Lipids最新文献 - Book学术

Cashew Nut Oil Improves Lipid Metabolism and Fat Liver Deposition in High-Fat Diet-Fed C57BL/6J Mice. 腰果油改善高脂饲料喂养C57BL/6J小鼠脂质代谢和脂肪肝沉积。

IF 1.6 4区医学

Lipids Pub Date : 2025-10-17 DOI: 10.1002/lipd.70015

Marcella Duarte Villas Mishima, Andressa Ladeira Bernardes, Carlos Alexandre Pinheiro, Luisa Gouveia Lana, Iasmim Xisto Campos, Valéria Silva de Lana, Izabela Maria Montezano de Carvalho, Patrícia Fontes Pinheiro, Renata Celi Lopes Toledo, Ana Paula Dionísio, Helen Hermana Hermsdorff, Maria do Carmo Gouveia Peluzio

{"title":"Cashew Nut Oil Improves Lipid Metabolism and Fat Liver Deposition in High-Fat Diet-Fed C57BL/6J Mice.","authors":"Marcella Duarte Villas Mishima, Andressa Ladeira Bernardes, Carlos Alexandre Pinheiro, Luisa Gouveia Lana, Iasmim Xisto Campos, Valéria Silva de Lana, Izabela Maria Montezano de Carvalho, Patrícia Fontes Pinheiro, Renata Celi Lopes Toledo, Ana Paula Dionísio, Helen Hermana Hermsdorff, Maria do Carmo Gouveia Peluzio","doi":"10.1002/lipd.70015","DOIUrl":"https://doi.org/10.1002/lipd.70015","url":null,"abstract":"Cashew nut oil adds value to the production chain of this Brazilian oilseed. It is a good source of monounsaturated and polyunsaturated fatty acids and bioactive compounds, such as phenolics. This study investigated the effects of cashew nut oil on the metabolism of animals subjected to a high-fat diet. C57BL/6J mice were fed a high-fat diet (12 weeks), then switched to diets containing cashew nut oil, soybean oil, or lard (12 weeks). Diets were characterized for their fatty acid profile. General parameters, metabolic markers, oxidative stress, gene expression, and liver steatosis were evaluated. Oleic acid was predominant in the cashew nut oil-added diet, linoleic acid in the soybean oil-added diet, and palmitic acid in the lard-added diet. Cashew nut oil reduced blood glucose, triglycerides, uric acid, and liver steatosis, and increased SOD expression and activity and catalase activity. Soybean oil reduced blood glucose, total cholesterol, LDL cholesterol, triglycerides, and liver steatosis. Both vegetable oils, rich in unsaturated fatty acids, demonstrated more benefits than animal fat. Cashew nut oil effects may be mediated by the reduction of hepatic fat accumulation and oxidative stress, leading to lower triglyceride levels, improved insulin signaling, and decreased uric acid, probably due to its fatty acid composition, rich in oleic acid. Phenolic compounds may enhance its antioxidant capacity. The quality of fatty acids and the bioactive compounds is a determinant of the metabolic effect of oils. Cashew nut oil may improve lipid metabolism, reduce liver steatosis, and enhance antioxidant effects.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome-Wide Identification, Characterization, and Nutrigenomics of ELOVL Genes in Laying Hens and Their Responses to Various Levels of Dietary Curcumin. 蛋鸡ELOVL基因的全基因组鉴定、表征和营养基因组学研究及其对饲粮中不同水平姜黄素的响应

