Lipids最新文献 - Book学术

The Binding Strength of Cytochrome C to Membranes Containing Phosphatidic Acid Corresponds to Its Peroxidase Activity. 细胞色素C与磷脂酸膜的结合强度与其过氧化物酶活性相对应。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-17 DOI: 10.1002/lipd.12451

G O Stepanov, V V Zakharov, A A Struchkova, E D Rumyantseva, V V Volkov, A Yu Makarov, Yu A Vladimirov, A N Osipov

{"title":"The Binding Strength of Cytochrome C to Membranes Containing Phosphatidic Acid Corresponds to Its Peroxidase Activity.","authors":"G O Stepanov, V V Zakharov, A A Struchkova, E D Rumyantseva, V V Volkov, A Yu Makarov, Yu A Vladimirov, A N Osipov","doi":"10.1002/lipd.12451","DOIUrl":"https://doi.org/10.1002/lipd.12451","url":null,"abstract":"The study of the molecular mechanisms of programmed cell death and the role of anionic phospholipids like cardiolipin in these processes is one of the most attractive topics in modern lipidomics. The aim of this study was the quantitative assessment of the presence of phosphatidic acid in the binding strength of cytochrome C to biological membranes, its peroxidase activity, and the role of phospholipase D in increasing the concentration of phosphatidic acid. Using the Langmuir method for fluorescence quenching analysis (Kd = 2.78 × 10-7 M) of the cytochrome C-phosphatidic acid complex was shown. The presence of phosphatidic acid (both synthetic and obtained from phosphatidylcholine using phospholipase D from mitochondrial lipids) increased the peroxidase activity of cytochrome C more than 100-fold (measured by luminol-enhanced chemiluminescence method). The obtained results emphasize the possibility of participation not only of cardiolipin but also of phosphatidic acid in the development of molecular proapoptotic processes.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Cobalt Levels on Fatty Acid Profile and Nutritional Quality of Common Carp Muscle (Cyprinus carpio). 钴水平对鲤鱼肌肉脂肪酸分布和营养品质的影响。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-16 DOI: 10.1002/lipd.12449

Imene Chetoui, Feriel Ghribi, Safa Bejaoui, Dalya Belhassen, Rym Baati, Najla Soudani

{"title":"Impact of Cobalt Levels on Fatty Acid Profile and Nutritional Quality of Common Carp Muscle (Cyprinus carpio).","authors":"Imene Chetoui, Feriel Ghribi, Safa Bejaoui, Dalya Belhassen, Rym Baati, Najla Soudani","doi":"10.1002/lipd.12449","DOIUrl":"https://doi.org/10.1002/lipd.12449","url":null,"abstract":"The aim of this study is to evaluate the toxic effects of cobalt chloride concentrations (2 μg/LCoCl2 (D1), 25 μg/LCoCl2 (D2), and 50 μg/LCoCl2 (D3)) on the fatty acid profile and nutritional quality of Cyprinus carpio muscle. After 3 days of treatment, our results have shown an induction of lipid peroxidation affirmed by significant increases in malondialdehyde (MDA) and peroxide value (PV) levels for fish treated with D2 and D3 doses. We noted decreases in saturated fatty acids (SFA) and an increase in polyunsaturated fatty acids (PUFA) in all treated groups. The docosahexaenoic (DHA) and eicosapentaenoic (EPA) acid levels declined in all fish exposed to CoCl2 graded doses (p ≤ 0.001). The decrease in the conversion enzyme ratios D5D and D6D desaturases explained these changes in EPA and DHA levels. However, PUFA (n-6) and arachidonic acid (ARA) increased (p < 0.001) in all treated groups. These increases in ARA were associated with the enhancement of linoleic acid (LA) and D5D' desaturases activity. Our treatment showed significant declines in PUFA (n-3)/PUFA (n-6) ratio and in flesh lipid quality (FLQ) and an increase in the PUFA/SFA ratio. Our experiment suggested the harmful effects of cobalt, confirmed by the alteration of fatty acid composition and deterioration of the nutritional quality of C. carpio muscle.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Lipid-Reducing Potential of Elsholtzia bodinieri Vaniot Essential Oil: Implications for HepG2 Cells and the Caenorhabditis elegans Obesity Models. 探索香草精油的降脂潜能：对HepG2细胞和秀丽隐杆线虫肥胖模型的影响。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-08 DOI: 10.1002/lipd.12450

