Lipids最新文献 - Book学术

Mass Spectrometry-Based Lipidomics Reveals a Strong Connection Between Lipid Homeostasis and Iron Acquisition in Candida albicans. 基于质谱的脂质组学揭示了白色念珠菌脂质稳态与铁获取之间的密切联系。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-30 DOI: 10.1002/lipd.12455

Sana Akhtar Usmani, Khushboo Arya, Basharat Ali, Shikha Chandra, Saumya Chaturvedi, Divyanshi Srivastava, Kunal Khanna, Nitin Bhardwaj, Rajendra Prasad, Ashutosh Singh

{"title":"Mass Spectrometry-Based Lipidomics Reveals a Strong Connection Between Lipid Homeostasis and Iron Acquisition in Candida albicans.","authors":"Sana Akhtar Usmani, Khushboo Arya, Basharat Ali, Shikha Chandra, Saumya Chaturvedi, Divyanshi Srivastava, Kunal Khanna, Nitin Bhardwaj, Rajendra Prasad, Ashutosh Singh","doi":"10.1002/lipd.12455","DOIUrl":"https://doi.org/10.1002/lipd.12455","url":null,"abstract":"Iron is a critical determinant in the development of drug tolerance in Candida albicans. Several genes essential for iron acquisition, transport, and regulation have been studied. Previous studies have shown that growth in an iron-limited medium alters the lipid compositions of C. albicans cells. In the present study, we performed a mass spectrometry-based lipid analysis of two major iron acquisition pathway proteins: an iron transporter, Ftr1 (ferrous permease), and a closely linked copper transporter, Ccc2. Deletions of FTR1 or CCC2 lead to significant changes in the lipid profile of C. albicans, especially the phospholipid and sphingolipid metabolism. For example, both Δftr1 and Δccc2 mutants showed depleted sphingolipid and steryl ester contents, but not much change in their DAG and TAG contents. The phospholipid profile of Δccc2 cells was quite unique with a much elevated PG content. The overall phospholipid profile of Δftr1 was not much different from the wild type. Both Δftr1 and Δccc2 cells showed significant differences in their molecular lipid species compositions. These lipid perturbations correlated with the susceptible response towards the drugs targeting lipid biogenesis and iron acquisition in Δftr1 and Δccc2 mutants. Taken together, this study shows that iron pathway proteins such as Ftr1 and Ccc2 are closely linked to lipid metabolism and iron acquisition in C. albicans. Understanding the mechanism of this lipid-iron association should be useful in exploring the two pathways for understanding the mechanism of iron uptake and designing the combinatorial drug therapies.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recognizing the Health Benefits of Plant-Sourced Omega-3 Stearidonic Acid: Exploring Its Complementary Role to Preformed EPA/DHA. 认识到植物来源的Omega-3硬脂酸的健康益处：探索其对预成型EPA/DHA的补充作用。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-27 DOI: 10.1002/lipd.12452

Ella J Baker, Greg Cumberford, Patrick Hanaway

引用次数: 0

The Effect of a Preparation Derived From Fish Skin on the Change in the Fatty Acid Composition of Sebum in Individuals With Demodicosis. 鱼皮提取物对蠕虫病患者皮脂脂肪酸组成变化的影响。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-26 DOI: 10.1002/lipd.12454

Joanna Igielska-Kalwat, Ewa Kilian-Pięta, Maciej Siedlecki

{"title":"The Effect of a Preparation Derived From Fish Skin on the Change in the Fatty Acid Composition of Sebum in Individuals With Demodicosis.","authors":"Joanna Igielska-Kalwat, Ewa Kilian-Pięta, Maciej Siedlecki","doi":"10.1002/lipd.12454","DOIUrl":"https://doi.org/10.1002/lipd.12454","url":null,"abstract":"Fatty acid (FA) metabolism is associated with Demodicosis, an increasingly common skin condition frequently observed in adolescents and adults, but it is not yet well defined whether the distribution or location of FAs in facial sebum differs according to the disease. In a study with a group of 50 patients diagnosed with Demodicosis and 40 control subjects, sebum samples were collected from the forehead, cheeks, and chin areas using Sebutape patches. Total FAs were analyzed using gas chromatography. The patients with Demodex were divided into two groups. Twenty-five individuals used only the placebo cosmetic base, while the other 25 applied the target product. The extraction of key active ingredients aligns with the trend of sustainable cosmetic production and upcycling. Compared to healthy women, the female patients showed higher levels of saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs) from both facial areas, while lower levels of polyunsaturated fatty acids (PUFAs) were observed in the chin area samples. Patients with Demodicosis exhibited more pronounced abnormalities in sebum and specific FA profiles in the chin area, consistent with the higher incidence of Demodicosis in adult women, particularly in these facial areas. The differential distribution of FAs in facial sebum and its correlation with the occurrence of Demodicosis led to the application of innovative upcycling ingredients. The purpose of the experiment was to determine the difference in the FA profile between individuals with and without Demodicosis.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Novel Lipid Indicators and the Risk of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes. 新型脂质指标与2型糖尿病患者非酒精性脂肪性肝病风险之间的关系

