Lipids最新文献

{"title":"Characteristics of intestinal flora in nonobese nonalcoholic fatty liver disease patients and the impact of ursodeoxycholic acid treatment on these features","authors":"Liyan Wang,&nbsp;Jiali Xu,&nbsp;Ningning You,&nbsp;Li Shao,&nbsp;Zhenjie Zhuang,&nbsp;Lili Zhuo,&nbsp;Jing Liu,&nbsp;Junping Shi","doi":"10.1002/lipd.12410","DOIUrl":"10.1002/lipd.12410","url":null,"abstract":"<p>The study aimed to investigate the alterations in gut microbiota among nonobese individuals with nonalcoholic fatty liver disease (NAFLD) and their response to treatment with ursodeoxycholic acid (UDCA). A total of 90 patients diagnosed with NAFLD and 36 healthy subjects were recruited to participate in this study. Among them, a subgroup of 14 nonobese nonalcoholic steatohepatitis (NASH) were treated with UDCA. Demographic and serologic data were collected for all participants, while stool samples were obtained for fecal microbiome analysis using 16S sequencing. In nonobese NAFLD patients, the alpha diversity of intestinal flora decreased (Shannon index, <i>p</i> &lt; 0.05), and the composition of intestinal flora changed (beta diversity, <i>p</i> &lt; 0.05). The abundance of 20 genera, including <i>Fusobacterium</i>, <i>Lachnoclostridium</i>, <i>Klebsiella</i>, etc., exhibited significant changes (<i>p</i> &lt; 0.05). Among them, nine species including <i>Fusobacterium</i>, <i>Lachnoclostridium</i>, <i>Klebsiella</i>, etc. were found to be associated with abnormal liver enzymes and glucolipid metabolic disorders. Among the 14 NASH patients treated with UDCA, improvements were observed in terms of liver enzymes, CAP values, and E values (<i>p</i> &lt; 0.05), however, no improve the glucolipid metabolism. While the alpha diversity of intestinal flora did not show significant changes after UDCA treatment, there was a notable alteration in the composition of intestinal flora (beta diversity, <i>p</i> &lt; 0.05). Furthermore, UCDA treatment led to an improvement in the relative abundance of <i>Alistipes</i>, <i>Holdemanella</i>, <i>Gilisia</i>, etc. among nonobese NASH patients (<i>p</i> &lt; 0.05). Nonobese NAFLD patients exhibit dysbiosis of the intestinal microbiota. UDCA can ameliorate hepatic enzyme abnormalities and reduce liver fat content in nonobese NASH patients, potentially through its ability to restore intestinal microbiota balance.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 6","pages":"193-207"},"PeriodicalIF":1.8,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics study of serum from patients with type 2 diabetes: Peripheral neuropathy could be associated with sphingosine and phospholipid molecules","authors":"Jingchen Zhong,&nbsp;Xiaojie Li,&nbsp;Mengqian Yuan,&nbsp;Dong Chen,&nbsp;Yancai Li,&nbsp;Xiaoyang Lian,&nbsp;Ming Wang","doi":"10.1002/lipd.12412","DOIUrl":"10.1002/lipd.12412","url":null,"abstract":"<p>Abnormal lipid metabolism is one of the risk factors for type 2 diabetes mellitus peripheral neuropathy (DPN). This study aimed to determine the differences in lipid metabolism in patients with type 2 diabetes and DPN and the possible pathogenesis caused by this difference. The participants comprised type 2 diabetes mellitus patients with DPN (<i>N</i> = 60) and healthy controls (<i>N</i> = 20). Blood samples were drawn from the participants in the morning in the fasting state, and then changes in serum lipids were explored using targeted metabolomics on the liquid chromatography-electrospray ionization-tandem mass spectrometry platform. Among the 1768 differentially abundant lipid metabolites, the results of orthogonal partial least squares-discriminant analysis combined with random forest analysis showed that the levels of sphingosine (SPH) (d18:0), carnitine 22:1, lysophosphatidylethanolamine (LPE) (18:0/0:0), LPC (16:0/0:0), lysophosphatidylcholine (LPC) (18:1/0:0), LPC (0:0/18:0) and LPE (0:0/18:1) were significantly different between the two groups. Spearman correlation analysis showed that SPH (d18:0), carnitine 22:1, LPE (18:0/0:0), and LPC (0:0/18:0) levels correlated highly with the patients' electromyography results. Kyoto Encyclopedia of Genes and Genomes pathway annotation and enrichment analysis of 538 differentially abundant lipid metabolites revealed that type 2 diabetes mellitus DPN was related to glycerophospholipid metabolism and glycerol metabolism. Our results further identified the dangerous lipid metabolites associated with DPN and abnormal lipid metabolism. The influence of lipid metabolites such as SPH and phospholipid molecules on DPN development in patients with type 2 diabetes mellitus were suggested and the possible pathogenic pathways were clarified, providing new insights into the clinical risk of DPN in patients with type 2 diabetes mellitus.