Xiaoying Liu, Mengyuan Zhang, Runyuan Wang, Fang Xu, Hua Bai, Wei Zou, Qi Wang

{"title":"Exploring the Lipid-Reducing Potential of Elsholtzia bodinieri Vaniot Essential Oil: Implications for HepG2 Cells and the Caenorhabditis elegans Obesity Models.","authors":"Xiaoying Liu, Mengyuan Zhang, Runyuan Wang, Fang Xu, Hua Bai, Wei Zou, Qi Wang","doi":"10.1002/lipd.12450","DOIUrl":"https://doi.org/10.1002/lipd.12450","url":null,"abstract":"Elsholtzia bodinieri Vaniot, a medicinal and edible plant native to Yunnan, China, was investigated for its lipid-reducing effects in this study. The essential oil of E. bodinieri Vaniot (EBVEO) demonstrated a significant reduction in lipid droplets, intracellular triglyceride (TG), and total cholesterol (TC) levels in HepG2 lipid-accumulating cells. EBVEO upregulated the expression of key proteins, including SIRT1, AMPK, PPARα, and CD36, promoting enhanced β-oxidation and fat breakdown. This regulatory effect on lipid metabolism was also observed in a high-fat Caenorhabditis elegans (C. elegans) model. qPCR and parallel reaction monitoring (PRM) revealed the activation of the AAK-2/NHR-49 pathway, homologs of PPARα and AMPK, leading to a substantial increase in fat oxidation and a notable reduction in fat accumulation in C. elegans. In conclusion, EBVEO exhibits promising potential in regulating cellular and C. elegans lipid metabolism through the SIRT1/AMPK and AAK-2/NHR-49 pathways, positioning it as a promising lipid metabolism enhancer.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASGR1 inhibitors, inflammation, and heart failure: A Mendelian randomization analysis. ASGR1抑制剂、炎症和心力衰竭：孟德尔随机分析

IF 1.8 4区医学

Lipids Pub Date : 2025-05-20 DOI: 10.1002/lipd.12446

Xingsheng Ye, Miaomiao Yang, Yinghao Hong, Zhizhan Lin, Jian Peng, Liwei He

{"title":"ASGR1 inhibitors, inflammation, and heart failure: A Mendelian randomization analysis.","authors":"Xingsheng Ye, Miaomiao Yang, Yinghao Hong, Zhizhan Lin, Jian Peng, Liwei He","doi":"10.1002/lipd.12446","DOIUrl":"https://doi.org/10.1002/lipd.12446","url":null,"abstract":"This study investigates the causal relationship between Asialoglycoprotein receptor 1 (ASGR1) inhibitors, inflammation, and heart failure (HF). Leveraging data from the Global Lipids Genetics Consortium (2021) and the UK Biobank, we identified instrumental variables for ASGR1 and validated these genetic instruments using coronary heart disease (CHD) patients as positive controls. We employed Instrumental variable weighted (IVW) and Summary-data-based Mendelian Randomization (SMR) methods to assess the association of ASGR1 with HF and its associated risk factors, comparing efficacy with PCSK9 and LDLR. Mediation analysis of inflammatory biomarkers was conducted using a two-step Mendelian randomization approach, with sensitivity analyses performed using conventional MR methods. IVW analysis demonstrates a significant positive correlation between ASGR1 expression and HF, myocardial infarction, non-ischemic cardiomyopathy, and calcific aortic valvular stenosis. Patients with HF comorbid with CHD showed an increased likelihood of benefit. ASGR1 exhibited a stronger effect on HF compared to PCSK9. Similar conclusions were drawn from SMR analysis. Additionally, LDLR shows no causal relationship with HF but appears negatively correlated with non-ischemic cardiomyopathy. Among the 91 inflammatory proteins studied, Leukemia inhibitory factor receptor (LIF-R) and Urokinase-type plasminogen activator (uPA) were found to mediate the effects of ASGR1 on HF. Sensitivity analyses indicate no evidence of pleiotropy in reported results. This study supports a causal association between ASGR1 inhibitors and HF, providing genetic evidence for the anti-inflammatory role of ASGR1 inhibitors in reducing HF risk. LIF-R and uPA, identified as potential mediators, introduce a novel therapeutic pathway for HF management.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum Insights Into Fatty Acids, Antioxidant Mechanisms, and Molecular Docking Studies in Anacamptis papilionacea. 脂肪酸、抗氧化机制和分子对接研究的量子洞察。

