Lipids最新文献 - Book学术

Point/Counterpoint on the Controversial 2025-2030 Dietary Guidelines for Americans. 有争议的2025-2030年美国人膳食指南的观点/对照。

IF 1.6 4区医学

Lipids Pub Date : 2026-10-16 DOI: 10.1002/lipd.70088

J Thomas Brenna, Yan Ning Li, Penny M Kris-Etherton, Philip C Calder

{"title":"Point/Counterpoint on the Controversial 2025-2030 Dietary Guidelines for Americans.","authors":"J Thomas Brenna, Yan Ning Li, Penny M Kris-Etherton, Philip C Calder","doi":"10.1002/lipd.70088","DOIUrl":"https://doi.org/10.1002/lipd.70088","url":null,"abstract":"The 2025-2030 Dietary Guidelines for Americans (DGAs) issued nutrition recommendations, some of which have been praised by the nutrition community while others have been questioned based on the lack of supporting evidence. The recommendations about calorie control, emphasis on nutrient density, vegetables, fruits, and whole grains, and limiting added sugars, sodium, and alcohol are based on strong evidence and have been carried forward from previous DGAs. The recommendations to limit ultra-processed foods and added sugars both per meal and per product have been well-received. The controversial recommendations relate to the type of fat recommended (e.g., \"healthy\" fats that include butter and beef tallow) and the omission of guidance about seed oils high in unsaturated fatty acids, notably polyunsaturated fatty acids. The food-based guidance (consuming full-fat dairy products, butter and beef tallow, and animal products such as red meat) does not align with the long-standing recommendation to limit saturated fat to < 10% of calories. Concerns have also been expressed about the higher protein recommendation as well as the recommendation to consume 20 g (or more) with each meal. Moreover, there are questions about the placement of animal foods at the top and whole grains at the bottom of the new \"food pyramid\". Herein we summarize the evidence in support of, and in disagreement with, the controversial new DGAs. Global dietary recommendations both in support of and not in alignment with some of the DGAs are reviewed. Strategies for widespread adoption of the DGAs are mentioned.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wild Edible Mushrooms, Including 10 Ramaria Taxa, Show Predominantly Unsaturated and Nutritionally Favorable Fatty-Acid Profiles. 野生食用菌（包括10个Ramaria类群）主要表现出不饱和脂肪酸和有益营养的脂肪酸谱。

IF 1.6 4区医学

Lipids Pub Date : 2026-10-15 DOI: 10.1002/lipd.70087

Mahfuz Elmastaş, Adem Zorlu, İbrahim Türkekul, Ömer Kayır

{"title":"Wild Edible Mushrooms, Including 10 Ramaria Taxa, Show Predominantly Unsaturated and Nutritionally Favorable Fatty-Acid Profiles.","authors":"Mahfuz Elmastaş, Adem Zorlu, İbrahim Türkekul, Ömer Kayır","doi":"10.1002/lipd.70087","DOIUrl":"https://doi.org/10.1002/lipd.70087","url":null,"abstract":"Edible mushrooms contain little lipid, so their nutritional standing rests on which fatty acids it contains rather than how much. Wild taxa are unevenly characterized, and the species-rich genus Ramaria hardly at all. We report the first fatty-acid dataset for the genus, determined by gas chromatography with flame-ionization detection (GC-FID) in 14 wild edible mushrooms from Akkuş (Ordu, Türkiye), 10 Ramaria taxa and four comparators, expressed as lipid-quality indices and used to test whether lipid quantity predicts quality. Total lipid was low (1.8-4.1 g per 100 g dry weight). Eleven fatty acids were detected. In 13 of the 14 taxa the lipid was predominantly unsaturated (62%-89% of total fatty acids), dominated by oleic (18:1; 6.1%-54.0%) and linoleic acid (18:2; 25.1%-45.9%) over a modest palmitic background (16:0; 6.4%-16.2%). The polyunsaturated-to-saturated ratio (0.10-6.97) exceeded unity in 12 of the 14 taxa, and across the 13 the index of atherogenicity (0.13-0.71), index of thrombogenicity (0.07-1.06) and hypocholesterolemic/hypercholesterolemic ratio (2.37-10.68) were generally favorable, R. broomei marking the least favorable end. Two departures stand out. Hydnum repandum and Cantharellus cibarius carried α-linolenic acid at 41.1% and 40.3% with near-balanced n - 6/n - 3 ratios, tentative pending mass-spectrometric confirmation; Lactarius piperatus inverted the pattern, stearic acid alone accounting for 73.9% and raising its index of thrombogenicity to 11.67. Total lipid bore no relation to saturated or unsaturated proportions (Spearman ρ = 0.05 and -0.05). Quantity and quality therefore vary independently: the nutritional case for these mushrooms rests on compositional profiling rather than on gravimetric fat content.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Microbial-Derived Octadecanoids. 微生物源十八烷酸的合成。

