Lipids最新文献

{"title":"Subtype-Specific Causal Effects of C16 and C24 Ceramides on Heart Failure: Evidence From Univariable and Multivariable Mendelian Randomization Analyses","authors":"Zeda Wang,&nbsp;Yakui Xue,&nbsp;Kaishan Han","doi":"10.1002/lipd.70054","DOIUrl":"10.1002/lipd.70054","url":null,"abstract":"<div>\u0000 \u0000 <p>Ceramides (Cer) are bioactive lipids implicated in cardiovascular disease (CVD), yet their subtype-specific causal effects remain unclear. We performed a two-sample Mendelian randomization (MR) analysis using publicly available GWAS summary statistics to investigate the effects of C16:0-ceramide homologs (Cer16:0) and C24:1-ceramide homologs (Cer24:1) on six CVD outcomes. Instrumental variables were rigorously selected, and multiple MR methods were applied to ensure robust inference. Univariable MR identified a significant inverse association between Cer(d18:1/24:1) and heart failure (HF), which remained significant after false discovery rate correction. In contrast, the association for Cer(d17:1/16:0) did not remain significant after correction. No causal associations were observed for other CVD outcomes. When aggregating subtypes, genetically predicted higher total Cer16:0 levels were associated with increased HF risk, while no significant association was found for total Cer24:1. Multivariable MR further demonstrated that the protective effect of Cer(d18:1/24:1) on HF was robust, while estimates for C16 subtypes were attenuated and sensitive to model specification. In conclusion, our findings support a stable protective role of Cer(d18:1/24:1) in HF and highlight the complexity of subtype-specific effects among structurally related ceramides. These results underscore the importance of considering ceramide heterogeneity in cardiovascular research. Further studies are warranted to validate these findings and explore their clinical implications.</p>\u0000 </div>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 5","pages":"569-582"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Vitamin E on Lipid Profile in Patients With Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD): A Systematic Review and Meta-Analysis","authors":"Mehdi Karimi,&nbsp;Maryam Abidi,&nbsp;Ayda Aghaei,&nbsp;Paris Kazemian,&nbsp;Negar Rafiezadeh Banadak,&nbsp;Ali Daneshmand Bahman,&nbsp;Omid Fakharzadeh Moghadam,&nbsp;Maryam Asadi Amin,&nbsp;Rana Kamali Khorgoo,&nbsp;Forough Sharifara,&nbsp;Mahsa Hosseini,&nbsp;Omid Asbaghi","doi":"10.1002/lipd.70042","DOIUrl":"10.1002/lipd.70042","url":null,"abstract":"<div>\u0000 \u0000 <p>Metabolic dysfunction–associated steatotic liver disease (MASLD) is associated with dyslipidemia and overweight. Vitamin E has been suggested to improve lipid metabolism, but clinical evidence in MASLD remains inconsistent. This meta-analysis evaluates the effects of vitamin E on serum lipid profiles and body mass index (BMI) in adults with MASLD. A literature search was conducted across databases through January 2026 to identify eligible randomized controlled trials (RCTs). Outcomes included triglycerides (TG), total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C &amp; HDL-C), and BMI. Pooled effect estimates were calculated as weighted mean difference (WMD) with 95% confidence intervals (CIs) using a random-effects model. The pooled analysis of 12 RCTs showed that vitamin E in patients with MASLD significantly reduced TG (−12.74 mg/dL, 95% CI: [−22.78, −2.70], <i>p</i> = 0.013), whereas no significant change was observed in TC (−2.11 mg/dL, 95% CI: [−4.89, 0.67], <i>p</i> = 0.137) and LDL-C (−5.32 mg/dL, 95% CI: [−11.15, 0.51], <i>p</i> = 0.074), HDL-C levels (0.23 mg/dL, 95% CI: [−0.48, 0.94], <i>p</i> = 0.527), and BMI (0.36 kg/m², 95% CI: [−0.86, 1.58], <i>p</i> = 0.563). Subgroup analyses revealed that TG was significantly reduced in low-dose, more prolonged supplementation and in overweight patients. For TC, LDL-C, and HDL-C, only a slight, significant improvement was observed in patients with obesity. Vitamin E in patients with MASLD selectively modulates lipid metabolism, predominantly reducing TG levels. Modest improvements in TC, LDL-C, and HDL-C were observed primarily in patients with obesity. These findings support the potential role of vitamin E as an adjunctive therapy for MASLD-associated dyslipidemia.