IF 1.8 4区医学

Lipids Pub Date : 2025-05-19 DOI: 10.1002/lipd.12448

Taşkın Basılı, Erdi Can Aytar, Mayker Lazaro Dantas Miranda, Bengisu Şentürk, Yasemin Özdener Kömpe

{"title":"Quantum Insights Into Fatty Acids, Antioxidant Mechanisms, and Molecular Docking Studies in Anacamptis papilionacea.","authors":"Taşkın Basılı, Erdi Can Aytar, Mayker Lazaro Dantas Miranda, Bengisu Şentürk, Yasemin Özdener Kömpe","doi":"10.1002/lipd.12448","DOIUrl":"https://doi.org/10.1002/lipd.12448","url":null,"abstract":"This study examines the antioxidant activities, fatty acid composition, cytotoxicity predictions, and endocrine-disrupting potential of metabolites from orchid methanolic-flower extracts. In silico analyses, including molecular docking, NCI-RDG, FMO, ELF, LOL, and MEP mapping, were conducted to explore noncovalent interactions, electronic properties, reactivity, and charge distribution of key metabolites, providing insights into their bioactivity and mechanisms of action. Antioxidant activity, evaluated via the DPPH assay, showed an IC50 value of 12.83 mg/mL for the methanolic extract, outperforming the positive control (BHT, IC50 = 18.00 mg/mL). High flavonoid content, expressed as quercetin equivalents, confirmed the presence of bioactive compounds, including quercetin and gallic acid. The fatty acid (FA) profile of Anacamptis papilionacea fixed oil, analyzed by GC-MS, revealed palmitic acid, α-linolenic acid, 8,11,14-eicosatrienoic acid, and docosahexaenoic acid as dominant FAs, constituting 79.47% of the total oil. Molecular docking showed strong binding interactions of these FAs with the human glucocorticoid receptor. Cytotoxicity predictions indicated promising activity against melanoma and lung carcinoma cells, particularly with 8,11,14-eicosatrienoic acid and docosahexaenoic acid. Endocrine-disrupting potential was evaluated through molecular binding with 14 nuclear receptors, showing varying affinities, particularly for estrogen, androgen, and glucocorticoid receptors. These findings highlight the bioactivity and therapeutic potential of A. papilionacea metabolites, emphasizing their antioxidant, cytotoxic, and receptor-binding capabilities. Further experimental studies are warranted for clinical validation.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anthropometric indicators of obesity as screening tools for low high-density lipoprotein cholesterol in older adults: A cross-sectional study. 肥胖人体测量指标作为老年人低高密度脂蛋白胆固醇筛查工具：一项横断面研究。

IF 1.8 4区医学

Lipids Pub Date : 2025-04-29 DOI: 10.1002/lipd.12447

Yuri Silva de Souza, Lucas Dos Santos, Débora Jesus da Silva, Emille Silva Santos, Sabrina da Silva Caires, Paulo da Fonseca Valença Neto, Claudio Bispo de Almeida, Pabline Dos Santos Santana, Raquel Dos Santos Barbosa, Cezar Augusto Casotti

