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Value of the monocyte-to-high-density lipoprotein cholesterol ratio in refining the detection of prevalent heart failure: Insights from the NHANES 1999–2018 单核细胞与高密度脂蛋白胆固醇比值在完善流行性心力衰竭检测中的价值:1999-2018年NHANES调查的启示
IF 1.8 4区 医学
Lipids Pub Date : 2024-04-18 DOI: 10.1002/lipd.12395
Letian Wang, Yang Liu, Wenrui Shi, Xu Liu, Mu Qin
{"title":"Value of the monocyte-to-high-density lipoprotein cholesterol ratio in refining the detection of prevalent heart failure: Insights from the NHANES 1999–2018","authors":"Letian Wang,&nbsp;Yang Liu,&nbsp;Wenrui Shi,&nbsp;Xu Liu,&nbsp;Mu Qin","doi":"10.1002/lipd.12395","DOIUrl":"10.1002/lipd.12395","url":null,"abstract":"<p>The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) is a novel marker that can help estimate the degree of atherosclerosis by considering inflammation and lipid abnormalities. This study aimed to assess the association between the MHR and prevalent heart failure (HF) and to explore the value of the MHR in detecting prevalent HF in the general US population. Our study included 25,374 participants from the National Health and Nutrition Examination Survey (1999–2018). Among the participants, 749 (2.95%) reported a history of HF, and the HF group had a significantly higher MHR than the non-HF group. Adjusted analyses revealed that each standard deviation increase in the MHR was associated with a 27.8% increase in the risk of HF. The association between the MHR and prevalent HF was linear across the entire MHR range. Adding the MHR to conventional cardiovascular risk factors significantly improved the area under the curve (0.875; <i>p</i> &lt; 0.001), continuous net reclassification index (0.187; <i>p</i> &lt; 0.001), and integrated discrimination index (0.004; <i>p</i> &lt; 0.001). Our study suggests a potential association between the MHR and HF risk, and the findings enhance HF risk stratification and provide novel insights into the interplay between the coronary atherosclerotic burden and HF in clinical settings.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 4","pages":"93-100"},"PeriodicalIF":1.8,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140629937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleiotropic beneficial cardiometabolic actions of a high-purity eicosapentaenoic acid product in high cardiovascular risk individuals 高纯度二十碳五烯酸产品对心血管疾病高危人群的多重有益心脏代谢作用。
IF 1.9 4区 医学
Lipids Pub Date : 2024-02-21 DOI: 10.1002/lipd.12391
Charalampos I. Liakos, Leonidas Lanaras, Magdalini Bristianou, Dimitrios P. Papadopoulos
{"title":"Pleiotropic beneficial cardiometabolic actions of a high-purity eicosapentaenoic acid product in high cardiovascular risk individuals","authors":"Charalampos I. Liakos,&nbsp;Leonidas Lanaras,&nbsp;Magdalini Bristianou,&nbsp;Dimitrios P. Papadopoulos","doi":"10.1002/lipd.12391","DOIUrl":"10.1002/lipd.12391","url":null,"abstract":"<p>The ideal approach to the secondary dyslipidemia goal of lowering triglycerides (TG) is not well established. The available ω-3 fatty acid products differ from each other in composition and content. The purpose of the present study was to investigate the effect of a highly purified eicosapentaenoic acid (EPA) formulation on cardiometabolic biomarkers in high cardiovascular (CV) risk patients. The study included 226 subjects with high TG and ≥1 of the following CV risk factors: arterial hypertension, diabetes mellitus, ultrasound-documented atheromatosis, peripheral artery disease, previous myocardial infarction, or ischemic stroke. Participants received 2 g EPA twice daily for 3 months, along with typical nutritional counseling. Cardiometabolic hematological parameters (TG, low-density lipoprotein [LDL], high-density