IF 1.6 4区医学

Lipids Pub Date : 2025-08-21 DOI: 10.1002/lipd.70001

Mariana Ventura, Natalia Llopis Monferrer, Marc Long, Luc Chauchat, Nelly Le Goïc, Fabienne Le Grand, Philippe Soudant

{"title":"Modulation of Membrane and Reserve Fatty Acids of the Thraustochytrid Aurantiochytrium mangrovei by Light and Temperature Culture Conditions.","authors":"Mariana Ventura, Natalia Llopis Monferrer, Marc Long, Luc Chauchat, Nelly Le Goïc, Fabienne Le Grand, Philippe Soudant","doi":"10.1002/lipd.70001","DOIUrl":"https://doi.org/10.1002/lipd.70001","url":null,"abstract":"This study aimed to investigate the effects of temperature, illumination, and growth stage on the cell morphology, lipid content, and fatty acid (FA) composition in neutral lipids (NL) and polar lipids (PL) of Aurantiochytrium mangrovei, a thraustochytrid, widely known for its capacity to accumulate docosahexaenoic acid (22:6n-3, DHA). Experiments were conducted at three different temperatures (15°C, 20°C, and 25°C) under both illuminated and non-illuminated conditions. Illumination of the culture significantly increased OCFA (15:0 + 17:0) in PL by 42%, 6%, and 11% at 15°C, 20°C, and 25°C. Proportions of 15:0 + 17:0 in NL and PL increased with increasing temperature, being highest at 20°C in the exponential phase (7% in PL and 9% in NL) and at 25°C in the stationary phase (15% in PL and 32% in NL). The temperature also increased the DPAn-6 proportion during the exponential phase, from 2.5% to 5.9% in NL and from 5.5% to 11% in PL, whereas DHA (22:6n-3) tended to decrease. The resulting DHA/Docosapentaenoic acid (22:5n-6, DPAn-6) ratio in both NL and PL was highest in cultures at 15°C during the exponential phase. Cultivation of A. mangrovei at 15°C was favorable to a high DHA proportion (61% of total FA in PL and 68% in NL) and a high DHA/DPAn-6 (> 11 in PL and 23 in NL) ratio during the exponential phase. Further research is needed to better understand why DHA and DPAn-6, two very long-chain PUFA, are regulated in an opposite manner in response to changing temperature.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating Inflammatory Cytokines, Lipoprotein Particles, and Gestational Diabetes Risk: A Mendelian Randomization Study. 循环炎症细胞因子，脂蛋白颗粒和妊娠糖尿病风险：孟德尔随机研究。

IF 1.6 4区医学

Lipids Pub Date : 2025-08-14 DOI: 10.1002/lipd.70002

Jing Xu, Wenjing Xu, Jia Song, Dongxue Wang, Jingli Sun

{"title":"Circulating Inflammatory Cytokines, Lipoprotein Particles, and Gestational Diabetes Risk: A Mendelian Randomization Study.","authors":"Jing Xu, Wenjing Xu, Jia Song, Dongxue Wang, Jingli Sun","doi":"10.1002/lipd.70002","DOIUrl":"https://doi.org/10.1002/lipd.70002","url":null,"abstract":"To explore the causal associations between inflammatory cytokines and lipoprotein particles and analyze the possible mediating role of lipoprotein particles. Independent single nucleotide polymorphisms (SNPs) were employed as instrumental variables (IVs). We employed Two-Sample Mendelian Randomization (TSMR) to examine the effects of 41 inflammatory cytokines and 17 lipoprotein particles on gestational diabetes mellitus (GDM) risk, with additional evaluation of lipoprotein particles' potential mediating effects. Our primary analysis utilized inverse variance weighted (IVW) estimation, complemented by secondary methods including weighted median and MR-Egger regression to verify result robustness. Inverse variance weighting (IVW) estimates revealed that genetically predicted lower levels of GROA (OR = 0.901 [95% CI: 0.831, 0.977], p = 0.011), VEGF (OR = 0.941 [95% CI: 0.891, 0.996], p = 0.034), IL_12_P70 (OR = 0.927 [95% CI: 0.862, 0.997], and p = 0.037), and CTACK (OR = 0.901 [95% CI: 0.831, 0.977], p = 0.011) with an increased risk of gestational diabetes mellitus (GDM). Conversely, higher levels of IL-1β (OR = 1.134 [95% CI: 1.006, 1.277], and p = 0.039) and HGF (OR = 1.292 [95% CI: 1.102, 1.515], p = 0.002) were associated with an elevated risk of GDM. Additionally, our study indicated a relationship between three HDL particles and GDM (p < 0.05). Furthermore, mediation analysis revealed that very large high-density lipoprotein (VLHDL) particles partially mediated the association between hepatocyte growth factor (HGF) and GDM, accounting for 1.29% of the total effect. The results of two-step Mendelian randomization analysis suggested a causal relationship between circulating inflammatory cytokines and lipoprotein particles and an increased risk of GDM.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Droplet-Mediated Extraction of Perilla Seed Oil: Stability, Absorbability and Carrier Potential. 脂滴法提取紫苏籽油：稳定性、可吸收性和载体潜能。