IF 1.6 4区医学

Lipids Pub Date : 2025-10-13 DOI: 10.1002/lipd.70013

Büşra Dumlu, Şaziye Canan Bölükbaşi, Abdulkadir Bayir

{"title":"Genome-Wide Identification, Characterization, and Nutrigenomics of ELOVL Genes in Laying Hens and Their Responses to Various Levels of Dietary Curcumin.","authors":"Büşra Dumlu, Şaziye Canan Bölükbaşi, Abdulkadir Bayir","doi":"10.1002/lipd.70013","DOIUrl":"https://doi.org/10.1002/lipd.70013","url":null,"abstract":"We investigated molecular characteristics and tissue distribution of elongation of very long chain fatty acids (ELOVL) genes in the chicken (Gallus gallus) genome. The research specifically examines the expression levels of these genes in chickens fed diets enriched with varying concentrations of curcumin. The aim is to uncover the potential roles and functions of ELOVL genes in the metabolism of fatty acids (FAs) in this species. In the experimental design, Hy-Line Brown commercial laying hens were selected for a feeding trial lasting 10 weeks. During this period, the hens were fed diets supplemented with curcumin at 100, 200, 300, and 400 mg/kg. The results revealed several critical insights: (1) It was confirmed that the ELOVL genes in Gallus gallus are orthologues of those found in vertebrates, indicating a shared evolutionary lineage; (2) There were noteworthy differences in how ELOVL genes, except ELOVL1 and ELOVL7, were distributed across various tissues and how they responded to dietary curcumin, prompting the need for comprehensive promoter analyses to better understand their functions in chickens; (3) The addition of curcumin to the diet did not increase omega-3 FAs in egg yolk; and (4) Dietary curcumin modulated ELOVL mRNA transcription in Gallus gallus. However, the intricate and multifaceted nature of FA metabolism presents challenges to fully grasping the implications of these results, highlighting the necessity for further in-depth investigations in this area.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Curcuminoids Plus Piperine Co-Supplementation on Serum Lipid Profile in Adults: A Systematic Review and Meta-Analysis of RCTs. 姜黄素和胡椒碱共同补充对成人血脂的影响：随机对照试验的系统回顾和荟萃分析

IF 1.6 4区医学

Lipids Pub Date : 2025-10-07 DOI: 10.1002/lipd.70004

Mehdi Karimi, Meysam Javadi, Maryam Sharifi, Kimia Kazemi, Sharareh Jahangiri, Niyousha Shirsalimi, Omid Asbaghi, Minoo Bassami

{"title":"Effects of Curcuminoids Plus Piperine Co-Supplementation on Serum Lipid Profile in Adults: A Systematic Review and Meta-Analysis of RCTs.","authors":"Mehdi Karimi, Meysam Javadi, Maryam Sharifi, Kimia Kazemi, Sharareh Jahangiri, Niyousha Shirsalimi, Omid Asbaghi, Minoo Bassami","doi":"10.1002/lipd.70004","DOIUrl":"https://doi.org/10.1002/lipd.70004","url":null,"abstract":"Dyslipidemia is a known risk factor for cardiovascular diseases (CVD). Research indicates that curcuminoids plus piperine co-supplementation (Curc + Pipe) can alter serum lipids. However, the findings from various studies are inconsistent. This meta-analysis aims to evaluate the efficacy of Curc + Pipe in serum lipid parameters in adults. A systematic search was conducted in databases until August 2025 to identify eligible randomized controlled trials (RCTs). To estimate the pooled effect size, weighted mean differences (WMDs) with corresponding 95% confidence intervals (CIs) were calculated, applying a random-effects model to account for potential variability between studies. A pooled analysis of 16 RCTs, encompassing a total of 1038 participants (Intervention: 522, Control: 516) revealed that Curc + Pipe significantly reduced triglycerides (TG) (WMD: -18.64 mg/mL, 95% CI: -29.94, -7.34, p < 0.001) and total cholesterol (TC) (WMD: -6.58 mg/mL, 95% CI: -12.60, -0.55, p = 0.032) and increased high-density lipoprotein cholesterol (HDL-C) (WMD: 1.51 mg/mL, 95% CI: 0.29, 2.72, p = 0.015). However, the reduction in low-density lipoprotein cholesterol (LDL-C) was not statistically significant (WMD: -2.20 mg/mL, 95% CI: -7.22, 2.80, p = 0.387). Curc + Pipe has clinically meaningful lipid-modulating effects, particularly in reducing TG and TC and modestly increasing HDL-C levels. These benefits were most pronounced in more prolonged supplementation in individuals with dyslipidemia, metabolic disorders, and overweight. Clinically, Curc + Pipe may serve as a valuable complementary therapy for dyslipidemia management to decrease the risk of CVD.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring Peripheral Tissue DHA Turnover Using a Novel ¹³C Enrichment Technique. 使用一种新的13C富集技术测量外周组织DHA周转率。