</p>\u0000 </div>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 5","pages":"607-623"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Heated Versus Unheated Cooking Oil on Postprandial Vascular Function and Metabolism","authors":"Rosiered Brownson-Smith,&nbsp;Jo Bruce,&nbsp;Esmat Abbas,&nbsp;Sarah Fissler,&nbsp;Wendy Hall,&nbsp;Sarah Berry","doi":"10.1002/lipd.70052","DOIUrl":"10.1002/lipd.70052","url":null,"abstract":"<p>The impact of repeated heating of seed-based culinary oils on cardiometabolic health has not been well established. Heating oils to high temperatures (&gt; 150°C) causes lipid peroxidation, thus generating potentially harmful compounds that may impair vascular function. This randomized, single-blind, crossover study investigated the acute effects of a high-fat meal containing either repeatedly heated (at 180°C, over 10 days, with 5 potato fries per day) sunflower oil-palm olein blend, compared with an unheated blend (containing 23.8% and 7.2% polar compounds respectively), on postprandial lipids and vascular function in 19 healthy male participants. Participants consumed each test meal on separate days, with measurements of flow-mediated dilation (FMD; primary outcome), arterial stiffness, plasma triacylglycerol (TAG), non-esterified fatty acid (NEFA), and glucose concentrations over 4 h. Postprandial vascular (FMD and arterial stiffness) responses as well as NEFA and glucose concentrations were comparable between meals. The postprandial TAG increase was lower after heated versus unheated oil (<i>p</i> &lt; 0.001). These findings indicate that repeated heating of oil modifies postprandial lipaemia without acutely impairing vascular function. However, these short-term results do not address the potential cumulative effects of chronic, long-term consumption.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 5","pages":"555-562"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Lipids as Molecular Targets in Obesity-Associated Insulin Resistance in Rodent Models: A Systematic Review and Meta-Analysis","authors":"Rogelio I. Servin-Uribe,&nbsp;Jara Pérez-Jiménez,&nbsp;Eduardo Castaño Tostado,&nbsp;Diego Hernández-Saavedra,&nbsp;Rosalía Reynoso Camacho","doi":"10.1002/lipd.70061","DOIUrl":"10.1002/lipd.70061","url":null,"abstract":"<div>\u0000 \u0000 <p>Obesity induced by a high-calorie diet (HCD) results in the accumulation of ectopic fat in tissues not typically associated with lipid storage. This accumulation can cause lipotoxicity, a type of cellular stress triggered by the accumulation of lipid intermediates such as diacylglycerols (DAG) and ceramides (Cer) in nonadipose tissues like the liver. The accumulation of these bioactive lipids has been directly linked to the development of insulin resistance induced by a HCD. However, the specific molecular species of lipids associated with such metabolic abnormalities remain poorly defined. In this study, we conducted a systematic review and meta-analysis to consolidate current evidence on how HCDs alter the liver lipidome in rodents. A search was performed in PubMed to identify lipidomic studies on the livers of mice (C57Bl/6) and rats (Wistar and Sprague–Dawley) fed high-calorie diets. We assessed the effect size by calculating the standardized mean difference (SMD) using Hedges' g with a 95% confidence interval. A total of 18 studies were identified. The HCD had a significant effect on insulin resistance (HOMA-IR, <i>p</i> &lt; 0.01) and significantly increased (<i>p</i> &lt; 0.05) hepatic levels of Cer(18:0_18:0), Cer(18:1_18:0), Cer(18:1_20:0), Cer(18:2_20:0), and DAG(16:0_18:1) (<i>p</i> &lt; 0.05). Furthermore, the HCD negatively affected three specific phosphatidylcholine (PC) species and four phosphatidylethanolamine (PE) species containing monounsaturated and polyunsaturated fatty acid chains. These findings may provide valuable insights for targeting the molecular mechanisms underlying tissue-specific insulin resistance, a significant condition in the context of obesity.