IF 1.6 4区医学

Lipids Pub Date : 2025-08-13 DOI: 10.1002/lipd.70003

Xiaofeng Guo, Shuni Zeng, Qiaoyu Huang, Qiwei Chen, Quandong Li, Yan Ma

{"title":"Lipid Droplet-Mediated Extraction of Perilla Seed Oil: Stability, Absorbability and Carrier Potential.","authors":"Xiaofeng Guo, Shuni Zeng, Qiaoyu Huang, Qiwei Chen, Quandong Li, Yan Ma","doi":"10.1002/lipd.70003","DOIUrl":"https://doi.org/10.1002/lipd.70003","url":null,"abstract":"Perilla seed oil (PSO), rich in unsaturated α-linolenic acid, faces challenges such as oxidation susceptibility, low solubility, and poor bioaccessibility, limiting its applications. In this study, PSO was extracted from Perilla seeds as lipid droplets (LDs) using sucrose density gradient centrifugation. The resulting PSLDs exhibited a spherical morphology with a diameter of 1.1 μm, featuring a hydrophobic neutral lipid core encapsulated by a monolayer of phospholipids and minimal proteins. Stability assessments revealed no significant changes in peroxide value (POV) or the content of α-linolenic acid in PSLDs. Pharmacokinetic analysis demonstrated that PSLDs significantly enhanced the bioavailability of α-linolenic acid, with a 266% increase in relative bioavailability and higher AUC0~∞ compared to free PSO. These findings highlight the role of LDs in improving the oxidative stability and bioavailability of PSO, attributed to their unique structural properties. This study provides valuable insights for advancing the development and application of PSO and other oils rich in unsaturated fatty acids.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Artificial Intelligence to Lipid Nutrition: A Narrative Review. 人工智能在脂质营养中的应用述评

IF 1.6 4区医学

Lipids Pub Date : 2025-07-29 DOI: 10.1002/lipd.70000

Elena N Naumova, Andrea Hsieh, Rinat Rivka Ran-Ressler, Chang Woon Jang, Samantha L Huey, Fabiola Dionisi

