IF 1.6 4区医学

Lipids Pub Date : 2026-05-01 Epub Date: 2026-01-19 DOI: 10.1002/lipd.70034

Zexing Sun, Yilei Hong, Yaonan Hong, Chuanao Xin, Qi Liu, Huijin Hu, Yingying Shen, Ying Chen, Shan Liu, Yiping Shen, Yuhong Zhou, Dijiong Wu

{"title":"Peripheral versus Marrow Lipidomics in Patients with Severe Aplastic Anemia: Potential Indicators for Early Immunosuppressive Treatment Response.","authors":"Zexing Sun, Yilei Hong, Yaonan Hong, Chuanao Xin, Qi Liu, Huijin Hu, Yingying Shen, Ying Chen, Shan Liu, Yiping Shen, Yuhong Zhou, Dijiong Wu","doi":"10.1002/lipd.70034","DOIUrl":"10.1002/lipd.70034","url":null,"abstract":"This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and November 2022, and six of the SAA patients received ATG-based IST. PB and BM serum were collected for further LC-MS/MS analysis. Compared to donors, SAA patients exhibited more pronounced abnormalities in lipid metabolism profiles within BM serum relative to PB serum. Specifically, elevated levels of free fatty acids (FA), fatty acid esters of hydroxyl fatty acids (FAHFA), and phosphatidylserine (PS) were noted in the BM serum of SAA patients. Following treatment, there was a noted increase in acylcarnitine (ACar), hexosylceramide non-hydroxy fatty acid-sphingosine (HexCer-NS), and sulfur hexosyl ceramide hydroxy fatty acid (SHexCer), while levels of lysophosphatidylcholine (LPC) and oxidized phosphatidylcholine (OxPC) diminished, particularly in complete or partial response (CR/PR) patients. Acknowledging the changes of BM lipidomics may contribute to earlier prediction of ATG-based IST response in SAA patients.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":"347-361"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guggulsterone, a Classical Lipid-Lowering Phytosteroidal FXR Antagonist, as a Modulator of Lipid Signaling and Metabolic Reprogramming in Cancer. Guggulsterone是一种经典的降脂植物甾体FXR拮抗剂，可调节肿瘤中的脂质信号和代谢重编程。

IF 1.6 4区医学

Lipids Pub Date : 2026-05-01 Epub Date: 2025-12-01 DOI: 10.1002/lipd.70030

Nila Ganamurali, Mohanapriya Devarajan, Sarvesh Sabarathinam

引用次数: 0

Elevated Triglyceride Levels and Increased Psychiatric Symptoms in Individuals With Major Depressive Disorder. 重度抑郁症患者甘油三酯水平升高与精神症状增加

IF 1.6 4区医学

Lipids Pub Date : 2026-05-01 Epub Date: 2026-02-11 DOI: 10.1002/lipd.70039

Sandra S Meirelles, Camila O Arent, Lucas C Pedro, Laísa N Dos Santos, Flávia S Niero, Gabriel S Mondo, Ritele H Silva, Margarete D Bagatini, João Quevedo, Luciane B Ceretta, Zuleide Maria Ignácio, Gislaine Z Réus

{"title":"Elevated Triglyceride Levels and Increased Psychiatric Symptoms in Individuals With Major Depressive Disorder.","authors":"Sandra S Meirelles, Camila O Arent, Lucas C Pedro, Laísa N Dos Santos, Flávia S Niero, Gabriel S Mondo, Ritele H Silva, Margarete D Bagatini, João Quevedo, Luciane B Ceretta, Zuleide Maria Ignácio, Gislaine Z Réus","doi":"10.1002/lipd.70039","DOIUrl":"10.1002/lipd.70039","url":null,"abstract":"Major depressive disorder (MDD) is a widely prevalent and rising global condition whose pathophysiology is not yet completely understood. Recent studies have shown that lipid changes are crucial in the manifestation and progression of MDD. Thus, this study aimed to evaluate the lipid profile and psychosocial aspects of MDD. Individuals with MDD and controls (non-MDD) were selected. The diagnosis of MDD was made using the MINI International Neuropsychiatric Interview (MINI-Plus). Functionality analysis used the Functional Assessment Short Test (FAST) scale. The severity of depressive and anxious symptoms was assessed using the Hamilton Depression and Anxiety Rating Scales (HAM-D and HAM-A). Biological rhythms were evaluated using the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). Stress levels were assessed using the stress symptoms inventory. Lipid profiles were evaluated in plasma. One hundred sixty individuals were included: 31 individuals with a diagnosis of MDD and 129 non-MDD. Individuals with MDD showed more significant functional impairment, greater severity of depressive and anxious symptoms, and higher levels of stress, in addition to greater impairment in biological rhythm when compared to controls. Individuals with MDD had higher triglyceride levels (TG). Total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol levels were not significantly different between individuals with MDD and controls. In conclusion, individuals with MDD present functional impairments, psychosocial changes, and changes in the lipid profile. Longitudinal studies are recommended to assess the long-term effects of these changes and to investigate how the lipid profile influences brain function.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":"407-415"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Insights Into the Central Role of Serine β-Lactamase-Like Protein in Lipid Metabolism, Metabolic Syndrome, and Chronic Kidney Disease. 丝氨酸β-内酰胺酶样蛋白在脂质代谢、代谢综合征和慢性肾脏疾病中的核心作用的遗传学见解。

