Macromolecular bioscience最新文献_第3页

Constructing an Injectable Multifunctional Antibacterial Hydrogel Adhesive to Seal Complex Interfaces Post-Dental Implantation to Improve Soft Tissue Integration. 构建一种可注射的多功能抗菌水凝胶胶粘剂，用于牙种植后复杂界面的密封，以改善软组织的整合。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-01-21 DOI: 10.1002/mabi.202400503

Yubing Hong, Siwei Wang, Abudusaimi Maimaiti, Jiarun Li, Dongying Li, Qinmei Wang, Wei Teng

{"title":"Constructing an Injectable Multifunctional Antibacterial Hydrogel Adhesive to Seal Complex Interfaces Post-Dental Implantation to Improve Soft Tissue Integration.","authors":"Yubing Hong, Siwei Wang, Abudusaimi Maimaiti, Jiarun Li, Dongying Li, Qinmei Wang, Wei Teng","doi":"10.1002/mabi.202400503","DOIUrl":"https://doi.org/10.1002/mabi.202400503","url":null,"abstract":"Soft tissue integration (STI) around dental implants determines their long-term success, and the key is to immediately construct a temporary soft tissue-like barrier to prevent bacterial invasion after implantation and then, promote STI. In response to this need, an injectable multi-crosslinked hydrogel (MCH) with abilities of self-healing, anti-swelling, degradability, and dry/wet adhesion to soft tissue/titanium is developed using gallic acid-graft-chitosan, oxidized sodium alginate, gelatin, and Cu2+ with water and borax solution as solvents, whose properties can be controlled by adjusting its composition and ratio. MCH can not only immediately build a sealing barrier to block the bacterial invasion in the oral simulation environment but also deliver outstanding antibacterial efficacy through the synergism of trapping bacteria and releasing bactericidal agents such as chitosan, gallic acid, aldehyde, and Cu2+. Moreover, MCH has an adjustable ROS-scavenging ability imparted by gallic acid, chitosan, and gelatin to reduce inflammation and can control the release of Cu2+. Based on these, it is believed that by injecting MCH around implants (percutaneous/transmucosal) after surgery, a universal non-aggressive strategy to promote STI can be developed for long-term implant success.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400503"},"PeriodicalIF":4.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GelMA Hydrogels Integrated With aptamer CH6-Functionalized Tetrahedral DNA Nanostructures for Osteoporotic Mandibular Regeneration. 与适配体ch6功能化四面体DNA纳米结构集成的凝胶用于骨质疏松颌骨再生。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-01-21 DOI: 10.1002/mabi.202400471

Shebin Hong, Ya Cui, Dongming He, Hao Wu, Weidong Jiang, Jian Cao, Xudong Wang

{"title":"GelMA Hydrogels Integrated With aptamer CH6-Functionalized Tetrahedral DNA Nanostructures for Osteoporotic Mandibular Regeneration.","authors":"Shebin Hong, Ya Cui, Dongming He, Hao Wu, Weidong Jiang, Jian Cao, Xudong Wang","doi":"10.1002/mabi.202400471","DOIUrl":"https://doi.org/10.1002/mabi.202400471","url":null,"abstract":"Osteoporotic bone regeneration is challenging due to impaired bone formation. Tetrahedral DNA nanostructures (TDN), promising nucleic acid nanomaterials, have garnered attention for their potential in osteoporotic mandibular regeneration owing to their ability to enhance cellular activity and promote osteogenic differentiation. Osteoblasts play a critical role in bone regeneration; however, intracellular delivery of TDN into osteoblasts remains difficult. In this study, a novel osteoblast-targeted CH6 aptamer-functionalized TDN (TDN-CH6) is aimed to develop for osteoporotic mandibular regeneration. This results demonstrated that TDN-CH6 exhibits superior osteoblast specificity and efficient recruitment to bone fracture sites. Furthermore, TDN-CH6 significantly enhances cellular activity and osteogenic differentiation compared to TDN alone. Notably, Gelatin Methacryloyl (GelMA) hydrogels incorporating TDN and TDN-CH6 shows improved biological performance and are favorable for osteoporotic mandibular regeneration, suggesting that this platform represents a promising strategy for addressing complex bone defects.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400471"},"PeriodicalIF":4.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CP/HA/HGF Conductive Composite Scaffolds with Synergistic Electrical Stimulation for Nerve Regeneration. CP/HA/HGF导电复合支架协同电刺激神经再生。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-01-21 DOI: 10.1002/mabi.202400265