IF 1.8 4区医学

Lipids Pub Date : 2025-06-24 DOI: 10.1002/lipd.12453

Yazhi Wang, Mingkang Zhang, Peng Wang

{"title":"Associations Between Novel Lipid Indicators and the Risk of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes.","authors":"Yazhi Wang, Mingkang Zhang, Peng Wang","doi":"10.1002/lipd.12453","DOIUrl":"https://doi.org/10.1002/lipd.12453","url":null,"abstract":"This study aimed to evaluate associations between emerging lipid parameters, including the ZJU index (ZJU), the hepatic steatosis index (HSI), the triglyceride-glucose index (TyG), the Framingham steatosis index (FSI) and the atherogenic index of plasma (AIP), and nonalcoholic fatty liver disease (NAFLD) risk in individuals with type 2 diabetes mellitus (T2DM) and assess their clinical utility for NAFLD prevention and diabetes management. Clinical data from 6378 participants were analyzed. Stepwise-adjusted multivariable logistic regression, restricted cubic splines (RCS), subgroup analysis, and sensitivity tests examined relationships between lipid parameters and NAFLD. Receiver operating characteristic (ROC) curves compared predictive performance. Among participants, 36.11% (2303/6378) had NAFLD. After full adjustment, each 1-unit increase in ZJU, HSI, TyG, FSI, and AIP conferred NAFLD odds ratios (95% CI) of 1.22 (1.14-1.31), 1.08 (1.05-1.11), 2.19 (1.82-2.63), 1.01 (1.00-1.02), and 4.75 (2.97-7.58), respectively. When divided into quartiles, the highest quartile of these parameters exhibited 2.13-fold, 2.86-fold, 2.04-fold, 1.80-fold, and 1.68-fold NAFLD risk compared to the lowest quartile. RCS revealed significant nonlinear relationships (poverall < 0.001, pnonlinear < 0.05). Sensitivity analysis confirmed robustness. ROC curves identified HSI as the strongest predictor (AUC = 0.709, 95% CI: 0.696-0.721). Elevated ZJU, HSI, TyG, FSI, and AIP were significantly associated with increased NAFLD risk in the T2DM population. HSI may demonstrate superior predictive performance for NAFLD in T2DM populations compared to other conventional lipid parameters.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Binding Strength of Cytochrome C to Membranes Containing Phosphatidic Acid Corresponds to Its Peroxidase Activity. 细胞色素C与磷脂酸膜的结合强度与其过氧化物酶活性相对应。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-17 DOI: 10.1002/lipd.12451

G O Stepanov, V V Zakharov, A A Struchkova, E D Rumyantseva, V V Volkov, A Yu Makarov, Yu A Vladimirov, A N Osipov

