Macromolecular bioscience最新文献

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A Tissue Engineering's Guide to Biomimicry. 组织工程仿生指南。
IF 4.4 4区 医学
Macromolecular bioscience Pub Date : 2025-06-29 DOI: 10.1002/mabi.202500093
Kenny A van Kampen, Carlos Mota, Lorenzo Moroni
{"title":"A Tissue Engineering's Guide to Biomimicry.","authors":"Kenny A van Kampen, Carlos Mota, Lorenzo Moroni","doi":"10.1002/mabi.202500093","DOIUrl":"https://doi.org/10.1002/mabi.202500093","url":null,"abstract":"<p><p>Biomimicry is a broadly used term in many fields such as in architecture and industrial design to pharmacology and many others. Biomimicry tries to replicate a product or process that occurs in the natural environment. However, due to the broad use of the term biomimicry it becomes unclear what is exactly being mimicked. Specifically, in tissue engineering and regenerative medicine (TERM) where research is focussed on mimicking complex native tissue, the term biomimicry is often used to designate a single aspect. Therefore, in TERM biomimicry can be clustered into to three different categories correlated to the aspect that is being mimicked: i) mechanical - that has a focus on obtaining the correct mechanical properties of a tissue; ii) morphological - that aims at recreating a scaffold that has a similar morphology to its native counterpart; iii) biological - that has a prime focus on recreating the biological microenvironment that is found in the targeted tissue. This review discusses the strategies and methods how these different forms of biomimicry can be achieved with the current techniques available.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00093"},"PeriodicalIF":4.4,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of Lithium/Strontium-Releasing Smart Bioactive Glasses with Anti-Inflammatory and Osteogenic Effects Tailored to Pathological Stages. 具有抗炎和成骨作用的锂/锶释放智能生物活性眼镜的制备
IF 4.4 4区 医学
Macromolecular bioscience Pub Date : 2025-06-29 DOI: 10.1002/mabi.202500268
Hirohiko Sakai, Jun-Ichi Sasaki, Haruaki Kitagawa, Gabriela L Abe, Tomoki Kohno, Naoya Funayama, Satoshi Imazato
{"title":"Fabrication of Lithium/Strontium-Releasing Smart Bioactive Glasses with Anti-Inflammatory and Osteogenic Effects Tailored to Pathological Stages.","authors":"Hirohiko Sakai, Jun-Ichi Sasaki, Haruaki Kitagawa, Gabriela L Abe, Tomoki Kohno, Naoya Funayama, Satoshi Imazato","doi":"10.1002/mabi.202500268","DOIUrl":"https://doi.org/10.1002/mabi.202500268","url":null,"abstract":"<p><p>Bioactive glasses (BGs) are highly biocompatible with affinity for hard tissues and exhibit high bioactivity through ion release. Smart BGs that allow controlled ion release are required because uncontrolled release can lead to unexpected adverse effects on tissue regeneration. Strontium promotes osteoblast differentiation of mesenchymal stem cells (MSCs) and inhibits osteoclast activity. In this study, the release profile of strontium is regulated by the incorporation of aluminum into a phosphate-based BG. Furthermore, composites of strontium-releasing BG and lithium-releasing BG (Li/Sr-BG) show stepwise ion release, with rapid lithium release followed by sustained strontium release. Li/Sr-BG increases the expression of osteogenic markers and mineral deposition in MSCs, but suppresses osteoclast maturation, including multinucleation and osteoclast marker expression. Additionally, application of Li/Sr-BG to inflammatory macrophages decreases phagocytic activity and inflammatory gene expression, while increasing the expression of anti-inflammatory markers. Analysis of signaling proteins reveals that osteogenic and anti-inflammatory effects of Li/Sr-BG are attributed to the release of strontium and lithium, respectively. This study demonstrates that Li/Sr-BGs can be used for the development of novel smart bioactive materials that effectively suppress inflammation and promote bone formation in a manner that follows the process of bone regeneration.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00268"},"PeriodicalIF":4.4,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticle-Embedded GelMA/NIPAm Hydrogels: A Temperature-Responsive Hybrid System for Controlled Drug Release. 纳米颗粒嵌入凝胶/NIPAm水凝胶:用于控制药物释放的温度响应混合系统。