IF 1.6 4区医学

Lipids Pub Date : 2025-10-03 DOI: 10.1002/lipd.70011

Brinley J Klievik, Adam H Metherel, Rodrigo Valenzuela, Richard P Bazinet

{"title":"Measuring Peripheral Tissue DHA Turnover Using a Novel 13C Enrichment Technique.","authors":"Brinley J Klievik, Adam H Metherel, Rodrigo Valenzuela, Richard P Bazinet","doi":"10.1002/lipd.70011","DOIUrl":"https://doi.org/10.1002/lipd.70011","url":null,"abstract":"Recently, through the use of compound-specific isotope analysis (CSIA), our lab validated the utility of 13C enrichment (δ13C) of docosahexaenoic acid (DHA) by using a very high δ13C in a diet switch study by measuring brain, liver, and plasma DHA turnover and half-lives via high-precision gas chromatography combustion isotope ratio mass spectrometry (GC/C/IRMS). Using this novel enrichment technique, the present study extends measures of DHA turnover in the peripheral tissues, including red blood cells (RBC), perirenal adipose tissue (PRAT), muscle, heart, and skin. Mice were fed a low δ13C diet (fish-DHA control) for 3 months, then switched to either a high δ13C treatment diet (algal-DHA) or a very high δ13C treatment diet (13C enriched-DHA), while some remained on the fish-DHA control diet as a reference group for the remainder of the study time course. In mice fed the algal and 13C enriched-DHA diets, the RBC DHA half-life was 22.8 and 19.5 days, the PRAT DHA half-life was 6.0 and 8.2 days, the muscle DHA half-life was 38.2 and 42.2 days, the heart DHA half-life was 12.4 and 10.5 days, and the skin DHA half-life was 13.6 and 13.0 days, respectively. Future studies could employ the 13C enrichment method to examine how DHA metabolism is altered in peripheral tissues according to genetics, stress, and development.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of Proportion of Process-Bearing Phenotype of Microglial Cell Line MG6 by Arachidonic Acid Generated From Exogenous Lysophosphatidylinositol. 外源性溶血磷脂酰肌醇产生花生四烯酸对MG6小胶质细胞系过程表型比例的影响。

IF 1.6 4区医学

Lipids Pub Date : 2025-09-25 DOI: 10.1002/lipd.70012

Kohei Kawabata, Saori Nonaka, Makoto Hirano, Yuya Ohtsuki, Masanori Inagaki, Hiroshi Nakanishi, Hiroyuki Nishi, Akira Tokumura

{"title":"Reduction of Proportion of Process-Bearing Phenotype of Microglial Cell Line MG6 by Arachidonic Acid Generated From Exogenous Lysophosphatidylinositol.","authors":"Kohei Kawabata, Saori Nonaka, Makoto Hirano, Yuya Ohtsuki, Masanori Inagaki, Hiroshi Nakanishi, Hiroyuki Nishi, Akira Tokumura","doi":"10.1002/lipd.70012","DOIUrl":"https://doi.org/10.1002/lipd.70012","url":null,"abstract":"Attention has recently been paid to the cross-talk between G protein-coupled receptor 55 for lysophosphatidylinositol as an endogenous agonist and cannabinoid receptors 1 and 2 for 2-arachidonoylglycerol as an endogenous agonists in mammalian neuronal cells. In relation to the functional coupling, in this study, exogenously added 1-arachidonoyl lysophosphatidylinositol (1-20:4 LPI) to MG6, a mouse microglial cell line, was found to be converted to 1-arachidonoyl glycerol (1-20:4 MAG) and arachidonic acid (20:4 FFA), possibly due to the combined action of ecto-lysophospholipaase C activity of glycerophosphodiesterase 3 and extracellular lipase toward MAG. Consistent with the above result, exogenous 1-20:4 MAG was found to be converted to 20:4 FFA by extracellular lipase activity toward MAG in the culture medium of MG6 cells. Not only was exogenous 20:4 FFA incubated with MG6 cells, but also 20:4 FFA produced from the exogenous 1-20:4 MAG and 1-20:4 LPI in the absence of fetal bovine serum, respectively, were postulated to be involved in the reduced population of process-bearing MG6 cells via its entry into the cells and the intracellular conversion of prostaglandins. This hypothesis was supported by our findings showing that the reducing effects of exogenous 1-20:4 LPI, 1-20:4 MAG, and 20:4 FFA were all found to be indomethacin-inhibitable, and that exogenous PGD2, but not PGE2 and PGF2α, was shown to reduce the population of process-bearing MG6 cells cultured without Fetal bovine serum.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues. 人体血液中脂肪酸水平与三叉神经血管组织之间的关系。

