms occurring in P(VDF-TrFE), but also offers guidance for new ferroelectric organic materials for flexible, biocompatible sensor and energy applications.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weaving Through Fire and Force: Fire Behavior and Fire Stability of Unidirectional, Bidirectional, and Woven Roving Glass-Fiber Composites","authors":"Maria Jauregui Rozo,&nbsp;Sruthi Sunder,&nbsp;Sneha Inasu,&nbsp;Dietmar Meinel,&nbsp;Holger Ruckdäschel,&nbsp;Bernhard Schartel","doi":"10.1002/mame.202400432","DOIUrl":"https://doi.org/10.1002/mame.202400432","url":null,"abstract":"<p>This study systematically investigates the transfer of flame retardants (FRs) from epoxy resins to composites. The flame-retardant composites are formulated using bisphenol A diglycidyl ether as the resin and dicyandiamide as the hardener, reinforced with glass fibers (GFs) using various textile architectures: unidirectional (UD), bidirectional (BD), and woven rovings (WR). These composites are evaluated using bench-scale fire stability tests and cone calorimeter experiments to assess critical parameters, including the temperature at failure, time to failure, and fire behavior. Among the tested configurations, UD-GFs demonstrate superior flame retardancy, fire stability, flammability, and mechanical performance, attributed to their higher residue yield, forming a more efficient protective char layer. However, the addition of FRs is limited by their impact on the material's mechanical properties. When the FR content increases to 30 and 50 wt.% of the resin, the composites exhibit a decrease in mechanical performance, adversely affecting both time to failure and temperature at failure. While adding FRs reduces the risk of fire propagation, it does not substantially enhance fire stability or mechanical performance.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conductive Open-Cell Silicone Foam for Tunable Damping and Impact Sensing Application","authors":"Rene Preuer,&nbsp;Jan Sleichrt,&nbsp;Daniel Kytyr,&nbsp;Philip Lindner,&nbsp;Umut Cakmak,&nbsp;Ingrid Graz","doi":"10.1002/mame.202400273","DOIUrl":"https://doi.org/10.1002/mame.202400273","url":null,"abstract":"<p>Nature has long served as a source of inspiration for the development of new materials, with foam-like structures in citrus fruits such as oranges and pomelos serving as examples of efficient energy dissipation. Inspired by the internal structure of citrus fruit, soft conductive silicone foams are fabricated. The foams are made from a polydimethylsiloxane (PDMS) by mold casting using sugar templates. Addition of silicone oil and carbon black to the silicone allows creation of extremely soft foams that serve as resistive sensor. Completed by a pneumatic radial compression actuator (PRCA) surrounding the foams like a ring in analogy to citrus fruit peel, smart tunable dampers with sensing capabilities are demonstrated. The foams are evaluated for their electrical and mechanical properties alone as well as in conjunction with the PRCA. When pressurized, the PRCA radially compresses the smart foams, allowing to tune their stiffness and thus damping properties. Tunability of this system is evaluated by means of ball drop tests with respect to damping as well as the sensor performance regarding its sensitivity and stability. Overall, the study provides valuable insights into the behavior of conductive silicone foams and their potential as cushioning and impact sensing material.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manufacturing and Biological Potential of Saliva-Loaded Core-Sheath Pressure-Spun Polymeric Fibers","authors":"Vansh Thukral,&nbsp;Nanang Qosim,&nbsp;Andre Kurniawan,&nbsp;Merve Gültekinoğlu,&nbsp;H.M. Thushari U. Herath,&nbsp;Gareth R. Williams,&nbsp;Mohan Edirisinghe","doi":"10.1002/mame.202400403","DOIUrl":"https://doi.org/10.1002/mame.202400403","url":null,"abstract":"<p>The rich array of antimicrobial components in saliva offers alternative treatments for drug-resistant bacteria. One therapeutic challenge associated with the effective delivery of salivary components is the quick degradation of salivary proteins outside the oral environment. In this study, polyethylene oxide (sheath) and polycaprolactone (core) based fibers are successfully synthesized using the pressurized gyration technique. Six different pressure-spun fibers are produced. These fibers are created by varying the quantity of artificial saliva in the sheath layer. This unique and effective methodology of embedding saliva within the sheath of the fiber exhibits enhanced bacterial inhibition against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> with 80% and 78% inhibition efficiency, respectively. This study showcases a novel technique for promoting wound healing, utilizing core-sheath fibers, which have tremendous potential because of their superior antimicrobial properties, while also aiding in the process of epithelialization. In vitro, cytotoxicity test results showed that there is no cytotoxic effect on the fibroblast cell line. As a result, it is evaluated that the produced fiber meshes can be ideal wound dressing material, considering their lack of toxic effects and high antibacterial activity levels.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}