</p>\u0000 </div>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 5","pages":"595-605"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin Promotes Improvement in Serum Lipid Levels and Liver Histopathology in Hyperlipidemic Rats","authors":"Ana Cláudia Carvalho de Sousa,&nbsp;Jaiurte Gomes Martins da Silva,&nbsp;Érique Ricardo Alves,&nbsp;Laís Caroline da Silva Santos,&nbsp;Bruno José do Nascimento,&nbsp;Marcelle Mariana Sales de França,&nbsp;Vanessa Bischoff Medina,&nbsp;Ismaela Maria Ferreira de Melo,&nbsp;Álvaro Aguiar Coelho Teixeira,&nbsp;Valéria Wanderley Teixeira","doi":"10.1002/lipd.70056","DOIUrl":"10.1002/lipd.70056","url":null,"abstract":"<p>Hyperlipidemia or dyslipidemia is the term used for the increase in lipid levels in blood plasma, usually occurring due to a high-fat diet associated with a sedentary lifestyle. The increase in lipid levels can cause fatty infiltration in the liver known as hepatic steatosis, which can lead to inflammation, fibrosis, and necrosis consecutively. Melatonin is the hormone primarily responsible for regulating the circadian cycle, but it has antioxidant and anti-inflammatory properties and can also control lipid metabolism. Thus, the present research aimed to evaluate the effects of melatonin on the liver of hyperlipidemic rats. The animals were divided into control, tyloxapol, tyloxapol+melatonin. Hyperlipidemia was induced by applying tyloxapol at a dose of 400 mg/kg of body weight. Melatonin was administered simultaneously with tyloxapol in daily injections at a dose of 20 mg/kg. Sorological profiles for lipids, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase, as well as liver histopathology and immunohistochemistry, were analyzed. Treatment with melatonin demonstrated an attenuating effect on the biochemical parameters of hyperlipidemic animals, reducing on average 80% the levels of triglycerides and very-low-density lipoprotein when compared to the tyloxapol group after 15 days of treatment, also showing a protective effect on the hepatic parenchyma that showed no changes. In addition, the administration of melatonin reduced the expression of proinflammatory cytokines and increased the expression of anti-inflammatory ones. The present study showed that melatonin administration has a protective effect on induction factors and the development of nonalcoholic fatty liver disease in Wistar rats with hyperlipidemia.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 5","pages":"583-593"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic Analysis of Shared Lipid Metabolism in Chronic Hepatitis B and Non-Alcoholic Fatty Liver Disease Using Weighted Gene Expression Network Analysis","authors":"Lihuan Wang","doi":"10.1002/lipd.70062","DOIUrl":"10.1002/lipd.70062","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD) frequently coexist, and lipid metabolic dysregulation may represent a shared biological feature between these conditions. However, the molecular mechanisms linking these conditions remain poorly defined. Transcriptomic datasets of CHB and NAFLD were analyzed to identify differentially expressed genes, followed by weighted gene co-expression network analysis (WGCNA), functional enrichment, and machine-learning-based feature selection. Gene set variation analysis (GSVA) was performed to assess pathway activity, and experimental validation was conducted in an FFA-induced steatosis model using HepG2 cells. Shared genes and lipid metabolism-related modules common to both CHB and NAFLD were identified. Functional enrichment revealed pathways associated with lipid metabolism and cellular stress regulation. Machine-learning analysis highlighted TRIM35 and MPP1 as potential key genes, which were further validated in vitro as upregulated in steatotic conditions. This integrative approach advances understanding of shared lipid metabolic features between CHB and NAFLD and suggests potential candidate genes for future investigation in disease diagnosis and therapy.