Macromolecular bioscience最新文献_第10页

Synthetic Peptide Antibodies via a Rational Approach Based on Disulfide-Stabilized α-Helical Peptides, for the Recognition of the Intrinsically Disordered Protein NUPR1 基于二硫稳定α-螺旋肽的合理合成肽抗体，用于识别内在无序蛋白NUPR1。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2025-05-13 DOI: 10.1002/mabi.202400605

Noel A. Kalacas, Bernadette Tse Sum Bui, Rodrigue Marquant, Franck Merlier, Irene Maffucci, Juliette Hadchouel, Pierre Galichon, Karsten Haupt

{"title":"Synthetic Peptide Antibodies via a Rational Approach Based on Disulfide-Stabilized α-Helical Peptides, for the Recognition of the Intrinsically Disordered Protein NUPR1","authors":"Noel A. Kalacas, Bernadette Tse Sum Bui, Rodrigue Marquant, Franck Merlier, Irene Maffucci, Juliette Hadchouel, Pierre Galichon, Karsten Haupt","doi":"10.1002/mabi.202400605","DOIUrl":"10.1002/mabi.202400605","url":null,"abstract":"Nuclear Protein 1 (NUPR1) is a ubiquitous protein playing an important role in cancer and acute kidney injury. Its specific targeting by natural or synthetic antibodies like molecularly imprinted polymers (MIPs), is therefore of interest. NUPR1 is an intrinsically disordered protein (IDP), such that it displays a high degree of flexibility and an unstable secondary/tertiary structure, resulting in a continuous fluctuation of its conformation in the free state. These characteristics are not in favor of the creation of homogeneous binding sites during molecular imprinting, so that imprinting using peptide epitopes is investigated. Based on an in silico rational approach, two α-helices from the model structure of NUPR1, as predicted by AlPhaFold, are selected. Two cysteine residues are added at both ends of the epitopes to form a disulfide bond, which provides high stability to the α-helix. The template peptides possess the same 3D structure as the epitope fragments in NUPR1. Consequently, they are effective in producing MIP nanogels that cross-react with high affinity (IC50 1 nm) only with NUPR1. The work indicates that α-helices, besides the preferred flexible loops, can be considered as viable template epitopes for MIPs, opening new opportunities for the obtention of selective antipeptide MIP nanogels for IDPs.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 9","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red-Light Triggered CO/ROS Release from Porphyrin-Flavonol Hybrid@PC7A Micelles for Eradicating Escherichia coli 红光触发卟啉-黄酮醇Hybrid@PC7A胶束CO/ROS释放对大肠杆菌的清除作用

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2025-05-12 DOI: 10.1002/mabi.202500079

Ishaq Lugoloobi, Feng Wu, Ye Kang, Xinsong Yuan, Wenjie Bi, Pan Li, Shanshan Shi, Huaze Dong, Jinmiao Zhu, Bin Zheng

{"title":"Red-Light Triggered CO/ROS Release from Porphyrin-Flavonol Hybrid@PC7A Micelles for Eradicating Escherichia coli","authors":"Ishaq Lugoloobi, Feng Wu, Ye Kang, Xinsong Yuan, Wenjie Bi, Pan Li, Shanshan Shi, Huaze Dong, Jinmiao Zhu, Bin Zheng","doi":"10.1002/mabi.202500079","DOIUrl":"10.1002/mabi.202500079","url":null,"abstract":"Photo-triggered carbon monoxide (CO) release, mediated by reactive oxygen species (ROS), shows a significant potential in therapeutic applications. However, the existing photosensitizers predominantly function as type II ROS generators. When ROS are present in excess, they are always wasted due to their short half-lives, which limit their ability to travel significant distances and effectively achieve therapeutic outcomes. In this study, the biological function of a single-component molecule, PdHF, is investigated. This molecule is formed by covalently conjugating 3-hydroxyflavone (3-HF) to a palladium(II) tetraphenyltetrabenzoporphyrin (PdTPTBP) photosensitizer. Subsequently, PdHF is loaded into the 2-hexamethyleneimino ethyl methacrylate (C7A)-modified PEG-b-PCL block copolymer (PC7A) to form a PdHF@PC7A micellar system capable of co-releasing CO and ROS under red-light irradiation. CO/ROS co-release can be attributed to the generation of singlet oxygen species that not only oxidize 3-HF to release CO but are concurrently reduced by the tertiary amine, C7A, to form cytotoxic superoxide anions and hydrogen peroxide. In vitro studies on these positively charged micelles validate a high biosafety and excellent antibacterial effects with competent elimination of Gram-negative bacteria, Escherichia coli. Furthermore, evidence of micelle uptake by bacterial cells supports synergistic photodynamic and gas therapy through intracellular CO/ROS co-release.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 9","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Decellularized Urinary Bladder Matrix and Heparin-Based Cryogel for Promoting Angiogenesis 脱细胞膀胱基质及肝素冷冻凝胶促进血管生成的研究。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2025-04-30 DOI: 10.1002/mabi.202500028

