Macromolecular bioscience最新文献_第2页

Silk Sericin in Dermatological Diseases: From Preclinical Studies to Future Clinical Applications. 丝胶蛋白在皮肤病中的应用：从临床前研究到未来临床应用。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-20 DOI: 10.1002/mabi.202500058

Monika Stradczuk-Mazurek, Łukasz Mazurek, Marek Konop

{"title":"Silk Sericin in Dermatological Diseases: From Preclinical Studies to Future Clinical Applications.","authors":"Monika Stradczuk-Mazurek, Łukasz Mazurek, Marek Konop","doi":"10.1002/mabi.202500058","DOIUrl":"https://doi.org/10.1002/mabi.202500058","url":null,"abstract":"Biomaterials in medicine are becoming more widespread as a single or complementary treatment option. One such biomaterial is silk, comprised of two primary proteins: fibroin and sericin. Recently, sericin's anti-inflammatory, antioxidant, moisturizing, elastase- and tyrosinase-inhibiting properties have been widely investigated. Sericin biomaterials are already used in wound healing and bone tissue engineering. Additionally, there are promising results for its usefulness in many other applications. This review focuses on sericin use in dermatological diseases, above all in atopic dermatitis and psoriasis. Sericin biomaterials have proven not only to be a promising drug carrier but also to improve the treatment outcome of atopic skin lesions. In psoriasis, sericin's therapeutic effect has reduced inflammation and abnormal epidermal maturation in plaques, with results comparable to standard treatment. Sericin is also observed to diminish skin pigmentation, improve moisture, and increase collagen production so that it can be used as an anti-aging product. There are also reports of its anti-skin-cancer activity. This paper describes the mechanisms behind skin diseases' pathogenesis and, based on the results of scientific studies, highlights and explains sericin's beneficial effects in their treatment. Its versatility, alone or combined with other therapeutic agents, provides new opportunities for dermatological treatments and cosmetic innovations.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00058"},"PeriodicalIF":4.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances of Silk Nanofibrils: Preparation, Properties, and Applications. 丝纳米原纤维的制备、性能及应用研究进展。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-19 DOI: 10.1002/mabi.202500066

Gongwen Yang, Yuanyuan Liu, Qiang Lu

引用次数: 0

Self-Healing, Hemostatic, and Antioxidant Chitosan Hydrogel Loaded with Sophora Japonica Carbon Dots and ZnO NPs for Wound Healing. 负载苦参碳点和氧化锌纳米粒子的自愈、止血和抗氧化壳聚糖水凝胶用于伤口愈合

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-19 DOI: 10.1002/mabi.202500018

Yuting Liu, Yating Wang, Zihao Wang, Yuanhong Ge, Yunbo Ge, Chaoyan Zhang

引用次数: 0

Facile Fabrication of Poly(N-vinyl pyrrolidone)-Iodine Coating on TiO₂ Nanotubes with Antibacterial and Osteoconductive Properties. 具有抗菌和骨导电性的TiO2纳米管上聚n -乙烯基吡咯烷酮碘涂层的制备。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-19 DOI: 10.1002/mabi.202500169

Huimin Cheng, Jing Zhang, Jinxi Liu, Rui Ding, Wenbin Zhong, Han Zheng, Zhenyan Zhang, Peng Li