Yahao Ma, Cong Wang, Jun Li, Pengfei Xie, Longyou Xiao, Seeram Ramakrishna, Nuan Chen, Xiaoying Wang, Liumin He

引用次数: 0

Designing Short Cardin-Motif Peptide and Biopolymer-Based Multicomponent Hydrogels for Developing Advanced Composite Scaffolds for Improving Cellular Behavior. 设计短基序肽和基于生物聚合物的多组分水凝胶用于开发先进的复合支架以改善细胞行为。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-01-21 DOI: 10.1002/mabi.202400555

Sourav Sen, Rakesh Kumar, Rahul Singh Tomar, Sangita Roy

{"title":"Designing Short Cardin-Motif Peptide and Biopolymer-Based Multicomponent Hydrogels for Developing Advanced Composite Scaffolds for Improving Cellular Behavior.","authors":"Sourav Sen, Rakesh Kumar, Rahul Singh Tomar, Sangita Roy","doi":"10.1002/mabi.202400555","DOIUrl":"https://doi.org/10.1002/mabi.202400555","url":null,"abstract":"Multicomponent self-assembly represents a cutting-edge strategy in peptide nanotechnology, enabling the creation of nanomaterials with enhanced physical and biological characteristics. This approach draws inspiration from the highly complex nature of the native extracellular matrix (ECM) constituting multicomponent biomolecular entities. In recent years, the combination of bioactive peptide with polymer has gained significant attention for the fabrication of novel biomaterials due to their inherent specificity, tunable physiochemical properties, biocompatibility, and biodegradability. This advanced strategy can address the limitation of the lower mechanical strength of the individual peptide hydrogel by incorporating the biopolymer, resulting in the formation of a composite scaffold. In this direction, this advanced strategy is explored using noncovalent interactions between cellulose nano-fiber (CNF) and cationic Cardin-motif peptide to develop advanced composite scaffolds. The bioactive cationic peptide otherwise failed to form hydrogel at physiological conditions. Interestingly, the differential mixing ratio of CNF and peptide modulated the surface charge, functionality, and mechanical properties of the composite scaffolds, resulting in diverse cellular responses. 10:1 (w/w) ratio of CNF and peptide-based composite scaffold demonstrates improved cellular survival and proliferation in 2D culture conditions. Notably, in 3D cultures, cell proliferation on the 10:1 matrix is comparable to Matrigel, highlighting its potential for advanced tissue engineering applications.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400555"},"PeriodicalIF":4.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Macromol. Biosci. 1/2025

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-01-13 DOI: 10.1002/mabi.202570001

引用次数: 0

Enhancing Hemocompatibility in ECMO Systems With a Fibrinolytic Interactive Coating: in Vitro Evaluation of Blood Clot Lysis Using a 3D Microfluidic Model. 增强血液相容性在ECMO系统与纤溶相互作用涂层：在体外评估血凝块溶解使用三维微流体模型。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-01-13 DOI: 10.1002/mabi.202400530

Lena Witzdam, Samarth Sandhu, Suji Shin, Yeahwa Hong, Shanzeh Kamal, Oliver Grottke, Keith E Cook, Cesar Rodriguez-Emmenegger

