Lipids最新文献

{"title":"Digestion and absorption of triacetin, a short-chain triacylglycerol.","authors":"Yukihiro Yoshimura, Tomoka Matsui, Nagisa Kaneko, Ikuha Kobayashi","doi":"10.1002/lipd.12433","DOIUrl":"https://doi.org/10.1002/lipd.12433","url":null,"abstract":"<p><p>Triacylglycerol (TG) is categorized into long-, medium-, and short-chain TG (SCTG). While the digestion of long- and medium-chain TG is well established, the process for SCTG remains unclear. This study investigated SCTG digestion by administering 2 mmol of triacetin to rats and analyzing acetin, acetic acid, and glycerol levels in the portal blood and small intestine. Triacetin was fully degraded in the upper gastrointestinal tract and absorbed as acetic acid and glycerol. Glycerol influx into the liver promoted gluconeogenesis, while acetate activated AMPK, resulting in the suppression of fatty acid synthesis-related genes and the upregulation of fatty acid β-oxidation-related genes. These findings demonstrate that triacetin not only serves as a substrate for energy metabolism but also regulates hepatic gene expression, highlighting its dual role as both a metabolic substrate and signaling molecule. Triacetin thus shows potential as a dietary modulator for improving metabolic health.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interracial Mendelian analysis revealed a link between lipid-lowering drugs and renal failure.","authors":"Naidan Zhang, Chaixia Ji, Baibing Xie, Yaoyang Liu, Chengliang Yuan","doi":"10.1002/lipd.12430","DOIUrl":"https://doi.org/10.1002/lipd.12430","url":null,"abstract":"<p><p>Lipid-lowering drugs have been used in clinics widely. It is unclear whether the drugs have an effect on renal failure. We chose high-density lipoprotein cholesterol (ieu-b-109), low-density lipoprotein cholesterol (ieu-a-300), triglyceride (ieu-b-111), and total cholesterol (ebi-a-GCST90038690) as exposures. SNPs near drug genes served as instrumental variables. Acute renal failure (ARF) and chronic renal failure (CRF) in Europeans from the GWAS catalog were selected as outcomes. Datasets on renal failure in East Asians and South Asians were used for validation. Inverse variance weighted (IVW) was the primary method for drug-targeted Mendelian randomization. In the Europeans, people who used PPARG reduced ARF risk by 69.3% (OR: 0.307, 95% CI: 0.171-0.553, p = 0.015). NPC1L1 inhibitors increased ARF risk by 2.684 times (OR: 2.684, 95% CI: 2.027-3.341, p = 0.003). APOE increased ARF risk by 1.987 times (OR: 1.987, 95% CI: 1.062-3.716, p = 0.032) but decreased CRF risk by 49.7% (OR: 0.503, 95% CI: 0.283-0.894, p = 0.019). TNFSF12 increased CRF risk by 3.866 times (OR: 3.866, 95% CI: 1.174-12.729, p = 0.026). In the East Asians, PPARG reduced CRF risk by 85.8% (OR: 0.142, 95% CI: 0.054-0.371, p < 0.001). And in the South Asians, APOE decreased ARF risk by 99.8% (OR: 0.002, 95% CI: 2.12e-05-0.179, p = 0.007). We revealed that PPARG could reduce the risk of renal failure in Europeans and Asians. APOE could cause ARF in the Europeans, but it was protective in the South Asians. Clinicians need to consider the characteristics of the local population before administering drugs to patients of different ethnicities.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regression of carotid atherosclerosis in high-risk individuals with proprotein convertase subtilisin/kexin type 9 inhibitors","authors":"Albert Z. Luu,&nbsp;Yasaman Hajiesmaeili,&nbsp;Sholeh Faezi,&nbsp;J. David Spence,&nbsp;Daniel G. Hackam,&nbsp;Hamed Hadizadeh,&nbsp;Seyyed M. Sohrevardi,&nbsp;M. Reza Azarpazhooh","doi":"10.1002/lipd.12432","DOIUrl":"10.1002/lipd.12432","url":null,"abstract":"<p>Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent a novel approach for reducing cholesterol and, accordingly, the burden of atherosclerosis. However, limited data are available regarding the possible effects of PCSK9 inhibitors on atherosclerotic plaque. To evaluate the efficacy of PCSK9 inhibitors in reducing carotid plaque progression in individuals with high-risk carotid atherosclerotic disease. We used carotid total plaque area (TPA) to assess the burden of atherosclerosis. Ultrasound imaging of the carotid was acquired before and after the initiation of PCSK9 inhibitor therapy. We selected high-risk cases with atherosclerosis with a minimum of three ultrasound examinations, 1 year before, one at the time of initiation of a PCSK9 inhibitor, and 1 year after initiating a PCSK9 inhibitor. Statistical analysis was conducted using the mixed-effects model with Restricted Maximum Likelihood (REML). We reviewed data from 131 patients with a mean follow-up of 6 (±4) years. Patients were high-risk, with the majority having diabetes or hypertension. There was a decrease in TPA, particularly during the first 3 years after initiating PCSK9 inhibitor therapy (<i>p</i> &lt; 0.05). Furthermore, we observed that individuals with higher baseline serum low-density lipoprotein cholesterol (LDL-C) levels experienced a greater decline in TPA (<i>p</i> &lt; 0.05). PCSK9 inhibitors are effective in achieving plaque regression in high-risk patients with atherosclerosis. This is important, as plaque regression is associated with a lower risk of stroke, myocardial infarction, or vascular death.