IF 1.6 4区医学

Lipids Pub Date : 2026-05-01 Epub Date: 2026-01-10 DOI: 10.1002/lipd.70032

Han Xu, Mengxiao Zou, Yichun Cheng, Shuwang Ge

{"title":"Genetic Insights Into the Central Role of Serine β-Lactamase-Like Protein in Lipid Metabolism, Metabolic Syndrome, and Chronic Kidney Disease.","authors":"Han Xu, Mengxiao Zou, Yichun Cheng, Shuwang Ge","doi":"10.1002/lipd.70032","DOIUrl":"10.1002/lipd.70032","url":null,"abstract":"Serine β-lactamase-like protein (LACTB), a mitochondrial protease, has incompletely characterized roles in metabolic pathways. We employed Mendelian randomization to investigate LACTB's causal relationships with lipid metabolism, metabolic syndrome (MetS), and chronic kidney disease (CKD). We performed a comprehensive Mendelian randomization (MR) analysis using genome-wide association study summary statistics. Cis-expression quantitative trait loci from the eQTLGen consortium identified genetic instruments for LACTB. Two-sample MR approaches, including inverse variance weighted, MR-Egger, and weighted median methods, were applied. The cisMR-conditional maximum likelihood (cisMR-cML) method validated LACTB-related causal associations. GTEx Portal data independently replicated the LACTB-CKD relationship. LACTB exhibited significant negative causal effects on metabolic syndrome (95% CI: 0.91-0.99, p = 0.02) and chronic kidney disease (95% CI: 0.83-0.97, p = 0.009). cisMR-cML validation confirmed significant causal associations between LACTB and lipid profiles after Bonferroni correction. Metabolic syndrome demonstrated a robust positive causal effect on CKD (95% CI: 1.15-1.42, p = 8.45 × 10-6), with high-density lipoprotein showing a significant negative causal relationship with CKD (95% CI: 0.89-0.97, p = 0.0009). Mediation analysis revealed metabolic syndrome mediated 11.8% of the total effect between LACTB and CKD (mediation effect: -0.01, 95% CI: -0.024 to -0.0003). Our study elucidates LACTB's critical role in metabolic regulation, identifying a potential therapeutic target for preventing chronic kidney disease progression. By delineating complex interactions between LACTB, lipid metabolism, metabolic syndrome, and kidney function, we provide novel insights for precision medicine in metabolic and renal health.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":"339-346"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Curcumin/Turmeric Supplementation on Lipid Profile in Subjects With Prediabetes and Diabetes: A Systematic Review and Meta-Analysis. 姜黄素/姜黄补充剂对糖尿病前期和糖尿病患者血脂的影响：一项系统综述和荟萃分析

IF 1.6 4区医学

Lipids Pub Date : 2026-05-01 Epub Date: 2026-02-08 DOI: 10.1002/lipd.70037

Hossein Bahari, Mahsa Malekahmadi, Mostafa Shahraki Jazinaki, Zahra Asadi, Kimia Soltaninejad, Haniyeh Golafrouz