lipoprotein [HDL], non-HDL, total cholesterol [TChol], apolipoprotein A<sub>1</sub> [Apo A<sub>1</sub>], apolipoprotein B [Apo B], glucose, glycated hemoglobin [HbA<sub>1</sub>c], and C-reactive protein [CRP]) were measured at baseline and at 3 months. The mean patients' age was 61.1 ± 1.4 years and the mean baseline TG was 2.97 ± 0.15 mmol/L. Apart from Apo A<sub>1</sub>, all other biomarkers significantly (<i>p</i> &lt; 0.05) improved at 3 months, regardless of sex (except Apo B) and age: TG 1.75 ± 0.09 versus 2.97 ± 0.15 mmol/L, LDL 2.46 ± 0.08 versus 3.05 ± 0.13 mmol/L, HDL 1.22 ± 0.03 versus 1.11 ± 0.03 mmol/L, non-HDL 3.29 ± 0.10 versus 4.14 ± 0.16 mmol/L, TChol 4.55 ± 0.10 versus 5.15 ± 0.13 mmol/L, Apo A<sub>1</sub> 26.8 ± 9.3 versus 22.5 ± 8.6 μmol/L, Apo B 1.25 ± 0.23 versus 1.29 ± 0.23 μmol/L, glucose 5.66 ± 0.11 versus 5.99 ± 0.17 mmol/L, HbA<sub>1</sub>c 5.83 ± 0.1 versus 5.97 ± 0.1% and CRP 1.92 ± 0.2 versus 5.26 ± 2.8 mg/L. In conclusion, adding highly purified EPA product (4 g daily) on nutritional counseling leads to a significant TG reduction. In addition, this treatment appears to have pleiotropic beneficial cardiometabolic actions.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 3","pages":"67-74"},"PeriodicalIF":1.9,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.12391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139931807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma sphingolipids in patients with sickle cell disease: Multiple-site vaso-occlusive crises could be associated with lower sphingolipid levels 镰状细胞病患者的血浆鞘磷脂:多部位血管闭塞危象可能与鞘脂水平较低有关。
IF 1.9 4区 医学
Lipids Pub Date : 2024-02-08 DOI: 10.1002/lipd.12389
Gokce Alp, Yesim Oztas, Ahmet Yalcinkaya, Selinay Ozel, Nazim Yildirim, Selma Unal
{"title":"Plasma sphingolipids in patients with sickle cell disease: Multiple-site vaso-occlusive crises could be associated with lower sphingolipid levels","authors":"Gokce Alp,&nbsp;Yesim Oztas,&nbsp;Ahmet Yalcinkaya,&nbsp;Selinay Ozel,&nbsp;Nazim Yildirim,&nbsp;Selma Unal","doi":"10.1002/lipd.12389","DOIUrl":"10.1002/lipd.12389","url":null,"abstract":"<p>Although sickle cell disease (SCD) and its manifestations have been associated with various lipid alterations, there are a few studies exploring the impact of sphingolipids in SCD. In this study, we determined plasma ceramide (Cer) and sphingomyelin (CerPCho) species and investigated their association with the crisis in SCD. SCD patients (<i>N</i> = 27) suffering from vaso-occlusive crisis (VOC) or acute chest syndrome (ACS) were involved in this study. Blood samples were drawn at crisis and later at steady state periods. Clinical history, white blood cell count (WBC), C-reactive protein and lactate dehydrogenase (LDH) levels were recorded. 16:0, 18:0, 20:0, 22:0 Cer and 16:0, 18:0, 24:0 CerPCho were measured via LC–MS/MS. All measured Cer and CerPCho levels of SCD patients at crisis and steady-state were found to be similar. Inflammation-related parameters were significantly higher in patients with ACS compared to single-site VOC. Patients with multiple-site VOC were found to have significantly lower sphingolipid levels compared with those with single-site VOC, at crisis (16, 18, 24 CerPCho and 18, 22 Cer) and at steady-state (24:0 CerPCho and 18 Cer). Our results show that sphingolipid levels in SCD patients are similar during crisis and at steady state. However, lower sphingolipid levels appear to be associated with the development of multiple-site VOC. Since the differences were observed at both crisis and steady-state, sphingolipid level could be an underlying factor associated with crisis characteristics in patients with SCD.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 3","pages":"75-82"},"PeriodicalIF":1.9,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alteration of serum bile acids in amyotrophic lateral sclerosis 肌萎缩性脊髓侧索硬化症患者血清胆汁酸的变化
