Macromolecular bioscience最新文献_第3页

Synthesis and Characterization of In Situ Chitosan/Cyclodextrin/Catechol Gel for Rapamycin Delivery. 雷帕霉素原位递送壳聚糖/环糊精/儿茶酚凝胶的合成与表征。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-03-19 DOI: 10.1002/mabi.202400596

Bingbing Cui, Haohao Cui, Xingchen Geng, Nan Zhang, Liuqi Shi, Zhanrong Li, Jianliang Shen, Jingguo Li

{"title":"Synthesis and Characterization of In Situ Chitosan/Cyclodextrin/Catechol Gel for Rapamycin Delivery.","authors":"Bingbing Cui, Haohao Cui, Xingchen Geng, Nan Zhang, Liuqi Shi, Zhanrong Li, Jianliang Shen, Jingguo Li","doi":"10.1002/mabi.202400596","DOIUrl":"https://doi.org/10.1002/mabi.202400596","url":null,"abstract":"Innovative in situ drug-releasing hydrogels are emerging as a promising therapeutic strategy for anterior segment ocular diseases, leveraging the unique anatomy of the eye. Rapamycin (RAP) is an effective immunosuppressive agent for organ transplantation; however, high hydrophobicity and low bioavailability have strongly constrained its clinical application. Chitosan (CS) is used as the backbone, and RAP can be loaded through supramolecular host-guest interactions of cyclodextrin (CD) to obtain chitosan-conjugated-(cydodextrin with 3,4-dihydroxyhrocinnamic acid) and loaded with rapamycin (CCH/RAP) with controlled drug release properties. Here, an in situ drug-releasing hydrogel prepared by a simple amidation reaction is reported. It is discovered that the prepared conjugated polymers can form hydrogel crosslinked networks through non-covalent bonds. The design of the in situ hydrogel allows for excellent transparency and suitable pore size, which can ensure that it can be used in ocular applications. Moreover, drug release results show that the introduction of CD effectively delays the initial release of RAP. This pioneering work presents an eco-friendly method for fabricating hydrogels with superior drug delivery capabilities, which hold significant potential in mitigating immune rejection following corneal transplantation.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400596"},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular Behaviors of Human Dermal Fibroblasts on Pyrolytically Stripped Carbon Nanofiber's Surface 人皮肤成纤维细胞在热解剥离碳纳米纤维表面的细胞行为

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-03-12 DOI: 10.1002/mabi.202570005

Iruthayapandi Selestin Raja, Moon Sung Kang, Jeesu Kim, Minseok Kwak, Dong-Wook Han

引用次数: 0

Issue Information: Macromol. Biosci. 3/2025 资料:宏mol。Biosci 3/2025。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-03-12 DOI: 10.1002/mabi.202570006

引用次数: 0

RETRACTION: Generation of Haploid Spermatids on Silk Fibroin-Alginate-Laminin-Based Porous 3D Scaffolds 摘要：单倍体精子在丝素-海藻酸盐-层粘连蛋白三维多孔支架上的生成。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-03-11 DOI: 10.1002/mabi.202570574

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Combination of Dendrimers and Exosomes: Implications for Biomedical Applications. 树状大分子和外泌体的结合：生物医学应用的意义。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-03-08 DOI: 10.1002/mabi.202500014

You Ji, Yunqi Guo, Guixiang Zhang, Amitav Sanyal, Mingwu Shen, Xiangyang Shi

引用次数: 0

Silk Fibroin-Based Hydrogels Supplemented with Decellularized Extracellular Matrix and Gelatin Facilitate 3D Bioprinting for Meniscus Tissue Engineering. 基于丝素蛋白的水凝胶添加脱细胞细胞外基质和明胶促进半月板组织工程的3D生物打印。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-03-06 DOI: 10.1002/mabi.202400515

Jennifer Fritz, Anna-Christina Moser, Alexander Otahal, Heinz Redl, Andreas H Teuschl-Woller, Karl H Schneider, Stefan Nehrer