IF 1.6 4区医学

Lipids Pub Date : 2025-09-21 DOI: 10.1002/lipd.70010

Daisy Zamora, Mark S Horowitz, Sharon F Majchrzak-Hong, Katherine Ness Shipley, Nicholas M Salem, Ann I Scher, Matthew R Sapio, Michael J Iadarola, Christopher E Ramsden

{"title":"Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues.","authors":"Daisy Zamora, Mark S Horowitz, Sharon F Majchrzak-Hong, Katherine Ness Shipley, Nicholas M Salem, Ann I Scher, Matthew R Sapio, Michael J Iadarola, Christopher E Ramsden","doi":"10.1002/lipd.70010","DOIUrl":"https://doi.org/10.1002/lipd.70010","url":null,"abstract":"Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are precursors to oxylipins that modulate pain and inflammation. We previously demonstrated that (1) a dietary intervention increasing omega-3 and reducing omega-6 PUFAs alters the concentration of these oxylipin precursors in blood, and (2) these changes are associated with reduced headache pain in humans. However, the extent to which blood levels reflect trigeminovascular tissues remains unclear. We sought to determine whether oxylipin precursor PUFA levels in blood reflect those in the meninges, cranial arteries, and trigeminal ganglia. Precursor PUFA compositions of post-mortem blood and trigeminovascular tissue specimens from 70 individuals, procured from the Human Brain Collection Core at the National Institute of Mental Health, were quantified. Regression models adjusted for confounders examined relationships between blood and tissue PUFA levels. Eicosapentaenoic acid in blood was associated with levels in cranial arteries, meninges, and trigeminal ganglia [logged coefficients (p value): 0.29 (0.019); 0.37 (< 0.001); 0.25 (0.009)]. Other PUFAs, including linoleic acid, arachidonic acid, n-6 docosapentaenoic acid, and docosahexaenoic acid, also showed significant associations between blood and meninges and/or trigeminal ganglia levels. These findings support using blood measurements of certain PUFAs as a proxy for their concentration in tissues directly involved in headache pathogenesis.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vegetarian Diets and Their Effect on n-3 Polyunsaturated Fatty Acids Status in Humans: Systematic Review. 素食饮食及其对人体n-3多不饱和脂肪酸状态的影响：系统综述。

IF 1.6 4区医学

Lipids Pub Date : 2025-09-16 DOI: 10.1002/lipd.70009

Rodrigo Chamorro, Claudia Tabilo, Yasna Muñoz, Hilda Núñez, María Catalina Hernández-Rodas, Camila Farías, Francisca Echeverría, Rodrigo Valenzuela