IF 1.8 4区 医学
Lipids Pub Date : 2024-02-06 DOI: 10.1002/lipd.12390
Ikjae Lee, Renu Nandakumar, Rebecca A. Haeusler
{"title":"Alteration of serum bile acids in amyotrophic lateral sclerosis","authors":"Ikjae Lee,&nbsp;Renu Nandakumar,&nbsp;Rebecca A. Haeusler","doi":"10.1002/lipd.12390","DOIUrl":"10.1002/lipd.12390","url":null,"abstract":"<p>Hydrophilic endogenous bile acids ursodeoxycholic acid (UDCA), tauroursodeoxycholic acid (TUDCA), and glucourosodeoxycholic acid (GUDCA) have suggested neuroprotective effects. We performed a case–control study to examine the association between ALS diagnosis and serum levels of bile acids. Sporadic and familial ALS patients, age- and sex-matched healthy controls, and presymptomatic gene carriers who donated blood samples were included. Non-fasted serum samples stored at −80°C were used for the analysis. Serum bile acid levels were measured by liquid chromatography-mass spectrometry (LC–MS). Concentrations of 15 bile acids were obtained, 5 non-conjugated and 10 conjugated, and compared between ALS versus control groups (presymptomatic gene carriers + healthy controls) using the Wilcoxon-Rank-Sum test. In total, 80 participants were included: 31 ALS (17 sporadic and 14 familial ALS); 49 controls (22 gene carriers, 27 healthy controls). The mean age was 50 years old and 50% were male. In the ALS group, 45% had familial disease with a pathogenic variant in <i>C9orf72</i> (29%), <i>TARDBP</i> (10%), <i>FUS</i> (3%), and <i>CHCHD10</i> (3%) genes. In the control group, 43% carried pathogenic variants: <i>C9orf72</i> (27%), <i>SOD1</i> (10%), and <i>FUS</i> (6%). The serum levels of UDCA, TUDCA, and GUDCA trended higher in the ALS group compared to controls (median 27 vs. 7 nM, 4 vs. 3 nM, 110 vs. 47 nM, <i>p</i>-values 0.04, 0.06, 0.04, respectively). No significant group differences were found in other bile acids serum levels. In conclusion, the serum level of UDCA, TUDCA, GUDCA trended higher in ALS patients compared to controls, and no evidence of deficiencies was found.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 4","pages":"85-91"},"PeriodicalIF":1.8,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A lipidomics approach reveals novel phospholipid changes in palmitate-treated C2C12 myotubes 脂质组学方法揭示了棕榈酸酯处理过的 C2C12 肌细胞中磷脂的新变化。
IF 1.9 4区 医学
Lipids Pub Date : 2024-02-01 DOI: 10.1002/lipd.12387
Wakako Tawara, Mizuki Morisasa, Risa Mukai, Rei Suo, Shiro Itoi, Tsukasa Mori, Naoko Goto-Inoue
{"title":"A lipidomics approach reveals novel phospholipid changes in palmitate-treated C2C12 myotubes","authors":"Wakako Tawara,&nbsp;Mizuki Morisasa,&nbsp;Risa Mukai,&nbsp;Rei Suo,&nbsp;Shiro Itoi,&nbsp;Tsukasa Mori,&nbsp;Naoko Goto-Inoue","doi":"10.1002/lipd.12387","DOIUrl":"10.1002/lipd.12387","url":null,"abstract":"<p>Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disorder. Insulin resistance and oxidative stress are associated with T2DM development. The hypothesis that patients with T2DM show excess accumulation of lipids, such as ceramides (Cers) and diacylglycerols (DAGs), in their skeletal muscles has been widely supported; however, detailed lipidomic data at the molecular species level are limited. Therefore, in this study, we aimed to investigate the in vitro dynamics of total lipids, including phospholipids (PLs), sphingolipids, and neutral lipids, in palmitic acid-induced insulin-resistant C2C12 skeletal muscle cells. Our data demonstrated that the profiles of not only Cers and DAGs but also those of PLs showed considerably differences after palmitate treatment. We found that PL synthesis reduced and PL degradation increased after palmitate treatment. These findings may aid in the development of treatments to ameliorate muscle dysfunction caused by lipid accumulation in muscles.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 2","pages":"55-63"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139651023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of dietary intake of specific polyunsaturated fatty acids (PUFAs) on colorectal cancer risk in Iran 伊朗人膳食中特定多不饱和脂肪酸 (PUFA) 摄入量对结直肠癌风险的影响。
