Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis

Arthritis is a degenerative disease characterized by chronic cartilage degeneration. It affects hundreds of millions of people worldwide and often has serious consequences such as joint pain and swelling, limited mobility, and joint deformity. However, conventional treatments still struggle to achieve satisfactory results. Finding more effective treatments for arthritis remains an important clinical challenge. As hydrogels have a unique 3D spatial mesh structure, significant material interaction ability, adjustable mechanical properties, and good biodegradability, they can provide a suitable cellular or tissue microenvironment, and their potential in scaffolding effect, lubrication, anti-inflammatory effect, or drug or cellular delivery is expected to be a potent therapeutic approach for the treatment of osteoarthritis. In this review, three aspects of hydrogel products for osteoarthritis treatment are comprehensively summarized and discussed, namely, material selection and gel design, exploration of cross-linking mechanisms, and mechanisms of hydrogel therapy for osteoarthritis, and focus on the advantages and limitations of their clinical applications, which point out the direction of the development strategy of innovative products in this field, applied research, and clinical transformation.