{"title":"Silk Fibroin-Based Hydrogels Supplemented with Decellularized Extracellular Matrix and Gelatin Facilitate 3D Bioprinting for Meniscus Tissue Engineering.","authors":"Jennifer Fritz, Anna-Christina Moser, Alexander Otahal, Heinz Redl, Andreas H Teuschl-Woller, Karl H Schneider, Stefan Nehrer","doi":"10.1002/mabi.202400515","DOIUrl":"https://doi.org/10.1002/mabi.202400515","url":null,"abstract":"The human meniscus transmits high axial loads through the knee joint. This function is compromised upon meniscus injury or treatment by meniscectomy. 3D printing of meniscus implants has emerged as a promising alternative treatment, as it allows for precise mimicry of the meniscus architecture. In this study, silk fibroin (SF) known for its excellent mechanical properties is used to fabricate hydrogels for 3D bioprinting with infrapatellar fat pad-derived mesenchymal stem cells (IFP-MSCs). Extracellular matrix (ECM) derived from bovine menisci and gelatin are added to 10% SF to promote cell adhesion and printability. To examine the mutual influence of cells and biomaterial, experiments are conducted with and without IFP-MSCs. The cells are found to influence crosslinking, β-sheet formation, and mechanical strength. Variations between printed and casted hydrogels are identified for cell number, metabolic activity, secondary structure, and mechanical strength. Remarkably, the printed hydrogels with IFP-MSCs exhibited a compressive Young's modulus of 0.16 MPa, which closely resembled that of human osteoarthritic menisci. After initial low viability, IFP-MSCs in the casted hydrogels are able to proliferate within the biomaterial. The chondrogenic differentiation medium upregulated the expression of chondrogenic markers in the casted hydrogels, indicating promising prospects for future meniscus tissue engineering (TE).","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400515"},"PeriodicalIF":4.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Poly (2-hydroxyethyl ethyleneimine) and Its Mucoadhesive Film Formulations When Blended with Chitosan for Buccal Delivery of Haloperidol. 聚（2-羟乙基乙烯亚胺）的合成及其与壳聚糖复配氟哌啶醇口腔给药的黏附膜配方

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-03-03 DOI: 10.1002/mabi.202400642

Sitthiphong Soradech, Adrian C Williams, Vitaliy V Khutoryanskiy

{"title":"Synthesis of Poly (2-hydroxyethyl ethyleneimine) and Its Mucoadhesive Film Formulations When Blended with Chitosan for Buccal Delivery of Haloperidol.","authors":"Sitthiphong Soradech, Adrian C Williams, Vitaliy V Khutoryanskiy","doi":"10.1002/mabi.202400642","DOIUrl":"https://doi.org/10.1002/mabi.202400642","url":null,"abstract":"Mucoadhesive films are attractive for buccal drug delivery because of their extended retention on the mucosal surface, enabling sustained drug delivery to and across the tissue. In this study, poly(2-hydroxyethyl ethyleneimine) (P2HEEI) was synthesized by reacting linear polyethyleneimine (L-PEI) with 2-bromoethanol and combined with chitosan to formulate mucoadhesive films for buccal delivery of haloperidol. The polymer displayed excellent solubility in water, a low glass transition temperature (-31.6 °C) and low toxicity in human dermal skin fibroblast cells. This polymer was then blended with chitosan before films were formed by a casting technique. Differential scanning calorimetry and scanning electron microscopy confirmed that chitosan and P2HEEI were fully miscible in the blends. The films based on chitosan-P2HEEI blends were more elastic and had enhanced mechanical properties. Films containing haloperidol were also formulated. The release of haloperidol from the films increased as the P2HEEI content in the blends was raised. Mucoadhesion of these films on ex vivo sheep buccal mucosal tissues was evaluated using a tensile method. All films were mucoadhesive but increasing P2HEEI content in the blend gradually reduced adhesion to the buccal mucosa.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400642"},"PeriodicalIF":4.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenol Microneedles for Dermatological Therapy. 用于皮肤病治疗的多酚微针。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-02-28 DOI: 10.1002/mabi.202400607

Chubao Liu, Jinhui Ran, Zhiping Xie, Xiong Lu, Xiaojing Liu, Chaoming Xie

{"title":"Polyphenol Microneedles for Dermatological Therapy.","authors":"Chubao Liu, Jinhui Ran, Zhiping Xie, Xiong Lu, Xiaojing Liu, Chaoming Xie","doi":"10.1002/mabi.202400607","DOIUrl":"https://doi.org/10.1002/mabi.202400607","url":null,"abstract":"Dermatological diseases represent one of the most prevalent health concerns globally, with associated care and treatment costs having consistently increased over the past decade. Current therapeutic modalities, including topical medications, oral pharmaceuticals, and physical therapies, frequently face challenges such as inadequate drug absorption and substantial adverse effects. Microneedles, recognized as minimally invasive drug delivery systems, effectively penetrate the cutaneous barrier to enhance drug permeability and therapeutic efficacy. Polyphenols-abundant in botanical and marine sources-demonstrate diverse pharmacological properties encompassing anti-inflammatory and antioxidant activities. The integration of polyphenols with microneedle technology has emerged as a promising therapeutic strategy for dermatological conditions, demonstrating significant clinical potential. This review examines the multifunctional capabilities of polyphenol-incorporated microneedles and elucidates their mechanisms of action in managing dermatological disorders. Furthermore, it synthesizes recent progress in polyphenol-based microneedle applications for various cutaneous pathologies, including acne vulgaris, psoriasis, and atopic dermatitis. Finally, current challenges is discussed and proposed future research directions for optimizing polyphenol microneedle systems in dermatological therapeutics.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400607"},"PeriodicalIF":4.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NIR-Responsive ZIF-8 Metal-Organic Framework Nanohybrids with Photothermal, Antimicrobial, and Osteoinductive Properties to Prevent Implant Infection. NIR-Responsive ZIF-8金属-有机框架纳米杂化物，具有光热、抗菌和骨诱导特性，以防止种植体感染。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-02-27 DOI: 10.1002/mabi.202400594