{"title":"Facile Fabrication of Poly(N-vinyl pyrrolidone)-Iodine Coating on TiO2 Nanotubes with Antibacterial and Osteoconductive Properties.","authors":"Huimin Cheng, Jing Zhang, Jinxi Liu, Rui Ding, Wenbin Zhong, Han Zheng, Zhenyan Zhang, Peng Li","doi":"10.1002/mabi.202500169","DOIUrl":"https://doi.org/10.1002/mabi.202500169","url":null,"abstract":"Implants made of titanium (Ti) and its alloys are widely used in orthopedics and dentistry. However, the Ti-based materials, due to their inherent surface bioinertness, lack antibacterial properties and osteoconductive activity, leading to an increased risk of bacterial infection post-implantation and suboptimal osseointegration efficiency. Herein, an antibacterial and osteoconductive coating via polydopamineassisted immobilization of poly(N-vinyl pyrrolidone)-iodine (PVP-I) on TiO2 nanotubes named TNT-DP-I is constructed. The TNT-DP-I coating could rapidly kill 97.80% Gram-positive Staphylococcus aureus (S. aureus) and 97.96% Gram-negative Escherichia coli (E. coli) within 1 h, highlighting its superior antibacterial efficiency. Additionally, this coating effectively promoted pre-osteoblasts MC3T3-E1 adhesion, growth, and proliferation, demonstrating enhanced osteoconductivity. Meanwhile, TNT-DP-I coating demonstrated good mammalian cytocompatibility and hemocompatibility, suggesting its promising biosafety. Overall, this study presents a facile approach for reducing bacterial contamination and enhancing osseointegration of Ti implants.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00169"},"PeriodicalIF":4.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Role of Aqueous Buffered Saline Solutions on the Macroscopic Properties of PEG/Carbomer/Agarose Hydrogels 探讨缓冲盐水水溶液对聚乙二醇/卡波姆/琼脂糖水凝胶宏观性能的影响

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-15 DOI: 10.1002/mabi.202570009

Zoe Giorgi, Valeria Veneruso, Emilia Petillo, Francesco Briatico Vangosa, Liebert Parreiras Nogueira, Håvard Jostein Haugen, Pietro Veglianese, Giuseppe Perale, Filippo Rossi

引用次数: 0

Issue Information: Macromol. Biosci. 5/2025 资料:宏mol。Biosci 5/2025。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-15 DOI: 10.1002/mabi.202570010

引用次数: 0

Development of an Injectable Synergistically Crosslinked Polysaccharide Hydrogel with Antioxidant and Antibacterial Properties for Promoting Wound Healing. 具有抗氧化和抗菌作用的可注射性交联多糖水凝胶的研制。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-15 DOI: 10.1002/mabi.202500084

Rongrong Li, Yue Zhao, Shangbo Zhang, Yongchao Liu, Chuanxi Chi, Dongjie Wu, Jianxi Song

{"title":"Development of an Injectable Synergistically Crosslinked Polysaccharide Hydrogel with Antioxidant and Antibacterial Properties for Promoting Wound Healing.","authors":"Rongrong Li, Yue Zhao, Shangbo Zhang, Yongchao Liu, Chuanxi Chi, Dongjie Wu, Jianxi Song","doi":"10.1002/mabi.202500084","DOIUrl":"https://doi.org/10.1002/mabi.202500084","url":null,"abstract":"The development of wound dressings that concurrently exhibit excellent injectability, antibacterial performance, and tissue adhesion is essential for the effective treatment of hard-to-heal wounds. Polysaccharide-based hydrogels have become a research hotspot due to their favorable biocompatibility and tunable functional properties. In this study, an in situ-forming hydrogel (QDTA) is fabricated by blending quaternized chitosan (QCS), tannic acid (TA), and difunctional polyethylene glycol (DF-PEG), utilizing both physical crosslinking and dynamic covalent bonding. The QDTA hydrogel demonstrated a suitable gelation time (60-240 s) and exhibited significant antibacterial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), with average inhibition rates of 98.96% and 98.91%, respectively. Moreover, it showed a biodegradation rate of up to 90% within 10 days, making it suitable for in vivo wound healing applications. In vivo experiments further confirmed that QDTA hydrogel effectively promoted tissue regeneration and wound healing by exerting antibacterial effects, scavenging reactive oxygen species (ROS) in the wound site, and enhancing cell migration, ultimately achieving a wound closure rate of ≈99.75% by day 14. These results highlight the significant potential of QDTA hydrogel as an effective wound dressing for clinical application.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00084"},"PeriodicalIF":4.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrically Guided Deposition of Electrospun Nanofibers for Fiber and Cell Pattern Formation. 用于纤维和细胞图案形成的静电纺丝纳米纤维的电引导沉积。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-14 DOI: 10.1002/mabi.202500151

Zishuo Yan, Jingwei Xie

引用次数: 0

Histidine Decapeptide-Incorporating Lipid Nanoparticles with Low Ionizable Lipids Proportion for Efficient Small Interfering RNA Delivery. 组氨酸十肽-含低电离脂质比例的脂质纳米颗粒，用于高效的小干扰RNA递送。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-14 DOI: 10.1002/mabi.202500165