{"title":"Vegetarian Diets and Their Effect on n-3 Polyunsaturated Fatty Acids Status in Humans: Systematic Review.","authors":"Rodrigo Chamorro, Claudia Tabilo, Yasna Muñoz, Hilda Núñez, María Catalina Hernández-Rodas, Camila Farías, Francisca Echeverría, Rodrigo Valenzuela","doi":"10.1002/lipd.70009","DOIUrl":"https://doi.org/10.1002/lipd.70009","url":null,"abstract":"Vegetarian diets limit the consumption of foods of animal origin to a variable extent, potentially leading to deficiencies in specific nutrients, particularly proteins and n-3 polyunsaturated fatty acids (n-3 PUFA) from fish or seafood. This systematic review aimed to assess the impact of vegetarian diets on n-6 and n-3 PUFA status in humans, with a focus on critical periods such as pregnancy and growth. Studies were included if they evaluated the relationship between vegetarian diets and PUFA status with clearly defined vegetarian diet types and PUFA measurement methods. Exclusion criteria included systematic reviews, meta-analyses, and studies that included occasional meat or fish consumption. A comprehensive literature search was conducted in PubMed, Springer, and ScienceDirect databases, considering articles published up to 2023. A total of 45 studies were involved; the review found that vegetarian diets increased linoleic acid (C18:2 n-6, LA) and alpha-linolenic acid (C18:3 n-3, ALA) intake but resulted in significantly reduced concentrations of eicosapentaenoic acid (C20:5 n-3, EPA) and docosahexaenoic acid (C22:6 n-3, DHA), particularly in vegan diets. DHA intake from microalgae oil was shown to effectively improve serum DHA status, particularly during pregnancy and lactation. The evidence included in this review is limited by variations in study designs, potential biases in dietary reporting, and inconsistencies in PUFA (especially intake) measurement methods. These findings highlight the need for strict dietary planning and supplementation strategies to mitigate deficiencies, particularly during critical developmental periods.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solubilization of Saturated Fatty Acids and Its Lysophosphatidylcholine by Complexation With Bovine Serum Albumin. 饱和脂肪酸及其溶血磷脂酰胆碱与牛血清白蛋白络合的增溶作用。

IF 1.6 4区医学

Lipids Pub Date : 2025-09-12 DOI: 10.1002/lipd.70005

Hanif Ali, Mone Yamanishi, Miki Tsuchiya, Rumana Yesmin Hasi, Motonori Matsusaki, Tomohide Saio, Mutsumi Aihara, Ryushi Kawakami, Tamotsu Tanaka

{"title":"Solubilization of Saturated Fatty Acids and Its Lysophosphatidylcholine by Complexation With Bovine Serum Albumin.","authors":"Hanif Ali, Mone Yamanishi, Miki Tsuchiya, Rumana Yesmin Hasi, Motonori Matsusaki, Tomohide Saio, Mutsumi Aihara, Ryushi Kawakami, Tamotsu Tanaka","doi":"10.1002/lipd.70005","DOIUrl":"https://doi.org/10.1002/lipd.70005","url":null,"abstract":"High plasma levels of saturated fatty acids (SFAs) are associated with lifestyle diseases such as atherosclerosis and diabetes, whereas the accumulation of very long-chain fatty acids (VLCFAs) is believed to be responsible for neuropathy in certain types of peroxisomal disorders. Despite their clinical relevance, the toxicity mechanisms of fatty acids (FAs) remain poorly understood, largely because of the challenges in solubilizing them for in vitro experiments. We recently developed a method to form stable complexes of FAs with bovine serum albumin (BSA) using isopropanol as the solvent. Here, we demonstrate the stability and concentration range of FA/BSA and lysophosphatidylcholine (LysoPtdCho)/BSA complexes prepared using this method. These complexes exhibit enhanced solubility, retain their biological activity in cellular uptake assays, and remain stable for up to 12 months. We believe that our method will contribute to a better understanding of the toxicity and metabolism of SFAs and SFA-LysoPtdChos, and offer new insights into their roles in metabolic diseases and peroxisomal disorders.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Per- and Polyfluoroalkyl Substances (PFAS) Exposure and LDL Cholesterol in US Adults: Evidence From NHANES. 美国成人全氟和多氟烷基物质（PFAS）暴露与低密度脂蛋白胆固醇之间的关系：来自NHANES的证据