{"title":"The Binding Strength of Cytochrome C to Membranes Containing Phosphatidic Acid Corresponds to Its Peroxidase Activity.","authors":"G O Stepanov, V V Zakharov, A A Struchkova, E D Rumyantseva, V V Volkov, A Yu Makarov, Yu A Vladimirov, A N Osipov","doi":"10.1002/lipd.12451","DOIUrl":"https://doi.org/10.1002/lipd.12451","url":null,"abstract":"The study of the molecular mechanisms of programmed cell death and the role of anionic phospholipids like cardiolipin in these processes is one of the most attractive topics in modern lipidomics. The aim of this study was the quantitative assessment of the presence of phosphatidic acid in the binding strength of cytochrome C to biological membranes, its peroxidase activity, and the role of phospholipase D in increasing the concentration of phosphatidic acid. Using the Langmuir method for fluorescence quenching analysis (Kd = 2.78 × 10-7 M) of the cytochrome C-phosphatidic acid complex was shown. The presence of phosphatidic acid (both synthetic and obtained from phosphatidylcholine using phospholipase D from mitochondrial lipids) increased the peroxidase activity of cytochrome C more than 100-fold (measured by luminol-enhanced chemiluminescence method). The obtained results emphasize the possibility of participation not only of cardiolipin but also of phosphatidic acid in the development of molecular proapoptotic processes.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Cobalt Levels on Fatty Acid Profile and Nutritional Quality of Common Carp Muscle (Cyprinus carpio). 钴水平对鲤鱼肌肉脂肪酸分布和营养品质的影响。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-16 DOI: 10.1002/lipd.12449

Imene Chetoui, Feriel Ghribi, Safa Bejaoui, Dalya Belhassen, Rym Baati, Najla Soudani

{"title":"Impact of Cobalt Levels on Fatty Acid Profile and Nutritional Quality of Common Carp Muscle (Cyprinus carpio).","authors":"Imene Chetoui, Feriel Ghribi, Safa Bejaoui, Dalya Belhassen, Rym Baati, Najla Soudani","doi":"10.1002/lipd.12449","DOIUrl":"https://doi.org/10.1002/lipd.12449","url":null,"abstract":"The aim of this study is to evaluate the toxic effects of cobalt chloride concentrations (2 μg/LCoCl2 (D1), 25 μg/LCoCl2 (D2), and 50 μg/LCoCl2 (D3)) on the fatty acid profile and nutritional quality of Cyprinus carpio muscle. After 3 days of treatment, our results have shown an induction of lipid peroxidation affirmed by significant increases in malondialdehyde (MDA) and peroxide value (PV) levels for fish treated with D2 and D3 doses. We noted decreases in saturated fatty acids (SFA) and an increase in polyunsaturated fatty acids (PUFA) in all treated groups. The docosahexaenoic (DHA) and eicosapentaenoic (EPA) acid levels declined in all fish exposed to CoCl2 graded doses (p ≤ 0.001). The decrease in the conversion enzyme ratios D5D and D6D desaturases explained these changes in EPA and DHA levels. However, PUFA (n-6) and arachidonic acid (ARA) increased (p < 0.001) in all treated groups. These increases in ARA were associated with the enhancement of linoleic acid (LA) and D5D' desaturases activity. Our treatment showed significant declines in PUFA (n-3)/PUFA (n-6) ratio and in flesh lipid quality (FLQ) and an increase in the PUFA/SFA ratio. Our experiment suggested the harmful effects of cobalt, confirmed by the alteration of fatty acid composition and deterioration of the nutritional quality of C. carpio muscle.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Lipid-Reducing Potential of Elsholtzia bodinieri Vaniot Essential Oil: Implications for HepG2 Cells and the Caenorhabditis elegans Obesity Models. 探索香草精油的降脂潜能：对HepG2细胞和秀丽隐杆线虫肥胖模型的影响。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-08 DOI: 10.1002/lipd.12450

Xiaoying Liu, Mengyuan Zhang, Runyuan Wang, Fang Xu, Hua Bai, Wei Zou, Qi Wang

{"title":"Exploring the Lipid-Reducing Potential of Elsholtzia bodinieri Vaniot Essential Oil: Implications for HepG2 Cells and the Caenorhabditis elegans Obesity Models.","authors":"Xiaoying Liu, Mengyuan Zhang, Runyuan Wang, Fang Xu, Hua Bai, Wei Zou, Qi Wang","doi":"10.1002/lipd.12450","DOIUrl":"https://doi.org/10.1002/lipd.12450","url":null,"abstract":"Elsholtzia bodinieri Vaniot, a medicinal and edible plant native to Yunnan, China, was investigated for its lipid-reducing effects in this study. The essential oil of E. bodinieri Vaniot (EBVEO) demonstrated a significant reduction in lipid droplets, intracellular triglyceride (TG), and total cholesterol (TC) levels in HepG2 lipid-accumulating cells. EBVEO upregulated the expression of key proteins, including SIRT1, AMPK, PPARα, and CD36, promoting enhanced β-oxidation and fat breakdown. This regulatory effect on lipid metabolism was also observed in a high-fat Caenorhabditis elegans (C. elegans) model. qPCR and parallel reaction monitoring (PRM) revealed the activation of the AAK-2/NHR-49 pathway, homologs of PPARα and AMPK, leading to a substantial increase in fat oxidation and a notable reduction in fat accumulation in C. elegans. In conclusion, EBVEO exhibits promising potential in regulating cellular and C. elegans lipid metabolism through the SIRT1/AMPK and AAK-2/NHR-49 pathways, positioning it as a promising lipid metabolism enhancer.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASGR1 inhibitors, inflammation, and heart failure: A Mendelian randomization analysis. ASGR1抑制剂、炎症和心力衰竭：孟德尔随机分析