{"title":"Anthropometric indicators of obesity as screening tools for low high-density lipoprotein cholesterol in older adults: A cross-sectional study.","authors":"Yuri Silva de Souza, Lucas Dos Santos, Débora Jesus da Silva, Emille Silva Santos, Sabrina da Silva Caires, Paulo da Fonseca Valença Neto, Claudio Bispo de Almeida, Pabline Dos Santos Santana, Raquel Dos Santos Barbosa, Cezar Augusto Casotti","doi":"10.1002/lipd.12447","DOIUrl":"https://doi.org/10.1002/lipd.12447","url":null,"abstract":"Low levels of high-density lipoprotein cholesterol (HDL-C) increase the risk of cardiovascular events and mortality in older individuals. Developing cost-effective screening tools for identifying this condition in large populations is essential. To evaluate the discriminatory capacity of anthropometric indicators of obesity in screening for low HDL-C among older adults. A cross-sectional population-based epidemiological study was conducted with 223 older individuals (57% women) living in a community. The following anthropometric indicators were evaluated: body mass index (BMI), waist circumference (WC), abdominal circumference (AC), body adiposity index (BAI), triceps skinfold (TSF), waist-hip ratio (WHR), waist-height ratio (WHtR), and conicity index (CIn). Low HDL-C was defined as values below 40 mg/dL. The prevalence of low HDL-C was 25.10% (men: 35.41%; women: 21.77%). Among older men, BAI showed the highest sensitivity (87.10%; accuracy: 0.70; 95% CI: 0.53-0.74), while WC had the highest specificity (83.05%; accuracy: 0.71; 95% CI: 0.60-0.80). Among older women, WHR demonstrated the highest sensitivity (100%; accuracy: 0.71; 95% CI: 0.62-0.79), and WHtR showed the highest specificity (67.68%; accuracy: 0.71; 95% CI: 0.62-0.79). BAI and WHR were the most effective indicators for screening older men and women with low HDL-C, respectively. Additionally, WC and WHtR were the most effective indicators for identifying older men and women without low HDL-C, respectively.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of low-dose atorvastatin plus ezetimibe for primary hypercholesterolemia: A randomized, double-blind, multicenter phase 3 trial. 低剂量阿托伐他汀加依折替贝治疗原发性高胆固醇血症的疗效和安全性：一项随机、双盲、多中心3期试验

IF 1.8 4区医学

Lipids Pub Date : 2025-04-18 DOI: 10.1002/lipd.12442

Tae Oh Kim, Kyounghoon Lee, Jin-Man Cho, Hyuck-Jun Yoon, Tae-Ho Park, Jung Hyun Choi, Jung-Won Suh, Seok-Yeon Kim, Hong-Seok Lim, Jong-Seon Park, Deok-Kyu Cho, Gyung-Min Park, Sung-Gyun Ahn, Sanghoon Shin, Sung Uk Kwon, Dae-Hyeok Kim, Sang-Rok Lee, Jung-Hoon Sung, Hwan-Cheol Park, Seung-Whan Lee