Yeonho Bae, Hyeondo Lee, Jun Hyuk Lee, Sangho Yeo, Hyejung Mok

{"title":"Histidine Decapeptide-Incorporating Lipid Nanoparticles with Low Ionizable Lipids Proportion for Efficient Small Interfering RNA Delivery.","authors":"Yeonho Bae, Hyeondo Lee, Jun Hyuk Lee, Sangho Yeo, Hyejung Mok","doi":"10.1002/mabi.202500165","DOIUrl":"https://doi.org/10.1002/mabi.202500165","url":null,"abstract":"The diversification of lipid compositions in lipid nanoparticles (LNPs) is crucial for expanding their clinical applications and overcoming current limitations. In this study, LNPs with varying lipid compositions are fabricated using three different mixing processes (pipette, vortex, and microfluidic mixing) for small interfering RNA (siRNA) delivery. While both siRNA and hydrophobic fluorescent dye are successfully incorporated within LNPs using pipette- and vortex-mixing, hydrophilic peptides cannot be encapsulated. Following optimization of ionizable lipid proportion via cost-efficient vortex-mixing method, LNPs with a lower ionizable lipid proportion (27.72%), termed LNP5, are selected and fabricated with histidine decapeptide (His10) during formulation via microfluidic mixing method to supplement the function of approximately half of the ionizable lipids by simple addition of His10. His10- incorporated LNP5 (LNP5H) exhibited a 1.6-fold increase in gene silencing efficiency, compared to conventional LNPs (cLNPs; ionizable lipid proportion of 47.95%). Furthermore, LNP5H maintained siRNA potency for 4 weeks when stored in a 1% sucrose solution at -70 °C. Taken together, it fabricates potent LNP5H with low proportion of ionizable lipids via fast and easy processes, which can be applied to a variety of siRNA therapeutics for their efficient intracellular delivery.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e70005"},"PeriodicalIF":4.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembly Pathway Influence on Dehydropeptide-Based Gel Properties and Drug Release. 自组装途径对脱氢肽凝胶性质和药物释放的影响。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-14 DOI: 10.1002/mabi.202400449

Sérgio R S Veloso, Thangavel Vijayakanth, Sudha Shankar, Natalia Fridman, Sigal Rencus-Lazar, Loic Hilliou, Pedro V Rodrigues, Cacilda Moura, Paula M T Ferreira, Miguel A Correa-Duarte, Elisabete M S Castanheira, Ehud Gazit

{"title":"Self-Assembly Pathway Influence on Dehydropeptide-Based Gel Properties and Drug Release.","authors":"Sérgio R S Veloso, Thangavel Vijayakanth, Sudha Shankar, Natalia Fridman, Sigal Rencus-Lazar, Loic Hilliou, Pedro V Rodrigues, Cacilda Moura, Paula M T Ferreira, Miguel A Correa-Duarte, Elisabete M S Castanheira, Ehud Gazit","doi":"10.1002/mabi.202400449","DOIUrl":"https://doi.org/10.1002/mabi.202400449","url":null,"abstract":"Low-molecular-weight peptide-based hydrogels formed through self-assembly have emerged as promising candidates for biomedical applications. While the self-assembly process is known to affect the network morphology, its impact on mechanical properties and drug delivery remains poorly understood. In this work, it is explored how different gelation conditions influence the morphology, properties, and drug release profiles of dehydropeptide-based gels. Additionally, it is presented and analyzed, for the first time, the crystal structure of a naphthalene N-capped dehydropeptide (2-Naph-L-Phe-Z-ΔPhe-OH), which reveals a maximum pore diameter of ≈4.08 Å. By changing the preparation conditions, it is found that the stiffness of the hydrogels can vary by nearly three orders of magnitude. Employing spectroscopic and imaging techniques, the relationship between the gelation methods and the resulting mechanical properties is investigated. These findings suggest that the assembly structure, morphology, and non-covalent interactions significantly influence the release profile of model drugs such as doxorubicin, methotrexate, and curcumin. These results provide valuable insights into how preparation conditions can impact the properties of peptide-based hydrogels and their drug release profiles.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e70003"},"PeriodicalIF":4.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0