IF 4.4 4区 医学
Macromolecular bioscience Pub Date : 2025-06-29 DOI: 10.1002/mabi.202400635
Maria Daaboul, Ayse Akkaya, Zehra Kanli, Oguzhan Gunduz, Banu Aydın, Emine Alarcin, Mehmet Murat Ozmen, Murat Topuzogullari
{"title":"Nanoparticle-Embedded GelMA/NIPAm Hydrogels: A Temperature-Responsive Hybrid System for Controlled Drug Release.","authors":"Maria Daaboul, Ayse Akkaya, Zehra Kanli, Oguzhan Gunduz, Banu Aydın, Emine Alarcin, Mehmet Murat Ozmen, Murat Topuzogullari","doi":"10.1002/mabi.202400635","DOIUrl":"https://doi.org/10.1002/mabi.202400635","url":null,"abstract":"<p><p>Temperature-responsive hydrogels incorporating drug-loaded polymeric nanoparticles represent a significant advancement in controlled release systems, enabling responsive and environmentally triggered drug delivery. In this study, a novel temperature-responsive drug delivery system was developed based on a gelatin methacryloyl/N-isopropylacrylamide (GelMA/NIPAm) hydrogel incorporating phenytoin (PHT)-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles. For this, empty nanoparticles, PHT-loaded nanoparticles, bare hydrogels (BH), empty nanoparticle-loaded hydrogels (eNP-H), and PHT-encapsulated nanoparticle-embedded hydrogels (PHT-H) were prepared and characterized using FTIR, SEM, DSC, XRD, DLS, swelling, drug release, and biocompatibility tests. The drug-loaded nanoparticles exhibited hydrodynamic diameter of 223.7  ±  8.4 nm with a PDI of 0.298 and a zeta potential of -20.4 mV. The BH, eNP-H, and PHT-H hydrogels displayed similar temperature-dependent swelling, with approximate weight swelling ratios of 9.0 at 25°C, 7.5 at 37°C, and 6.0 at 40°C. Swelling kinetics showed that all hydrogels reached equilibrium within 20 min. Moreover, the hydrogels demonstrated consistent cyclic swelling and shrinking at 37°C and 40°C. Drug release studies revealed that PHT-H hydrogels released ∼20% of phenytoin at 37°C and ∼34% at 40°C over 7 days, confirming sustained, temperature-responsive drug release. Cell viability assays indicated no cytotoxicity and potential promotion of cell proliferation. Thus, these hydrogels offer a promising platform for efficient, temperature-sensitive, and controlled drug delivery applications.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00635"},"PeriodicalIF":4.4,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrohydrodynamic Jetting of Mucoadhesive Protein Nanoparticles as a Chemopreventive Strategy for Oral Squamous Cell Carcinoma. 电流体动力喷射黏附蛋白纳米颗粒作为口腔鳞状细胞癌的化学预防策略。
IF 4.4 4区 医学
Macromolecular bioscience Pub Date : 2025-06-25 DOI: 10.1002/mabi.202400661
Albert Chang, Brianna Mae, Ping Pei, Fortune Shea, Darren Wang, Jeffery Raymond, Susan R Mallery, Joerg Lahann
{"title":"Electrohydrodynamic Jetting of Mucoadhesive Protein Nanoparticles as a Chemopreventive Strategy for Oral Squamous Cell Carcinoma.","authors":"Albert Chang, Brianna Mae, Ping Pei, Fortune Shea, Darren Wang, Jeffery Raymond, Susan R Mallery, Joerg Lahann","doi":"10.1002/mabi.202400661","DOIUrl":"https://doi.org/10.1002/mabi.202400661","url":null,"abstract":"<p><p>Intraepithelial delivery of cancer preventive therapies for oral squamous cell carcinoma (OSCC) has been limited by factors such as rapid mucus turnover, enzymatic degradation, and salivary