{"title":"Application of Artificial Intelligence to Lipid Nutrition: A Narrative Review.","authors":"Elena N Naumova, Andrea Hsieh, Rinat Rivka Ran-Ressler, Chang Woon Jang, Samantha L Huey, Fabiola Dionisi","doi":"10.1002/lipd.70000","DOIUrl":"https://doi.org/10.1002/lipd.70000","url":null,"abstract":"Artificial intelligence (AI) has made significant progress in life sciences, with promising results in medical diagnostics, treatment, personalization, drug discovery, and repurposing. In contrast, the applications of AI in nutrition remain in its infancy, with specific applications to lipid nutrition being less frequent. This narrative review highlights AI applications in medicine and pharmaceuticals through a nutrition lens and examines emerging opportunities in lipid nutrition. Beginning at the molecular level with nutrient interactions, lipidomics, and modes and mechanisms of action (MoA), we describe potential applications of AI tools at the community level and global level for personalized nutrition, health claims, product development, and ultimately predictions for public health. We offer a summary of AI approaches, focusing on MoA of lipids and their metabolic pathways, biomarker discovery for health and disease, measuring dietary intake, and an overview of key lipid databases. AI methodologies are well-positioned to transform nutrition research and practice by assisting in data collection, processing, and analysis; monitoring nutritional status of populations; elucidating MoA; predicting bioactive compounds, nutrients, and the health effects of diets; and facilitating nutrition recommendations tailored to individuals. With this review, we encourage further research to advance innovation through the integration of AI and lipid nutrition for the benefit of public health.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass Spectrometry-Based Lipidomics Reveals a Strong Connection Between Lipid Homeostasis and Iron Acquisition in Candida albicans. 基于质谱的脂质组学揭示了白色念珠菌脂质稳态与铁获取之间的密切联系。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-30 DOI: 10.1002/lipd.12455

Sana Akhtar Usmani, Khushboo Arya, Basharat Ali, Shikha Chandra, Saumya Chaturvedi, Divyanshi Srivastava, Kunal Khanna, Nitin Bhardwaj, Rajendra Prasad, Ashutosh Singh

{"title":"Mass Spectrometry-Based Lipidomics Reveals a Strong Connection Between Lipid Homeostasis and Iron Acquisition in Candida albicans.","authors":"Sana Akhtar Usmani, Khushboo Arya, Basharat Ali, Shikha Chandra, Saumya Chaturvedi, Divyanshi Srivastava, Kunal Khanna, Nitin Bhardwaj, Rajendra Prasad, Ashutosh Singh","doi":"10.1002/lipd.12455","DOIUrl":"https://doi.org/10.1002/lipd.12455","url":null,"abstract":"Iron is a critical determinant in the development of drug tolerance in Candida albicans. Several genes essential for iron acquisition, transport, and regulation have been studied. Previous studies have shown that growth in an iron-limited medium alters the lipid compositions of C. albicans cells. In the present study, we performed a mass spectrometry-based lipid analysis of two major iron acquisition pathway proteins: an iron transporter, Ftr1 (ferrous permease), and a closely linked copper transporter, Ccc2. Deletions of FTR1 or CCC2 lead to significant changes in the lipid profile of C. albicans, especially the phospholipid and sphingolipid metabolism. For example, both Δftr1 and Δccc2 mutants showed depleted sphingolipid and steryl ester contents, but not much change in their DAG and TAG contents. The phospholipid profile of Δccc2 cells was quite unique with a much elevated PG content. The overall phospholipid profile of Δftr1 was not much different from the wild type. Both Δftr1 and Δccc2 cells showed significant differences in their molecular lipid species compositions. These lipid perturbations correlated with the susceptible response towards the drugs targeting lipid biogenesis and iron acquisition in Δftr1 and Δccc2 mutants. Taken together, this study shows that iron pathway proteins such as Ftr1 and Ccc2 are closely linked to lipid metabolism and iron acquisition in C. albicans. Understanding the mechanism of this lipid-iron association should be useful in exploring the two pathways for understanding the mechanism of iron uptake and designing the combinatorial drug therapies.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recognizing the Health Benefits of Plant-Sourced Omega-3 Stearidonic Acid: Exploring Its Complementary Role to Preformed EPA/DHA. 认识到植物来源的Omega-3硬脂酸的健康益处：探索其对预成型EPA/DHA的补充作用。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-27 DOI: 10.1002/lipd.12452

Ella J Baker, Greg Cumberford, Patrick Hanaway

引用次数: 0

The Effect of a Preparation Derived From Fish Skin on the Change in the Fatty Acid Composition of Sebum in Individuals With Demodicosis. 鱼皮提取物对蠕虫病患者皮脂脂肪酸组成变化的影响。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-26 DOI: 10.1002/lipd.12454

