Macromolecular bioscience最新文献_第3页

Immunological Evaluation of PLLA/GO Scaffolds in Goat Mandibular Bone Regeneration 聚乳酸/氧化石墨烯支架在山羊下颌骨再生中的免疫学评价。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2026-03-17 Epub Date: 2025-12-05 DOI: 10.1002/mabi.202500362

Thamires Santos-Silva, Fernando Gonçalves da Silva Petrônio, Inácio Silva Viana, Raí André Querino Candelaria, Ana Caroline dos Santos, Paulo Alescio Canola, Luís Gustavo Gosuen G. Dias, Rodrigo da Silva Nunes Barreto, Michel Matar, Marcelo Melo Soares, Maria Angelica Miglino

{"title":"Immunological Evaluation of PLLA/GO Scaffolds in Goat Mandibular Bone Regeneration","authors":"Thamires Santos-Silva, Fernando Gonçalves da Silva Petrônio, Inácio Silva Viana, Raí André Querino Candelaria, Ana Caroline dos Santos, Paulo Alescio Canola, Luís Gustavo Gosuen G. Dias, Rodrigo da Silva Nunes Barreto, Michel Matar, Marcelo Melo Soares, Maria Angelica Miglino","doi":"10.1002/mabi.202500362","DOIUrl":"10.1002/mabi.202500362","url":null,"abstract":"<p>Bone repair remains a significant challenge in orthopedics and reconstructive surgery, especially in complex fractures and large tissue defects. Biomaterials such as graphene oxide (GO) and poly-L-lactic acid (PLLA) are promising due to their physicochemical properties and biocompatibility. However, the immune response plays a critical role in graft success. In this study, PLLA/GO scaffolds are implanted in the right antimeres of nine goat mandibles, while the left antimeres are stabilized with titanium plates and serve as controls. Samples are collected at 15-, 45-, and 60-days post- implantation and examined using histology and immunohistochemistry to assess inflammation, bone organization, and bone–implant integration. At 15 days, hematoxylin and eosin staining show early inflammatory reactions at the PLLA/GO interface, whereas control samples display regular histological patterns. At 45 days, denser and more compact bone tissue indicate progressive structural organization. By 60 days, the samples present advanced bone maturation and active osteogenesis. Steven's Blue staining confirms mineral deposition, and osteoblast-like cells deposit new matrix at the scaffold–tissue interface. Immunohistochemical detection of osteocalcin and VEGF reveals osteoblastic activity and angiogenesis. These results demonstrate that PLLA/GO scaffolds promote bone regeneration and integration, supporting their potential for clinical application in mandibular repair.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"26 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12993262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polydopamine-Antibiotic Composite Coating for Antibiofilm Applications 应用于抗生素膜的聚多巴胺-抗生素复合涂层。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2026-03-17 Epub Date: 2025-12-05 DOI: 10.1002/mabi.202500501

Gillian A. Kropp, Hannah Q. Karp, Jayasimha Rao, Henriette Suzanne Muller, Nammalwar Sriranganathan, Elizabeth S. Nowak, Michael D. Schulz

{"title":"Polydopamine-Antibiotic Composite Coating for Antibiofilm Applications","authors":"Gillian A. Kropp, Hannah Q. Karp, Jayasimha Rao, Henriette Suzanne Muller, Nammalwar Sriranganathan, Elizabeth S. Nowak, Michael D. Schulz","doi":"10.1002/mabi.202500501","DOIUrl":"10.1002/mabi.202500501","url":null,"abstract":"<p>Urinary catheterization is a common procedure, affecting 15%–25% of hospitalized patients. This procedure, however, often results in bacterial infections, primarily caused by biofilm-forming Gram-negative bacteria that adhere to the catheter surface. To address this challenge, we developed a polymer-based antimicrobial coating using polydopamine (PD) embedded with gentamicin (Gent). We evaluated the antibiofilm efficacy of this coating (PD-Gent) using a biofilm-forming isolate of <i>Pseudomonas aeruginosa</i> (PAO1) as <i>P. aeruginosa</i> is commonly implicated in catheter-related infections. We observed that the PD-Gent coating significantly reduced biofilm formed by PAO1 compared to the uncoated control. Importantly, the coating maintained its antibiofilm activity across diverse substrates, including polystyrene, poly(vinyl chloride), and silicone. The approach was further extended to incorporate other antibiotics (tobramycin, amikacin), demonstrating adaptability to multiple antimicrobial agents. Finally, artificial urine inoculated with PAO1 was deployed through PD-Gent–coated silicone Foley catheters under continuous flow for 24 h. Despite this continuous introduction of PAO1, the coated catheters inhibited biofilm formation by three-fold compared to the uncoated control catheters. These findings underscore the promise of PD-Gent as a robust, versatile coating with strong potential to significantly reduce the incidence of catheter-associated infections in clinical settings.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"26 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12993261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vegetable Oil-Based Materials for Drug Delivery Systems and Wound Dressings 用于药物输送系统和伤口敷料的植物油基材料。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2026-03-17 Epub Date: 2025-11-27 DOI: 10.1002/mabi.202500486