clearance. These challenges, coupled with poor solubility and associated low bioavailability, have hampered clinical progress. To address these challenges, we present an effective method for encapsulation and sustained release of poorly soluble, apolar therapeutics via mucoadhesive protein nanoparticles (PNPs). To demonstrate feasibility, PNPs loaded with N-(4-hydroxyphenyl) retinamide (4HPR, fenretinide), a hydrophobic chemopreventive compound with low solubility were produced via a three-step process: 1) high-pressure homogenization to solubilize and stabilize 4HPR via association with human serum albumin (HSA), 2) electrohydrodynamic (EHD) jetting of albumin-bound 4HPR to formulate 4HPR-HSA PNPs, and 3) collection of the nanoparticles in the presence of a polycationic compound to infer mucoadhesive properties and physiological stability. This methodology resulted in the effective synthesis of environmentally stable 4HPR-loaded PNPs, which featured an average size of 192 ± 21 nm, a surface zeta potential of +31 ± 6 mV in water, and overall 4HPR loadings of up to 7.1 wt.%. In vitro activation of the apoptosis execution phase enzyme, caspase-3, confirmed sustained release and biological activity of 4HPR. Enhanced binding capacity with mucin (K<sub>D</sub> = 6.1*10<sup>-11</sup> M) was confirmed through surface plasmon resonance (SPR) spectroscopy. This generalizable nanoparticle technology addresses a critical challenge in chemopreventive and targeted drug delivery, where clinical efficacy is limited by limited bioavailability and low drug concentrations of highly apolar agents.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00661"},"PeriodicalIF":4.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amphiphilic Poly(γ-glutamic acid) Derivatives for Delivering Doxorubicin in Cancer Cells. 两亲性聚γ-谷氨酸衍生物在癌细胞中递送阿霉素。
IF 4.4 4区 医学
Macromolecular bioscience Pub Date : 2025-06-22 DOI: 10.1002/mabi.202500090
Porochista Dorost, Miguel R G Morais, Sofia Cunha Guimarães, Ana Paula Pêgo, Montserrat García-Alvarez, Antxon Martínez de Ilarduya
{"title":"Amphiphilic Poly(γ-glutamic acid) Derivatives for Delivering Doxorubicin in Cancer Cells.","authors":"Porochista Dorost, Miguel R G Morais, Sofia Cunha Guimarães, Ana Paula Pêgo, Montserrat García-Alvarez, Antxon Martínez de Ilarduya","doi":"10.1002/mabi.202500090","DOIUrl":"https://doi.org/10.1002/mabi.202500090","url":null,"abstract":"<p><p>One of the most limiting factors in cancer treatment is the difficulty of delivering anticancer agents effectively to tumor sites. To overcome this challenge, this research focuses on developing a carrier that has been modified to possess amphiphilic properties while remaining biodegradable and biocompatible. Amphiphilic esters derived from poly(γ-glutamic acid) by modifying the carboxylate side groups with 4-phenyl-butyl bromide were prepared. These copolymers self-assembled into nanoparticles via nanoprecipitation. The cytocompatibility of the nanoparticles was assessed through lactate dehydrogenase release and metabolic activity of U-87 glioma cells. Fluorescein isothiocyanate labeling demonstrated effective cellular uptake of nanoparticles. These nanoparticles were further decorated with polyethylene glycol (PEG) and a PEG-folic acid conjugate (FA-PEG-NH<sub>2</sub>), their sizes being 174 and 156 nm, respectively. Successful grafting was confirmed through <sup>1</sup>H-NMR and FTIR spectroscopy. The nanoparticles were loaded with doxorubicin, and release studies showed their sensitivity to the pH of the environment, the encapsulated drug being released faster at pH 4.2 compared to pH 7.4. Encapsulated doxorubicin's effect on U-87 cells was tested at various concentrations and time points, showing significantly better performance compared to free doxorubicin. These results suggest that those poly(γ-glutamic acid) derivatives hold great promise for improving the delivery of hydrophobic drugs and enhancing cancer treatment.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00090"},"PeriodicalIF":4.4,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Heparin-Mimic Macromolecule Promoted Endothelial Cell Adhesion. 一种模拟肝素的大分子促进内皮细胞粘附。