IF 1.6 4区医学

Lipids Pub Date : 2026-09-25 DOI: 10.1002/lipd.70067

Johanna Revol-Cavalier, Katarína Bankóová, Olivier Salamin, Alessandro Quaranta, Juan Du, Mats Hamberg, Craig E Wheelock

{"title":"Synthesis of Microbial-Derived Octadecanoids.","authors":"Johanna Revol-Cavalier, Katarína Bankóová, Olivier Salamin, Alessandro Quaranta, Juan Du, Mats Hamberg, Craig E Wheelock","doi":"10.1002/lipd.70067","DOIUrl":"https://doi.org/10.1002/lipd.70067","url":null,"abstract":"Gut bacteria can convert dietary fatty acids into oxygenated metabolites called oxylipins, which can exert potent lipid mediator functions. The oxylipins derived from C-18 fatty acids are termed octadecanoids and associate with multiple disorders including allergy and metabolic dysregulation. This study presents the synthesis of 17 octadecanoids possessing a hydroxy group (n = 9) or a ketone (n = 8) on the 10- or 13-positions. The products of these two series were prepared for the linoleic acid (LA), α-linolenic acid (ALA) and γ-linolenic acid (GLA) pathways. The synthetic strategies provided 17 putative microbial metabolites of C-18 polyunsaturated fatty acids (PUFAs) with high purities, in 5-13 steps and overall yields from 1.5%-37%. To study the biological formation of these compounds, the parent PUFAs (LA, ALA, GLA) were fed to cultures of Enterococcus faecalis U150 and Lactobacillus acidophilus CCUG 5917, and the octadecanoid products were measured by chiral supercritical fluid chromatography coupled to tandem mass spectrometry (SFC-MS/MS). The compounds containing a hydroxy group on the 10- or 13-position are racemic, forming 9 enantiomeric pairs. Accordingly, of the 17 compounds synthesized, 9 were chiral and 8 were achiral resulting in 26 compounds. An additional 7 commercial bacteria-derived octadecanoids were measured to provide a screen of 33 compounds. Generally, PUFA supplementation resulted in selective formation of the associated octadecanoids. Of the 33 studied compounds, 16 were observed to be formed by E. faecalis and 13 by L. acidophilus. These findings demonstrate the bacteria species-specific formation of octadecanoids, which may have ramifications for associated biological response in the host.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Analysis of Serum Apolipoprotein Profiles and Lipoprotein(a) in Type 2 Diabetic Patients With Coronary Heart Disease. 2型糖尿病合并冠心病患者血清载脂蛋白谱和脂蛋白(A)的比较分析

IF 1.6 4区医学

Lipids Pub Date : 2026-09-21 DOI: 10.1002/lipd.70086

Xuchen Song, Haiyan Yu, Fang Miao, Wenling Su, Yingnan Ye

{"title":"A Comparative Analysis of Serum Apolipoprotein Profiles and Lipoprotein(a) in Type 2 Diabetic Patients With Coronary Heart Disease.","authors":"Xuchen Song, Haiyan Yu, Fang Miao, Wenling Su, Yingnan Ye","doi":"10.1002/lipd.70086","DOIUrl":"https://doi.org/10.1002/lipd.70086","url":null,"abstract":"Traditional lipid parameters poorly capture coronary heart disease (CHD) risk in type 2 diabetes mellitus (T2DM). This study compared apolipoprotein (ApoA1, ApoB) and lipoprotein(a) [Lp(a)] profiles between T2DM patients with and without CHD and evaluated their combined predictive value. This retrospective study included 140 T2DM patients, 70 with angiographically confirmed CHD and 70 age- and sex-matched without CHD (defined by the absence of cardiac symptoms, normal electrocardiogram, and normal echocardiogram). Fasting serum levels of traditional lipids, ApoA1, ApoB, and Lp(a) were measured, and the ApoB/ApoA1 ratio was calculated. Multivariate logistic regression and ROC curve analysis identified independent predictors and assessed predictive performance. Traditional lipid parameters showed no significant differences between groups (all p > 0.05). CHD patients had significantly lower ApoA1 (1.33 vs. 1.56 g/L, p < 0.001) and higher ApoB (1.40 vs. 1.21 g/L, p < 0.001), ApoB/ApoA1 ratio (1.05 vs. 0.78, p < 0.001), and Lp(a) (20.65 vs. 14.10 mg/dL, p = 0.009). Multivariate analysis identified smoking, ApoB/ApoA1 ratio, and Lp(a) as independent predictors. The ApoB/ApoA1 ratio yielded an AUC of 0.912. A combined model achieved an AUC of 0.976, with bootstrap internal validation confirming robustness (optimism-corrected AUC = 0.959, 95% CI: 0.921-0.982). The ApoB/ApoA1 ratio and Lp(a) were independently associated with CHD in T2DM patients. The combined model demonstrated excellent predictive performance, maintained after internal validation, though external validation is needed.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VLDL Phospholipid Composition, Remnant Cholesterol, ApoB, and Coronary Artery Disease: A Network Mendelian Randomization Study. VLDL磷脂组成、残余胆固醇、载脂蛋白b与冠状动脉疾病：一项网络孟德尔随机研究。

