Macromolecular bioscience最新文献_第10页

Hyaluronic Acid-Dopamine-NCSN Hydrogel Combined With Extracellular Matrix Promotes Wound Healing 透明质酸-多巴胺-NCSN 水凝胶与细胞外基质相结合可促进伤口愈合。

IF 4.6 4区医学

Macromolecular bioscience Pub Date : 2024-03-21 DOI: 10.1002/mabi.202300549

Yingjie Zhou, Yongbiao Xu, Rui Zhang, Haiyang Wang, Fangfang Wang, Zonghuan Wang, Chi Zhang, Zhihan Zhang, Jin Mei, Shengxiang Tao

{"title":"Hyaluronic Acid-Dopamine-NCSN Hydrogel Combined With Extracellular Matrix Promotes Wound Healing","authors":"Yingjie Zhou, Yongbiao Xu, Rui Zhang, Haiyang Wang, Fangfang Wang, Zonghuan Wang, Chi Zhang, Zhihan Zhang, Jin Mei, Shengxiang Tao","doi":"10.1002/mabi.202300549","DOIUrl":"10.1002/mabi.202300549","url":null,"abstract":"The skin barrier is essential to prevent pathogenic invasion. When injury occurs, multiple biological pathways are promptly activated and wound repair processes are triggered. The effective healing of wounds is essential for survival, and dysfunction could result from aberrant wound repair. Preparation of many hydrogels, which involve the addition of growth/cell factors or mimic extracellular matrix (ECM) components, has not resulted in significant advances in tissue recovery. ECM contains a large number of biologically active molecules that activate a variety of cellular transduction pathways, which are essential for wound repair. Here, this work prepares hyaluronic acid-dopamine-thiourea (HA-DA-NCSN) hydrogels exhibiting ultrafast gelation in situ, following the methods of Xu et al., and subsequently designs a hydrogel containing ECM particles. In addition, the loaded ECM material, specifically decellularized ECM material, not only enhances the strength of the hydrogel network, but also delivers bioactive substances that make it a suitable platform for skin wound repair. The ECM hydrogel has great potential as an efficient bioactive wound dressing. This research suggests that this strategy is likely to improve skin wound closure in rat skin wound models.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to Oxymatrine Loaded Cross-Linked PVA Nanofibrous Scaffold: Design and Characterization and Anticancer Properties 更正为 "Oxymatrine Loaded Cross-Linked PVA Nanofibrous Scaffold"：设计、表征和抗癌特性。

IF 4.6 4区医学

Macromolecular bioscience Pub Date : 2024-03-21 DOI: 10.1002/mabi.202300583

引用次数: 0

Mucus-Mimicking Mucin-Based Hydrogels by Tandem Chemical and Physical Crosslinking 通过化学和物理串联交联模拟粘蛋白水凝胶

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-03-21 DOI: 10.1002/mabi.202400028

Natalia N. Porfiryeva, Ivan Zlotver, Maya Davidovich-Pinhas, Alejandro Sosnik

{"title":"Mucus-Mimicking Mucin-Based Hydrogels by Tandem Chemical and Physical Crosslinking","authors":"Natalia N. Porfiryeva, Ivan Zlotver, Maya Davidovich-Pinhas, Alejandro Sosnik","doi":"10.1002/mabi.202400028","DOIUrl":"10.1002/mabi.202400028","url":null,"abstract":"Mucosal tissues represent a major interface between the body and the external environment and are covered by a highly hydrated mucins gel called mucus. Mucus lubricates, protects and modulates the moisture levels of the tissue and is capitalized in transmucosal drug delivery. Pharmaceutical researchers often use freshly excised animal mucosal membranes to assess mucoadhesion and muco-penetration of pharmaceutical formulations which may struggle with limited accessibility, reproducibility, and ethical questions. Aiming to develop a platform for the rationale study of the interaction of drugs and delivery systems with mucosal tissues, in this work mucus-mimicking mucin-based hydrogels are synthesized by the tandem chemical and physical crosslinking of mucin aqueous solutions. Chemical crosslinking is achieved with glutaraldehyde (0.3% and 0.75% w/v), while physical crosslinking by one or two freeze-thawing cycles. Hydrogels after one freeze-thawing cycle show water content of 97.6–98.1%, density of 0.0529-0.0648 g cm⁻3, and storage and loss moduli of ≈40–60 and ≈3–5 Pa, respectively, that resemble the properties of native gastrointestinal mucus. The mechanical stability of the hydrogels increases over the number of freeze-thawing cycles. Overall results highlight the potential of this simple, reproducible, and scalable method to produce artificial mucus-mimicking hydrogels for different applications in pharmaceutical research.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202400028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutral Block Copolymer Assisted Gene Delivery using Hydrodynamic Limb Vein Injection 中性嵌段共聚物利用水动力肢体静脉注射辅助基因递送。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-03-21 DOI: 10.1002/mabi.202300568

