Macromolecular bioscience最新文献_第9页

Investigating the Impact of Pore Size and Specification on Soft Tissue Ingrowth in 3D-Printed PEEK Material 研究三维打印 PEEK 材料中孔隙大小和规格对软组织生长的影响

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-09-30 DOI: 10.1002/mabi.202400278

Zibo Zhang, Zenghuai Li, Donglai Wang, Jiangang Feng, Qi Feng

{"title":"Investigating the Impact of Pore Size and Specification on Soft Tissue Ingrowth in 3D-Printed PEEK Material","authors":"Zibo Zhang, Zenghuai Li, Donglai Wang, Jiangang Feng, Qi Feng","doi":"10.1002/mabi.202400278","DOIUrl":"10.1002/mabi.202400278","url":null,"abstract":"Bone pelvis tumor resection and reconstruction is a complex surgical procedure that poses challenges in soft tissue reconstruction despite advancements in stabilizing pelvic structure. This study aims to investigate the potential of using Polyetheretherketone (PEEK) material in repairing and reconstructing soft tissues surrounding pelvic implants. Specifically, the study focuses on exploring the effectiveness of 3D printed porous PEEK material in promoting cell growth and adhesion. The interaction between PEEK materials with different pore sizes (200, 400, 600 µm) and different specifications (through-hole (T)/non-through-hole (C)) is evaluated by cell experiments and animal experiments. The soft tissue ingrowth potential of PEEK materials is evaluated by cell growth and adhesion observation. The findings indicate that PEEK material, particularly the T400 variant, exhibits stronger interaction with muscle tissue compared to its interaction with bone and fibrous tissue. The moderately sized pores present in the T400 material facilitate enhanced cell adhesion and penetration, thereby promoting cell growth and differentiation. PEEK materials with through-hole structures show promise for applications involving the repair and reconstruction of soft tissues and muscle tissue. The study provides valuable insights into the development and application of biomedical materials, specifically PEEK, contributing to the advancement of pelvic tumor resection and reconstruction techniques.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"24 12","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into Advances and Applications of Biomaterials for Nerve Tissue Injuries and Neurodegenerative Disorders 深入了解神经组织损伤和神经退行性疾病生物材料的进展和应用。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-09-30 DOI: 10.1002/mabi.202400150

Varsha Pai, Bhisham Narayan Singh, Abhishek Kumar Singh

{"title":"Insights into Advances and Applications of Biomaterials for Nerve Tissue Injuries and Neurodegenerative Disorders","authors":"Varsha Pai, Bhisham Narayan Singh, Abhishek Kumar Singh","doi":"10.1002/mabi.202400150","DOIUrl":"10.1002/mabi.202400150","url":null,"abstract":"The incidence of nerve tissue injuries, such as peripheral nerve injury, spinal cord injury, traumatic brain injury, and various neurodegenerative diseases (NDs), is continuously increasing because of stress, physical and chemical trauma, and the aging population worldwide. Restoration of the damaged nervous system is challenging because of its structural and functional complexity and limited regenerative ability. Additionally, there is no cure available for NDs except for medications that provide symptomatic relief. Stem cells offer an alternative approach for promoting damage repair, but their efficacy is limited by a compromised survival rate and neurogenesis process. To address these challenges, neural tissue engineering has emerged as a promising strategy in which stem cells are seeded or encapsulated within a suitable biomaterial construct, increasing cell survival and neurogenesis. Numerous biomaterials are utilized to create different types of constructs for this purpose. Researchers are trying to develop ideal scaffolds that combine biomaterials, cells, and molecules that exactly mimic the biological and mechanical properties of the tissue to achieve functional recovery associated with neurological dysfunction. This review focuses on exploring the development and applications of different biomaterials for their potential use in the diagnosis, therapy, nerve tissue regeneration, and treatment of neurological disorders.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"24 12","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202400150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Responding to Hitch in Fighting Mycobacterium Tuberculosis Through Arginine Multi Functionalized Mucoadhesive SNEDDS of Rifampicin 通过精氨酸多功能黏附性 SNEDDS（利福平 SNEDDS）抗击结核分枝杆菌。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-09-25 DOI: 10.1002/mabi.202400288

Sana Saeed, Muhammad Farooq, Rabia Arshad, Sherjeel Adnan, Hammad Ahmad, Zeeshan Masood, Abdul Malik, Ayesha Saeed, Tanveer A Tabish