Dayeon Roo, Minkyu Lee, Sivashanmugam Amirthalingam, Kyung Min Ryu, Beom Seok Kim, Juan M. Melero-Martin, Kyoung-Ha So, Nathaniel S. Hwang

{"title":"Development of a Decellularized Urinary Bladder Matrix and Heparin-Based Cryogel for Promoting Angiogenesis","authors":"Dayeon Roo, Minkyu Lee, Sivashanmugam Amirthalingam, Kyung Min Ryu, Beom Seok Kim, Juan M. Melero-Martin, Kyoung-Ha So, Nathaniel S. Hwang","doi":"10.1002/mabi.202500028","DOIUrl":"10.1002/mabi.202500028","url":null,"abstract":"Decellularized extracellular matrix(dECM)-based scaffolds have demonstrated potential in promoting cellular migration and tissue regeneration. In this study, dECM-based cryogel scaffolds are developed with sustained vascular endothelial growth factor (VEGF) release properties to enhance angiogenesis in ischemic tissues. VEGF plays a critical role in angiogenesis by stimulating cell proliferation and migration, but its therapeutic delivery remains challenging due to the need for precise dosing to avoid adverse effects. Cryogels, with their microporous structure, elasticity, and shape-recovery characteristics, offer an ideal platform for controlled VEGF delivery. Using decellularized porcine urinary bladder matrix extracellular matrix (dECM) and heparin, a VEGF-releasing cryogel scaffold is fabricated. The resulting dECM/heparin cryogel is a biocompatible scaffold capable of binding VEGF and releasing it over an extended period. This platform demonstrates significant angiogenic potential both in vitro and in a murine hindlimb ischemia model, highlighting its promise for therapeutic applications in tissue regeneration.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 8","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202500028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of Piezoelectric Materials in Biomedical Engineering 压电材料在生物医学工程中的应用

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2025-04-28 DOI: 10.1002/mabi.202500033

Zian Wang, Yanan Wang, Chenglin Yang, Tiantian Zheng, Rifang Luo, Yunbing Wang

引用次数: 0

A Novel 3D Bioprinting Crosslinking Method Based on Solenoid Valve Control 一种基于电磁阀控制的生物3D打印交联方法。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2025-04-24 DOI: 10.1002/mabi.202500039

Jiaxin Wu, Luxiao Sang, Rihui Kang, Meng Li, Caiwang Cheng, Anguo Liu, Jianlong Ji, Aoqun Jian

{"title":"A Novel 3D Bioprinting Crosslinking Method Based on Solenoid Valve Control","authors":"Jiaxin Wu, Luxiao Sang, Rihui Kang, Meng Li, Caiwang Cheng, Anguo Liu, Jianlong Ji, Aoqun Jian","doi":"10.1002/mabi.202500039","DOIUrl":"10.1002/mabi.202500039","url":null,"abstract":"The crosslinking method of bioinks is essential for scaffold formation in 3D bioprinting. Currently, the crosslinking process of bioinks presents challenges in control, resulting in diminished stability and reliability of the gel and the presence of residual crosslinking agents that may adversely affect cell viability within the gel. This study utilizes sodium alginate as the printing ink and calcium chloride as the crosslinking agent, employing a dual-mode 3D bioprinter for alternating printing. A crosslinking agent is injected through a solenoid valve after using an extrusion-based printing method to create multilayer cell scaffolds. By controlling the printing intervals and opening times of the valve, precise localized crosslinking is achieved, and multiple alternating prints can be performed according to the required thickness of the scaffold. The results indicate that this solenoid valve crosslinking technology significantly enhances the stability and biological properties of the scaffolds, including excellent hydrophilicity, decreased swelling rate, slow degradation rate, and improved mechanical properties. Additionally, due to the reduced residual crosslinking agent, the cell proliferation rate has significantly increased. This technology advances 3D bioprinting toward a more mature stage and provides significant implications for the development of dual-mode printing.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 8","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclodextrin-Derived Macromolecular Therapies for Inflammatory Diseases 环糊精衍生的大分子治疗炎症性疾病。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-04-24 DOI: 10.1002/mabi.202400637

