Macromolecular Materials and Engineering最新文献_第10页

Transdermal Administration of Nanobody Molecules using Hydrogel-Forming Microarray Patch Technology: A Unique Delivery Approach 利用水凝胶成型微阵列贴片技术透皮给药纳米抗体分子：一种独特的给药方法

IF 3.9 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-03-18 DOI: 10.1002/mame.202400029

Aaron R. J. Hutton, Melissa Kirkby, Tom Van Bogaert, Peter Casteels, Christelle Nonne, Veronique De Brabandere, Ortwin Van de Vyver, Lalit K. Vora, Ismaiel A. Tekko, Helen O. McCarthy, Ryan F. Donnelly

{"title":"Transdermal Administration of Nanobody Molecules using Hydrogel-Forming Microarray Patch Technology: A Unique Delivery Approach","authors":"Aaron R. J. Hutton, Melissa Kirkby, Tom Van Bogaert, Peter Casteels, Christelle Nonne, Veronique De Brabandere, Ortwin Van de Vyver, Lalit K. Vora, Ismaiel A. Tekko, Helen O. McCarthy, Ryan F. Donnelly","doi":"10.1002/mame.202400029","DOIUrl":"10.1002/mame.202400029","url":null,"abstract":"Nanobody molecules, derived from heavy-chain only antibodies in camelids, represent the next generation of biotherapeutics. In addition to low immunogenicity, high stability, and potency, their single-domain format facilitates the construction of multivalent molecules for therapeutic applications. Although predominantly administered using a hypodermic syringe and needle, alternative delivery methods are under investigation. That said, the transdermal route has yet to be explored. Therefore, microarray patch (MAP) technology, offering a potentially high dose, pain-free transdermal system, is employed in this study. Trivalent Nanobody molecules, with and without half-life extension (VHH and VHH[HLE]), are formulated into hydrogel-forming MAPs, with pharmacokinetic parameters assessed in Sprague–Dawley rats. VHH MAPs exhibited a sustained release profile, with a serum concentration of 19 ± 9 ng mL−1 24 h post-administration. In contrast, a subcutaneous (SC) injection showed faster clearance, with a serum concentration of 1.1 ± 0.4 ng mL−1 at 24 h. For VHH(HLE), both SC and MAP cohorts achieved a maximum serum concentration (Tmax) at 24 h. The MAP cohort displayed a notable increase in VHH(HLE) serum levels between 6–24 h, dropping after MAP removal. This study has exemplified MAPs potential for delivering advanced biologics, indicating the transdermal route's promise for pain-free, patient-friendly administration of Nanobody molecules.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140169736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visible Light-Triggered Supramolecular Hydrogel Based on Cyclic Dipeptides Stabilized with Coulomb Interactions 基于库仑相互作用稳定的环状二肽的可见光触发超分子水凝胶

IF 3.9 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-03-15 DOI: 10.1002/mame.202400007

Angelika Seliwjorstow, Marius Bach, Susanne Kirchner, Sarah Palloks, Zbigniew L. Pianowski

引用次数: 0

The Effect of a Low Degree of Fluorine Substitution on Cotton Fiber Properties 低度氟替代对棉纤维性能的影响

IF 3.9 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-03-14 DOI: 10.1002/mame.202470005

Ofir Aharon Kuperman, Peterson de Andrade, Tanguy Terlier, Jacob Judas Kain Kirkensgaard, Robert A. Field, Filipe Natalio

引用次数: 0

Masthead: Macromol. Mater. Eng. 3/2024 刊头：Macromol.Mater.Eng.3/2024

IF 3.9 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-03-14 DOI: 10.1002/mame.202470006

引用次数: 0

Investigating the Effect of ABS on the Mechanical Properties, Morphology, Printability, and 4D Printing of PETG-ABS Blends 研究 ABS 对 PETG-ABS 混合物的机械性能、形态、可印刷性和 4D 印刷的影响

IF 3.9 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-03-13 DOI: 10.1002/mame.202400038

Kiandokht Mirasadi, Davood Rahmatabadi, Ismaeil Ghasemi, Mohammad Khodaei, Majid Baniassadi, Mostafa Baghani