IF 1.6 4区医学

Lipids Pub Date : 2026-09-20 DOI: 10.1002/lipd.70085

Haiyang Yu, Xin Zhang, Shujia Yang, Zixuan Fan, Di Zhang, Dan Wang

{"title":"VLDL Phospholipid Composition, Remnant Cholesterol, ApoB, and Coronary Artery Disease: A Network Mendelian Randomization Study.","authors":"Haiyang Yu, Xin Zhang, Shujia Yang, Zixuan Fan, Di Zhang, Dan Wang","doi":"10.1002/lipd.70085","DOIUrl":"https://doi.org/10.1002/lipd.70085","url":null,"abstract":"Remnant cholesterol and apolipoprotein B (ApoB) are established contributors to coronary artery disease (CAD), but their relationship with very-large VLDL phospholipid composition remains uncertain. We evaluated whether genetically proxied VLDL phospholipid composition is linked to CAD through a connected remnant cholesterol-ApoB axis. Summary-level GWAS data were analyzed using network Mendelian randomization. Primary pairwise analyses used genome-wide significant instruments (P < 5 × 10-8) and inverse-variance weighted random-effects models, with weighted median, MR-Egger, MR-PRESSO, Steiger directionality, leave-one-out analyses, multivariable MR (MVMR), and locus-level colocalization as complementary analyses. Higher VLDL phospholipid ratio was associated with higher remnant cholesterol (β = 0.86, 95% CI 0.74-0.99) and higher CAD risk (OR = 1.80, 95% CI 1.54-2.11). Remnant cholesterol was associated with higher ApoB (β = 1.04, 95% CI 1.01-1.08), and ApoB with higher CAD risk (OR = 1.40, 95% CI 1.23-1.59). In MVMR models with adequate conditional instrument strength, VLDL phospholipid ratio remained associated with CAD after adjustment for remnant cholesterol (OR = 1.44, 95% CI 1.07-1.94) or ApoB (OR = 1.60, 95% CI 1.21-2.11), whereas their conditional effects were not independently significant. Remnant cholesterol and ApoB showed near-complete genetic collinearity, limiting reliable separation of their independent effects. colocalization supported shared causal signals at multiple loci. The findings support a genetically connected VLDL-remnant cholesterol-ApoB lipid axis associated with CAD, but do not establish formal serial mediation. VLDL phospholipid composition may capture CAD-relevant biology not fully explained by remnant cholesterol or ApoB alone.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role and Assessment of Lipid Profile in Patients With a Chronic Total Coronary Occlusion. 慢性全冠状动脉闭塞患者血脂水平的作用和评估。

IF 1.6 4区医学

Lipids Pub Date : 2026-09-17 DOI: 10.1002/lipd.70084

Karol Sadowski, Dominika Tomkiel, Roel Hoek, Ruben W de Winter, Nick S Nurmohamed, Bimmer E P M Claessen, Niels J Verouden, Alexander Nap, Sebastiaan A Kleijn, Mariusz Tomaniak, Yvemarie B O Somsen, Paul Knaapen

