Macromolecular bioscience最新文献

Development and Characterization of Levofloxacin-Loaded Vitamin A-Poly(Ethylene Brassylate-Co-Squaric Acid) Nanoemulsions. 左旋氧氟沙星负载维生素a -聚乙烯花椰菜酸纳米乳的研制与表征。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-28 DOI: 10.1002/mabi.202500088

Alexandru-Mihail Serban, Alexandra Vieru, Irina Rosca, Isabella Nacu, Alina Gabriela Rusu, Alina Ghilan, Liliana Verestiuc, Loredana Elena Nita, Aurica P Chiriac

{"title":"Development and Characterization of Levofloxacin-Loaded Vitamin A-Poly(Ethylene Brassylate-Co-Squaric Acid) Nanoemulsions.","authors":"Alexandru-Mihail Serban, Alexandra Vieru, Irina Rosca, Isabella Nacu, Alina Gabriela Rusu, Alina Ghilan, Liliana Verestiuc, Loredana Elena Nita, Aurica P Chiriac","doi":"10.1002/mabi.202500088","DOIUrl":"https://doi.org/10.1002/mabi.202500088","url":null,"abstract":"Currently, increased interest has been attributed to oil-in-water nanoemulsions, as their remarkable intrinsic properties fulfill the requirements to be employed as ophthalmic drug delivery systems. In this regard, the main purpose of the present study is to develop nanoemulsions consisting of vitamin A, poly(ethylene brassylate-co-squaric acid) (PEBSA), and levofloxacin as a potential ophthalmic drug delivery system with dual therapeutic effect. Two PEBSA variants with different ratios between comonomers are synthesized via ethylene brassylate macrolactone ring-opening and copolymerization with squaric acid using the emulsion technique and subsequently characterized. Furthermore, six nanoemulsions consisting of vitamin A and PEBSA are prepared. The effect of the dispersed phase concentration and the chemical composition of the copolymer on their dimensional distribution is appraised through laser diffraction analysis. All nanoemulsions has nanometric sizes, the optimal variants exhibiting an average diameter of 159 and 134 nm, respectively. The optimal formulations are loaded in situ with levofloxacin, a bioactive principle prescribed for ocular bacterial diseases. In vitro drug release results disclosed that levofloxacin is released in a controlled manner, reaching 84%, respectively 98%, after 24 h, depending on the copolymer squaric acid content. At the same time, nanoemulsions demonstrated good antimicrobial activity against the tested bacterial strains and are cytocompatible with the MG-63 cell line.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00088"},"PeriodicalIF":4.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Polymer-Coated Xenogeneic Extracellular Matrix to Prevent Postoperative Adhesion Readily Applicable in the Clinic. 一种新型聚合物包被异种细胞外基质预防术后粘连的临床应用。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-26 DOI: 10.1002/mabi.202500171

Kyung Hyun Kim, Younghak Cho, Yunyoung Choi, Seeun Jeon, Yun Jin Lee, Hyejeong Seong, Ji Yeoun Lee

{"title":"A New Polymer-Coated Xenogeneic Extracellular Matrix to Prevent Postoperative Adhesion Readily Applicable in the Clinic.","authors":"Kyung Hyun Kim, Younghak Cho, Yunyoung Choi, Seeun Jeon, Yun Jin Lee, Hyejeong Seong, Ji Yeoun Lee","doi":"10.1002/mabi.202500171","DOIUrl":"https://doi.org/10.1002/mabi.202500171","url":null,"abstract":"Post-neurosurgical dura reconstruction is crucial for preventing CSF leakage and reducing infection risk. When primary closure is not possible, synthetic and semisynthetic dura substitutes are commonly used, but postoperative adhesions remain a major complication, particularly in reoperations for brain tumors and spinal surgeries. To address this, the use of initiated chemical vapor deposition (iCVD) is investigated to create a polymer-coated dura substitute that minimizes adhesions. iCVD, a dry, solvent-free technique, enables uniform polymer film deposition at low temperatures, ensuring biocompatibility and purity. A widely used dura substitute (Lyoplant) is coated with three biocompatible polymers (pHEMA, EGDMA, V4D4) and assessed cytotoxicity using fibroblasts. Adhesion levels are compared in vitro, and an intracranial adhesion model in mice is used for in vivo evaluation. All polymers exhibit minimal cytotoxicity, with pHEMA showing the least adhesion in vitro and selected for further testing. The uncoated dura causes severe adhesion to the cortex, leading to gross damage, whereas the pHEMA-coated dura prevents adhesion in 90% of cases. Histological analysis reveals inflammatory cell infiltration beneath the uncoated dura. These findings suggest that polymer-coated dura substitutes may reduce reoperation risks and improve patient recovery. Further studies are needed to assess long-term safety for clinical application.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00171"},"PeriodicalIF":4.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Anti-Adhesion Silk@Extracellular Matrix Composite Patch for the Treatment of Abdominal Wall Defects. 仿生抗粘连Silk@Extracellular基质复合贴片治疗腹壁缺损。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-25 DOI: 10.1002/mabi.202500209