{"title":"Investigating the Effect of ABS on the Mechanical Properties, Morphology, Printability, and 4D Printing of PETG-ABS Blends","authors":"Kiandokht Mirasadi, Davood Rahmatabadi, Ismaeil Ghasemi, Mohammad Khodaei, Majid Baniassadi, Mostafa Baghani","doi":"10.1002/mame.202400038","DOIUrl":"10.1002/mame.202400038","url":null,"abstract":"In this study, Acrylonitrile butadiene styrene (ABS) with three different ratios of 30%, 50%, and 70% is used to enhance the shape memory and mechanical properties of Polyethylene terephthalate glycol (PETG). Additionally, morphology, printability, and dynamic thermomechanical analysis are also examined. The thermal test results show that PETG-ABS compounds have two transition temperatures in the range of 80 and 110 °C, which are related to the components. By changing the weight percentage of PETG from 30 to 70%, three morphologies of matrix-droplet, sea-island, and combination of co-continuous and matrix-droplet are observed. The results of the mechanical properties show an increase in strength with the increase of ABS, which can be justified due to the higher strength of ABS compared to PETG. The highest tensile strength of 32.48 MPa and 15.16% elongation is obtained for PETG-ABS(30-70) and PETG-ABS(70-30), respectively. Due to the better shape memory performance of PETG, PETG-ABS(50-50) and PETG-ABS(70-30) have complete shape recovery, and with the increase of PETG, the shape recovery rate also increased. This diversity in morphology, mechanical properties, and shape memory effect is one of the goals of this research which is well fulfilled.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140128830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recycling of Polyolefins for Multiple Lifecycles 多生命周期的聚烯烃回收利用

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-03-13 DOI: 10.1002/mame.202300421

Megan Matthews, Albert van Reenen

引用次数: 0

Electrospun PCL-Based Materials for Health-Care Applications: An Overview 用于保健应用的电纺 PCL 基材料：概述

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-03-13 DOI: 10.1002/mame.202300388

Teboho Clement Mokhena, Mandla Brian Chabalala, Sivuyisiwe Mapukata, Asanda Mtibe, Lerato Hlekelele, Zamani Cele, Mokgaotsa Jonas Mochane, Bulelwa Ntsendwana, Toitoi Amos Nhlapo, Teboho Patrick Mokoena, Mokae Fanuel Bambo, Kgabo Phillemon Matabola, Suprakas Sinha Ray, Emmanuel Rotimi Sadiku, Katekani Shingange

{"title":"Electrospun PCL-Based Materials for Health-Care Applications: An Overview","authors":"Teboho Clement Mokhena, Mandla Brian Chabalala, Sivuyisiwe Mapukata, Asanda Mtibe, Lerato Hlekelele, Zamani Cele, Mokgaotsa Jonas Mochane, Bulelwa Ntsendwana, Toitoi Amos Nhlapo, Teboho Patrick Mokoena, Mokae Fanuel Bambo, Kgabo Phillemon Matabola, Suprakas Sinha Ray, Emmanuel Rotimi Sadiku, Katekani Shingange","doi":"10.1002/mame.202300388","DOIUrl":"10.1002/mame.202300388","url":null,"abstract":"Polycaprolactone (PCL) is one of the durable polymers with potential in a plethora of healthcare applications. Its biological properties, degradability, chemical properties, and mechanical properties can further be modified to manufacture desired products for modern biomedical applications. Electrospinning of PCL offers the opportunity to design treatment materials that resemble human tissues and facilitate regeneration at the target site. The resultant materials can also be modified by loading other active functional materials to broaden their applications. Herein, the recent advances in the preparation and modification of PCL-based materials for healthcare applications are elucidated. The challenges and future trends for its application in modern biomedical applications are also outlined.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202300388","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140128762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of Short Collagen Nanofibers for Injectable Hydrogels: Comparative Assessment of Fragmentation Methods, Physicomechanical Properties, and Biocompatibility 用于注射水凝胶的短胶原纳米纤维的制备：碎裂方法、物理力学性能和生物相容性的比较评估

IF 3.9 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-03-13 DOI: 10.1002/mame.202300460

Ayoob Karimizade, Amir Mellati

{"title":"Preparation of Short Collagen Nanofibers for Injectable Hydrogels: Comparative Assessment of Fragmentation Methods, Physicomechanical Properties, and Biocompatibility","authors":"Ayoob Karimizade, Amir Mellati","doi":"10.1002/mame.202300460","DOIUrl":"10.1002/mame.202300460","url":null,"abstract":"Collagen nanofibers can be employed in hydrogels to create injectable nanocomposite hydrogels, mimicking the fibrous architecture of the natural extracellular matrix (ECM). As long continuous electrospun collagen nanofibers are not applicable, fragmentation is inevitable to obtain injectable hydrogels with a fine viscosity. Here, four methods: hand grinding (HG), homogenizer (HM), mixer milling (MM), and ultrasonication (UH) are used to disintegrate and shorten collagen nanofiber mats before incorporation into an injectable hyaluronic acid hydrogel as a matrix. The Length-to-diameter (L/d) ratio and morphology of fragmented collagen are compared by SEM. The injection force, mechanical properties, and cell viability of the selected collagen-incorporated hydrogels are also evaluated. UH emerges as the most effective method, yielding the highest L/d ratio of 46 and a notable compressive modulus of 8.7 ± 0.92 kPa. Assessment of the in vitro cell viability of the encapsulated chondrocytes in the collagen-incorporated hydrogels demonstrates good biocompatibility, and hydrogels containing UH short nanofiber, in particular, show an increase in cell proliferation. This work indicates how collagen mats can be effectively broken down and combined with injectable hydrogels to enhance both their mechanical behavior and biocompatibility.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202300460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140128839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Nitrogen-Containing Monomers on the Thermal Degradation and Combustion Attributes of Polystyrenes Chemically Modified With Phosphonate Groups 含氮单体对用膦酸盐基团化学修饰的聚苯乙烯的热降解和燃烧特性的影响