{"title":"The Role and Assessment of Lipid Profile in Patients With a Chronic Total Coronary Occlusion.","authors":"Karol Sadowski, Dominika Tomkiel, Roel Hoek, Ruben W de Winter, Nick S Nurmohamed, Bimmer E P M Claessen, Niels J Verouden, Alexander Nap, Sebastiaan A Kleijn, Mariusz Tomaniak, Yvemarie B O Somsen, Paul Knaapen","doi":"10.1002/lipd.70084","DOIUrl":"https://doi.org/10.1002/lipd.70084","url":null,"abstract":"Adequate lipid management is a crucial component in the treatment of chronic coronary syndromes, a group of conditions that also encompasses patients with chronic total coronary occlusions (CTOs). Importantly, atherosclerotic progression may be especially rapid in patients with a CTO, yet it is unknown whether specific lipid thresholds for this population are appropriate or need to be adjusted compared to non-CTO patients. The present review aimed to provide insight into the lipid profiles of CTO patients and their association with clinical outcome compared to non-CTO patients. Furthermore, we investigated the impact of lipid levels on coronary collateral circulation (CCC) development. The available data suggest a tendency towards a more adverse lipid profile in CTO patients compared with non-CTO patients, characterized by elevated TG, Lp(a), and AIP, and reduced HDL levels. While lipid parameters are frequently reported as baseline characteristics, few studies have directly evaluated their prognostic significance. The current evidence supports the hypothesis that a greater atherogenic burden in CTO patients may be associated with worse clinical outcomes and poorer CCC formation, particularly when advanced lipidomic markers or composite indices are considered. If confirmed in larger prospective studies, incorporating a more comprehensive assessment of the lipid profile into the clinical management of CTO patients may improve risk stratification and provide a basis for more personalized lipid-lowering strategies in this high-risk population.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Report of Δ5,8,11,14,17-Octadecapentaenoic Acid (18:5n-1) in Diatoms (Bacillariophyceae: Thalassiosirales) 硅藻（硅藻门：海硅藻门）中Δ5,8,11,14,17- octadecapentaenoic Acid （18:5n-1）的首次报道。

IF 1.6 4区医学

Lipids Pub Date : 2026-09-11 Epub Date: 2026-04-05 DOI: 10.1002/lipd.70055

Ksenia Chadova

引用次数: 0

Lipid-Soluble Signaling Molecular Model Predicts Prognosis and Immunotherapy Response in Gastric Cancer 脂溶性信号分子模型预测胃癌预后和免疫治疗反应。

IF 1.6 4区医学

Lipids Pub Date : 2026-09-11 Epub Date: 2026-05-08 DOI: 10.1002/lipd.70063

Wenwen Zhu, Yanna Yu

{"title":"Lipid-Soluble Signaling Molecular Model Predicts Prognosis and Immunotherapy Response in Gastric Cancer","authors":"Wenwen Zhu, Yanna Yu","doi":"10.1002/lipd.70063","DOIUrl":"10.1002/lipd.70063","url":null,"abstract":"<div>\u0000 \u0000 Lipid-soluble signaling molecule-related genes (LSMRGs) are critical in various tumors, but their role in gastric cancer (GC) prognosis and therapy remains unclear. Using transcriptomic data, this study analyzed LSMRG expression patterns, molecular subtypes, prognostic significance, and immune-microenvironment interactions in GC to identify new prognostic biomarkers and support precision medicine approaches. Using GC data from TCGA and GEO, LSMRGs from Genecard were analyzed. Unsupervised clustering defined LSMRG-based subtypes. Differentially expressed LSMRGs were identified by intersecting tumor-normal DEGs. A prognostic risk-score model was built via univariate Cox, LASSO, and multivariate Cox analyses, with model genes validated by qRT-PCR in cell lines. Comprehensive transcriptomic analyses included nomogram development, gene enrichment, immune infiltration, somatic mutations, and drug sensitivity. LSMRG-based clustering identified two patient subtypes with distinct survival and immunotherapy responses. From 83 differentially expressed LSMRGs, a 6-gene prognostic risk-score model was constructed, validated as an independent prognostic factor. Model gene expression was confirmed via qRT-PCR. The risk score accurately predicted 1-, 3-, and 5-year survival. High- and low-risk groups exhibited differential enrichment in pathways including neuroactive ligand-receptor interaction and hormone signaling. The high-risk group had a higher mutation burden, lower immune infiltration, and distinct drug sensitivity profiles compared to the low-risk group. This study delineates the expression landscape of LSMRGs in GC and clarifies their associations with molecular subtypes, prognosis, and immune regulation. The findings provide novel prognostic biomarkers and a molecular basis for targeting lipid-soluble signaling pathways in GC therapy.\u0000 </div>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 5","pages":"625-639"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Value of Combined Detection of Serum miR-302a-3p and Low Density Lipoprotein Cholesterol in the Diagnosis of Coronary Heart Disease 血清miR-302a-3p与低密度脂蛋白胆固醇联合检测在冠心病诊断中的价值分析