{"title":"Efficacy and safety of low-dose atorvastatin plus ezetimibe for primary hypercholesterolemia: A randomized, double-blind, multicenter phase 3 trial.","authors":"Tae Oh Kim, Kyounghoon Lee, Jin-Man Cho, Hyuck-Jun Yoon, Tae-Ho Park, Jung Hyun Choi, Jung-Won Suh, Seok-Yeon Kim, Hong-Seok Lim, Jong-Seon Park, Deok-Kyu Cho, Gyung-Min Park, Sung-Gyun Ahn, Sanghoon Shin, Sung Uk Kwon, Dae-Hyeok Kim, Sang-Rok Lee, Jung-Hoon Sung, Hwan-Cheol Park, Seung-Whan Lee","doi":"10.1002/lipd.12442","DOIUrl":"https://doi.org/10.1002/lipd.12442","url":null,"abstract":"Studies have suggested that low-dose statin monotherapy may be insufficient for target LDL-C levels. In this randomized, double-blind, multicenter phase 3 trial, we evaluated the efficacy of combined ezetimibe and low-dose atorvastatin in 222 Korean patients with primary hypercholesterolemia. Participants received either 10-mg ezetimibe/5-mg atorvastatin (EZE10/ATV5), 10-mg ezetimibe (EZE10), 5-mg atorvastatin (ATV5), or 10-mg atorvastatin (ATV10). At 8 weeks, EZE10/ATV5 achieved the greatest LDL-C reduction (-44.8%) compared with EZE10 (-12.7%, p < 0.0001), ATV5 (-27.3%, p < 0.0001), and ATV10 (-32.0%, p = 0.0012). The combination therapy showed the highest LDL-C goal achievement rate (41.1% vs. EZE10 8.9%, p < 0.0001; ATV5 10.9%, p < 0.0001; ATV10 27.3%, p = 0.0342), particularly in moderate to high-risk patients. Additionally, EZE10/ATV5 had the lowest adverse events among all groups (6.9% vs. 15.0%, 12.3%, and 27.6%, p = 0.017), with most events being mild. These findings suggest that the combination of ezetimibe and low-dose atorvastatin provides superior lipid-lowering efficacy with an improved safety profile, offering an effective treatment for primary hypercholesterolemia in Korean patients.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exogenous oxidized phytosterol may modulate linoleic acid metabolism through upregulation of fatty acid desaturase in rats. 外源性氧化植物甾醇可能通过上调脂肪酸去饱和酶调节大鼠亚油酸代谢。

IF 1.8 4区医学

Lipids Pub Date : 2025-04-09 DOI: 10.1002/lipd.12444

Tomonari Koyama, Kyoichi Osada

{"title":"Exogenous oxidized phytosterol may modulate linoleic acid metabolism through upregulation of fatty acid desaturase in rats.","authors":"Tomonari Koyama, Kyoichi Osada","doi":"10.1002/lipd.12444","DOIUrl":"https://doi.org/10.1002/lipd.12444","url":null,"abstract":"Previous in vitro studies have indicated that oxidized phytosterol (OPS) exhibits some toxicity; however, the harmful effects of OPS on fatty acid metabolism are not completely understood yet. Therefore, this study examined the effects of exogenous phytosterol (PS) and OPS on growth parameters and lipid metabolism in rats. Rats were provided with AIN-76 basal diet, basal diet +0.5% PS, or basal diet +0.5% OPS. We found that the level of cholesterol and triacylglycerols in the liver was significantly lower in OPS-fed rats than in basal diet-fed rats. The ratio of Δ6 desaturation index (20:3(n-6) + 20:4(n-6))/18:2(n-6) in the plasma was significantly higher in the OPS-fed rats than in the PS-fed rats. Additionally, the proportion of arachidonic acid (20:4) in the liver was significantly higher in the OPS-fed group compared with the control group. The mRNA expression levels of Δ6 and Δ5 desaturases were significantly higher in OPS-fed rats than in basal diet-fed rats, but remained unchanged in PS-fed rats. Moreover, the protein level of Δ6 desaturase was significantly higher in both PS- and OPS-fed rats compared with basal diet-fed rats, while the protein level of Δ5 desaturase tended to be higher only in OPS-fed rats than in basal diet-fed rats. Thus, exogenous OPS, but not PS, altered fatty acid composition through the upregulation of mRNA and protein levels of fatty acid desaturation enzymes in the liver. This indicates that exogenous OPS, unlike PS, may modulate the production of eicosanoids from arachidonic acid, potentially promoting allergic reactions, inflammation, and atherosclerosis.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid and lipoprotein particle profiles in patients with type 2 diabetes mellitus: A comparative study between highlanders and lowlanders. 2型糖尿病患者的脂质和脂蛋白颗粒谱：高地人和低地人的比较研究。

IF 1.8 4区医学

Lipids Pub Date : 2025-04-03 DOI: 10.1002/lipd.12441

Chenghui Zhang, Rong Du, Suyuan Wang, Yan Ye, Xueping Sun, Yunhong Wu, Mingxia Li