Long Qi, Deyi Zhang, Wei Yue, Linlin Guo, Luyao Zhang, Zhangjie Pu, Guoqiang Li, Hongjun Yang, Zhaowei Zhang, Ruoyun Zhang

{"title":"Biomimetic Anti-Adhesion Silk@Extracellular Matrix Composite Patch for the Treatment of Abdominal Wall Defects.","authors":"Long Qi, Deyi Zhang, Wei Yue, Linlin Guo, Luyao Zhang, Zhangjie Pu, Guoqiang Li, Hongjun Yang, Zhaowei Zhang, Ruoyun Zhang","doi":"10.1002/mabi.202500209","DOIUrl":"https://doi.org/10.1002/mabi.202500209","url":null,"abstract":"Abdominal wall defects are predisposed to life-threatening complications. Biocompatible hernia patches are crucial for the effective repair and reconstruction of abdominal wall defects. However, conventional polymer-based hernia patches are prone to inducing inflammation and reaction to foreign body. The biomimetic Silk@Extracellular Matrix (S@ECM) patch is composed of naturally derived silk and extracellular matrix. The mechanical properties of S@ECM are provided by silk as the template and the incorporation of ECM facilitates cell adhesion and proliferation. Thus, S@ECM patch leads to the abilities of anti-adhesion and rapid reconstruction of the abdominal wall by recruiting cells. In vitro experiments using mechanical property tests demonstrate excellent mechanical properties (8.0 ± 0.1 MPa). In vivo experiments using a rat abdominal wall defect model demonstrate outstanding resistance to adhesions and rapid repair of the abdominal wall. The biomimetic S@ECM patch offers excellent therapeutic effects on abdominal wall defects, anti-adhesion effects and accelerates the repair of abdominal wall defects through in biomimetic reconstruction of abdominal wall defects. It offers significant values for repairing abdominal wall defects and provides design ideas for repairing other soft tissues.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00209"},"PeriodicalIF":4.4,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Self-healing, Antibacterial, Antioxidant, Injectable Hydrogel Containing Tannic Acid for Skin Wound Repair. 一种自愈，抗菌，抗氧化，含有单宁酸的可注射水凝胶，用于皮肤伤口修复。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-23 DOI: 10.1002/mabi.202500044

Xuechang Cai, Zuoxiang Dong, Wenshuai Deng, Zhiguo Chen, Peng Sun

{"title":"A Self-healing, Antibacterial, Antioxidant, Injectable Hydrogel Containing Tannic Acid for Skin Wound Repair.","authors":"Xuechang Cai, Zuoxiang Dong, Wenshuai Deng, Zhiguo Chen, Peng Sun","doi":"10.1002/mabi.202500044","DOIUrl":"https://doi.org/10.1002/mabi.202500044","url":null,"abstract":"Skin defects resulting from various causes are common issues in clinical practice. The predominant approach to skin wound repair involves the application of wound dressings to facilitate healing. However, the current treatment methods face significant limitations, including insufficient functional restoration and inadequate blood supply. In this study, an injectable, self-healing composite hydrogel for skin wound repair is developed using a dynamic Schiff base reaction and hydrogen bonding. The hydrogel incorporates oxidized sodium hyaluronate (OHA), carboxymethyl chitosan (CMCS), and tannic acid (TA). Results indicate that the bio-functional hydrogel demonstrates excellent injectability, self-healing capability, and antibacterial properties. Subcutaneous implantation experiments in rats confirm the in vivo biocompatibility and biodegradability of the hydrogel. Both in vitro and in vivo findings suggest that the bio-functional hydrogel can expedite full-thickness skin wound healing in SD rats by promoting skin regeneration, suppressing inflammatory responses, increasing collagen deposition, and facilitating blood vessel formation. This research introduces a novel approach to the development of bio-functional hydrogels for full-thickness skin wound healing and regeneration.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00044"},"PeriodicalIF":4.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triblock Polyampholyte-Based Nanovesicles for Targeted Spleen Delivery. 靶向脾脏递送的三阻断聚两性聚合物纳米囊泡。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-22 DOI: 10.1002/mabi.202500147