{"title":"Effects of Curcumin/Turmeric Supplementation on Lipid Profile in Subjects With Prediabetes and Diabetes: A Systematic Review and Meta-Analysis.","authors":"Hossein Bahari, Mahsa Malekahmadi, Mostafa Shahraki Jazinaki, Zahra Asadi, Kimia Soltaninejad, Haniyeh Golafrouz","doi":"10.1002/lipd.70037","DOIUrl":"10.1002/lipd.70037","url":null,"abstract":"Dyslipidemia is a key comorbidity in prediabetes and type 2 diabetes (T2D). Curcumin, from turmeric, may improve lipid levels, but evidence is inconsistent. This meta-analysis evaluates its efficacy on lipid profiles in this population. We searched PubMed, Web of Science, and Scopus until August 2025 for RCTs on curcumin/turmeric in adults with prediabetes/T2DM. Data on lipids (triglycerides, total cholesterol, LDL-C, HDL-C) were pooled using a random-effects model, expressed as weighted mean differences (WMD) with 95% confidence intervals (CIs). Twenty-seven RCTs (31 arms) were included. Curcumin/turmeric supplementation significantly reduced triglycerides (WMD: -13.73 mg/dL; 95% CI: -19.49, -7.96), total cholesterol (WMD: -5.24 mg/dL; 95% CI: -9.42, -1.07), and LDL-C (WMD: -5.72 mg/dL; 95% CI: -8.62, -2.82) and increased HDL-C (WMD: 2.14 mg/dL; 95% CI: 1.08, 3.20). Effects on apolipoproteins were non-significant. Significant heterogeneity was observed (I2 > 80%). Subgroup analyses indicated greater benefits in diabetic patients, those with higher baseline lipids, and with specific formulations. The certainty of evidence (GRADE) was low for all outcomes. Curcumin/turmeric supplementation yields modest improvements in the lipid profile of individuals with prediabetes and diabetes. However, significant heterogeneity and low certainty of evidence limit the robustness and clinical applicability of these findings. Therefore, the results should be interpreted with caution. Future trials should prioritize enhanced formulations and longer durations.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":"381-406"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-4458/PRTG Axis Promotes Vascular Smooth Muscle Cell Dedifferentiation in Atherosclerosis. miR-4458/PRTG轴促进动脉粥样硬化血管平滑肌细胞去分化。

IF 1.6 4区医学

Lipids Pub Date : 2026-05-01 Epub Date: 2026-02-03 DOI: 10.1002/lipd.70038

Xinxian Liu, Lianglei Jiang, Han'e Yi, Jin Zheng

{"title":"miR-4458/PRTG Axis Promotes Vascular Smooth Muscle Cell Dedifferentiation in Atherosclerosis.","authors":"Xinxian Liu, Lianglei Jiang, Han'e Yi, Jin Zheng","doi":"10.1002/lipd.70038","DOIUrl":"10.1002/lipd.70038","url":null,"abstract":"miR-4458 is linked to cancer, and PRTG, an AS-related RA pathway gene, is a predicted target. This study clarifies miR-4458's role in AS and whether it modulates VSMC behaviors via PRTG and the RA pathway. Vascular smooth muscle cells (VSMCs) were treated with oxidized low-density lipoprotein (ox-LDL) to establish AS models, and RT-qPCR was applied to detect expression levels of miR-4458, PRTG, α-SMA, SM22α, vimentin, osteopontin, CRABP2, and RARRES1. Cell viability and migration ability were assessed via Cell Counting Kit-8 (CCK-8) and Transwell assay. Targeting between miR-4458 and PRTG was verified via dual-luciferase reporter gene assay (DLR assay).ox-LDL treatment upregulated miR-4458, downregulated PRTG, and enhanced cell viability and migration. miR-4458 overexpression promoted ox-LDL-mediated cell viability and migration, and facilitated VSMC phenotypic transformation. In contrast, miR-4458 knockdown counteracted the aforementioned ox-LDL effects. PRTG was confirmed as a target of miR-4458 via DLR assay, and its knockdown significantly enhanced the stimulatory effect of miR-4458 knockdown on cell viability and migration. miR-4458 is highly expressed in AS, which can promote the transformation of smooth muscle cells (SMCs) to smooth muscle cells (SEMs), as well as the proliferation and migration of SMCs, thereby accelerating the progression of AS. Interaction between the miR-4458/PRTG axis and retinoic acid (RA) signaling pathway could be harnessed therapeutically to modulate VSMC phenotype in ox-LDL-induced AS.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":"371-379"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyunsaturated Fatty Acids in Celiac Disease: Intake Patterns While on Gluten-Free Diet. 乳糜泻中的多不饱和脂肪酸：无麸质饮食时的摄入模式。

IF 1.6 4区医学

Lipids Pub Date : 2026-05-01 Epub Date: 2026-01-06 DOI: 10.1002/lipd.70029

Valentina Rosas, Juan Rodríguez, Magdalena Araya, Rodrigo Valenzuela, Karla A Bascuñán