Lucas M. Favre, Nicolas Masurier, Anne Aubert-Pouëssel

引用次数: 0

Advancements in Promoting Angiogenesis in Tissue-Engineered Grafts in Various Organs: A Comprehensive Review 促进不同器官组织工程移植血管生成的研究进展综述。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2026-03-17 DOI: 10.1002/mabi.202500453

Saeedeh Zare Jalise, Peiman Brouki milan, Elham Kialashaki, Masoud Ghane, Sina Habibi, Arezou Mehrabi

{"title":"Advancements in Promoting Angiogenesis in Tissue-Engineered Grafts in Various Organs: A Comprehensive Review","authors":"Saeedeh Zare Jalise, Peiman Brouki milan, Elham Kialashaki, Masoud Ghane, Sina Habibi, Arezou Mehrabi","doi":"10.1002/mabi.202500453","DOIUrl":"10.1002/mabi.202500453","url":null,"abstract":"<div>\u0000 \u0000 <p>Vascularization remains a fundamental challenge in tissue engineering, directly impacting the survival, integration, and function of engineered grafts across diverse organ systems. This comprehensive review explores the latest advancements in promoting angiogenesis within tissue-engineered constructs, focusing on strategies that emulate natural vascular development to overcome ischemic limitations post-implantation. We examine three core domains of pro-angiogenic intervention: controlled delivery of growth factors (e.g., VEGF, FGF, PDGF), development of bioactive and mechanically tuned biomaterials (such as collagen, gelatin, hyaluronic acid, and decellularized matrices), and cell-based approaches leveraging stem and progenitor cells, including embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells. Novel technologies such as 3D bioprinting, nanofabrication, and the use of extracellular vesicles have further enabled spatial and temporal control over vascular network formation. Organ-specific applications in cardiac, hepatic, dermal, osseous, pancreatic, musculoskeletal, adipose, and corneal tissues illustrate the translational potential of these techniques, while also highlighting the unique vascular requirements of each tissue type. Additionally, unconventional angiogenic inducers, such as parasite-derived proteins, are emerging as potential therapeutic tools. Despite significant progress, challenges remain in achieving long-term vessel stability, synchronizing vascularization with lymphangiogenesis and immunomodulation, and navigating regulatory complexities for clinical implementation. This review underscores the centrality of angiogenesis in regenerative medicine and advocates for continued interdisciplinary efforts to refine vascular integration strategies that will enable durable, functional, and patient-specific tissue replacements.</p>\u0000 </div>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"26 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Agent-Loaded Hydrogels for Implant-Associated Osteomyelitis: A Review 负载抗菌剂的水凝胶治疗种植体相关性骨髓炎：综述。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2026-03-17 Epub Date: 2025-12-18 DOI: 10.1002/mabi.202500528