IF 1.9 4区 医学
Lipids Pub Date : 2024-01-29 DOI: 10.1002/lipd.12386
Monireh Sadat Seyyedsalehi, Maryam Hadji, Giulia Collatuzzo, Hamideh Rashidian, Bahareh Sasanfar, Inge Huybrechts, Veronique Chajes, Paolo Boffetta, Kazem Zendehdel
{"title":"Role of dietary intake of specific polyunsaturated fatty acids (PUFAs) on colorectal cancer risk in Iran","authors":"Monireh Sadat Seyyedsalehi,&nbsp;Maryam Hadji,&nbsp;Giulia Collatuzzo,&nbsp;Hamideh Rashidian,&nbsp;Bahareh Sasanfar,&nbsp;Inge Huybrechts,&nbsp;Veronique Chajes,&nbsp;Paolo Boffetta,&nbsp;Kazem Zendehdel","doi":"10.1002/lipd.12386","DOIUrl":"10.1002/lipd.12386","url":null,"abstract":"<p>High-fat diets have been associated with colorectal cancer (CRC) risk, and the role of polyunsaturated fatty acids (PUFAs) has been reported to vary based on the length of PUFAs. We explored the association between dietary omega-6 and omega-3 PUFAs intake and CRC. We analyzed 865 CRC patients and 3206 controls from a case–control study of Iran (IROPICAN study). We used multivariate logistic regression models to calculate the odds ratios (OR) and 95% confidence intervals (CI) for the association between PUFAs intake and CRC risk. Our results showed that gamma-linolenic acid (18:3 n-6, GLA), arachidonic acid (20:4n-6, ARA), a-linolenic acid (Cis-18:3n-3, ALA), eicosapentaenoic acid (20:5n-3, EPA), docosahexaenoic acid (22:6n-3, DHA) consumption was not associated with the risk of CRC. However, the OR of linoleic acid (18: 2n-6, LA) intake was 1.47 (95% CI 1.01–2.14, <i>p</i> = 0.04) for proximal colon and that of docosapentaenoic acid (22:5n-3, DPA) intake was 1.33 (95% CI 1.05–1.69, <i>p</i> = 0.01) for rectum. This study indicates a high level of LA is associated with an increased risk of proximal colon cancer, and DPA intake was positively associated with rectum cancer risk. Furthermore, our study noted a high intake of n-6 (from vegetable oils) compared to n-3 PUFAs (from fish and seafood) in this population. Public awareness and government support is needed to increase fish and seafood production and consumption in Iran.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 2","pages":"41-53"},"PeriodicalIF":1.9,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific association between monocyte to high-density lipoprotein cholesterol and extensive abdominal aortic calcification in humans 人类单核细胞至高密度脂蛋白胆固醇与腹主动脉广泛钙化之间的性别特异性关联。
IF 1.9 4区 医学
Lipids Pub Date : 2024-01-28 DOI: 10.1002/lipd.12385
Yuyu Niu, Guifang Wang, Xianjun Feng, Hongyi Niu, Wenrui Shi, Yingxue Shen
{"title":"Sex-specific association between monocyte to high-density lipoprotein cholesterol and extensive abdominal aortic calcification in humans","authors":"Yuyu Niu,&nbsp;Guifang Wang,&nbsp;Xianjun Feng,&nbsp;Hongyi Niu,&nbsp;Wenrui Shi,&nbsp;Yingxue Shen","doi":"10.1002/lipd.12385","DOIUrl":"10.1002/lipd.12385","url":null,"abstract":"<p>Recent studies have identified monocyte-to-high-density lipoprotein cholesterol ratio (MHR) as a simple marker of atherosclerosis. Abdominal aortic calcification (AAC) is a direct result of vascular atherosclerosis. Our study aims to investigate the association between MHR and the prevalent extensive AAC and assess the value of MHR