{"title":"Responding to Hitch in Fighting Mycobacterium Tuberculosis Through Arginine Multi Functionalized Mucoadhesive SNEDDS of Rifampicin","authors":"Sana Saeed, Muhammad Farooq, Rabia Arshad, Sherjeel Adnan, Hammad Ahmad, Zeeshan Masood, Abdul Malik, Ayesha Saeed, Tanveer A Tabish","doi":"10.1002/mabi.202400288","DOIUrl":"10.1002/mabi.202400288","url":null,"abstract":"The study aimed to develop thiolated pluronic-based self-emulsifying drug delivery system (SNEDDS) targeted delivery of Rifampicin coated by arginine for enhanced drug loading, mucoadhesion, muco penetration, site-specific delivery, stabilized delivery against intracellular mycobacterium tuberculosis (M. tb), decreased bacterial burden and production by intracellular targeting. Oleic oil, PEG 200 and Tween 80 are selected as oil, co-surfactant and surfactant based on solubilizing capacity and pseudo ternary diagram region. Coating of thiolated polymer on SNEDDS with ligand arginine (Arg-Th-F407 SNEDDDS) decreased bacterial burden and production by intracellular targeting in macrophages. Formulation are evaluated through scanning electron microscope (SEM), EDAX analysis, diffraction laser scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, and thermal analysis (DSC & TGA). Hydrodynamic diameter of thiolated polymeric SNEDDS (Th-F407 SNEDDS) and Arg-Th-F407 SNEDDS is observed to be 148.4 and 188.5 nm with low PDI of 0.4 and 0.3, respectively. Invitro drug release study from Arg-Th-F407 SNEDDS indicates 80% sustained release in 72 h under controlled conditions. Arg-Th-F407 SNEDDDS shows excellent capability of killing M.tb strains in macrophages even at low dose as compared to traditional rifampicin (RIF) and is found biocompatible, non-cytotoxic, and hemocompatible. Therefore, Arg-Th-F407 SNEDDDS of RIF proved ideal for targeting and treating M.tb strains within macrophages.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"24 12","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible, Electrochemical Skin-Like Platform for Inflammatory Biomarker Monitoring 用于炎症生物标记物监测的灵活电化学类肤平台

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-09-18 DOI: 10.1002/mabi.202400287

Carolina Lourenço, Felismina Moreira, Rui Igreja, Gabriela Martins

{"title":"Flexible, Electrochemical Skin-Like Platform for Inflammatory Biomarker Monitoring","authors":"Carolina Lourenço, Felismina Moreira, Rui Igreja, Gabriela Martins","doi":"10.1002/mabi.202400287","DOIUrl":"10.1002/mabi.202400287","url":null,"abstract":"Addressing global challenges in wound management has greatly encouraged the emergence of home diagnosis and monitoring devices. This technological shift has accelerated the development of new skin patch sensors for continuous health monitoring. A key requirement is the creation of flexible platforms capable of mimicking human skin features. Here, for the first time, an innovative, highly adaptable electrochemical biosensor with molecularly imprinted polymers (MIPs) is customized for the detection of the inflammatory biomarker interleukin-6 (IL-6). The 3-electrode gold pattern is geometrically standardized onto a 6 µm thick polyimide flexible membrane, an optically transparent, and biocompatible polymeric substrate. Subsequently, a biomimetic sensing layer specifically designed for the detection of IL-6 target is produced on these transducers. The obtained MIP biosensor shows a good linear response within the concentration range 50 pg mL−1-50 ng mL−1, with a low limit of detection (8 pg mL−1). X-ray photoelectron spectroscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy characterizations confirm the modifications of the flexible gold transducer. After optimization, the biosensing device shows remarkable potential in terms of sensitivity, selectivity, and reproducibility. Overall, the integration of a low-cost electrochemical sensor on biocompatible flexible polymers opens the way for a new generation of monitoring tools with higher accuracy, less invasiveness, and greater patient comfort.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"24 12","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Masthead: Macromol. Biosci. 9/2024 刊头：Macromol.Biosci.9/2024

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-09-16 DOI: 10.1002/mabi.202470021

引用次数: 0

Viral Vector Eluting Lenses for Single-Step Targeted Expression of Genetically-Encoded Activity Sensors for in Vivo Microendoscopic Calcium Imaging 用于体内显微内窥镜钙成像的基因编码活动传感器单步靶向表达的病毒载体洗脱透镜。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-09-16 DOI: 10.1002/mabi.202400359

Carolyn K. Jons, David Cheng, Changxin Dong, Emily L. Meany, Jonathan J. Nassi, Eric A. Appel