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"60 1","pages":"3-13"},"PeriodicalIF":1.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern","authors":"","doi":"10.1002/lipd.12413","DOIUrl":"10.1002/lipd.12413","url":null,"abstract":"<p>Expression of Concern: M. Taghizadeh, T. Hashemi, H. Shakeri, F. Abedi, S.-S. Sabihi, S.-A. Alizadeh, and Z. Asemi, “Synbiotic Food Consumption Reduces Levels of Triacylglycerols and VLDL, but not Cholesterol, LDL, or HDL in Plasma from Pregnant Women,” Lipids 49, no. 2 (2014): 155–161, https://doi.org/10.1007/s11745-013-3867-2.</p><p>This Expression of Concern is for the above article, published online on 23 November 2013 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Philip C. Calder, American Oil Chemists' Society, and John Wiley &amp; Sons, Inc. The Expression of Concern has been agreed due to concerns raised regarding the integrity of the research and discrepancies in reporting. An investigation has been conducted by the National Committee for Ethics in Biomedical Research Iran, in coordination with Kashan University of Medical Sciences (KAUMS). However, without the verification of clinical records there remain sufficient doubts about the feasibility and integrity of the research undertaken. As a result, the journal has decided to issue an Expression of Concern to alert readers.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 5","pages":"159"},"PeriodicalIF":1.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.12413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern","authors":"","doi":"10.1002/lipd.12414","DOIUrl":"10.1002/lipd.12414","url":null,"abstract":"<p><b>Expression of Concern:</b> H. Shakeri, H. Hadaegh, F. Abedi, M. Tajabadi-Ebrahimi, N. Mazroii, Y. Ghandi, and Z. Asemi, “Consumption of Synbiotic Bread Decreases Triacylglycerol and VLDL Levels While Increasing HDL Levels in Serum from Patients with Type-2 Diabetes,” <i>Lipids</i> 49, no. 7 (2014): 695–701, https://doi.org/10.1007/s11745-014-3901-z.</p><p>This Expression of Concern is for the above article, published online on 06 April 2014 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Philip C. Calder, American Oil Chemists' Society, and John Wiley &amp; Sons, Inc. The Expression of Concern has been agreed due to concerns raised regarding the integrity of the research and discrepancies in reporting. An investigation has been conducted by the National Committee for Ethics in Biomedical Research Iran, in coordination with Kashan University of Medical Sciences (KAUMS). However, without the verification of clinical records there remain sufficient doubts about the feasibility and integrity of the research undertaken. As a result, the journal has decided to issue an Expression of Concern to alert readers.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 5","pages":"161"},"PeriodicalIF":1.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.12414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern","authors":"","doi":"10.1002/lipd.12415","DOIUrl":"10.1002/lipd.12415","url":null,"abstract":"<p><b>Expression of Concern:</b> M. Jamilian, M. Karamali, M. Taghizadeh, N. Sharifi, Z. Jafari, M. R. Memarzadeh, M. Mahlouji, and Z. Asemi, “Vitamin D and Evening Primrose Oil Administration Improve Glycemia and Lipid Profiles in Women with Gestational Diabetes,” <i>Lipids</i> 51, no. 3 (2016): 349–356, https://doi.org/10.1007/s11745-016-4123-3.</p><p>This Expression of Concern is for the above article, published online on 19 January 2016 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Philip C. Calder, American Oil Chemists' Society, and John Wiley &amp; Sons, Inc. The Expression of Concern has been agreed due to concerns raised regarding the integrity of the research and discrepancies in reporting. An investigation has been conducted by the National Committee for Ethics in Biomedical Research Iran, in coordination with Kashan University of Medical Sciences (KAUMS). However, without the verification of clinical records there remain sufficient doubts about the feasibility and integrity of the research undertaken. As a result, the journal has decided to issue an Expression of Concern to alert readers.