Lipids最新文献 - Book学术

Effects of a high-fat diet on gut microbiota and possible implications for bone health in male Wistar rats.

IF 1.8 4区医学

Lipids Pub Date : 2025-03-18 DOI: 10.1002/lipd.12440

Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Renata Meca, Horácio Montenegro, Lilian Cuppari, Martin H de Borst, Ita Pfeferman Heilberg

{"title":"Effects of a high-fat diet on gut microbiota and possible implications for bone health in male Wistar rats.","authors":"Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Renata Meca, Horácio Montenegro, Lilian Cuppari, Martin H de Borst, Ita Pfeferman Heilberg","doi":"10.1002/lipd.12440","DOIUrl":"https://doi.org/10.1002/lipd.12440","url":null,"abstract":"Diet plays an important role in the composition of gut microbiota. Emerging research suggests that bone homeostasis can also be influenced by the gut microbiota. The aim of this study was to assess possible alterations in gut microbiota in an experimental obesity model induced by a high-fat diet (HFD) and the possible effects on parameters of bone metabolism and remodeling. Male Wistar rats were fed a HFD (60% lipids) or standard (control) diet for 14 weeks. Biochemical and hormonal parameters, bone histomorphometry, bone protein levels, and gut microbiota composition were analyzed. HFD animals exhibited a greater gut microbiota α-diversity represented by the Shannon Index and an increased relative abundance of the Proteobacteria phylum. Histomorphometry detected lower bone formation in the HFD group, accompanied by increased levels of serum and bone leptin and FGF-23 (fibroblast growth factor-23). The Shannon Index was correlated directly with bone FGF-23 (R 0.96, p = 0.04) and inversely with the osteoblastic surface (R -0.95, p = 0.04). The present study disclosed a significant increase in gut microbiota α-diversity and relative abundance of Proteobacteria phylum in obese animals fed a high-fat diet in parallel with increased levels of bone and serum leptin and FGF-23 and lower bone formation. The associations of Shannon Index with bone levels of FGF-23 and reduced osteoblastic surface suggest a link between HFD-induced higher gut microbiota diversity and low bone formation.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-regression of the relationship between dietary 18C n-3 concentration and enrichment of n-3 fatty acids in liver and breast muscle of broiler chickens.

IF 1.8 4区医学

Lipids Pub Date : 2025-03-14 DOI: 10.1002/lipd.12439

Usman Ali, Ahmed El-Zenary, Kevin J Harvatine

{"title":"Meta-regression of the relationship between dietary 18C n-3 concentration and enrichment of n-3 fatty acids in liver and breast muscle of broiler chickens.","authors":"Usman Ali, Ahmed El-Zenary, Kevin J Harvatine","doi":"10.1002/lipd.12439","DOIUrl":"https://doi.org/10.1002/lipd.12439","url":null,"abstract":"The long-chain n-3 fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have human health benefits, and many experiments have investigated the ability of plant n-3 sources to enrich n-3 FA in broiler meat. A meta-regression was conducted to evaluate the relationship between dietary 18-carbon n-3 FA content and the deposition of EPA, docosapentaenoic acid (DPA), and DHA in broiler breast and liver tissue. Bivariate regression of total diet 18-carbon n-3 and tissue FA profile was modeled with the random effect of experiment and the partial R2 was calculated. Increasing 18C n-3 FA in the diet quadratically increased the log10 concentration of all n-3 FA in breast tissue. The strongest relationship was found for breast alpha-linolenic (partial R2 = 0.55), followed by EPA, DPA, and DHA (partial R2 = 0.20, 0.14, and 0.05). Liver enrichment of EPA, DPA, and DHA (all partial R2 > 0.43) and EPA + DHA (partial R2 = 0.55) was quadratically related to dietary 18C n-3 FA, while liver EPA + DPA + DHA (partial R2 = 0.43) was linearly related to dietary 18C n-3 FA. In both breast and liver, the plateau in tissue enrichment was more apparent for DHA than EPA, with DPA being intermediate. A linear plateau model fit the data with a break point for enriching EPA and DHA in breast muscle at 22.4 and 17.9 g/kg of 18C n-3 FA in the diet, respectively. Enrichment of long-chain n-3 FA in broiler chickens was saturable, with little justification for feeding beyond approximately 20 g/kg 18C n-3 FA.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactobacillus plantarum fermented barley extract attenuates obesity in HFD-induced obese rats by regulating gut microbiota.