Joanna Igielska-Kalwat, Ewa Kilian-Pięta, Maciej Siedlecki

{"title":"The Effect of a Preparation Derived From Fish Skin on the Change in the Fatty Acid Composition of Sebum in Individuals With Demodicosis.","authors":"Joanna Igielska-Kalwat, Ewa Kilian-Pięta, Maciej Siedlecki","doi":"10.1002/lipd.12454","DOIUrl":"https://doi.org/10.1002/lipd.12454","url":null,"abstract":"Fatty acid (FA) metabolism is associated with Demodicosis, an increasingly common skin condition frequently observed in adolescents and adults, but it is not yet well defined whether the distribution or location of FAs in facial sebum differs according to the disease. In a study with a group of 50 patients diagnosed with Demodicosis and 40 control subjects, sebum samples were collected from the forehead, cheeks, and chin areas using Sebutape patches. Total FAs were analyzed using gas chromatography. The patients with Demodex were divided into two groups. Twenty-five individuals used only the placebo cosmetic base, while the other 25 applied the target product. The extraction of key active ingredients aligns with the trend of sustainable cosmetic production and upcycling. Compared to healthy women, the female patients showed higher levels of saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs) from both facial areas, while lower levels of polyunsaturated fatty acids (PUFAs) were observed in the chin area samples. Patients with Demodicosis exhibited more pronounced abnormalities in sebum and specific FA profiles in the chin area, consistent with the higher incidence of Demodicosis in adult women, particularly in these facial areas. The differential distribution of FAs in facial sebum and its correlation with the occurrence of Demodicosis led to the application of innovative upcycling ingredients. The purpose of the experiment was to determine the difference in the FA profile between individuals with and without Demodicosis.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Novel Lipid Indicators and the Risk of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes. 新型脂质指标与2型糖尿病患者非酒精性脂肪性肝病风险之间的关系

IF 1.8 4区医学

Lipids Pub Date : 2025-06-24 DOI: 10.1002/lipd.12453

Yazhi Wang, Mingkang Zhang, Peng Wang

{"title":"Associations Between Novel Lipid Indicators and the Risk of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes.","authors":"Yazhi Wang, Mingkang Zhang, Peng Wang","doi":"10.1002/lipd.12453","DOIUrl":"https://doi.org/10.1002/lipd.12453","url":null,"abstract":"This study aimed to evaluate associations between emerging lipid parameters, including the ZJU index (ZJU), the hepatic steatosis index (HSI), the triglyceride-glucose index (TyG), the Framingham steatosis index (FSI) and the atherogenic index of plasma (AIP), and nonalcoholic fatty liver disease (NAFLD) risk in individuals with type 2 diabetes mellitus (T2DM) and assess their clinical utility for NAFLD prevention and diabetes management. Clinical data from 6378 participants were analyzed. Stepwise-adjusted multivariable logistic regression, restricted cubic splines (RCS), subgroup analysis, and sensitivity tests examined relationships between lipid parameters and NAFLD. Receiver operating characteristic (ROC) curves compared predictive performance. Among participants, 36.11% (2303/6378) had NAFLD. After full adjustment, each 1-unit increase in ZJU, HSI, TyG, FSI, and AIP conferred NAFLD odds ratios (95% CI) of 1.22 (1.14-1.31), 1.08 (1.05-1.11), 2.19 (1.82-2.63), 1.01 (1.00-1.02), and 4.75 (2.97-7.58), respectively. When divided into quartiles, the highest quartile of these parameters exhibited 2.13-fold, 2.86-fold, 2.04-fold, 1.80-fold, and 1.68-fold NAFLD risk compared to the lowest quartile. RCS revealed significant nonlinear relationships (poverall < 0.001, pnonlinear < 0.05). Sensitivity analysis confirmed robustness. ROC curves identified HSI as the strongest predictor (AUC = 0.709, 95% CI: 0.696-0.721). Elevated ZJU, HSI, TyG, FSI, and AIP were significantly associated with increased NAFLD risk in the T2DM population. HSI may demonstrate superior predictive performance for NAFLD in T2DM populations compared to other conventional lipid parameters.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Binding Strength of Cytochrome C to Membranes Containing Phosphatidic Acid Corresponds to Its Peroxidase Activity. 细胞色素C与磷脂酸膜的结合强度与其过氧化物酶活性相对应。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-17 DOI: 10.1002/lipd.12451