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 5","pages":"163"},"PeriodicalIF":1.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.12415","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern","authors":"","doi":"10.1002/lipd.12416","DOIUrl":"10.1002/lipd.12416","url":null,"abstract":"<p><b>Expression of Concern:</b> A.A. Hashemzadeh, N. Nasoohi, F. Raygan, E. Aghadavod, E. Akbari, M. Taghizadeh, M.R. Memarzadeh, and Z. Asemi, “Flaxseed Oil Supplementation Improve Gene Expression Levels of PPAR-γ, LP(a), IL-1 and TNF-α in Type 2 Diabetic Patients with Coronary Heart Disease,” <i>Lipids</i> 52, no. 11 (2017): 907–915, https://doi.org/10.1007/s11745-017-4295-5.</p><p>This Expression of Concern is for the above article, published online on 15 September 2017 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Philip C. Calder, American Oil Chemists' Society, and John Wiley &amp; Sons, Inc. The Expression of Concern has been agreed due to concerns raised regarding the integrity of the research and discrepancies in reporting. An investigation has been conducted by the National Committee for Ethics in Biomedical Research Iran, in coordination with Kashan University of Medical Sciences (KAUMS). However, without the verification of clinical records there remain sufficient doubts about the feasibility and integrity of the research undertaken. As a result, the journal has decided to issue an Expression of Concern to alert readers.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 5","pages":"165"},"PeriodicalIF":1.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.12416","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of TyG and lipid ratios on the development of complications and hyperuricemia in patients with type 2 diabetes mellitus","authors":"Jie Yang,&nbsp;Kai-fan Zhou,&nbsp;Guo-dong Tao,&nbsp;Bin Wei,&nbsp;Yu-wei Lu","doi":"10.1002/lipd.12411","DOIUrl":"10.1002/lipd.12411","url":null,"abstract":"<p>Investigate the predictive value of TyG and lipid ratios on the development of complications and HUA in patients with T2DM. A retrospective cross-sectional study involving 9488 T2DM patients was conducted. They were divided into HUA and NUA group base on SUA level and divided into with and without complications groups according to the diagnosis of the endocrinologist. Necessary information and biochemical parameters were recorded during outpatient visit. TyG index and lipid ratios were calculated, and statistical analysis was carried out to correlate the calculated values and HUA using SPSS version 26.0 for Windows. TyG and lipid ratios were significantly higher in T2DM with HUA or with complications than those with NUA or without complications (<i>p</i> &lt; 0.05). Regression analysis adjusting for confounding factors found TyG (adjusted OR = 1.54; 95% CI: 1.31–1.82; <i>p</i> &lt; 0.05), TG/HDL-C (adjusted OR = 1.21; 95% CI: 1.04–1.40; <i>p</i> &lt; 0.05) and TC/HDL (adjusted OR = 1.36; 95% CI: 1.17–1.57; <i>p</i> &lt; 0.05) was risk factor of HUA in T2DM patients. TyG (adjusted OR = 1.21; 95% CI: 1.02–1.44; <i>p</i> &lt; 0.05), TG/HDL (adjusted OR = 1.19; 95% CI: 1.03–1.38; <i>p</i> &lt; 0.05) and Apo A/Apo B (adjusted OR = 1.41; 95% CI: 1.26–1.58; <i>p</i> &lt; 0.05) was risk factor of complications in T2DM patients. TyG, TG/HDL-C, and TC/HDL can be used as early sensitive target in the occurrence of HUA in T2DM patients and TyG was the most influential risk factor. TyG, TG/HDL-C, and Apo A/Apo B can be used as early sensitive target in the occurrence of complications in T2DM patients and Apo A/Apo B was the most influential risk factor.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 6","pages":"209-219"},"PeriodicalIF":1.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear receptors behind the therapeutic effects of plant sterols on metabolism: A review","authors":"María C. Brañes,&nbsp;Raimundo Gillet,&nbsp;Rodrigo Valenzuela","doi":"10.1002/lipd.12409","DOIUrl":"10.1002/lipd.12409","url":null,"abstract":"<p>Plant sterols are known for their hypocholesterolemic action, and the molecular mechanisms behind this within the gut have been extensively discussed and demonstrated to the point that there is a degree of consensus. However, recent studies show that these molecules exert an additional umbrella of therapeutic effects in other tissues, which are related to immune function, lipid metabolism, and glucose metabolism. A strong hypothesis to explain these effects is the structural relationship between plant sterols and the ligands of a group of nuclear receptors. This review delves into the molecular aspects of therapeutic effects related with lipid and energy metabolism that have been observed and demonstrated for plant sterols, and turns the perspective to explore the involvement of nuclear receptors as part of these mechanisms.