{"title":"Polyunsaturated Fatty Acids in Celiac Disease: Intake Patterns While on Gluten-Free Diet.","authors":"Valentina Rosas, Juan Rodríguez, Magdalena Araya, Rodrigo Valenzuela, Karla A Bascuñán","doi":"10.1002/lipd.70029","DOIUrl":"10.1002/lipd.70029","url":null,"abstract":"Celiac disease (CD), an autoimmune disorder triggered by gliadin, is treated with a strict gluten-free diet. While omega-3 intake is known to reduce inflammation in other autoimmune diseases, its role in CD remains unclear due to limited data on fatty acid intake in this population. To assess the dietary intake of polyunsaturated fatty acids (PUFAs) in patients with CD compared with healthy controls. In this cross-sectional study, patients with CD and age- and sex-matched healthy controls were evaluated. Sociodemographic data and dietary intake were assessed using a validated food frequency questionnaire administered by a trained dietitian. Intakes of total fat, saturated, monounsaturated, polyunsaturated (omega-6 and omega-3) fatty acids, and micronutrients were analyzed along with the food sources of these fats. Compared with controls, CD patients had significantly higher intakes of total fat, saturated fat, total PUFA, omega-6, omega-3 (all p < 0.041), and calcium (p = 0.013), but lower iron intake (p < 0.020). The omega-6/omega-3 ratio did not differ between groups. Relative to FAO/WHO recommendations, CD patients consumed more energy, protein, cholesterol, zinc, vitamin B12, and fiber, but less trans fats, iron (p < 0.001), and vitamin D (p < 0.006). In both groups, omega-3 intake came mainly from fatty fish and lipid-rich foods, while omega-6 intake was primarily from oils. Both groups showed inadequate omega-3 intake, potentially predisposing them to low-grade inflammation. The findings suggest that optimizing fatty acid intake, particularly in gluten-free diets, may benefit CD patients and warrant further research.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":"331-338"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Key Lipid Molecules of Primary Dysmenorrhea for Elucidating the Biological Effects of Danggui Shaoyao San Using UPLC-Q-TOF-MS-Based Lipidomics. 基于uplc - q - tof - ms的脂质组学研究当归少药散在原发性痛经中的关键脂质分子

IF 1.6 4区医学

Lipids Pub Date : 2026-05-01 Epub Date: 2025-12-02 DOI: 10.1002/lipd.70027

Na Li, Yuxin Dong, Shengnan Zhao, Yueyue Wang, Yanrong Li, Yilong Du, Chunying Zhao, Hui Xiong

{"title":"Exploring Key Lipid Molecules of Primary Dysmenorrhea for Elucidating the Biological Effects of Danggui Shaoyao San Using UPLC-Q-TOF-MS-Based Lipidomics.","authors":"Na Li, Yuxin Dong, Shengnan Zhao, Yueyue Wang, Yanrong Li, Yilong Du, Chunying Zhao, Hui Xiong","doi":"10.1002/lipd.70027","DOIUrl":"10.1002/lipd.70027","url":null,"abstract":"Primary dysmenorrhea (PD) has always been a significant clinical challenge affecting women's health. Traditional Chinese medicine (TCM) has attracted considerable research interest owing to its advantages of multiple target and multiple pathway. This study employed urinary lipidomics technology combined with ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-O-TOF-MS) to systematically elucidate the preventive mechanisms and therapeutic targets of Danggui Shaoyao San (DSS) in a PD rat model. A total of 34 lipid biomarkers representing the dysregulated lipid metabolism in PD were preliminarily identified. Except for 3alpha-hydroxy-5beta-chola-7,9(11)-dien-24-oic acid and 16-oxoandrostenediol, all 32 lipids had high diagnostic significance. And then, the metabolic alterations related to DSS intervention through the regulation of lipid biomarkers and related pathways were discovered. Among the differentially expressed lipids, 29 lipid biomarkers were significantly restored by DSS administration. Through the pathway enrichment analysis, two key perturbation pathways related to DSS therapy were found, including arachidonic acid metabolism, and primary bile acid biosynthesis, which had the potential to become new therapeutic targets for treating PD. These investigations demonstrated that DSS may have a significant efficacy on the progression of PD by multi-target regulation of lipid biomarkers and lipidomics-guided biochemical pathways, providing a scientific foundation for its clinical application.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":"285-298"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Cloning, Characterization, Tissue-Specific Transcription, and Nutritional Regulation of FADS Genes by Dietary Curcumin in Chicken, Gallus gallus. 姜黄素对鸡FADS基因的克隆、表征、组织特异性转录及营养调控