for identifying prevalent extensive AAC. 2857 subjects (28.07%) from the cross-sectional National Health and Nutrition Examination Survey 2013–2014 were included in our study. AAC was detected through dual-energy x-ray absorptiometry and quantified by Kauppila score. Extensive AAC was identified in 153 (10.44% of 1465) females and 146 (10.49% of 1392) males. With the full adjustment, each SD increase of MHR resulted in an 87.3% additional risk for extensive AAC in females. When dividing into quartiles, the top quartile had a 3.472 times risk of prevalent extensive AAC than the bottom quartile. However, no significant association was observed in males. Furthermore, smooth curve fitting implicated that the significant association was linear in the whole range of MHR among females. Additionally, ROC demonstrated an improvement in the identification of extensive AAC only among females when introducing MHR into established risk factors of atherosclerosis (0.808 vs. 0.864, <i>p</i> &lt; 0.001). Finally, category-free net reclassification index and integrated discrimination index also supported the improvement by MHR in females. Our study revealed a linear association between MHR and prevalent extensive AAC in females. Moreover, our results implicated the potential value of MHR to refine the identification of prevalent extensive AAC in females.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 2","pages":"29-40"},"PeriodicalIF":1.9,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The futile creatine cycle and the synthesis of fatty acids in inguinal white adipose tissue from growing rats, submitted to a hypoprotein-hyperglycidic diet for 15 days 生长期大鼠腹股沟白色脂肪组织中的徒劳肌酸循环和脂肪酸合成(低蛋白高糖饮食 15 天)。
IF 1.9 4区 医学
Lipids Pub Date : 2024-01-15 DOI: 10.1002/lipd.12384
Edgar Willibaldo Allebrandt Neto, Jadyellen Rondon e Silva, Stephanie Figueiredo Santos, Suélem Aparecida de França Lemes, Nair Honda Kawashita, Mayara Peron Pereira
{"title":"The futile creatine cycle and the synthesis of fatty acids in inguinal white adipose tissue from growing rats, submitted to a hypoprotein-hyperglycidic diet for 15 days","authors":"Edgar Willibaldo Allebrandt Neto,&nbsp;Jadyellen Rondon e Silva,&nbsp;Stephanie Figueiredo Santos,&nbsp;Suélem Aparecida de França Lemes,&nbsp;Nair Honda Kawashita,&nbsp;Mayara Peron Pereira","doi":"10.1002/lipd.12384","DOIUrl":"10.1002/lipd.12384","url":null,"abstract":"<p>The low-protein, high-carbohydrate (LPHC) diet administered to growing rats soon after weaning, for 15 days, promoted an increase in energy expenditure by uncoupling protein 1 (UCP1) in interscapular brown adipose tissue, and also due to the occurrence of the browning process in the perirenal white adipose tissue (periWAT). However, we believe that inguinal white adipose tissue (ingWAT) may also contribute to energy expenditure through other mechanisms. Therefore, the aim of this work is to investigate the presence of the futile creatine cycle, and the origin of lipids in ingWAT, since that tissue showed an increase in the lipids content in rats submitted to the LPHC diet for 15 days. We observed increases in creatine kinase and alkaline phosphatase activity in ingWAT, of the LPHC animals. The mitochondrial Nicotinamide adenine dinucleotide reduced/nicotinamide adenine dinucleotide oxidized ratio is lower in ingWAT of LPHC animals. In the LPHC animals treated with β-guanidinopropionic acid, the extracellular uptake of creatine in ingWAT was lower, as was the rectal temperature. Regarding lipid metabolism, we observed that in ingWAT, lipolysis in vitro when stimulated with noradrenaline is lower, and there were no changes in baseline levels. In addition, increases in the activity of enzymes were also observed: malic, glucose-6-phosphate dehydrogenase, and ATP-citrate lyase, in addition to an increase in the PPARγ content. The results show the occurrence of the futile creatine cycle in ingWAT, and that the increase in the relative mass may be due to an increase in de novo fatty acid synthesis.