</p>\u0000 </div>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 5","pages":"641-650"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effects of Lipoproteins and Lipids on Atrial Fibrillation: A Mendelian Randomization Study.","authors":"Shuo Liu, Qi Zhang, Thida Sok, Xuan Zhang, Lian Lou, Rong Jiang, Wen Shi, Zhao-Ming Fu, Jie Han, Yu-Xiao Chen, Jian Yang","doi":"10.1002/lipd.70080","DOIUrl":"https://doi.org/10.1002/lipd.70080","url":null,"abstract":"<p><p>Background and AimsThe relationship between blood lipids and atrial fibrillation (AF) remains unclear. Nuclear magnetic resonance (NMR) spectroscopy enables the profiling of size-defined lipoproteins and their contained lipid components. This study aimed to analyze the genetic causal relationships between lipoproteins, NMR-measured lipids, and AF, providing insights into the prediction and treatment of AF. Methods and Results. Summary-level data on lipoprotein and lipid concentrations measured by NMR were obtained from the UK Biobank. Summary-level data on AF were sourced from the FinnGen project. Mendelian Randomization (MR) analysis using inverse-variance weighting was employed as the primary analytical method. Genetically predicted elevated low-density lipoprotein (LDL) cholesterol, LDL free cholesterol, LDL phospholipids, and LDL total lipids measured by NMR were associated with an increased risk of AF. MR analyses did not identify robust causal associations between lipids contained in high-density lipoproteins (HDL), intermediate-density lipoproteins (IDL), or very-low-density lipoproteins (VLDL) and AF. Among size-defined LDL particles, elevated lipids of large LDL (L-LDL) were strongly associated with increased risk of AF. Hypertension and coronary heart disease mediated these effects. Genetic variation alleles at ABCG5, LDLR, and PCSK9 genes, which reduce lipid levels, were associated with lower risk of AF. Conclusions Increased lipids contained in LDL were associated with elevated risk of AF. L-LDL particles exhibited a clear association with increased AF risk. LDL is identified as a critical lipoprotein for predicting and treating AF.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint Exposure to Estimated Small Dense LDL-C and Long-Term PM 2.5 and Risk of Incident Stroke: A Chinese Longitudinal Cohort Study.","authors":"Luzhao Wang, Ruixing Zhang, Nina Ma, Zijie Li","doi":"10.1002/lipd.70072","DOIUrl":"https://doi.org/10.1002/lipd.70072","url":null,"abstract":"<p><p>The joint effects of small dense low-density lipoprotein cholesterol (sd-LDL-C) and ambient PM_2.5 exposure on stroke risk remain unclear. This longitudinal cohort study included 6457 stroke-free participants from the China Health and Retirement Longitudinal Study (2011-2020). PM_2.5 exposure was estimated from the ChinaHighPM_2.5 dataset. Cox regression models assessed hazard ratios (HR) with 95% confidence intervals (CI). K-means trajectory analysis identified sd-LDL-C risk groups. The restricted cubic spline examined the dose-response relationship. During a median 9-year follow-up, 710 stroke cases occurred. Both sd-LDL-C (HR per 1-SD: 1.116, 95% CI: 1.018-1.224) and PM_2.5 (HR per 1-SD: 1.321, 95% CI: 1.222-1.428) independently predicted stroke risk. Significant multiplicative interaction was detected (p = 0.037). Combined high sd-LDL-C and high PM_2.5 exposure conferred the greatest risk (HR: 1.713, 95% CI: 1.335-2.198) versus double-low exposure. Sustained high sd-LDL-C trajectory increased stroke risk by 36% (HR: 1.361, 95% CI: 1.086-1.706). Cumulative sd-LDL-C (cu-sd-LDL-C) exposure showed dose-dependent associations (Q4 vs. Q1: HR = 1.580, 95% CI: 1.115-2.239). Baseline sd-LDL-C (p = 0.009), annual average PM_2.5 (p < 0.001), and cu-sd-LDL-C exposure (p = 0.037) all showed significant nonlinear relationship with incident stroke. sd-LDL-C demonstrated superior predictive ability over conventional LDL-C (AUC: 0.578 vs. 0.534, p < 0.001). Long-term elevated sd-LDL-C and PM_2.5 exposure were independently associated with incident stroke risk, and participants with dual-high exposure showed the highest risk. sd-LDL-C outperforms LDL-C in stroke prediction, supporting its integration into risk assessment strategies and the importance of simultaneous lipid and pollution control.