IF 1.8 4区医学

Lipids Pub Date : 2025-05-20 DOI: 10.1002/lipd.12446

Xingsheng Ye, Miaomiao Yang, Yinghao Hong, Zhizhan Lin, Jian Peng, Liwei He

{"title":"ASGR1 inhibitors, inflammation, and heart failure: A Mendelian randomization analysis.","authors":"Xingsheng Ye, Miaomiao Yang, Yinghao Hong, Zhizhan Lin, Jian Peng, Liwei He","doi":"10.1002/lipd.12446","DOIUrl":"https://doi.org/10.1002/lipd.12446","url":null,"abstract":"This study investigates the causal relationship between Asialoglycoprotein receptor 1 (ASGR1) inhibitors, inflammation, and heart failure (HF). Leveraging data from the Global Lipids Genetics Consortium (2021) and the UK Biobank, we identified instrumental variables for ASGR1 and validated these genetic instruments using coronary heart disease (CHD) patients as positive controls. We employed Instrumental variable weighted (IVW) and Summary-data-based Mendelian Randomization (SMR) methods to assess the association of ASGR1 with HF and its associated risk factors, comparing efficacy with PCSK9 and LDLR. Mediation analysis of inflammatory biomarkers was conducted using a two-step Mendelian randomization approach, with sensitivity analyses performed using conventional MR methods. IVW analysis demonstrates a significant positive correlation between ASGR1 expression and HF, myocardial infarction, non-ischemic cardiomyopathy, and calcific aortic valvular stenosis. Patients with HF comorbid with CHD showed an increased likelihood of benefit. ASGR1 exhibited a stronger effect on HF compared to PCSK9. Similar conclusions were drawn from SMR analysis. Additionally, LDLR shows no causal relationship with HF but appears negatively correlated with non-ischemic cardiomyopathy. Among the 91 inflammatory proteins studied, Leukemia inhibitory factor receptor (LIF-R) and Urokinase-type plasminogen activator (uPA) were found to mediate the effects of ASGR1 on HF. Sensitivity analyses indicate no evidence of pleiotropy in reported results. This study supports a causal association between ASGR1 inhibitors and HF, providing genetic evidence for the anti-inflammatory role of ASGR1 inhibitors in reducing HF risk. LIF-R and uPA, identified as potential mediators, introduce a novel therapeutic pathway for HF management.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum Insights Into Fatty Acids, Antioxidant Mechanisms, and Molecular Docking Studies in Anacamptis papilionacea. 脂肪酸、抗氧化机制和分子对接研究的量子洞察。

IF 1.8 4区医学

Lipids Pub Date : 2025-05-19 DOI: 10.1002/lipd.12448

Taşkın Basılı, Erdi Can Aytar, Mayker Lazaro Dantas Miranda, Bengisu Şentürk, Yasemin Özdener Kömpe