{"title":"Viral Vector Eluting Lenses for Single-Step Targeted Expression of Genetically-Encoded Activity Sensors for in Vivo Microendoscopic Calcium Imaging","authors":"Carolyn K. Jons, David Cheng, Changxin Dong, Emily L. Meany, Jonathan J. Nassi, Eric A. Appel","doi":"10.1002/mabi.202400359","DOIUrl":"10.1002/mabi.202400359","url":null,"abstract":"Optical methods for studying the brain offer powerful approaches for understanding how neural activity underlies complex behavior. These methods typically rely on genetically encoded sensors and actuators to monitor and control neural activity. For microendoscopic calcium imaging, injection of a virus followed by implantation of a lens probe is required to express a calcium sensor and enable optical access to the target brain region. This two-step process poses several challenges, chief among them being the risks associated with mistargeting and/or misalignment between virus expression zone, lens probe and target brain region. Here, an adeno-associated virus (AAV)-eluting polymer coating is engineered for gradient refractive index (GRIN) lenses enabling the expression of a genetically encoded calcium indicator (GCaMP) directly within the brain region of interest upon implantation of the lens. This approach requires only one surgical step and guarantees alignment between GCaMP expression and lens in the brain. Additionally, the slow virus release from these coatings increases the working time for surgical implantation, expanding the brain regions and species amenable to this approach. These enhanced capabilities should accelerate neuroscience research utilizing optical methods and advance the understanding of the neural circuit mechanisms underlying brain function and behavior in health and disease.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"25 2","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One Stone Several Birds: Self-Localizing Submicrocages With Dual Loading Points for Multifunctional Drug Delivery 一石数鸟：具有双装载点的自定位亚微囊用于多功能药物输送

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-09-16 DOI: 10.1002/mabi.202470020

Shuxuan Liu, Jifei Wang, Yong Jiang, Yao Wang, Bin Yang, Hao Li, Guofu Zhou

引用次数: 0

Unlocking the Potential: PEGylation and Molecular Weight Reduction of Ionenes for Enhanced Antifungal Activity and Biocompatibility 释放潜力：离子烯的 PEG 化和分子量降低可增强抗真菌活性和生物相容性

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-09-16 DOI: 10.1002/mabi.202470022

Jan M. Kurzyna, Rafał J. Kopiasz, Martyna Paul, Magdalena Flont, Patrycja Baranowska, Jolanta Mierzejewska, Karolina Drężek, Waldemar Tomaszewski, Elżbieta Jastrzębska, Dominik Jańczewski

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Preparation, Structural Analysis, and Growth-Promoting Effects of Amomum longiligulare Polysaccharide 1-Mg (II) Complex 长日月藻多糖 1-Mg (II) 复合物的制备、结构分析和促进生长作用

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-09-13 DOI: 10.1002/mabi.202400297

Yijing Chen, Haowen Wu, Chenglong Zhang, Qiyuan Luo, Yun Chen

引用次数: 0

Phytotherapeutic Hierarchical PCL-Based Scaffolds as a Multifunctional Wound Dressing: Combining 3D Printing and Electrospinning 以植物疗法为基础的分层 PCL 支架作为多功能伤口敷料：三维打印与电纺丝的结合

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-09-10 DOI: 10.1002/mabi.202400253

Irem Unalan, Benedikt Slavik, Andrea Buettner, Aldo R. Boccaccini

{"title":"Phytotherapeutic Hierarchical PCL-Based Scaffolds as a Multifunctional Wound Dressing: Combining 3D Printing and Electrospinning","authors":"Irem Unalan, Benedikt Slavik, Andrea Buettner, Aldo R. Boccaccini","doi":"10.1002/mabi.202400253","DOIUrl":"10.1002/mabi.202400253","url":null,"abstract":"This study focuses on developing hybrid scaffolds incorporating phytotherapeutic agents via a combination of three-dimensional (3D) printing and electrospinning to enhance mechanical properties and provide antibacterial activity, in order to address the limitations of traditional antibiotics. In this regard, 3D-printed polycaprolactone (PCL) struts are first fabricated using fused deposition modeling (FDM). Then, alkaline surface treatment is applied to improve the adhesion of electrospun nanofibers. Finally, peppermint oil (PEP) or clove oil (CLV)-incorporated PCL-gelatin (GEL) electrospun nanofibers are collected on top of the 3D-printed PCL scaffolds by electrospinning. Incorporating PEP or CLV into PCL-GEL electrospun nanofibers enhances the scaffold's layer detachment and adhesion force. In addition, the DPPH free radical scavenging activity assay indicates that incorporating PEP or CLV improves the antioxidant properties of the scaffolds. Further, antibacterial activity results reveal that PEP or CLV incorporated scaffolds exhibit inhibition against Staphylococcus aureus and Escherichia coli bacteria. Moreover, anti-inflammatory assays show that scaffolds reduce the concentration of nitric oxide (NO) released from Raw 264.7 macrophage-like cells. On the other hand, the phytotherapeutic hierarchical scaffolds have no toxic effect on normal human dermal fibroblast (NHDF) cells, and PEP or CLV enhance cell attachment and proliferation. Overall, incorporating natural phytotherapeutic agents into hierarchical scaffolds shows promise for advancing wound healing applications.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":"24 11","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202400253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142182648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0