IF 1.6 4区医学

Lipids Pub Date : 2026-05-01 Epub Date: 2026-02-17 DOI: 10.1002/lipd.70036

Büşra Dumlu, Şaziye Canan Bölükbaşı, Abdulkadir Bayır

{"title":"Molecular Cloning, Characterization, Tissue-Specific Transcription, and Nutritional Regulation of FADS Genes by Dietary Curcumin in Chicken, Gallus gallus.","authors":"Büşra Dumlu, Şaziye Canan Bölükbaşı, Abdulkadir Bayır","doi":"10.1002/lipd.70036","DOIUrl":"10.1002/lipd.70036","url":null,"abstract":"In this study, five FADS genes-FADS1a, FADS1b, FADS1c, FADS2, and FADS6-were cloned and characterized in chickens. Their nutritional regulations by diets containing various levels (100, 200, 300, and 400 mg/kg) of curcumin ( Curcuma longa ) were also determined. We aimed to determine the functions of FADS genes in fatty acid (FA) metabolism in chickens. We identified two critical conserved regions in chicken FADS: DWXXGH and GEXA, likely conferring structural stability to the iron-binding center and modulating the electrostatic potential. The chicken FADS genes are orthologs of vertebrate FADS genes. FADS1a/FADS1b and FADS1c exhibited markedly different tissue-specific transcription. However, FADS1a, FADS1b, and FADS1c responded differently to dietary curcumin, suggesting their functional divergence. Therefore, we propose that FADS1a, FADS1b, and FADS1c were retained in the chicken genome due to neo- or sub-functionalization. Dietary curcumin upregulated four of five chicken FADS genes (except FADS1a), indicating its effect on FA metabolism in chickens. Analyzing the promoter regions of FADS1 genes is essential for identifying their regulatory mechanisms, which may explain their evolutionary fates and functions.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":"427-434"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between the TyG Index and Liver Fat Content Measured by Quantitative CT in Individuals With T2DM: A Cross-Sectional Study T2DM患者定量CT测量的TyG指数与肝脏脂肪含量的相关性：一项横断面研究

IF 1.6 4区医学

Lipids Pub Date : 2026-03-10 Epub Date: 2025-11-11 DOI: 10.1002/lipd.70020

Jie Zhang, Yan Ye, Xiangwei Li, Suyuan Wang, Shuyao Sun, Mingxia Li, Chenghui Zhang

{"title":"Association Between the TyG Index and Liver Fat Content Measured by Quantitative CT in Individuals With T2DM: A Cross-Sectional Study","authors":"Jie Zhang, Yan Ye, Xiangwei Li, Suyuan Wang, Shuyao Sun, Mingxia Li, Chenghui Zhang","doi":"10.1002/lipd.70020","DOIUrl":"10.1002/lipd.70020","url":null,"abstract":"<div>\u0000 \u0000 The triglyceride glucose (TyG) index is increasingly recognized as a simple yet reliable surrogate marker of insulin resistance. This study aimed to explore the relationship between the TyG index and liver fat content (LFC) quantified via quantitative computed tomography (QCT) in individuals with type 2 diabetes mellitus (T2DM). This cross-sectional analysis included patients with T2DM who underwent QCT examinations at our institution between January and December 2024. QCT was used to measure tissue components at the mid-L2 vertebral level, including subcutaneous fat area (SFA), visceral fat area (VFA), and LFC. A multiple linear regression model was employed to assess the independent association between the TyG index and LFC. The study enrolled 168 participants, comprising 112 males and 56 females. Subjects in the highest TyG index tertile exhibited a more adverse cardiometabolic risk profile and higher LFC compared to those in the lowest tertile. Correlation analyses indicated that the TyG index was significantly associated with both SFA and LFC. After adjusting for age and gender, multiple linear regression confirmed that the TyG index remained independently and positively associated with LFC (β = 1.73, 95% CI: 0.08–3.38, p = 0.042). Stratified analyses revealed that the positive association between the TyG index and LFC was consistent across all strata, with no significant interactions observed for age, gender, duration of T2DM, and body mass index. Our findings suggest that the TyG index may serve as a reliable, noninvasive surrogate marker for evaluating LFC in individuals with T2DM.\u0000 </div>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 2","pages":"187-194"},"PeriodicalIF":1.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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