Takayoshi Watanabe, Keita Masuda, Pengwen Chen, Horacio Cabral

引用次数: 0

In Vitro Behavior of Boron-Doped Baghdadite/Poly(vinylidene fluoride) Membrane Scaffolds Produced via Non-Solvent Induced Phase Separation. 非溶剂诱导相分离制备掺硼巴格达迪石/聚偏氟乙烯膜支架的体外行为

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-22 DOI: 10.1002/mabi.202400619

Büşra Mutlu, Fatma Demirci, Merve Erginer, Şeyma Duman

{"title":"In Vitro Behavior of Boron-Doped Baghdadite/Poly(vinylidene fluoride) Membrane Scaffolds Produced via Non-Solvent Induced Phase Separation.","authors":"Büşra Mutlu, Fatma Demirci, Merve Erginer, Şeyma Duman","doi":"10.1002/mabi.202400619","DOIUrl":"https://doi.org/10.1002/mabi.202400619","url":null,"abstract":"This study explores the potential of boron-doped baghdadite (BAG) powders incorporated into poly(vinylidene fluoride) (PVDF)-based membrane scaffolds for bone tissue engineering applications. The aim is to enhance the scaffolds' microstructure, surface wettability, thermal behavior, mechanical properties, and biological performance. Composite scaffolds are fabricated by integrating the powders into the PVDF matrix, yielding scaffolds with enhanced material characteristics and functionality. The incorporation of the powders significantly enhances the hydrophilicity of the scaffolds, as evidenced by a notable reduction in contact angle measurements. Mechanical analyses demonstrate that the addition of boron-doped BAG powders reduces the tensile strength and elongation at the break of PVDF scaffolds, attribute to increased pore size, reduced crystallinity, and structural heterogeneity, though the values remain within the range of human cancellous bone. Furthermore, in vitro bioactivity studies reveal the superior apatite-forming ability of the composite scaffolds, indicating their enhanced potential for biomineralization. The results of the cellular adhesion assays indicate an enhanced affinity and proliferation of cells on the membrane scaffolds, which is indicative of improved biocompatibility. In conclusion, the developed PVDF-based membrane scaffolds, reinforce with BAG powders, show promise as effective alternatives to traditional bone graft materials, offering scalable and versatile solutions for regenerative medicine.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00619"},"PeriodicalIF":4.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stimuli-Responsive Polymeric Nanoprobes for Bioimaging of Cancer Metastasis. 刺激反应聚合物纳米探针用于肿瘤转移的生物成像。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-21 DOI: 10.1002/mabi.202500168

Cheng Li, Zhidong Wang, Zhishen Ge

引用次数: 0

Protein-Based Multifunctional Hydrogel Adhesive for Wound Healing. 基于蛋白质的伤口愈合多功能水凝胶粘合剂。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-20 DOI: 10.1002/mabi.202500205

Kai Zhang, Heyuan Sun, Yuna Qian, Jianliang Shen, Zhongke Zhang

{"title":"Protein-Based Multifunctional Hydrogel Adhesive for Wound Healing.","authors":"Kai Zhang, Heyuan Sun, Yuna Qian, Jianliang Shen, Zhongke Zhang","doi":"10.1002/mabi.202500205","DOIUrl":"https://doi.org/10.1002/mabi.202500205","url":null,"abstract":"Wound healing is a complex and highly orchestrated biological process that encompasses four distinct stages including: hemostasis, inflammation, proliferation, and remodeling. Each stage is characterized by specific physiological responses and tissue repair mechanisms that collectively facilitate the restoration of tissue integrity. To achieve comprehensive wound management, the development of targeted hydrogel bioadhesives is of paramount importance. Hydrogel-based bioadhesives, characterized by their excellent physical properties and biocompatibility, have demonstrated significant potential in the field of wound treatment. However, the current research on protein-based hydrogel bioadhesives for wound healing remains limited. This review systematically examines the design principles of ideal hydrogel bioadhesives and their essential functions in wound repair. It provides an overview of the latest advancements multifunctional hydrogel bioadhesives derived from various proteins, including collagen, silk fibroin (SF), sericin, fibrin, gelatin (Gel), keratin, and casein. It also evaluates their performance in practical applications. Finally, the review highlights the primary challenges facing protein-based hydrogel bioadhesives in the field of wound healing and outlines prospective research directions, with the goal of advancing the development and clinical application of these technologies.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00205"},"PeriodicalIF":4.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Performance of Hydrogel-Derived Extracellular Wharton's Jelly Matrix and Wharton's Jelly Mesenchymal Stem Cells in Repairing Infarcted Myocardium of Ischemic Rats: a Preclinical Study. 水凝胶来源的细胞外Wharton’s Jelly基质和Wharton’s Jelly间充质干细胞修复缺血大鼠梗死心肌的临床前研究