IF 1.8 4区医学

Lipids Pub Date : 2025-03-07 DOI: 10.1002/lipd.12435

Ruirong Pan, Tingwei Wang, Juan Bai, Jiayan Zhang, Yaoguang Gu, Zhicong Zhao, Ruixue Tang, Zifan Qian, Lirong Yan, Xiang Xiao, Shuang Liang, Ying Dong

{"title":"Lactobacillus plantarum fermented barley extract attenuates obesity in HFD-induced obese rats by regulating gut microbiota.","authors":"Ruirong Pan, Tingwei Wang, Juan Bai, Jiayan Zhang, Yaoguang Gu, Zhicong Zhao, Ruixue Tang, Zifan Qian, Lirong Yan, Xiang Xiao, Shuang Liang, Ying Dong","doi":"10.1002/lipd.12435","DOIUrl":"https://doi.org/10.1002/lipd.12435","url":null,"abstract":"Lactobacillus plantarum fermented barley extract (LFBE) has a potent anti-obesity effect on high-fat-diet fed (HFD) obese rats. However, the underlying mechanism remains unclear. Herein, we investigated the anti-obesity effect and mechanism of LFBE in 3 T3-L1 preadipocytes and HFD-induced obese rats. LFBE significantly inhibited lipid accumulation by decreasing the expression of adipogenesis-related transcription factors, including peroxisome proliferator-activated receptor (PPAR-γ) and CCAAT/enhancer binding protein (C/EBP-α) in differentiated 3 T3-L1 cells. The expression levels of adiponectin, acetyl CoA carboxylase (ACC), and fatty acid synthase (FAS) were also suppressed in differentiated three T3-L1 cells. Administration of LFBE significantly reduced insulin resistance, blood lipid profiles, and improved metabolic hormones in HFD-induced obese rats. Furthermore, the serum pro-inflammatory cytokines including CRP, IL-6, TNFα, and INFγ in HFD-induced obese rats were significantly decreased after LFBE administration. LFBE treatment also attenuated oxidative stress in HFD-induced obese rats by decreasing MDA production and restoring SOD and catalase enzymatic activity. Administration of LFBE could modulate gut microbiota imbalance by increasing the abundance of Lactobacillus and Ruminococcaceae UCG-014 and decreasing Prevotella-9 at the genus level and restoring intestinal barrier dysfunction in HFD-induced obesity rats. Taken together, our study indicated that LFBE is a promising candidate for treating obesity through multiple mechanisms.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cosupplementation with DHA and medium-chain triglycerides ameliorates NAFLD and reduces amyloid-β accumulation by modulating hepatic lipid metabolism in APP/PS1 mice.

IF 1.8 4区医学

Lipids Pub Date : 2025-02-25 DOI: 10.1002/lipd.12436

Dalong Zhang, Zehao Wang, Xiaojun Wang, Wenbo Yue, Lu Zhang, Zheng Gao, Min Li, Xiaoli Zhou, Zhenshu Li, Guowei Huang, Wen Li, Dianming Zhou, Zhiyong Qian

{"title":"Cosupplementation with DHA and medium-chain triglycerides ameliorates NAFLD and reduces amyloid-β accumulation by modulating hepatic lipid metabolism in APP/PS1 mice.","authors":"Dalong Zhang, Zehao Wang, Xiaojun Wang, Wenbo Yue, Lu Zhang, Zheng Gao, Min Li, Xiaoli Zhou, Zhenshu Li, Guowei Huang, Wen Li, Dianming Zhou, Zhiyong Qian","doi":"10.1002/lipd.12436","DOIUrl":"https://doi.org/10.1002/lipd.12436","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and is associated with Alzheimer's disease (AD). Both docosahexaenoic acid (DHA) and medium chain triglycerides (MCTs) play essential roles in lipid metabolism and the inhibition of amyloid-β (Aβ) accumulation. We aimed to explore the possible association between cerebral Aβ deposition and the development of NAFLD and to investigate the effect of DHA combined with MCTs on delaying NAFLD progression and Aβ accumulation. To this end, 40 three-month-old APP/PS1 male mice were randomly assigned to 4 groups. The mice were fed a control diet, a DHA (2.91 g/kg) diet, an MCTs (100 g/kg) diet, or a DHA + MCTs diet for 8 months. Ten C57BL/6J mice were fed a control diet and used as the wild-type (WT) group. The results indicated that APP/PS1 mice exhibited NAFLD and cerebral Aβ accumulation. DHA combined with MCTs decreased blood and liver lipids, relieved hepatic steatosis and fat accumulation, and decreased the level of Aβ in the brain and serum. Moreover, DHA combined with MCTs significantly upregulated the levels of Aβ clearance-related proteins in the liver, modulated the expression of key hepatic lipid metabolism enzymes and upstream hepatic lipid metabolism factors. In conclusion, compared with wild-type mice, APP/PS1 mice may be more sensitive to changes in lipid metabolism due to the accumulation of Aβ. DHA combined with MCTs alleviated NAFLD and decreased brain and serum Aβ levels in APP/PS1 mice compared with the control group. The possible mechanism may involve affecting hepatic fat and cholesterol metabolism and increasing hepatic Aβ clearance by modulating liver lipid metabolism enzymes.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of blood lipids with mortality in COVID-19 patients.