Cho-E Choi, Yasmeen Shamiya, Wei Luo, Arghya Paul

{"title":"NIR-Responsive ZIF-8 Metal-Organic Framework Nanohybrids with Photothermal, Antimicrobial, and Osteoinductive Properties to Prevent Implant Infection.","authors":"Cho-E Choi, Yasmeen Shamiya, Wei Luo, Arghya Paul","doi":"10.1002/mabi.202400594","DOIUrl":"https://doi.org/10.1002/mabi.202400594","url":null,"abstract":"Current treatments for bone injuries face notable limitations such as adverse reactions to implant materials and increased risks of infection. There is an essential need for a therapeutic that will address these issues and decrease recovery times. Herein, a multifunctional nanohybrid zinc-based metal-organic framework integrated with gold nanoparticles (Au@ZIF-8) is synthesized to promote antibacterial and osteogenic benefits. Au@ZIF-8 is capable of converting light energy into heat and has demonstrated its ability to increase the surrounding temperature by ≈30 °C. As a result, Au@ZIF-8 has exhibited bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) upon exposure to near-infrared (NIR) irradiation. Concurrently, Au@ZIF-8 sustains the release of zinc ions from the nanohybrid for the potential of bone repair. When combined with a gelatin-based hydrogel, Au@ZIF-8 significantly elevated osteogenic gene expression and promoted preosteoclast differentiation through the sustained zinc ion release, as opposed to a gel-only control. The potential of the multifunctional nanohybrid is further demonstrated as a coating material for titanium orthopedic implants to introduce antibacterial properties and promote osteogenic differentiation of preosteoblasts for bone healing. Given its excellent antibacterial in response to NIR irradiation and osteogenic abilities, Au@ZIF-8 is a promising photothermal therapy for bone injuries.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e2400594"},"PeriodicalIF":4.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan/Sodium Tripolyphosphate Microemulsion Enhanced Oral Insulin Delivery via Intestinal Lymphoid 壳聚糖/三聚磷酸钠微乳增强胰岛素经肠淋巴组织的口服递送。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-02-27 DOI: 10.1002/mabi.202400520

Zhengpeng Zhong, Fuping Wang, Xue Gong, Changfu Hu, Guobao Chen, Zhongmin Chen

{"title":"Chitosan/Sodium Tripolyphosphate Microemulsion Enhanced Oral Insulin Delivery via Intestinal Lymphoid","authors":"Zhengpeng Zhong, Fuping Wang, Xue Gong, Changfu Hu, Guobao Chen, Zhongmin Chen","doi":"10.1002/mabi.202400520","DOIUrl":"10.1002/mabi.202400520","url":null,"abstract":"Oral insulin delivery systems are currently being explored as the best alternative to subcutaneous injections, aiming to overcome gastrointestinal barriers and achieve efficient oral insulin delivery. This study presents a microemulsion delivery system that utilizes chitosan/sodium tripolyphosphate (CS/STPP) to enhance the stability of kernel-loaded insulin and increase bioavailability via intestinal absorption and lymphatic transport. The insulin/chitosan/sodium tripolyphosphate-microemulsion (Ins/CS/STPP-ME) is a particle size of (81.03 ± 7.19) nm and a polydispersity index (PDI) of (0.313 ± 0.013). Infrared spectroscopy confirms insulin encapsulation. Ins/CS/STPP-ME exhibits favorable stability and releasesproperties in gastrointestinal fluids, retaining a maximum of (53.076 ± 12.587)% insulin in a pepsin environment and (62.982 ± 13.105)% in a trypsin environment after 60 min. In vivo studies have demonstrated that the addition of CS/STPP to the internal phase of Ins/CS/STPP-ME results in a rapid onset of action and sustained hypoglycaemic effect in diabetic rats. Lymphatic blockade by cycloheximide verified Ins/CS/STPP-ME and its ability to cross the gut and enter the bloodstream via lymphatic transport. This work demonstrates that Ins/CS/STPP-ME can stabilize proteins in the gastrointestinal environment, facilitate lymphatic absorption, enhance bioavailability, and provide longer-lasting hypoglycemic effects, thus providing the possibility for oral biomacromolecule delivery.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0