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"60 3","pages":"165-169"},"PeriodicalIF":1.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverse association of triglyceride-glucose and triglyceride/HDL-c indexes with serum 25(OH) vitamin D levels in US adults","authors":"Li Ji,&nbsp;Shuying Li,&nbsp;Tangbing Yuan,&nbsp;Shaoping Li,&nbsp;Ruilu Shu,&nbsp;Haiming Yang","doi":"10.1002/lipd.12429","DOIUrl":"10.1002/lipd.12429","url":null,"abstract":"<p>The triglyceride-glucose index (TyG) and the triglyceride to high-density lipoprotein ratio (TG/HDL-c) are novel indicators for assessing insulin resistance (IR) in epidemiological studies. This study aimed to evaluate the association between 25-hydroxy-vitamin D [25(OH)D] levels and these two indicators in the adult population of the United States. 14,380 participants aged 20 years and older were included from the National Health and Nutrition Examination Survey (NHANES). Multivariable linear regression models were used to analyze the association between 25(OH)D and TyG, as well as TG/HDL-c. Smooth fitting curves were employed to identify potential non-linear relationships between 25(OH)D, TyG, and TG/HDL-c. The findings revealed a negative association between 25(OH)D and TyG, with the effect being more pronounced in males and individuals with diabetes (<i>p</i> &lt; 0.01). Similarly, 25(OH)D was negatively associated with TG/HDL-c, with a stronger impact observed in males compared to females. The study population was divided into four quartiles based on 25(OH)D concentration, and TyG and TG/HDL-c levels in Q3 and Q4 were lower than those in Q1. Furthermore, a non-linear relationship was observed between 25(OH)D and TyG, with an inflection point at 19.352 ng/mL. A non-linear relationship was also found between TG/HDL-c and 25(OH)D, with an inflection point at 37.211 ng/mL. 25(OH)D is an independent factor significantly associated with TyG and TG/HDL-c indexes. This negative association may be related to the role of 25(OH)D in insulin resistance.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"60 3","pages":"155-163"},"PeriodicalIF":1.8,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two rodent suborders have evolved missing amino acids in the lipid-binding region of apolipoprotein E","authors":"Don L. Puppione","doi":"10.1002/lipd.12426","DOIUrl":"10.1002/lipd.12426","url":null,"abstract":"<p>The order Rodentia comprises nearly 45% of all extant taxa, currently organized into 31 living families, some 450 genera, and roughly 2010 species (Kelt &amp; Patton, 2020). Considering that rodents began evolving at least 66 million years ago, it is not surprising that they have diversified into five distinct suborders. With the advent of molecular biology, this difference can often be seen at the molecular level as well. Previous studies have indicated that the apolipoprotein E (APOE) of guinea pigs, belonging to the suborder <i>Hystricomorpha</i>, have fewer amino acids than have been reported for other suborders of <i>Rodentia</i>. Searching the genomic database for hystricomorph <i>APOE</i> genes, it was found that hystricomorphs were missing residues both in the vicinity of the hinge region and in the lipid-binding region of the apolipoprotein. In the hinge region, missing residues varied between 5 and 3, and in the latter region, seven residues were missing. The search also revealed that castorimorphs, although lacking the smaller of the two deletions, were also missing the same seven residue deletion as found in APOE of the hystricomorphs.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"60 3","pages":"143-153"},"PeriodicalIF":1.