Bingcheng Ji, Liangmin Zhang, Lin Xiao, Zengchao Guo, Zhijun Liu

{"title":"Antibacterial Agent-Loaded Hydrogels for Implant-Associated Osteomyelitis: A Review","authors":"Bingcheng Ji, Liangmin Zhang, Lin Xiao, Zengchao Guo, Zhijun Liu","doi":"10.1002/mabi.202500528","DOIUrl":"10.1002/mabi.202500528","url":null,"abstract":"<div>\u0000 \u0000 <p>Implant-associated osteomyelitis (IAO) is a major clinical challenge due to persistent biofilms, antibiotic resistance, and impaired osteogenesis. Hydrogels, with tunable physicochemical properties, biocompatibility, and localized drug delivery capabilities, offer advanced solutions to these problems. This review systematically examines advanced hydrogel-based strategies for IAO treatment, categorized into two primary approaches. Antibiotic-loaded hydrogels leverage nanomaterial integration and hybrid composites to achieve precise, spatiotemporal drug release, thereby minimizing toxicity and resistance. Non-antibiotic approaches, including nanomaterial-based agents such as metals and photothermal nanohybrids, as well as peptides, plant polyphenols, and phage therapy, provide alternative options to circumvent antibiotic resistance. Crucially, we highlight key optimization strategies that encompass controlled cross-linking, stimuli-responsive systems (e.g., pH and temperature), anti-biofilm mechanisms, and biomimicry, synergistically enhancing both antibacterial and osteogenic functions in these platforms. Collectively, these advances signify a shift from passive drug carriers to multifunctional, bioactive platforms that both eradicate resistant bacteria and support bone regeneration. This transformative shift, however, reveals persistent challenges while suggesting promising research avenues for advancing hydrogel-based therapies against IAO.</p>\u0000 </div>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"26 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green-Synthesized Bio-ZnO Nanoparticle-Integrated PVA-Chitosan-PMMA Nanofibers Enhanced Antimicrobial and Tissue-Regenerative Diabetic Wound Healing 绿色合成生物氧化锌纳米颗粒-集成pva -壳聚糖- pmma纳米纤维增强抗微生物和组织再生糖尿病伤口愈合。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2026-03-15 DOI: 10.1002/mabi.70172

Teshale Ayano Begeno, Tibebu Shiferaw Kassa, Tassew Belete Bahru, Chen Shuhuan, Shi Jialei, Yong Liu, Lingling Qin, Yaqi Zhang, Zhenxia Du

{"title":"Green-Synthesized Bio-ZnO Nanoparticle-Integrated PVA-Chitosan-PMMA Nanofibers Enhanced Antimicrobial and Tissue-Regenerative Diabetic Wound Healing","authors":"Teshale Ayano Begeno, Tibebu Shiferaw Kassa, Tassew Belete Bahru, Chen Shuhuan, Shi Jialei, Yong Liu, Lingling Qin, Yaqi Zhang, Zhenxia Du","doi":"10.1002/mabi.70172","DOIUrl":"10.1002/mabi.70172","url":null,"abstract":"<div>\u0000 \u0000 <p>Skin wound healing involves proliferation, inflammation, regeneration, and remodeling. These processes are severely impaired in diabetes due to advanced glycation end-product accumulation, excessive reactive oxygen species, and vascular dysfunction, requiring multifunctional therapeutic and innovative wound care approaches. Thus, many electrospun polymeric matrices were investigated to enhance wound-healing efficacy; however, few studies have examined ZnO NPs embedded multi-component polymeric nanofibers for diabetic wound healing, where infection, oxidative stress, and delayed regeneration persist as major impediments to diabetic wound repair. Addressing these challenges, this study developed a novel therapeutic strategy using electrospun nanofibers of poly(vinyl alcohol)-chitosan-poly(methyl methacrylate) (PVA-Cs-PMMA) integrated with biogenic zinc oxide nanoparticles (Bio-ZnO NPs) synthesized from <i>Syzygium guineense</i>. Comprehensively characterized using UV-vis, FTIR, XRD, TEM, SEM-EDX, and XPS analyses, confirming nanoscale crystalline structure and strong polymer-nanoparticle interactions. Bio-ZnO NPs exhibited potent antibacterial activity against <i>Staphylococcus aureus</i> (29.38 ± 0.91 mm) and <i>Escherichia coli</i> (27.82 ± 0.95 mm), alongside strong antioxidant performance (IC<sub>50</sub> = 11.60 mg mL<sup>−1</sup>, R<sup>2</sup> = 0.966). <i>In vivo</i> diabetic wound demonstrated accelerated healing (≥99% closure in 14 days) with enhanced re-epithelialization and collagen deposition, without histopathological abnormalities in major organs. These findings underscore Bio-ZnO NPs@PVA-Cs-PMMA nanofibers as an effective biomaterial with strong potential for advanced diabetic wound management.</p>\u0000 </div>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"26 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Administration of Bombyx mori Silk Fibroin Nanoparticles Modulates the Gut Microbiota in Healthy Mice 口服家蚕丝素纳米颗粒调节健康小鼠肠道微生物群。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2026-03-13 DOI: 10.1002/mabi.202500517