IF 1.8 4区医学

Lipids Pub Date : 2025-02-25 DOI: 10.1002/lipd.12437

Cansu Memiç-İnan, Mustafa Çapraz, Aylin Çapraz

{"title":"Association of blood lipids with mortality in COVID-19 patients.","authors":"Cansu Memiç-İnan, Mustafa Çapraz, Aylin Çapraz","doi":"10.1002/lipd.12437","DOIUrl":"https://doi.org/10.1002/lipd.12437","url":null,"abstract":"The aim of this study was to investigate the association between lipid levels and mortality in individuals hospitalized (ward/intensive care unit) for coronavirus disease 2019 (COVID-19). This retrospective cohort study was conducted with COVID-19 patients admitted to a public hospital between April 2020 and 2021. Age, sex, and chronic disease status of the participants were analyzed as general information. Information on biochemical tests (high-density lipoprotein [HDL], low-density lipoprotein [LDL], triglycerides, total cholesterol, c-reactive protein [CRP]) and haemogram parameters were obtained from the hospital's automated system. The study sample consisted of 501 COVID-19 patients aged 24-94 years. According to mortality status, total cholesterol, HDL, LDL, and lymphocyte levels were higher, while CRP, neutrophil, and white blood cell levels were lower in survivors (p < 0.05). The risk of mortality was found to be higher with lower LDL and HDL cholesterol levels in COVID-19 patients (p < 0.05). The results of this study showed that alterations in lipoprotein metabolism are associated with mortality in COVID-19 patients. Therefore, it is important to evaluate and monitor the blood lipid profile in COVID-19 patients.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A miniaturized iodine value assay for quantifying the unsaturated fatty acid content of lipids, lipid mixtures, and biological membranes.

IF 1.8 4区医学

Lipids Pub Date : 2025-02-23 DOI: 10.1002/lipd.12438

Maria Monserrat Roman-Lara, Katie J Chong, Roslyn M Bill, Alan D Goddard

{"title":"A miniaturized iodine value assay for quantifying the unsaturated fatty acid content of lipids, lipid mixtures, and biological membranes.","authors":"Maria Monserrat Roman-Lara, Katie J Chong, Roslyn M Bill, Alan D Goddard","doi":"10.1002/lipd.12438","DOIUrl":"https://doi.org/10.1002/lipd.12438","url":null,"abstract":"Various methods exist for identifying and quantifying lipid unsaturation, including mass spectrometry and Raman spectroscopy. A disadvantage of these existing approaches is the need for sophisticated equipment and software, placing them beyond the means of many laboratories. The iodine value (IV) is a colorimetric unsaturation index; however, it uses iodine monochloride, a hazardous chemical, and considerable amounts of sample. Here, we demonstrate the first use of a miniaturized IV method that requires only milliliter quantities of hazardous chemicals and sample sizes such that it is feasible to assay biological membranes. Briefly, lipids are exposed to iodine monochloride, resulting in the replacement of unsaturated bonds with di-halogenated single bonds. Potassium iodide then reacts with unreacted iodine monochloride forming I2, which is quantified through titration with sodium thiosulfate. To demonstrate the biological relevance of our assay, membrane lipids of Escherichia coli grown at 30, 37, and 42°C were analyzed, with IV increasing as temperature decreased, as would be expected. Importantly, multiple samples could be rapidly and simultaneously analyzed in a reproducible assay that did not require sophisticated equipment or data analysis methods. Our miniaturized IV assay will benefit laboratories with limited access to sophisticated equipment and enable the rapid determination of lipid unsaturation in milligram-scale samples.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated lipoprotein(a) levels in rheumatic heart valvular disease: A new link?