{"title":"Enhancing Hemocompatibility in ECMO Systems With a Fibrinolytic Interactive Coating: in Vitro Evaluation of Blood Clot Lysis Using a 3D Microfluidic Model.","authors":"Lena Witzdam, Samarth Sandhu, Suji Shin, Yeahwa Hong, Shanzeh Kamal, Oliver Grottke, Keith E Cook, Cesar Rodriguez-Emmenegger","doi":"10.1002/mabi.202400530","DOIUrl":"https://doi.org/10.1002/mabi.202400530","url":null,"abstract":"Blood-contacting medical devices, especially extracorporeal membrane oxygenators (ECMOs), are highly susceptible to surface-induced coagulation because of their extensive surface area. This can compromise device functionality and lead to life-threatening complications. High doses of anticoagulants, combined with anti-thrombogenic surface coatings, are typically employed to mitigate this risk, but such treatment can lead to hemorrhagic complications. Therefore, bioactive surface coatings that mimic endothelial blood regulation are needed. However, evaluating these coatings under realistic ECMO conditions is both expensive and challenging. This study utilizes microchannel devices to simulate ECMO fluid dynamics and assess the clot-lysis efficacy of a self-activating fibrinolytic coating system. The system uses antifouling polymer brushes combined with tissue plasminogen activator (tPA) to induce fibrinolysis at the surface. Here, tPA catalyzes the conversion of blood plasminogen into plasmin, which dissolves clots. This positive feedback loop enhances clot digestion under ECMO-like conditions. This findings demonstrate that this coating system can significantly improve the hemocompatibility of medical device surfaces.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400530"},"PeriodicalIF":4.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4-O-Methylglucuronoxylan from Hygrophila Ringens var. Ringens Seeds: Chemical Composition and Anti-Inflammatory Activity. 4- o -甲基葡萄糖醛酸氧化酶来自喜湿草的种子：化学成分和抗炎活性。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-01-13 DOI: 10.1002/mabi.202400434

Vo Hoai Bac, Tat Cuong Trinh, Andreas Koschella, Thomas Heinze, Yu Ping Fu, Kari Tvete Inngjerdingen, Le Van Truong, Berit Smestad Paulsen, Martin Gericke

{"title":"4-O-Methylglucuronoxylan from Hygrophila Ringens var. Ringens Seeds: Chemical Composition and Anti-Inflammatory Activity.","authors":"Vo Hoai Bac, Tat Cuong Trinh, Andreas Koschella, Thomas Heinze, Yu Ping Fu, Kari Tvete Inngjerdingen, Le Van Truong, Berit Smestad Paulsen, Martin Gericke","doi":"10.1002/mabi.202400434","DOIUrl":"https://doi.org/10.1002/mabi.202400434","url":null,"abstract":"Hygrophila ringens var. ringens is a medicinal plant of the Acanthaceae family. A soluble polysaccharide is extracted from H. ringens seeds using warm water, followed by deproteinization and purification using column chromatography. DL1 is characterized comprehensively using spectroscopic and chromatographic techniques and identified as a polymer containing xylose (Xyl; 78.5%) and 4-O-methyl-d-glucuronic acid (4-O-MeGlcA; 21.5 %). The most prominent glycosidic linkages detected are terminal-xylose (T-Xyl); 1,2,3,4-Xylp; 1,2,4-Xylp; and T-4-O-MeGlcA. DL1 belongs to the xylan group and is a 4-O-methylglucuronoxylan. DL1 exhibits inhibition of bovine serum albumin denaturation with IC50 values of 0.35 mg mL-1 and a similar activity to diclofenac (non-steroidal anti-inflammatory drug). In a model of lipopolysaccharide-stimulated macrophages, DL1 (20-40 µg mL-1) strongly inhibits inflammatory cytokines and reactive oxygen species release without having significant macrophage cytotoxicity. The inhibitory effect of DL1 on inflammatory cytokines is mediated by the activation of mitogen-activated protein kinases by inhibiting the phosphorylation of p38 and extracellular signal-regulated kinase. These results highlight the potential of DL1 for treating inflammation through its cytokine-suppressive activity.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400434"},"PeriodicalIF":4.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Thin Polymer Layer Prepared from Liposomes and Polyelectrolytes for TGF-β₃ Release in Tissue Engineering. 脂质体和聚电解质制备TGF-β3在组织工程中释放的薄聚合物层的表征

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-01-13 DOI: 10.1002/mabi.202400447

Nils Meier, Leonie Berten-Schunk, Yvonne Roger, Robert Hänsch, Andrea Hoffmann, Heike Bunjes, Wibke Dempwolf, Henning Menzel