Yann Le Guen, Gwendoline Delecourt, Tony Le Gall, Haiqin Du, Nicolas Illy, Cécile Huin, Véronique Bennevault, Patrick Midoux, Tristan Montier, Philippe Guégan

{"title":"Neutral Block Copolymer Assisted Gene Delivery using Hydrodynamic Limb Vein Injection","authors":"Yann Le Guen, Gwendoline Delecourt, Tony Le Gall, Haiqin Du, Nicolas Illy, Cécile Huin, Véronique Bennevault, Patrick Midoux, Tristan Montier, Philippe Guégan","doi":"10.1002/mabi.202300568","DOIUrl":"10.1002/mabi.202300568","url":null,"abstract":"Three different amphiphilic block copolymer families are synthesized to investigate new opportunities to enhance gene delivery via Hydrodynamic Limb Vein (HLV) injections. First a polyoxazoline-based family containing mostly one poly(2-methyl-2-oxazoline) (PMeOx) block and a second block POx with an ethyl (EtOx), isopropyl (iPrOx) or phenyl substituent (PhOx) is synthesized. Then an ABC poly(2-ethyl-2-oxazoline)-b-poly(2-n-propyl-2-oxazoline)-b-poly(2-methyl-2-oxazoline) triblock copolymer is synthesized, with a thermosensitive middle block. Finally, polyglycidol-b-polybutylenoxide-b-polyglycidol copolymers with various molar masses and amphiphilic balance are produced. The simple architecture of neutral amphiphilic triblock copolymer is not sufficient to obtain enhanced in vivo gene transfection. Double or triple amphiphilic neutral block copolymers are improving the in vivo transfection performances through HLV administration as far as a block having an lower critical solution temperature is incorporated in the vector. The molar mass of the copolymer does not seem to affect the vector performances in a significant manner.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202300568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosustainable Hybrid Nanoplatforms as Photoacoustic Agents 作为光声剂的生物可持续混合纳米平台。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-03-20 DOI: 10.1002/mabi.202400013

Giulio Pota, Paolo Armanetti, Brigida Silvestri, Bruno de Gennaro, Anna Zanfardino, Michela Di Napoli, Mario Varcamonti, Gianluca Landi, Alessandro Pezzella, Aniello Costantini, Giuseppina Luciani, Luca Menichetti

{"title":"Biosustainable Hybrid Nanoplatforms as Photoacoustic Agents","authors":"Giulio Pota, Paolo Armanetti, Brigida Silvestri, Bruno de Gennaro, Anna Zanfardino, Michela Di Napoli, Mario Varcamonti, Gianluca Landi, Alessandro Pezzella, Aniello Costantini, Giuseppina Luciani, Luca Menichetti","doi":"10.1002/mabi.202400013","DOIUrl":"10.1002/mabi.202400013","url":null,"abstract":"The development of biosafe theranostic nanoplatforms has attracted great attention due to their multifunctional behavior, reduced potential toxicity, and improved long-term safety. When considering photoacoustic contrast agents and photothermal conversion tools, melanin and constructs like melanin are highly appealing due to their ability to absorb optical energy and convert it into heat. Following a sustainable approach, in this study, silver-melanin like-silica nanoplatforms are synthesized exploiting different bio-available and inexpensive phenolic acids as potential melanogenic precursors and exploring their role in tuning the final systems architecture. The UV–Vis combined with X-Ray Diffraction investigation proves metallic silver formation, while Transmission Electron Microscopy analysis reveals that different morphologies can be obtained by properly selecting the phenolic precursors. By looking at the characterization results, a tentative formation mechanism is proposed to explain how phenolic precursors' redox behavior may affect the nanoplatforms' structure. The antibacterial activity experiments showed that all synthesized systems have a strong inhibitory effect on Escherichia coli, even at low concentrations. Furthermore, very sensitive Photoacoustic Imaging capabilities and significant photothermal behavior under laser irradiation are exhibited. Finally, a marked influence of phenol nature on the final system architecture is revealed resulting in a significant effect on both biological and photoacoustic features of the obtained systems. These melanin-based hybrid systems exhibit excellent potential as triggerable nanoplatforms for various biomedical applications.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Efficacy Comparison of pH-Sensitive and Non-pH-Sensitive Taxol Delivery Nanoparticles in Cancer Therapy pH 敏感型和非 pH 敏感型紫杉醇递送纳米粒子在癌症治疗中的药效比较

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-03-15 DOI: 10.1002/mabi.202400009