G O Stepanov, V V Zakharov, A A Struchkova, E D Rumyantseva, V V Volkov, A Yu Makarov, Yu A Vladimirov, A N Osipov

{"title":"The Binding Strength of Cytochrome C to Membranes Containing Phosphatidic Acid Corresponds to Its Peroxidase Activity.","authors":"G O Stepanov, V V Zakharov, A A Struchkova, E D Rumyantseva, V V Volkov, A Yu Makarov, Yu A Vladimirov, A N Osipov","doi":"10.1002/lipd.12451","DOIUrl":"https://doi.org/10.1002/lipd.12451","url":null,"abstract":"The study of the molecular mechanisms of programmed cell death and the role of anionic phospholipids like cardiolipin in these processes is one of the most attractive topics in modern lipidomics. The aim of this study was the quantitative assessment of the presence of phosphatidic acid in the binding strength of cytochrome C to biological membranes, its peroxidase activity, and the role of phospholipase D in increasing the concentration of phosphatidic acid. Using the Langmuir method for fluorescence quenching analysis (Kd = 2.78 × 10-7 M) of the cytochrome C-phosphatidic acid complex was shown. The presence of phosphatidic acid (both synthetic and obtained from phosphatidylcholine using phospholipase D from mitochondrial lipids) increased the peroxidase activity of cytochrome C more than 100-fold (measured by luminol-enhanced chemiluminescence method). The obtained results emphasize the possibility of participation not only of cardiolipin but also of phosphatidic acid in the development of molecular proapoptotic processes.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Cobalt Levels on Fatty Acid Profile and Nutritional Quality of Common Carp Muscle (Cyprinus carpio). 钴水平对鲤鱼肌肉脂肪酸分布和营养品质的影响。

IF 1.8 4区医学

Lipids Pub Date : 2025-06-16 DOI: 10.1002/lipd.12449

Imene Chetoui, Feriel Ghribi, Safa Bejaoui, Dalya Belhassen, Rym Baati, Najla Soudani

{"title":"Impact of Cobalt Levels on Fatty Acid Profile and Nutritional Quality of Common Carp Muscle (Cyprinus carpio).","authors":"Imene Chetoui, Feriel Ghribi, Safa Bejaoui, Dalya Belhassen, Rym Baati, Najla Soudani","doi":"10.1002/lipd.12449","DOIUrl":"https://doi.org/10.1002/lipd.12449","url":null,"abstract":"The aim of this study is to evaluate the toxic effects of cobalt chloride concentrations (2 μg/LCoCl2 (D1), 25 μg/LCoCl2 (D2), and 50 μg/LCoCl2 (D3)) on the fatty acid profile and nutritional quality of Cyprinus carpio muscle. After 3 days of treatment, our results have shown an induction of lipid peroxidation affirmed by significant increases in malondialdehyde (MDA) and peroxide value (PV) levels for fish treated with D2 and D3 doses. We noted decreases in saturated fatty acids (SFA) and an increase in polyunsaturated fatty acids (PUFA) in all treated groups. The docosahexaenoic (DHA) and eicosapentaenoic (EPA) acid levels declined in all fish exposed to CoCl2 graded doses (p ≤ 0.001). The decrease in the conversion enzyme ratios D5D and D6D desaturases explained these changes in EPA and DHA levels. However, PUFA (n-6) and arachidonic acid (ARA) increased (p < 0.001) in all treated groups. These increases in ARA were associated with the enhancement of linoleic acid (LA) and D5D' desaturases activity. Our treatment showed significant declines in PUFA (n-3)/PUFA (n-6) ratio and in flesh lipid quality (FLQ) and an increase in the PUFA/SFA ratio. Our experiment suggested the harmful effects of cobalt, confirmed by the alteration of fatty acid composition and deterioration of the nutritional quality of C. carpio muscle.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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