IF 1.6 4区医学

Lipids Pub Date : 2025-09-06 DOI: 10.1002/lipd.70008

Akshaya Srikanth Bhagavathula, Dhwani Krishnan, Melinda B Chu

{"title":"Association Between Per- and Polyfluoroalkyl Substances (PFAS) Exposure and LDL Cholesterol in US Adults: Evidence From NHANES.","authors":"Akshaya Srikanth Bhagavathula, Dhwani Krishnan, Melinda B Chu","doi":"10.1002/lipd.70008","DOIUrl":"https://doi.org/10.1002/lipd.70008","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants increasingly implicated in cardiometabolic risk. This study evaluates the association between serum PFAS exposure and lipid dysregulation, focusing on low-density lipoprotein cholesterol (LDL-C), a key cardiovascular risk factor. We analyzed 998 adults from the 2017 to 2020 National Health and Nutrition Examination Survey (NHANES), representing a weighted sample of 240 million US adults. Serum concentrations of nine PFAS compounds including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluoroundecanoic acid (PFUnDA), and perfluorohexane sulfonic acid (PFHxS) were measured. Double/debiased machine learning (DML) estimated the association between PFAS exposure and LDL-C and triglyceride levels, adjusting for demographics, clinical, and behavioral covariates. The median total PFAS concentration was 9.23 ng/mL (interquartile range: 9.67 ng/mL). The weighted mean LDL-C and triglyceride levels were 112.5 mg/dL (95% CI: 112.5-112.5) and 115.6 mg/dL (95% CI: 115.6-115.6), respectively. Total PFAS exposure was significantly associated with higher LDL-C (β = 0.30; 95% CI: 0.05-0.54; p = 0.016). Perfluoroundecanoic acid (PFUnDA), linear PFOS, and methyl-perfluorooctane sulfonic acid (Sm-PFOS) were also significantly associated with elevated LDL-C (β = 12.1, 0.44, 2.83; all p < 0.05). PFHxS was inversely associated with triglycerides (β = -2.26; p = 0.031). In this representative sample of US adults, PFAS exposure is independently associated with lipid dysregulation, particularly elevated LDL-C. However, results should be interpreted with caution given the cross-sectional design, modest effect sizes, and potential residual confounding from unmeasured environmental or dietary factors.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomics Investigation of a Multi-Ingredient Supplements-Modulated Changes in Metabolism in Mice After Endurance Exercise. 多成分补充剂对耐力运动后小鼠代谢变化的代谢组学研究。

IF 1.6 4区医学

Lipids Pub Date : 2025-09-04 DOI: 10.1002/lipd.70007

Xu Haixia, Chen Hui

{"title":"Metabolomics Investigation of a Multi-Ingredient Supplements-Modulated Changes in Metabolism in Mice After Endurance Exercise.","authors":"Xu Haixia, Chen Hui","doi":"10.1002/lipd.70007","DOIUrl":"https://doi.org/10.1002/lipd.70007","url":null,"abstract":"Energy metabolism manipulation strategy, enhancing fat metabolism while reducing the dependence on glucose, is beneficial to improve exercise performance. The multi-ingredient supplements (MIS) mixed with valine, isoleucine, leucine, β-alanine, creatine, L-carnitine, quercetin, and betaine were found to be able to improve the endurance performance of mice, which was associated with a shift of energy substrates from glucose to fatty acids. Thus, we hypothesized that the MIS regulating lipid metabolism contributes to enhancing exercise endurance in mice. The present study aimed to explore the alterations in the biochemical composition of mice treated with the MIS using a metabolomics strategy after they were subjected to endurance exercise. The serum metabolite profile was investigated using ultrahigh performance liquid chromatography tandem mass spectrometry. Results showed that significant changes in lipid metabolism were observed in the MIS-treated mice during endurance exercise compared with the vehicle control. Specifically, the MIS treatment reduced glycerophospholipids, glycerolipids, long-chain fatty acids, and inflammatory signaling arachidonic acid derivatives, and increased medium-long-chain acylcarnitine levels relative to the exercised group. Furthermore, the levels of dimethylglycine (DMG), citrate (CA), glycerol, creatine, and corticosterone were also increased after the MIS supplementation, which was associated with the changes in the pathways of serotoninergic synapses, CA cycles, and amino acid metabolisms. In conclusion, the MIS tested in this study effectively alters serum metabolomics profiles, which provides further evidence to support a shift in energy substrate utilization contributing to the ability of the MIS to improve exercise performance.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0