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 1","pages":"3-12"},"PeriodicalIF":1.9,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary linoleic acid lowering alone does not lower arachidonic acid or endocannabinoids among women with overweight and obesity: A randomized, controlled trial 在超重和肥胖的女性中,单纯降低膳食亚油酸不会降低花生四烯酸或内源性大麻素:随机对照试验
IF 1.9 4区 医学
Lipids Pub Date : 2023-12-15 DOI: 10.1002/lipd.12382
Amber B. Courville, Sharon Majchrzak-Hong, Shanna Yang, Sara Turner, Breanne Wilhite, Katherine Ness Shipley, Yvonne Horneffer, Anthony F. Domenichiello, Melanie Schwandt, Roy G. Cutler, Kong Y. Chen, Joseph R. Hibbeln, Christopher E. Ramsden
{"title":"Dietary linoleic acid lowering alone does not lower arachidonic acid or endocannabinoids among women with overweight and obesity: A randomized, controlled trial","authors":"Amber B. Courville,&nbsp;Sharon Majchrzak-Hong,&nbsp;Shanna Yang,&nbsp;Sara Turner,&nbsp;Breanne Wilhite,&nbsp;Katherine Ness Shipley,&nbsp;Yvonne Horneffer,&nbsp;Anthony F. Domenichiello,&nbsp;Melanie Schwandt,&nbsp;Roy G. Cutler,&nbsp;Kong Y. Chen,&nbsp;Joseph R. Hibbeln,&nbsp;Christopher E. Ramsden","doi":"10.1002/lipd.12382","DOIUrl":"https://doi.org/10.1002/lipd.12382","url":null,"abstract":"<p>The linoleic acid (LA)-arachidonic acid (ARA)-inflammatory axis suggests dietary LA lowering benefits health because it lowers ARA and ARA-derived endocannabinoids (ECB). Dietary LA reduction increases concentrations of omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and DHA derived ECB. The aim of this study was to examine targeted reduction of dietary LA, with and without EPA and DHA, on plasma EPA and DHA and ECB (2-arachidonoyl glycerol [2-AG], anandamide [AEA], and docosahexaenoyl ethanolamide [DHA-EA]). Healthy, pre-menopausal women (<i>n</i> = 62, BMI 30 ± 3 kg/m<sup>2</sup>, age 35 ± 7 years; mean ± SD) were randomized to three 12-week controlled diets: (1) high LA, low omega-3 EPA and DHA (H6L3); (2) low LA, low omega-3 EPA and DHA (L6L3); or (3) low LA, high omega-3 EPA and DHA (L6H3). Baseline plasma fatty acids and ECB were similar between diets. Starting at 4 weeks, L6L3 and L6H3 lowered plasma LA compared to H6L3 (<i>p</i> &lt; 0.001). While plasma ARA changed from baseline by 8% in L6L3 and −8% in L6H3, there were no group differences. After 4 weeks, plasma EPA and DHA increased from baseline in women on the L6H3 diet (<i>p</i>s &lt; 0.001) and were different than the H6L3 and L6L3 diets. No differences were found between diets for AEA or 2-AG, however, in L6L3 and L6H3, AEA increased by 14% (<i>p</i>s <i>&lt;</i> 0.02). L6H3 resulted in 35% higher DHA-EA (<i>p</i> = 0.013) whereas no changes were seen with the other diets. Lowering dietary LA did not result in the expected changes in fatty acids associated with the LA-ARA inflammatory axis in women with overweight and obesity.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"58 6","pages":"271-284"},"PeriodicalIF":1.9,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138678962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of sample preparation influence on bacterial lipids profile in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry 研究基质辅助激光解吸/电离飞行时间质谱法中样品制备对细菌脂质特征的影响
IF 1.9 4区 医学
Lipids Pub Date : 2023-12-07 DOI: 10.1002/lipd.12383
Adrian Arendowski, Ewelina Sibińska, Wioletta Miśta, Piotr Fijałkowski, Michał Złoch, Dorota Gabryś, Paweł Pomastowski
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