Jianquan Wang, Xinyan Ruan, Hangmin Guan, Hailuo Fu, Shichao Ai, Yiqing Wang

引用次数: 0

Beyond Nanoparticle-Based Intracellular Drug Delivery: Cytosol/Organelle-Targeted Drug Release and Therapeutic Synergism 超越基于纳米颗粒的细胞内给药：细胞质/细胞器靶向药物释放与治疗增效。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-03-15 DOI: 10.1002/mabi.202300590

Hana Cho, Kang Moo Huh, Min Suk Shim, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang

{"title":"Beyond Nanoparticle-Based Intracellular Drug Delivery: Cytosol/Organelle-Targeted Drug Release and Therapeutic Synergism","authors":"Hana Cho, Kang Moo Huh, Min Suk Shim, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang","doi":"10.1002/mabi.202300590","DOIUrl":"10.1002/mabi.202300590","url":null,"abstract":"Nanoparticle (NP)-based drug delivery systems are conceived to solve poor water-solubility and chemical/physical instability, and their purpose expanded to target specific sites for maximizing therapeutic effects and minimizing unwanted events of payloads. Targeted sites are also narrowed from organs/tissues and cells to cytosol/organelles. Beyond specific site targeting, the particular release of payloads at the target sites is growing in importance. This review overviews various issues and their general strategies during multiple steps, from the preparation of drug-loaded NPs to their drug release at the target cytosol/organelles. In particular, this review focuses on current strategies for “first” delivery and “later” release of drugs to the cytosol or organelles of interest using specific stimuli in the target sites. Recognizing or distinguishing the presence/absence of stimuli or their differences in concentration/level/activity in one place from those in another is applied to stimuli-triggered release via bond cleavage or nanostructural transition. In addition, future directions on understanding the intracellular balance of stimuli and their counter-stimuli are demonstrated to synergize the therapeutic effects of payloads released from stimuli-sensitive NPs.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202300590","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Masthead: Macromol. Biosci. 3/2024 刊头：Macromol.Biosci.3/2024

IF 4.6 4区医学

Macromolecular bioscience Pub Date : 2024-03-14 DOI: 10.1002/mabi.202470008

引用次数: 0

A Versatile Elastin-Like Carrier for Bioactive Antimicrobial Peptide Production and Delivery 生产和输送生物活性抗菌肽的多功能弹性蛋白载体

IF 4.6 4区医学

Macromolecular bioscience Pub Date : 2024-03-14 DOI: 10.1002/mabi.202470007

Laura Colomina – Alfaro, Paola Sist, Silvia Marchesan, Ranieri Urbani, Artemis Stamboulis, Antonella Bandiera

引用次数: 0

Vitamin B3 Containing Polymers for Nanodelivery 用于纳米输送的含维生素 B3 的聚合物。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-03-14 DOI: 10.1002/mabi.202400002

Prosper P. Mapfumo, Jana I. Solomun, Friedrich Becker, Elisabeth Moek, Meike N. Leiske, Lenhard K. Rudolph, Johannes C. Brendel, Anja Traeger

{"title":"Vitamin B3 Containing Polymers for Nanodelivery","authors":"Prosper P. Mapfumo, Jana I. Solomun, Friedrich Becker, Elisabeth Moek, Meike N. Leiske, Lenhard K. Rudolph, Johannes C. Brendel, Anja Traeger","doi":"10.1002/mabi.202400002","DOIUrl":"10.1002/mabi.202400002","url":null,"abstract":"Polymeric nanoparticles (NPs) with an integrated dual delivery system enable the controlled release of bioactive molecules and drugs, providing therapeutic advantages. Key design targets include high biocompatibility, cellular uptake, and encapsulating efficiency. In this study, a polymer library derived from niacin, also known as vitamin B3 is synthesized. The library comprises poly(2-(acryloyloxy)ethyl nicotinate) (PAEN), poly(2-acrylamidoethyl nicotinate) (PAAEN), and poly(N-(2-acrylamidoethyl)nicotinamide) (PAAENA), with varying hydrophilicity in the backbone and pendant group linker. All polymers are formulated, and those with increased hydrophobicity yield NPs with homogeneous spherical distribution and diameters below 150 nm, as confirmed by scanning electron microscopy and dynamic light scattering. Encapsulation studies utilizing a model drug, neutral lipid orange (NLO), reveal the influence of polymer backbone on encapsulation efficiency. Specifically, efficiencies of 46% and 96% are observed with acrylate and acrylamide backbones, respectively. Biological investigations showed that P(AEN) and P(AAEN) NPs are non-toxic up to 300 µg mL−1, exhibit superior cellular uptake, and boost cell metabolic activity. The latter is attributed to the cellular release of niacin, a precursor to nicotinamide adenine dinucleotide (NAD), a central coenzyme in metabolism. The results underline the potential of nutrient-derived polymers as pro-nutrient and drug-delivery materials.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202400002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0