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-20 DOI: 10.1002/mabi.202400578

Zahra Tavajjohi, Faraz Sigaroodi, Shahram Rabbani, Maryam Barekat, Maryam Rouhani, Safieh Boroumand, Mohammad-Mehdi Khani

{"title":"Therapeutic Performance of Hydrogel-Derived Extracellular Wharton's Jelly Matrix and Wharton's Jelly Mesenchymal Stem Cells in Repairing Infarcted Myocardium of Ischemic Rats: a Preclinical Study.","authors":"Zahra Tavajjohi, Faraz Sigaroodi, Shahram Rabbani, Maryam Barekat, Maryam Rouhani, Safieh Boroumand, Mohammad-Mehdi Khani","doi":"10.1002/mabi.202400578","DOIUrl":"https://doi.org/10.1002/mabi.202400578","url":null,"abstract":"Following myocardial infarction (MI), progressive death of cardiomyocytes and subsequent loss of the extracellular matrix leads to drastic alterations in the structure and mechanical performance of the heart, thereby leading to infarct expansion and cardiac dysfunction. To compensate for the lack of reparative potency in infarcted hearts and to inhibit negative remodeling in the myocardium after MI, stem cell-based therapy in combination with hydrogels has emerged as a promising strategy to improve cardiac function recovery. In this study, a novel injectable hydrogel derived from decellularized Wharton's jelly extracellular matrix (DWJM) is prepared and examined the therapeutic performance of a combination of bioactive DWJM hydrogels and Wharton's jelly mesenchymal stem cells (WJMSCs) for myocardial repair in ischemic rats. In vitro examinations indicated that the DWJM hydrogel exhibited appropriate rheological performance and is capable of undergoing sol-gel transition at 37 °C. After intramyocardial injection in MI rats, DWJM-trapped WJMSCs significantly improved cardiac function recovery, reduced scar formation, and promoted cardiomyogenesis and microvascular renewal compared to WJMSCs or DWJM hydrogels alone. The results demonstrated that the DWJM hydrogel and WJMSCs synergistically promoted myocardial repair, which further confirmed the promising stem cell therapy using the bioactive ECM hydrogel.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e70007"},"PeriodicalIF":4.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silk Sericin in Dermatological Diseases: From Preclinical Studies to Future Clinical Applications. 丝胶蛋白在皮肤病中的应用：从临床前研究到未来临床应用。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2025-05-20 DOI: 10.1002/mabi.202500058

Monika Stradczuk-Mazurek, Łukasz Mazurek, Marek Konop

{"title":"Silk Sericin in Dermatological Diseases: From Preclinical Studies to Future Clinical Applications.","authors":"Monika Stradczuk-Mazurek, Łukasz Mazurek, Marek Konop","doi":"10.1002/mabi.202500058","DOIUrl":"https://doi.org/10.1002/mabi.202500058","url":null,"abstract":"Biomaterials in medicine are becoming more widespread as a single or complementary treatment option. One such biomaterial is silk, comprised of two primary proteins: fibroin and sericin. Recently, sericin's anti-inflammatory, antioxidant, moisturizing, elastase- and tyrosinase-inhibiting properties have been widely investigated. Sericin biomaterials are already used in wound healing and bone tissue engineering. Additionally, there are promising results for its usefulness in many other applications. This review focuses on sericin use in dermatological diseases, above all in atopic dermatitis and psoriasis. Sericin biomaterials have proven not only to be a promising drug carrier but also to improve the treatment outcome of atopic skin lesions. In psoriasis, sericin's therapeutic effect has reduced inflammation and abnormal epidermal maturation in plaques, with results comparable to standard treatment. Sericin is also observed to diminish skin pigmentation, improve moisture, and increase collagen production so that it can be used as an anti-aging product. There are also reports of its anti-skin-cancer activity. This paper describes the mechanisms behind skin diseases' pathogenesis and, based on the results of scientific studies, highlights and explains sericin's beneficial effects in their treatment. Its versatility, alone or combined with other therapeutic agents, provides new opportunities for dermatological treatments and cosmetic innovations.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":" ","pages":"e00058"},"PeriodicalIF":4.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0