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 6","pages":"169-180"},"PeriodicalIF":1.8,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obeticholic acid's effect on HDL function in MASH varies by diabetic status","authors":"Chunki Kim,&nbsp;Tsung-Heng Tsai,&nbsp;Rocio Lopez,&nbsp;Arthur McCullough,&nbsp;Takhar Kasumov","doi":"10.1002/lipd.12408","DOIUrl":"10.1002/lipd.12408","url":null,"abstract":"<p>Inflammation and oxidative stress are the key factors in the pathogenesis of both metabolic dysfunction-associated steatohepatitis (MASH) and atherosclerosis. Obeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, improves hepatic inflammation and fibrosis in patients with MASH. However, it also reduces HDL cholesterol, suggesting that OCA may increase cardiovascular disease (CVD) risk in patients with MASH. We assessed HDL cholesterol efflux function, antioxidant (paraoxonase and ceruloplasmin activity), pro-inflammatory index, and particle sizes in a small group of patients with and without diabetes (<i>n</i> = 10/group) at baseline and after 18 months of OCA treatment. Patients on lipid-lowering medications (statins, fibrates) were excluded. At baseline, ferritin levels were higher in patients with MASH without diabetes (336.5 [157.0, 451.0] vs. 83 [36.0, 151.0] ng/mL, <i>p</i> &lt; 0.005). Markers of HDL functions were similar in both groups. OCA therapy significantly improved liver histology and liver enzymes but increased alkaline phosphatase levels in nondiabetic patients with MASH (<i>p</i> &lt; 0.05). However, it did not have any significant effect on cholesterol efflux and the antioxidant paraoxonase functions. In nondiabetics, ceruloplasmin (CP) antioxidant activity decreased (<i>p</i> &lt; 0.005) and the pro-inflammatory index of HDL increased (<i>p</i> &lt; 0.005) due to OCA therapy. In contrast, in diabetics, OCA increased levels of pre-β-HDL—the HDL particles enhanced protective capacity (<i>p</i> = 0.005) with no alteration in HDL functionality. In all patients, serum glucose levels were negatively correlated with OCA-induced change in pro-inflammatory function in HDL (<i>p</i> &lt; 0.001), which was primarily due to diabetes (<i>p</i> = 0.05). These preliminary results suggest a distinct effect of OCA therapy on diabetic and nondiabetic patients with MASH and warrant a future large-scale study.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 6","pages":"221-231"},"PeriodicalIF":1.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute ultraviolet B irradiation increases cholesterol and decreases Cyp7a1 expression in the liver of female mice","authors":"Takumi Yamane,&nbsp;Takahiro Okumoto,&nbsp;Tomoko Tamura,&nbsp;Yuichi Oishi","doi":"10.1002/lipd.12407","DOIUrl":"10.1002/lipd.12407","url":null,"abstract":"<p>Recent studies have demonstrated that ultraviolet B (UVB) irradiation impacts both skin and hepatic functions. In this study, we investigated the effects of UVB irradiation on cholesterol metabolism in the liver. Hairless mice were exposed to UVB (1.6 J/cm²) irradiation. Dorsal skin and liver samples were collected 24 h after exposure. Total RNA was extracted from the skin and liver tissues, and used for DNA microarray analysis and real-time polymerase chain reaction (PCR). Hepatic mRNA expression of <i>Cyp7a1</i> revealed a 4.4-fold decrease in the UVB (+) group compared to that in the UVB (−) group. No differences were observed in the expression of the other genes related to cholesterol metabolism. Additionally, the level of hepatic total cholesterol in the UVB (+) group was significantly higher than in the UVB (−) group. These findings suggest that acute UVB irradiation increases total cholesterol levels and decreases Cyp7a1 expression in the liver.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 6","pages":"181-191"},"PeriodicalIF":1.8,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}