Yige Tang, Tao Guo, Xuanran Wang, Chenwen Li, Xiangjun Zhang, Jianxiang Zhang

{"title":"Cyclodextrin-Derived Macromolecular Therapies for Inflammatory Diseases","authors":"Yige Tang, Tao Guo, Xuanran Wang, Chenwen Li, Xiangjun Zhang, Jianxiang Zhang","doi":"10.1002/mabi.202400637","DOIUrl":"10.1002/mabi.202400637","url":null,"abstract":"Inflammation is an essential physiological defense mechanism against harmful stimuli, yet dysregulated inflammatory responses are closely associated with the pathogenesis of numerous acute and chronic diseases. Recent advances highlight the remarkable anti-inflammatory potential of bioactive macromolecules, particularly cyclodextrins (CDs) and their engineered derivatives, which are emerging as promising therapeutic agents. This review systematically introduces different CDs and CD-derived macromolecules that demonstrate anti-inflammatory properties, with emphasis on their molecular mechanisms of action. Native CDs exhibit direct therapeutic effects through host-guest interactions, enabling selective sequestration of pathogenic components such as cholesterol crystals and proteins that drive inflammatory cascades. Moreover, chemically modified CD derivatives incorporating functional groups demonstrate enhanced capabilities in neutralizing inflammatory mediators and modulating immune cell responses. This work further discusses the expanding therapeutic applications of these macromolecules across diverse inflammatory conditions, ranging from acute tissue injuries to chronic autoimmune disorders. Finally, this work critically analyzes the crucial challenges and emerging opportunities in translating CD-based macromolecular therapies into clinical practice, addressing key considerations in biocompatibility, targeted delivery, and therapeutic efficacy optimization.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 7","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Enhanced Maturation of 3D Bioprinted Skeletal Muscle Tissue Constructs Encapsulating Soluble Factor-Releasing Microparticles” 更正“包裹可溶性因子释放微粒的生物3D打印骨骼肌组织结构增强成熟”。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-04-24 DOI: 10.1002/mabi.202500216

{"title":"Correction to “Enhanced Maturation of 3D Bioprinted Skeletal Muscle Tissue Constructs Encapsulating Soluble Factor-Releasing Microparticles”","authors":"","doi":"10.1002/mabi.202500216","DOIUrl":"10.1002/mabi.202500216","url":null,"abstract":"N. R. de Barros, M. A. Darabi, X. Ma, S. E. Diltemiz, M. Ermis, A. Hassani Najafabadi, S. Nadine, E. A. Banton, K. Mandal, R. Abbasgholizadeh, N. Falcone, J. F. Mano, R. Nasiri, R. D. Herculano, Y. Zhu, S. Ostrovidov, J. Lee, H.-J. Kim, V. Hosseini, M. R. Dokmeci, S. Ahadian, and A. Khademhosseini, “Enhanced Maturation of 3D Bioprinted Skeletal Muscle Tissue Constructs Encapsulating Soluble Factor-Releasing Microparticles,” Macromolecular Bioscience 23, no. 12 (2023): 2300276, https://doi.org/10.1002/mabi.202300276.Concerns were raised by a third party regarding overlapping image panels within the Supporting Information of the article (Figure S1, Supporting Information ii-Kidney and iv-Lung panels). The authors acknowledged the image compilation error and were able to provide the underlying original raw data. To ensure further accuracy and transparency, the authors returned to the original tissue paraffin blocks and performed new tissue processing. The original and new analyses consistently demonstrated no evidence of toxicity across all experimental groups. Therefore, the corresponding experimental results and the overall conclusions of the paper remain unaffected, and the authors apologize for this error.The corrected Figure S1 (Supporting Information) is below, and the Supporting information has been updated accordingly:Figure S1. Biocompatibility with a mouse subcutaneous implant. Gross hematoxylin and Eosin (H&E) histological image of day 7 implant cross-section of different organs. i) Heart. ii) Kidney. iii) Liver. iv) Lung. v) Skin (Skin contact with scaffold).","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 6","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202500216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis 高分子水凝胶治疗和保护骨关节炎的研究现状及展望。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2025-04-24 DOI: 10.1002/mabi.202500016

