Damion T. Dixon, Darian K. Kanu, Melissa A. Grunlan
{"title":"PCL/Chitosan/Bioglass Hybrid Composite Shape Memory Scaffolds With Accelerated Degradation and Enhanced Bioactivity","authors":"Damion T. Dixon, Darian K. Kanu, Melissa A. Grunlan","doi":"10.1002/mame.70250","DOIUrl":"https://doi.org/10.1002/mame.70250","url":null,"abstract":"<p>“Self-fitting” shape memory polymer (SMP) scaffolds based on cross-linked poly(ε-caprolactone)-diacrylate (PCL-DA) represent a promising regenerative strategy for treating irregular craniomaxillofacial bone defects. Beyond conformal fitting, such scaffolds should exhibit intrinsic bioactivity as well as controlled and robust degradation rates. In prior reports, chitosan (CS) and 45S5 Bioglass (BG) were separately incorporated to form SMP scaffolds. “CS-only” hybrid scaffolds suppressed fungal biofilm formation and accelerated degradation, whereas “BG-only” composite scaffolds induced hydroxyapatite (HAp) mineralization and also accelerated degradation. Herein, “hybrid composite” scaffolds incorporating both CS and BG were developed. Semi-interpenetrating networks were fabricated using PCL-DA and CS-<i>graft</i>-PCL at 90:10 and 75:25 wt% ratios, corresponding to 1 and 2.5 wt% CS, respectively. BG was introduced at 5 and 10 wt%, and localized on the pore walls. These scaffolds retained excellent shape memory behavior despite a reduction in PCL crystallinity. Degradation was faster versus corresponding BG-only and CS-only scaffolds, and robust HAp mineralization was observed after just 1 day in 1X simulated body fluid. The hybrid composite scaffolds were mechanically robust, and HAp mineralization induced a substantial increase in modulus.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148146983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Uniqueness of Supramolecular Systems","authors":"José A. Sánchez-Fernández","doi":"10.1002/mame.70238","DOIUrl":"https://doi.org/10.1002/mame.70238","url":null,"abstract":"<p>Structural innovation requires molecular diversity, and new applications arising from life's challenges demand materials and systems that fulfill a wide range of functions. While supramolecular materials have long been a fundamental source of inspiration for materials engineering, modern nanoscience tools allow the construction of materials with molecular complexity that surpasses supramolecular singularity. While non-covalent interactions on the structure and chemistry of various molecules, complexes, and materials have been extensively investigated, the understanding, utilization, and true nature of supramolecular chemistry have not yet been fully explored and exploited. Therefore, its impact on materials science seems counterintuitive given the increasing demand for diverse functional materials in industrial applications. The aim of this review is to illustrate to the reader the state of the art in the construction of supramolecular architectures, their structural complexity, and the detailed studies of the kinetics and thermodynamics inherent in this challenge. In addition to describing coordination compounds as a whole, such as metal-organic frameworks (MOFs), covalent-organic frameworks (COFs), and metal-organic cages (MOCs), the analyzes of the directionality and tunable interaction strength of mechanically interlocked molecules (MIMs), including catenanes and rotaxanes, which constitute a fascinating class of synthetic molecular architectures with potential applications in molecular switches.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"311 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.70238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148174689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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