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yinchen Tea Ameliorates Hyperlipidemia in Rats Through Hepatic and Intestinal Lipid Lowering.","authors":"Xilin Luo, Wei Wang, Yuanyuan Fang, Meilin Tong, Bing Qin, Jinyu Cao, Yinjie Yang","doi":"10.1002/lipd.70083","DOIUrl":"https://doi.org/10.1002/lipd.70083","url":null,"abstract":"<p><p>This study investigated the effects of Yinchen lipid-lowering tea (YCLLT) in a rat model of hyperlipidemia. A hyperlipidemic rat model was established using a high-fat diet. After 60 days of low-, middle-, and high-dose YCLLT intragastric administration, body weight, serum total cholesterol (TC), serum triglyceride (TG), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDL-C), liver TC, liver TG and small intestinal niemann-Pick C1-Like 1 (NPC1L1), apolipoprotein B-48 (ApoB48), and cholesterol acyltransferase 2 (ACAT2) protein expression were measured. The pathological changes of the liver were observed under a light microscope. Compared with the model group, high-dose YCLLT significantly decreased serum TC, TG and LDL-C levels, and elevated high-density lipoprotein cholesterol (HDL-C). Hepatic TC and TG levels were also significantly decreased. Histopathological analysis showed that YCLLT alleviated hepatocellular steatosis and degenerative injury in hyperlipidemic rats. Immunohistochemistry showed that YCLLT significantly downregulated the protein expression of NPC1L1, ApoB48 and ACAT2. Furthermore, serum ApoB48 levels were significantly reduced in all YCLLT-treated groups and positively correlated with serum TG, TC, and LDL-C. In conclusion, these findings demonstrate that YCLLT exerts potent lipid-lowering and liver-protective effects in hyperlipidemic rats, supporting its potential use as a dietary intervention for the management of hyperlipidemia in the future.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148829748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Omega-3 and Omega-6 Fatty Acid Intake and Breast Cancer Risk: A Systematic Review and Meta-Analysis of Cohort Studies.","authors":"Mehdi Karimi, Shirin Maghboulian, Omid Asbaghi, Kimia Kazemi, Amirhossein Goodarzi Olfat, Kosar Omidian, Hossein Rafiei","doi":"10.1002/lipd.70079","DOIUrl":"https://doi.org/10.1002/lipd.70079","url":null,"abstract":"<p><p>Breast cancer remains the most commonly diagnosed malignancy among women worldwide. Although dietary fatty acids have been widely investigated, the relationship between polyunsaturated fatty acids intake and breast cancer risk remains unclear. This study aimed to conduct a systematic review and meta-analysis of cohort studies to elucidate the association between higher dietary intake of omega-3 (ω-3) and omega-6 (ω-6) fatty acids and breast cancer risk. A systematic search of major databases was conducted up to January 2026 to identify eligible cohort studies. Random-effects models were used to pool multivariable-adjusted effect sizes (ESs). Heterogeneity was assessed using the I² statistic, and publication bias was evaluated using Begg's and Egger's tests. Sixteen studies on ω-3 and 18 on ω-6 were included. ω-3 intake was not significantly associated with breast cancer risk (ES: 0.97; 95% CI: 0.92-1.02; p = 0.248; I² = 10.2%). ω-6 intake also demonstrated no significant overall effect (ES: 1.03; 95% CI: 0.97-1.10; p = 0.384; I² = 43.9%). Subgroup analyses revealed regional variability, with American studies showing a significant, small inverse association with ω-6 intake (ES: 0.95; 95% CI: 0.92-0.98; p = 0.002). Sensitivity analyses confirmed the robustness of findings, and funnel plots indicated no substantial publication bias. This meta-analysis found no significant association between higher dietary intake of ω-3 or ω-6 and the risk of breast cancer.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}