Suting Zhong, Xin Zhao, Qichao Cheng, Lixia Cheng, Mei Yang, Meng Zhang, Quan Wan, Jie Wang, Zongpu Xu, Yajun Shuai, Mingying Yang

{"title":"Oral Administration of Bombyx mori Silk Fibroin Nanoparticles Modulates the Gut Microbiota in Healthy Mice","authors":"Suting Zhong, Xin Zhao, Qichao Cheng, Lixia Cheng, Mei Yang, Meng Zhang, Quan Wan, Jie Wang, Zongpu Xu, Yajun Shuai, Mingying Yang","doi":"10.1002/mabi.202500517","DOIUrl":"10.1002/mabi.202500517","url":null,"abstract":"<div>\u0000 \u0000 <p>Silk fibroin nanoparticles (SFNPs) have shown great promise as oral drug delivery carriers due to their favorable biocompatibility and tunable release properties. However, their effects on the gut microbiota under physiological conditions remain poorly understood. Herein, we systematically investigated the impact of orally administered SFNPs on the composition and temporal dynamics of the gut microbiome in healthy mice. SFNPs were thoroughly characterized, showing stability in intestinal fluid and structural transition to β-sheet conformation. Our results revealed that SFNP administration induced significant, dose-dependent shifts in microbial communities, notably increasing the <i>Firmicutes</i>/<i>Bacteroidota</i> ratio and enriching potentially beneficial genera such as <i>Faecalibaculum</i> and <i>Dubosiella</i>, while reducing taxa associated with inflammation and metabolic disorders. Medium doses (2.4 and 12 mg/kg) promoted sustained potentially beneficial effects, whereas a high dose (60 mg/kg) led to transient dysbiosis and enrichment of the inflammation-related genus <i>Enterorhabdus</i>. These findings underscore the dose-responsive modulatory effects of SFNPs on gut microbiota and highlight the importance of microecological safety in the design of nanocarrier systems for oral administration. This study provides critical insights into the gut-nanoparticle interface and supports the potential of SFNPs in microbiome-based therapeutics.</p>\u0000 </div>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"26 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Vertical-Oriented Microstructures on the Properties of 3D-Printed 5Gt-7Alg-3HA Cartilage Scaffolds 垂直取向微结构对3d打印5Gt-7Alg-3HA软骨支架性能的影响。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2026-03-10 DOI: 10.1002/mabi.202500651

Xiaofang Wu, Kai Chen, Qin Chen, Xinyue Zhang, Cunao Feng, Xiaowei Li, Dekun Zhang

{"title":"The Influence of Vertical-Oriented Microstructures on the Properties of 3D-Printed 5Gt-7Alg-3HA Cartilage Scaffolds","authors":"Xiaofang Wu, Kai Chen, Qin Chen, Xinyue Zhang, Cunao Feng, Xiaowei Li, Dekun Zhang","doi":"10.1002/mabi.202500651","DOIUrl":"10.1002/mabi.202500651","url":null,"abstract":"<div>\u0000 \u0000 <p>The engineering cartilage scaffolds with biomimetic structural features hold critical importance for effective repair and regeneration of damaged cartilage tissue. Recent advancements in 3D printing technology have facilitated the fabrication of multi-layered, gradient scaffolds with precisely controlled macrostructural geometries. However, current 3D-printed scaffolds still fall short of replicating the full spectrum of biomechanical and functional properties inherent to native cartilage. In this study, a 5Gt-7Alg-3HA composite scaffold featuring vertical-oriented microstructures was fabricated by integrating template-freezing orientation and 3D printing technologies. The influence of vertical-oriented microstructures on the scaffold's multifaceted properties was evaluated through comparative analysis with non-oriented scaffolds in the control group. The results revealed that, compared to non-oriented scaffolds, the vertical-oriented scaffolds exhibited a more uniform and interconnected 3D network structure, higher porosity, more suitable swelling and degradation rates, as well as superior biocompatibility. Notably, significant improvements were observed in the mechanical properties of the vertical-oriented scaffolds. In conclusion, these findings may offer a strategic approach for developing next-generation cartilage scaffolds with biomimetic properties.</p>\u0000 </div>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"26 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling Rheology and Structural Properties of Polysaccharides from Porphyridium Purpureum After Alkali Pre-Treatment 紫花卟啉多糖碱预处理后的解旋流变学及结构性质研究。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2026-03-05 DOI: 10.1002/mabi.202500522