IF 3.9 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-03-12 DOI: 10.1002/mame.202300432

Aloshy Baby, Svetlana Tretsiakova-McNally, Paul Joseph, Jianping Zhang, Malavika Arun

{"title":"The Effects of Nitrogen-Containing Monomers on the Thermal Degradation and Combustion Attributes of Polystyrenes Chemically Modified With Phosphonate Groups","authors":"Aloshy Baby, Svetlana Tretsiakova-McNally, Paul Joseph, Jianping Zhang, Malavika Arun","doi":"10.1002/mame.202300432","DOIUrl":"10.1002/mame.202300432","url":null,"abstract":"In the present study, polystyrene (PS) is chemically modified with diethyl(acryloyloxymethyl)phosphonate (DEAMP) and an N-containing monomer, selected from different classes of compounds, via a ter-polymerization route; thus, exploring possible P–N synergistic effects on fire retardance of the base polymer. The successful incorporation of P and N monomeric units is confirmed by Fourier Transform Infrared (FT-IR), 1H and 31P Nuclear Magnetic Resonance (NMR) spectroscopies. The thermal degradation and combustion attributes of modified polymeric materials are measured using standard techniques, including Thermo-Gravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), “bomb” calorimetry, and Pyrolysis Combustion Flow Calorimetry (PCFC). The thermal and combustion studies demonstrate that the thermal stability and combustion characteristics of styrenic polymers are significantly altered by the presence of even nominal amounts of P- and N-containing groups, and in certain cases, synergistic interactions of these groups are also evident. For instance, as revealed by TGA, the extent of char formation, under the oxidative atmosphere, in the prepared ter-polymers, is enhanced by 16–44%, when compared to the unmodified PS. The heat release rates and heat release capacities of ter-polymers, measured using the PCFC technique, are reduced by 18–50%, in comparison to the same parameters obtained for the unmodified counterpart.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202300432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140117302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of Silk Fibroin-Derived Fibrous Scaffold for Biomedical Frontiers 为生物医学前沿制造蚕丝纤维素衍生纤维支架

IF 3.9 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2024-03-12 DOI: 10.1002/mame.202300422

Mustafijur Rahman, Tanvir Mahady Dip, Md Golam Nur, Rajiv Padhye, Shadi Houshyar

{"title":"Fabrication of Silk Fibroin-Derived Fibrous Scaffold for Biomedical Frontiers","authors":"Mustafijur Rahman, Tanvir Mahady Dip, Md Golam Nur, Rajiv Padhye, Shadi Houshyar","doi":"10.1002/mame.202300422","DOIUrl":"10.1002/mame.202300422","url":null,"abstract":"Silk fibroin (SF), a natural protein derived from silkworms, has emerged as a promising biomaterial due to its biocompatibility, biodegradability, degradation rate, and tunable mechanical properties. This review delves into the intrinsic attributes of SF that make it an attractive candidate for scaffold development in tissue engineering and regenerative medicine. The distinctiveness of this comprehensive review resides in its detailed exploration of recent advancements in the fabrication techniques of SF-based fibrous scaffolds, namely electrospinning, freeze-drying, and 3D printing. An in-depth analysis of these fabrication techniques is conducted to illustrate their versatility in customizing essential scaffold characteristics, such as porosity, fiber diameter, and mechanical strength. The article meticulously discusses process parameters, advantages, and challenges of each fabrication technique, highlighting the innovative advancements made in the respective field. Furthermore, the review goes beyond fabrication techniques to provide an overview of the latest biomedical applications and research endeavors utilizing SF-derived scaffolds. From nerve regeneration and wound healing to drug delivery, bone regeneration, and vascular tissue engineering, the diverse applications underscore the versatility of SF in adopting various biomedical challenges. Finally, the article emphasizes the need for standardized characterization techniques, scalable manufacturing processes, and long-term in vivo studies.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202300422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140128946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0