Wanjun Liang, Rui Yang, Lijing Qin, Tongjuan Liang, Wei Chen

{"title":"Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis","authors":"Wanjun Liang, Rui Yang, Lijing Qin, Tongjuan Liang, Wei Chen","doi":"10.1002/mabi.202500016","DOIUrl":"10.1002/mabi.202500016","url":null,"abstract":"Arthritis is a degenerative disease characterized by chronic cartilage degeneration. It affects hundreds of millions of people worldwide and often has serious consequences such as joint pain and swelling, limited mobility, and joint deformity. However, conventional treatments still struggle to achieve satisfactory results. Finding more effective treatments for arthritis remains an important clinical challenge. As hydrogels have a unique 3D spatial mesh structure, significant material interaction ability, adjustable mechanical properties, and good biodegradability, they can provide a suitable cellular or tissue microenvironment, and their potential in scaffolding effect, lubrication, anti-inflammatory effect, or drug or cellular delivery is expected to be a potent therapeutic approach for the treatment of osteoarthritis. In this review, three aspects of hydrogel products for osteoarthritis treatment are comprehensively summarized and discussed, namely, material selection and gel design, exploration of cross-linking mechanisms, and mechanisms of hydrogel therapy for osteoarthritis, and focus on the advantages and limitations of their clinical applications, which point out the direction of the development strategy of innovative products in this field, applied research, and clinical transformation.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 8","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computer-Aided Technology for Bioactive Protein Design and Clinical Application 生物活性蛋白设计与临床应用的计算机辅助技术。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-04-22 DOI: 10.1002/mabi.202500007

Chufan Wang, Yeyun Chen, Lei Ren

{"title":"Computer-Aided Technology for Bioactive Protein Design and Clinical Application","authors":"Chufan Wang, Yeyun Chen, Lei Ren","doi":"10.1002/mabi.202500007","DOIUrl":"10.1002/mabi.202500007","url":null,"abstract":"Computer-aided protein design (CAPD) has become a transformative field, harnessing advances in computational power and deep learning to deepen the understanding of protein structure, function, and design. This review provides a comprehensive overview of CAPD techniques, with a focus on their application to protein-based therapeutics such as monoclonal antibodies, protein drugs, antigens, and protein polymers. This review starts with key CAPD methods, particularly those integrating deep learning-based predictions and generative models. These approaches have significantly enhanced protein drug properties, including binding affinity, specificity, and the reduction of immunogenicity. This review also covers CAPD's role in optimizing vaccine antigen design, improving protein stability, and customizing protein polymers for drug delivery applications. Despite considerable progress, CAPD faces challenges such as model overfitting, limited data for rare protein families, and the need for efficient experimental validation. Nevertheless, ongoing advancements in computational methods, coupled with interdisciplinary collaborations, are poised to overcome these obstacles, advancing protein engineering and therapeutic development. In conclusion, this review highlights the future potential of CAPD to transform drug development, personalized medicine, and biotechnology.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 7","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond 非规范肽的自组装：癌症治疗的新前沿。

IF 4.1 4区医学

Macromolecular bioscience Pub Date : 2025-04-22 DOI: 10.1002/mabi.202500153

Lin Bai, Meihui Yi, Bing Xu

{"title":"Self-Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond","authors":"Lin Bai, Meihui Yi, Bing Xu","doi":"10.1002/mabi.202500153","DOIUrl":"10.1002/mabi.202500153","url":null,"abstract":"In addition to the 20 standard amino acids that form the building blocks of proteins, nature employs alternative amino acids to create specialized “noncanonical peptides.” These unique peptides, found in organisms from bacteria to humans, often exhibit unconventional structures and functionalities, playing critical roles in modulating cellular processes, particularly as antibiotics. Their potential has attracted significant interest for designing novel functional materials based on noncanonical peptides. This review highlights recent advances in the generation and application of noncanonical peptide assemblies. It begins with a definition of noncanonical peptides, including classic examples that showcase their distinct structures and useful biological activities. Then the applications of noncanonical peptide assemblies in developing anticancer therapeutics are discussed, focusing on recent and representative studies that demonstrate their efficacy and versatility in targeting tumor cells. Beyond oncology, it is explored how noncanonical peptide assemblies have been utilized in biomaterials, regenerative medicine, molecular imaging and catalysis. Finally, perspectives are offered on future directions in this rapidly evolving field, emphasizing exciting opportunities and remaining challenges that will drive continued innovation in designing and applying noncanonical peptide-based assemblies.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 8","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202500153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0