Farjana Akter, Anjon Kumar Mondal, Gemma Mestres, Jonas Gustafsson, Peter J. Ralph, Unnikrishnan Kuzhiumparambil

{"title":"Unravelling Rheology and Structural Properties of Polysaccharides from Porphyridium Purpureum After Alkali Pre-Treatment","authors":"Farjana Akter, Anjon Kumar Mondal, Gemma Mestres, Jonas Gustafsson, Peter J. Ralph, Unnikrishnan Kuzhiumparambil","doi":"10.1002/mabi.202500522","DOIUrl":"10.1002/mabi.202500522","url":null,"abstract":"<p>In the quest for sustainable biomaterials, polysaccharides from marine organisms caught attention for their unique chemical and bioactive properties. Their functional properties are significantly dependent on the extraction and preparation methods. Reports on the effect of alkali pre-treatment of the microalgal biomass before extraction on the rheology and structural properties of polysaccharides are limited. In this study, polysaccharides were extracted and fractionated after alkaline pre-treatment of the <i>Porphyridium purpureum</i> biomass at different alkali concentrations (0%, 1%, 3%, and 5% w/v). The effects of alkali concentration on the extraction rate, rheology, and other significant microstructural properties were investigated. The results showed that among all tested conditions, 1% alkali pre-treatment provided the most favorable combination of extractability and functional properties retention. It preserved essential structural features, sustained moderate to high viscosity and viscoelasticity, and yielded a polymer population suitable for viscoelastic applications. Higher alkali concentrations (3% and 5%) were found to cause de-esterification and breakage of glycosidic linkages, resulting in lower polysaccharide yields, lower molecular weight, and weaker viscoelastic properties. These findings not only inform the structural-functional relationship of <i>Porphyridium</i> cellular polysaccharides but also highlight their potential as sustainable alternatives to plant/ macroalgal- or synthetic-derived hydrocolloids for industrial applications.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"26 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Dual-Functional Hydrogel-Based Conductive Electrodes for Accelerated Wound Healing and Motion Sensing 用于加速伤口愈合和运动传感的双功能水凝胶导电电极的研制。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2026-02-28 Epub Date: 2025-11-21 DOI: 10.1002/mabi.202500409

Cihangir Boztepe, Fırat Orhan Bulucu, Reyhan Zengin

{"title":"Development of Dual-Functional Hydrogel-Based Conductive Electrodes for Accelerated Wound Healing and Motion Sensing","authors":"Cihangir Boztepe, Fırat Orhan Bulucu, Reyhan Zengin","doi":"10.1002/mabi.202500409","DOIUrl":"10.1002/mabi.202500409","url":null,"abstract":"<div>\u0000 \u0000 <p>Flexible conductive hydrogel-based electrodes are promising for biomedical use, combining enhanced wound healing, bioelectrical signaling, and real-time motion sensing, with broad potential in personalized medicine, wearable electronics, and smart prosthetics. In this study, electrically conductive hydrogels with dual functionality were developed for accelerated wound healing and motion sensing applications. The hydrogel electrodes were synthesized via a freeze–thaw cross-linking method using polyvinyl alcohol (PVA), crystalline nanocellulose (CNC), Laponite (LAP), and polyaniline (PANI). The influence of CNC and LAP content on the electrical conductivity, mechanical strength, swelling capacity, and degradation behavior of the hydrogels was systematically investigated. The PVA–CNC–LAP/PANI hydrogel optimized for electrical conductivity (1.5 wt.% CNC and 1.25 wt.% LAP) demonstrated outstanding multifunctional performance, combining robust mechanical strength (490 kPa tensile strength, 2.57 mm/mm elongation, 162 kPa elastic modulus, and 656 kJ/m<sup>3</sup> toughness) with excellent electrical properties, including high conductivity (33.65 S/m), reliable sensitivity (gauge factor = 1.74), and remarkable durability (>500 cycles at 20% strain). Biocompatibility and cell migration potential of this hydrogel electrode were assessed through scratch assays using human dermal fibroblasts (HDF). Additionally, the hydrogel's performance was evaluated in flexible sensor, smart finger actuator, and electrocardiogram (ECG) electrode applications. The biocompatible PVA/CNC/PANI-LAP hydrogel electrodes exhibited satisfactory electrical conductivity, excellent mechanical integrity, and electroresponsive behavior, thereby effectively supporting HDF proliferation, directed migration, and motion detection capabilities.</p>\u0000 </div>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"26 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0