IF 4.4 4区 医学
Macromolecular bioscience Pub Date : 2025-06-19 DOI: 10.1002/mabi.202500117
Wanyi Zhao, Haoran Chen, Man Zhang, Zhongbing Huang, Changsheng Zhao
{"title":"A Heparin-Mimic Macromolecule Promoted Endothelial Cell Adhesion.","authors":"Wanyi Zhao, Haoran Chen, Man Zhang, Zhongbing Huang, Changsheng Zhao","doi":"10.1002/mabi.202500117","DOIUrl":"10.1002/mabi.202500117","url":null,"abstract":"<p><p>Vascular restenosis, a significant complication after stent implantation, originates from the migration of vascular smooth muscle cells to the intima and the excessive extracellular matrix deposition, resulting in intimal hyperplasia. Thus, enhancing endothelial cell adhesion and reducing smooth muscle cell adhesion capacity are crucial to address this issue. Heparin, a naturally derived glycosaminoglycan, exhibits excellent anticoagulant activity and endothelial cell promoting effects, yet its clinical utility is constrained by bleeding risks, supply instability, immunogenicity, and demanding storage conditions. In this study, sulfonated carboxymethyl chitosan (SCCS) is employed as a heparin-mimicking polymer, immobilized on a glass substrate via dopamine-mediated adhesion. Compared with carboxymethyl chitosan, the SCCS-coated substrate significantly promotes endothelial cell adhesion while effectively inhibiting smooth muscle cell attachment. Additionally, the whole blood cell analysis and complement activation results exhibit that the SCCS coating has excellent blood compatibility. These findings suggest that the SCCS coating has the potential to be applied on various vascular stents to prevent restenosis, offering a nobel strategy for improving vascular interventional therapy.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00117"},"PeriodicalIF":4.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: Macromol. Biosci. 6/2025
IF 4.4 4区 医学
Macromolecular bioscience Pub Date : 2025-06-16 DOI: 10.1002/mabi.202570011
{"title":"Front Cover: Macromol. Biosci. 6/2025","authors":"","doi":"10.1002/mabi.202570011","DOIUrl":"https://doi.org/10.1002/mabi.202570011","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 6","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202570011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144299788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information: Macromol. Biosci. 6/2025 资料:宏mol。Biosci 6/2025。
IF 4.4 4区 医学
Macromolecular bioscience Pub Date : 2025-06-16 DOI: 10.1002/mabi.202570012
{"title":"Issue Information: Macromol. Biosci. 6/2025","authors":"","doi":"10.1002/mabi.202570012","DOIUrl":"https://doi.org/10.1002/mabi.202570012","url":null,"abstract":"","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 6","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202570012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144299870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyvinylpyrrolidone-Encapsulated Total Flavonoids Nanoparticles for Enhancing Antioxidant and Anticancer Activities. 聚乙烯吡咯烷酮包封的总黄酮纳米颗粒增强抗氧化和抗癌活性。
IF 4.4 4区 医学
Macromolecular bioscience Pub Date : 2025-06-15 DOI: 10.1002/mabi.202500106
Yinshu Zhang, Ling Bai, Yang Li, Xiaoling Zhang, Xingfu Tao, Ningning Zhang, Jiuwei Cui, Yang Yang, Kun Liu