{"title":"Quantum Insights Into Fatty Acids, Antioxidant Mechanisms, and Molecular Docking Studies in Anacamptis papilionacea.","authors":"Taşkın Basılı, Erdi Can Aytar, Mayker Lazaro Dantas Miranda, Bengisu Şentürk, Yasemin Özdener Kömpe","doi":"10.1002/lipd.12448","DOIUrl":"https://doi.org/10.1002/lipd.12448","url":null,"abstract":"This study examines the antioxidant activities, fatty acid composition, cytotoxicity predictions, and endocrine-disrupting potential of metabolites from orchid methanolic-flower extracts. In silico analyses, including molecular docking, NCI-RDG, FMO, ELF, LOL, and MEP mapping, were conducted to explore noncovalent interactions, electronic properties, reactivity, and charge distribution of key metabolites, providing insights into their bioactivity and mechanisms of action. Antioxidant activity, evaluated via the DPPH assay, showed an IC50 value of 12.83 mg/mL for the methanolic extract, outperforming the positive control (BHT, IC50 = 18.00 mg/mL). High flavonoid content, expressed as quercetin equivalents, confirmed the presence of bioactive compounds, including quercetin and gallic acid. The fatty acid (FA) profile of Anacamptis papilionacea fixed oil, analyzed by GC-MS, revealed palmitic acid, α-linolenic acid, 8,11,14-eicosatrienoic acid, and docosahexaenoic acid as dominant FAs, constituting 79.47% of the total oil. Molecular docking showed strong binding interactions of these FAs with the human glucocorticoid receptor. Cytotoxicity predictions indicated promising activity against melanoma and lung carcinoma cells, particularly with 8,11,14-eicosatrienoic acid and docosahexaenoic acid. Endocrine-disrupting potential was evaluated through molecular binding with 14 nuclear receptors, showing varying affinities, particularly for estrogen, androgen, and glucocorticoid receptors. These findings highlight the bioactivity and therapeutic potential of A. papilionacea metabolites, emphasizing their antioxidant, cytotoxic, and receptor-binding capabilities. Further experimental studies are warranted for clinical validation.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anthropometric indicators of obesity as screening tools for low high-density lipoprotein cholesterol in older adults: A cross-sectional study. 肥胖人体测量指标作为老年人低高密度脂蛋白胆固醇筛查工具：一项横断面研究。

IF 1.8 4区医学

Lipids Pub Date : 2025-04-29 DOI: 10.1002/lipd.12447

Yuri Silva de Souza, Lucas Dos Santos, Débora Jesus da Silva, Emille Silva Santos, Sabrina da Silva Caires, Paulo da Fonseca Valença Neto, Claudio Bispo de Almeida, Pabline Dos Santos Santana, Raquel Dos Santos Barbosa, Cezar Augusto Casotti

{"title":"Anthropometric indicators of obesity as screening tools for low high-density lipoprotein cholesterol in older adults: A cross-sectional study.","authors":"Yuri Silva de Souza, Lucas Dos Santos, Débora Jesus da Silva, Emille Silva Santos, Sabrina da Silva Caires, Paulo da Fonseca Valença Neto, Claudio Bispo de Almeida, Pabline Dos Santos Santana, Raquel Dos Santos Barbosa, Cezar Augusto Casotti","doi":"10.1002/lipd.12447","DOIUrl":"https://doi.org/10.1002/lipd.12447","url":null,"abstract":"Low levels of high-density lipoprotein cholesterol (HDL-C) increase the risk of cardiovascular events and mortality in older individuals. Developing cost-effective screening tools for identifying this condition in large populations is essential. To evaluate the discriminatory capacity of anthropometric indicators of obesity in screening for low HDL-C among older adults. A cross-sectional population-based epidemiological study was conducted with 223 older individuals (57% women) living in a community. The following anthropometric indicators were evaluated: body mass index (BMI), waist circumference (WC), abdominal circumference (AC), body adiposity index (BAI), triceps skinfold (TSF), waist-hip ratio (WHR), waist-height ratio (WHtR), and conicity index (CIn). Low HDL-C was defined as values below 40 mg/dL. The prevalence of low HDL-C was 25.10% (men: 35.41%; women: 21.77%). Among older men, BAI showed the highest sensitivity (87.10%; accuracy: 0.70; 95% CI: 0.53-0.74), while WC had the highest specificity (83.05%; accuracy: 0.71; 95% CI: 0.60-0.80). Among older women, WHR demonstrated the highest sensitivity (100%; accuracy: 0.71; 95% CI: 0.62-0.79), and WHtR showed the highest specificity (67.68%; accuracy: 0.71; 95% CI: 0.62-0.79). BAI and WHR were the most effective indicators for screening older men and women with low HDL-C, respectively. Additionally, WC and WHtR were the most effective indicators for identifying older men and women without low HDL-C, respectively.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0