IF 1.8 4区医学

Lipids Pub Date : 2025-02-13 DOI: 10.1002/lipd.12434

Mehmet Rasih Sonsöz, Duygu Inan, Nazime Karadamar, Kadir Şahin, Zehra Eroğlu, Sevil Tuğrul, İlyas Çetin, Mehmet Nail Bilen, İhsan Demirtaş, Hüseyin Akgün, Gülsen Şener, Alev Kılıçgedik

{"title":"Elevated lipoprotein(a) levels in rheumatic heart valvular disease: A new link?","authors":"Mehmet Rasih Sonsöz, Duygu Inan, Nazime Karadamar, Kadir Şahin, Zehra Eroğlu, Sevil Tuğrul, İlyas Çetin, Mehmet Nail Bilen, İhsan Demirtaş, Hüseyin Akgün, Gülsen Şener, Alev Kılıçgedik","doi":"10.1002/lipd.12434","DOIUrl":"https://doi.org/10.1002/lipd.12434","url":null,"abstract":"Rheumatic heart valvular disease (RHVD) is primarily characterized by immune-mediated damage following infection with Streptococcus pyogenes, leading to inflammation and subsequent valvular dysfunction. Traditionally, the focus has been on the immunological aspects of this disease; however, emerging evidence suggests that lipoprotein(a) [Lp(a)] may play a crucial role not only in atherosclerosis but also in the pathophysiology of calcific aortic valve disease. Given the inflammatory nature of RHVD and the pro-inflammatory and pro-calcific properties of Lp(a), this study aimed to investigate the relationship between serum Lp(a) levels and the severity of RHVD. In this cross-sectional study, we included 40 RHVD patients and 40 age- and sex-matched controls. Serum Lp(a) analysis was performed in all patients. We analyzed demographic and echocardiographic parameters and the relationship between serum Lp(a) concentrations and echocardiographic parameters. The mean age of the patient population was 50 ± 11 years and 47 (72%) were female. Lp(a) was higher in the RHVD group than in the control group (21 [19-49] vs. 17 [12-19] mg/dL; p < 0.001). Serum Lp(a) correlated positively with left atrial diameter (rho = 0.438; p = 0.005), estimated pulmonary artery systolic pressure (rho = 0.390; p = 0.019), Wilkins score (rho = 0.482; p = 0.002), number of valves involved (rho = 0.397; p = 0.011), aortic regurgitation grade (rho = 0.373; p = 0.018) and negatively correlated with mitral valve area (rho = -0.413; p = 0.008). In conclusion, serum Lp(a) concentrations were higher in patients with RHVD than in the control group and were positively correlated with disease severity indicators, including mitral stenosis grade, Wilkins score, aortic regurgitation grade, left atrial diameter, and estimated pulmonary artery systolic pressure.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digestion and absorption of triacetin, a short-chain triacylglycerol.

IF 1.8 4区医学

Lipids Pub Date : 2025-01-31 DOI: 10.1002/lipd.12433

Yukihiro Yoshimura, Tomoka Matsui, Nagisa Kaneko, Ikuha Kobayashi

引用次数: 0

An interracial Mendelian analysis revealed a link between lipid-lowering drugs and renal failure.