{"title":"Lipid and lipoprotein particle profiles in patients with type 2 diabetes mellitus: A comparative study between highlanders and lowlanders.","authors":"Chenghui Zhang, Rong Du, Suyuan Wang, Yan Ye, Xueping Sun, Yunhong Wu, Mingxia Li","doi":"10.1002/lipd.12441","DOIUrl":"https://doi.org/10.1002/lipd.12441","url":null,"abstract":"The lipid profiles of highlanders and lowlanders differ. However, studies of the lipid profiles of patients with type 2 diabetes mellitus (T2DM) living at high altitudes are limited. This study aimed to compare lipid profiles and lipoprotein particles in individuals with T2DM permanently residing in the Tibetan Plateau and those residing in the lowlands. This cross-sectional study included 117 individuals with T2DM from the lowlands (n = 78) and highlands (n = 39). Demographic information, clinical features, blood biochemical indices, and standard lipid concentrations were recorded and evaluated. Low-density lipoprotein particles (LDL-Ps) and LDL subfractions were compared between the groups. Additionally, the risk for atherosclerotic cardiovascular disease (ASCVD) was assessed. The standard lipid profile and nuclear magnetic resonance-measured lipid panel showed no significant differences in terms of triglyceride, total cholesterol, and high-density lipoprotein cholesterol levels. However, highlanders exhibited a higher mean level of LDL cholesterol (LDL-C) than lowlanders. The LDL-P mean level was significantly higher in highlanders than in lowlanders. Small-density LDL (sdLDL) showed no distinct difference between the two groups. Furthermore, the 10-year risks of ASCVD were slightly higher in highlanders than in lowlanders, although the difference was not statistically significant. Individuals with T2DM living at highland altitudes have higher LDL-C and LDL-P levels than those living in lowlands. No difference was observed in the sdLDL levels between the two populations. These discrepancies may carry profound implications for the clinical management of T2DM and the prevention of cardiovascular diseases in high-altitude areas.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysophosphatidylcholine, rich in n-3 polyunsaturated fatty acids, inhibits leukotriene production by mouse mast cells. 富含n-3多不饱和脂肪酸的溶血磷脂酰胆碱可抑制小鼠肥大细胞产生白三烯。

IF 1.8 4区医学

Lipids Pub Date : 2025-04-02 DOI: 10.1002/lipd.12443

Mikako Takasugi, Hirofumi Arai, Koki Sugimoto, Tadahiro Tsushima, Ryota Hosomi, Kenji Fukunaga, Koretaro Takahashi

{"title":"Lysophosphatidylcholine, rich in n-3 polyunsaturated fatty acids, inhibits leukotriene production by mouse mast cells.","authors":"Mikako Takasugi, Hirofumi Arai, Koki Sugimoto, Tadahiro Tsushima, Ryota Hosomi, Kenji Fukunaga, Koretaro Takahashi","doi":"10.1002/lipd.12443","DOIUrl":"https://doi.org/10.1002/lipd.12443","url":null,"abstract":"In fishery industries, large amounts of byproducts are discarded during processing; therefore, their use as a source of n-3 polyunsaturated fatty acids (PUFAs) is beneficial. In this study, we evaluated the potential anti-allergic effect of lysophosphatidylcholine (Lyso-PtdCho) derived from squid skin phosphatidylcholine (PtdCho) by measuring the production of leukotriene (LT) B4 and C4, which are chemical mediators produced by mast cells in immediate allergic reactions. Squid Lyso-PtdCho, with docosahexaenoic acid exclusively esterified at the sn-2 position, significantly inhibited LT production, whereas the original PtdCho obtained from squid skin showed no inhibitory activity. Lyso-PtdCho prepared from starfish viscera PtdCho, which exclusively binds eicosapentaenoic acid at the sn-2 position, also inhibited LT production, although the effect was moderate compared with that of the squid Lyso-PtdCho. It has been suggested that Lyso-PtdCho containing n-3 PUFA may alleviate allergic symptoms and contribute to the effective utilization of fishery wastes and processing byproducts.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0