{"title":"Polyvinylpyrrolidone-Encapsulated Total Flavonoids Nanoparticles for Enhancing Antioxidant and Anticancer Activities.","authors":"Yinshu Zhang, Ling Bai, Yang Li, Xiaoling Zhang, Xingfu Tao, Ningning Zhang, Jiuwei Cui, Yang Yang, Kun Liu","doi":"10.1002/mabi.202500106","DOIUrl":"https://doi.org/10.1002/mabi.202500106","url":null,"abstract":"<p><p>Total flavonoids (TFs) extracted from Rosa davurica Pall. are known for their diverse biological activities, including antioxidant and anticancer properties. However, their application is significantly constrained by low solubility and poor bioavailability. In this study, the complex extract was transformed into total flavonoid nanoparticles (TFNPs) using the anti-solvent coprecipitation technique in the presence of polyvinylpyrrolidone (PVP). The resulting TFNPs possess a spherical shape, 61.9% encapsulation efficiency, and 46.3% loading capacity. Fourier transform infrared spectroscopy confirmed the hydrogen bonding interaction between the hydroxyl group (─OH) of total flavonoid components and the carbonyl group (C═O) of PVP. The TFNPs demonstrated significantly improved solubility under simulated gastrointestinal conditions compared to the raw TFs. Most importantly, in vitro studies showed that TFNPs exhibited not only higher anti-acute oxidative injury effects but also stronger anticancer ability than the raw TFs due to their higher solubility. These findings suggest that the encapsulation of TFs by polymeric nanoparticles could serve as a promising strategy to improve the solubility and bioavailability of these bioactive compounds.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00106"},"PeriodicalIF":4.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrospun Mats of Fluorosiloxane Copolymers with Antifouling and Antibacterial Performances. 具有防污和抗菌性能的氟硅氧烷共聚物静电纺毡。
IF 4.4 4区 医学
Macromolecular bioscience Pub Date : 2025-06-15 DOI: 10.1002/mabi.202500149
Teng Wang, Tianqi Xu, Hao Yuan, Wenjing Liu, Fei Wang, Ying Cai, Jiawen Zhang, Lingmin Yi
{"title":"Electrospun Mats of Fluorosiloxane Copolymers with Antifouling and Antibacterial Performances.","authors":"Teng Wang, Tianqi Xu, Hao Yuan, Wenjing Liu, Fei Wang, Ying Cai, Jiawen Zhang, Lingmin Yi","doi":"10.1002/mabi.202500149","DOIUrl":"https://doi.org/10.1002/mabi.202500149","url":null,"abstract":"<p><strong>Background: </strong>The adsorption and accumulation of biomolecules and microorganisms on materials can significantly shorten the service life of materials. Fibrous materials featuring hydrophobic and anti-protein adsorption properties are urgently required for numerous applications, particularly in environments requiring liquid repellency and biofouling resistance.</p><p><strong>Methods: </strong>In this work, electrospun fibers are fabricated via the electrospinning of fluorosiloxane copolymers of methyl methacrylate (MMA), isobornyl methacrylate (IBMA), and methacryloyl-terminated poly[methyl(3,3,3-trifluoropropyl)siloxane] (PMTFPS-MA). Porous microstructures are achieved by adjusting the composition and concentration of the spinning solution.</p><p><strong>Results: </strong>The resultant electrospun fiber mats exhibite high hydrophobicity and self-cleaning properties, owing to their multi-scale surface roughness resulting from porous microstructures. Moreover, the combined effects of the fouling release of PMTFPS and the surface stereochemistry of IBMA significantly endow the mats with superior protein-resistant and antibacterial properties.</p><p><strong>Conclusions: </strong>These hydrophobic electrospun fiber mats are promising candidates for applications requiring hydrophobic fibrous materials.</p>","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00149"},"PeriodicalIF":4.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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