IF 1.8 4区医学

Lipids Pub Date : 2025-01-25 DOI: 10.1002/lipd.12430

Naidan Zhang, Chaixia Ji, Baibing Xie, Yaoyang Liu, Chengliang Yuan

{"title":"An interracial Mendelian analysis revealed a link between lipid-lowering drugs and renal failure.","authors":"Naidan Zhang, Chaixia Ji, Baibing Xie, Yaoyang Liu, Chengliang Yuan","doi":"10.1002/lipd.12430","DOIUrl":"https://doi.org/10.1002/lipd.12430","url":null,"abstract":"Lipid-lowering drugs have been used in clinics widely. It is unclear whether the drugs have an effect on renal failure. We chose high-density lipoprotein cholesterol (ieu-b-109), low-density lipoprotein cholesterol (ieu-a-300), triglyceride (ieu-b-111), and total cholesterol (ebi-a-GCST90038690) as exposures. SNPs near drug genes served as instrumental variables. Acute renal failure (ARF) and chronic renal failure (CRF) in Europeans from the GWAS catalog were selected as outcomes. Datasets on renal failure in East Asians and South Asians were used for validation. Inverse variance weighted (IVW) was the primary method for drug-targeted Mendelian randomization. In the Europeans, people who used PPARG reduced ARF risk by 69.3% (OR: 0.307, 95% CI: 0.171-0.553, p = 0.015). NPC1L1 inhibitors increased ARF risk by 2.684 times (OR: 2.684, 95% CI: 2.027-3.341, p = 0.003). APOE increased ARF risk by 1.987 times (OR: 1.987, 95% CI: 1.062-3.716, p = 0.032) but decreased CRF risk by 49.7% (OR: 0.503, 95% CI: 0.283-0.894, p = 0.019). TNFSF12 increased CRF risk by 3.866 times (OR: 3.866, 95% CI: 1.174-12.729, p = 0.026). In the East Asians, PPARG reduced CRF risk by 85.8% (OR: 0.142, 95% CI: 0.054-0.371, p < 0.001). And in the South Asians, APOE decreased ARF risk by 99.8% (OR: 0.002, 95% CI: 2.12e-05-0.179, p = 0.007). We revealed that PPARG could reduce the risk of renal failure in Europeans and Asians. APOE could cause ARF in the Europeans, but it was protective in the South Asians. Clinicians need to consider the characteristics of the local population before administering drugs to patients of different ethnicities.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regression of carotid atherosclerosis in high-risk individuals with proprotein convertase subtilisin/kexin type 9 inhibitors. 蛋白转化酶枯草杆菌素/ keexin 9型抑制剂对高危人群颈动脉粥样硬化的消退作用

IF 1.8 4区医学

Lipids Pub Date : 2025-01-22 DOI: 10.1002/lipd.12432

Albert Z Luu, Yasaman Hajiesmaeili, Sholeh Faezi, J David Spence, Daniel G Hackam, Hamed Hadizadeh, Seyyed M Sohrevardi, M Reza Azarpazhooh

{"title":"Regression of carotid atherosclerosis in high-risk individuals with proprotein convertase subtilisin/kexin type 9 inhibitors.","authors":"Albert Z Luu, Yasaman Hajiesmaeili, Sholeh Faezi, J David Spence, Daniel G Hackam, Hamed Hadizadeh, Seyyed M Sohrevardi, M Reza Azarpazhooh","doi":"10.1002/lipd.12432","DOIUrl":"https://doi.org/10.1002/lipd.12432","url":null,"abstract":"Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent a novel approach for reducing cholesterol and, accordingly, the burden of atherosclerosis. However, limited data are available regarding the possible effects of PCSK9 inhibitors on atherosclerotic plaque. To evaluate the efficacy of PCSK9 inhibitors in reducing carotid plaque progression in individuals with high-risk carotid atherosclerotic disease. We used carotid total plaque area (TPA) to assess the burden of atherosclerosis. Ultrasound imaging of the carotid was acquired before and after the initiation of PCSK9 inhibitor therapy. We selected high-risk cases with atherosclerosis with a minimum of three ultrasound examinations, 1 year before, one at the time of initiation of a PCSK9 inhibitor, and 1 year after initiating a PCSK9 inhibitor. Statistical analysis was conducted using the mixed-effects model with Restricted Maximum Likelihood (REML). We reviewed data from 131 patients with a mean follow-up of 6 (±4) years. Patients were high-risk, with the majority having diabetes or hypertension. There was a decrease in TPA, particularly during the first 3 years after initiating PCSK9 inhibitor therapy (p < 0.05). Furthermore, we observed that individuals with higher baseline serum low-density lipoprotein cholesterol (LDL-C) levels experienced a greater decline in TPA (p < 0.05). PCSK9 inhibitors are effective in achieving plaque regression in high-risk patients with atherosclerosis. This is important, as plaque regression is associated with a lower risk of stroke, myocardial infarction, or vascular death.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0