{"title":"Characterization of Thin Polymer Layer Prepared from Liposomes and Polyelectrolytes for TGF-β3 Release in Tissue Engineering.","authors":"Nils Meier, Leonie Berten-Schunk, Yvonne Roger, Robert Hänsch, Andrea Hoffmann, Heike Bunjes, Wibke Dempwolf, Henning Menzel","doi":"10.1002/mabi.202400447","DOIUrl":"https://doi.org/10.1002/mabi.202400447","url":null,"abstract":"Implant-integrated drug delivery systems that enable the release of biologically active factors can be part of an in situ tissue engineering approach to restore biological function. Implants can be functionalized with drug-loaded nanoparticles through a layer-by-layer assembly. Such coatings can release biologically active levels of growth factors. Sustained release is desired for many in vivo applications. The layer-by-layer technique also allows for the addition of extra layers, which can serve as \"barriers\" to delay the release. Electrospun Polycaprolactone (PCL) fiber mats are modified with a Chitosan (CS) grafted with PCL sidechains (CS-g-PCL24) and coated with transforming growth factor beta 3 (TGF-β3) loaded Chitosan/tripolyphosphate nanoparticles as a drug delivery system. Additional layers including polystyrene sulfonate, alginate, carboxymethyl cellulose, and liposomes (phosphatidylcholine) are applied. Streaming potential and X-ray photoelectron spectroscopy (XPS) measurements indicated a strong interpenetration of the chitosan and polyanion layers, while liposomes formed separate layers, which are more promising for sustained release. All samples release TGF-β3 at different cumulative levels without altering release kinetics. Variations in layer structure, interpenetration, and stability depending on the chitosan used are observed, which ultimately has minimal impact on the release kinetics. Polyelectrolyte layers strongly interpenetrated the active layers and therefore do not act as effective diffusion barriers, while the liposome layer, though separated, lacked sufficient stability.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400447"},"PeriodicalIF":4.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Macromol. Biosci. 1/2025

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-01-13 DOI: 10.1002/mabi.202570002

引用次数: 0

Development of Antibacterial Hydrogels Based on Biopolymer Aloe Vera/Gelatin/Sodium Alginate Composited With SM-AgNPs Loaded Curcumin-Nanoliposomes. 生物聚合物芦荟/明胶/海藻酸钠复合SM-AgNPs负载姜黄素纳米脂质体抗菌水凝胶的研制

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-01-02 DOI: 10.1002/mabi.202400504

Apichart Saenchoopa, Kittiya Plaeyao, Chanon Talodthaisong, Wonn Shweyi Thet Tun, Pitak Nasomjai, Sarawut Lapmanee, La-Or Somsakeesit, James A Hutchison, Sirinan Kulchat

{"title":"Development of Antibacterial Hydrogels Based on Biopolymer Aloe Vera/Gelatin/Sodium Alginate Composited With SM-AgNPs Loaded Curcumin-Nanoliposomes.","authors":"Apichart Saenchoopa, Kittiya Plaeyao, Chanon Talodthaisong, Wonn Shweyi Thet Tun, Pitak Nasomjai, Sarawut Lapmanee, La-Or Somsakeesit, James A Hutchison, Sirinan Kulchat","doi":"10.1002/mabi.202400504","DOIUrl":"https://doi.org/10.1002/mabi.202400504","url":null,"abstract":"To address the rising prevalence of bacterial infections and the need for innovative therapeutic solutions, this study has developed a novel antibacterial hydrogel composite composed of Aloe vera, gelatin, sodium alginate, and Sterculia monosperma-silver nanoparticles (SM-AgNPs) loaded curcumin-nanoliposomes (NLPs). The aloe vera/gelatin/sodium alginate hydrogels (AGS) are prepared using different weight ratios of Aloe vera, gelatin, and sodium alginate, aiming to optimize mechanical properties and biocompatibility for biomedical applications. The incorporation of SM-AgNPs and curcumin-loaded NLPs enhanced the hydrogels' antibacterial properties. Characterizations of the hydrogels are performed by using Fourier-transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. Additional examinations, such as water absorption analysis, rheology measurements, thermal stability, and injectability, along with pH and temperature responsiveness, are also conducted. The AGS-3 hydrogel formulation, with a 1:5:3 ratio of Aloe vera to gelatin to sodium alginate, exhibited significant performance in all tests, making it suitable for further experiments. Furthermore, antimicrobial activity assays showed that AGS hydrogels containing SM-AgNPs/NLP composites effectively inhibited the growth of both gram-positive Staphylococcus aureus (S.aureus) and gram-negative Escherichia coli (E.coli) bacteria. These results indicate that the SM-AgNPs/NLP-AGS hydrogel is a promising material for biomedical applications including wound healing, infection prevention, and targeted drug delivery.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400504"},"PeriodicalIF":4.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0