IF 1.6 4区医学

Lipids Pub Date : 2026-09-11 Epub Date: 2026-05-29 DOI: 10.1002/lipd.70064

Rongguo Sun, Guangli Zhang, Wei Zhang, Zhihao Guo, Ming Zhao, Guowei Jia

{"title":"Analysis of the Value of Combined Detection of Serum miR-302a-3p and Low Density Lipoprotein Cholesterol in the Diagnosis of Coronary Heart Disease","authors":"Rongguo Sun, Guangli Zhang, Wei Zhang, Zhihao Guo, Ming Zhao, Guowei Jia","doi":"10.1002/lipd.70064","DOIUrl":"10.1002/lipd.70064","url":null,"abstract":"<div>\u0000 \u0000 The diagnosis of premature coronary heart disease (PCHD) continues to pose challenges. miR-302a-3p serves as a potential diagnostic marker. This study investigated the diagnostic value of the combination serum miR-302a-3p and LDL-C for PCHD. This study encompassed a total of 116 patients with coronary artery stenosis (CAS), 116 patients with PCHD, and 108 control subjects. The levels of miR-302a-3p, TNF, IL6, and IL1B were detected by RT-qPCR. ROC curves and logistic regression analysis were used to evaluate diagnostic value and risk factors for disease progression, respectively. In vitro models of HUVECs were established by treating the cells with ox-LDL. Cell proliferation and apoptosis were detected by CCK-8 and flow cytometry, respectively. SOD and MDA were assessed using commercial kits. Serum levels of miR-302a-3p and LDL-C were increased in both the CAS and PCHD groups. miR-302a-3p, LDL-C, Apo B-100, and Gensini scores are independent risk factors for the progression of CAS to PCHD. The AUC of the combined diagnostic model of miR-302a-3p and LDL-C for differentiating PCHD from the control group was 0.902, whereas the diagnostic value of miR-302a-3p alone was 0.885. In cellular experiments, inhibition of miR-302a-3p can mitigate the release of inflammatory factors and oxidative stress induced by ox-LDL. miR-302a-3p serves as an independent risk factor for PCHD. The combination of miR-302a-3p with LDL-C can significantly enhance the accuracy of diagnostic value. miR-302a-3p may participate in the pathological process of PCHD, and its function is related to inflammatory responses and oxidative stress.\u0000 </div>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 5","pages":"663-672"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between C-Reactive Protein-Triglyceride Glucose Index, and the Risk of Osteoarthritis and Rheumatoid Arthritis: Results From NHANES 1999–2010 c反应蛋白-甘油三酯葡萄糖指数与骨关节炎和类风湿关节炎风险之间的关系：NHANES 1999-2010的结果

IF 1.6 4区医学

Lipids Pub Date : 2026-09-11 Epub Date: 2026-05-14 DOI: 10.1002/lipd.70065

Bo Hu, Zhijun Chen, Yonghua Chen, Ping Zhou

{"title":"Association Between C-Reactive Protein-Triglyceride Glucose Index, and the Risk of Osteoarthritis and Rheumatoid Arthritis: Results From NHANES 1999–2010","authors":"Bo Hu, Zhijun Chen, Yonghua Chen, Ping Zhou","doi":"10.1002/lipd.70065","DOIUrl":"10.1002/lipd.70065","url":null,"abstract":"<div>\u0000 \u0000 The serum C-reactive protein-triglyceride glucose index (CTI) is a parameter integrating inflammation and insulin resistance, which are potential mechanisms for osteoarthritis (OA) or rheumatoid arthritis (RA). Our study aims to investigate its association with the risk of OA or RA. This study is based on cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 1999–2010, involving 6395 participants aged ≥ 20 years. Weighted logistic regression, restricted cubic splines (RCS), and subgroup analysis were employed to assess the relationship between CTI and OA, RA. After adjusting for confounding factors, CTI showed a significant positive correlation with the risk of OA (p < 0.05), and a non-linear relationship was observed (p = 0.0069). The risk of OA peaked when CTI reached 8.35 and gradually declined beyond this threshold. Subgroup analyses confirmed that this association consistently existed across different populations (all interaction p > 0.05). For RA, after adjustment for metabolic and lifestyle factors, the association between CTI and RA was not statistically significant (p > 0.05). There is a significant non-linear association between CTI and the risk of OA, suggesting that CTI may serve as a comprehensive indicator for assessing OA risk.\u0000 </div>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 5","pages":"651-662"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0