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.12426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of flaxseed oil blends to modulate tissue fatty acid composition and determination of safety parameters in Wistar rats","authors":"Asavari Anirudha Joshi,&nbsp;Mahabaleshwar Vishnu Hegde,&nbsp;Anand Arvind Zanwar","doi":"10.1002/lipd.12431","DOIUrl":"10.1002/lipd.12431","url":null,"abstract":"<p>Non-communicable diseases (NCD) are associated with inflammation and oxidative stress which is further associated with omega-6 (ω6) and omega-3 (ω3) fatty acid (FA) imbalance favoring ω6 FA. By improving ω3 FA consumption, this imbalance can be altered to control NCD. Previously we have reported blends of flaxseed oil (FSO, ω3 FA) with palm olein (PO) or coconut oil (CO) were thermo-oxidatively stable with good storage stability and could improve ω6:ω3 ratio in cell lines. In the present study safety of these blends along with their efficacy to improve tissue FA composition particularly ω6:ω3 ratio was evaluated in Wistar rats. Institutional ethics committee approval was obtained initially. Wistar rats were supplemented with individual oils or blends (FSO with PO or CO, 20:80 by volume, 1.0 mL/day/200 gm body weight) for 3 months. Throughout the study period, there were no adverse effect of blends on feed intake and body weight gain. After 3 months, blood and serum were subjected for hematological, biochemical assessment. Vital organs were harvested for histopathological and FA composition investigations. Hematological, biochemical, and tissue histopathological parameters were comparable with Control (group receiving only normal diet). Interestingly serum lipid profile was improved by the blend supplementation. Except brain, FA composition was altered in liver, heart, adipose tissue, and RBC with lowering of ω6:ω3 ratio but there was no favorable effect on inflammatory markers and adipokines in the blend supplemented groups. Thus, to conclude, FSO blends with PO or CO were able to lower tissue ω6:ω3 ratio without adverse effects.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"60 3","pages":"125-141"},"PeriodicalIF":1.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal associations of lipid profiles with sleep disorders in patients with Parkinson's disease","authors":"Meijie Ye,&nbsp;Qianqian Ji,&nbsp;Qi Liu,&nbsp;Xiaoying Kang,&nbsp;Yiqiang Zhan","doi":"10.1002/lipd.12428","DOIUrl":"10.1002/lipd.12428","url":null,"abstract":"<p>To examine the associations of apolipoprotein E (APOE) carrier status and lipid profiles with sleep disorders, including excessive daytime sleepiness (EDS) and probable rapid eye movement sleep behavior disorder (pRBD), among patients with early Parkinson's disease (PD) over 5-year follow-up periods. The Parkinson's Progression Markers Initiative is a multicenter cohort study based on an ongoing and open-ended registry. Data from baseline and 5-year follow-up visits from participants of de novo PD were analyzed. Longitudinal associations of APOE carrier status and lipid profiles with sleep disorders were estimated via linear mixed-effects models. A total of 657 participants with complete APOE genotypes were enrolled at baseline. Among them, 153 (25.3%) had available lipid profiles at baseline. In the linear mixed-effects models, baseline APOE ε2/ε3/ε4 carrier status did not exhibit significant associations with EDS and pRBD (all <i>p</i> &gt; 0.05) in all models. However, reduced high-density lipoprotein (HDL) and elevated triglycerides (TG) were associated with developing EDS (β = −0.04, 95% CI: −0.07, −0.00) and pRBD (β = 0.01, 95% CI: 0.00, 0.02) in PD patients, respectively. In the APOE ε4+ subgroup, decreased HDL and increased TG displayed substantial associations with developing EDS and sleep disorders (all <i>p</i> &lt; 0.05) in all models, respectively, whereas no significant differences were noted in the APOE ε4− subgroup (all <i>p</i> &gt; 0.05). Our study did not demonstrate a clear association between APOE ε2/ε3/ε4 and sleep disorders in PD patients. However, the presence of APOE ε4 was associated with changes in lipid profiles, notably affecting TG and HDL levels.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"60 3","pages":"115-123"},"PeriodicalIF":1.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy analysis of cholesterol analyzer in detecting dyslipidemia in truck drivers","authors":"Alessandra Aparecida Vieira Machado,&nbsp;Rosemeyre Vasconcelos Carvalho Cunha,&nbsp;Renato Bichat Pinto de Arruda,&nbsp;Tays Oliveira Silva,&nbsp;Julliete Cristina de Oliveira,&nbsp;Eunice Stella Jardim Cury,&nbsp;Antonio Sales,&nbsp;Stella Hissami Korin,&nbsp;Flavio Júnior Ferraz Cabral,&nbsp;Leonardo Roever,&nbsp;Antonio José Grande","doi":"10.1002/lipd.12427","DOIUrl":"10.1002/lipd.12427","url":null,"abstract":"<p>Cardiovascular diseases (CVD) are a leading cause of mortality and morbidity worldwide. Rapid diagnostic tools are crucial for timely intervention, especially in high-risk groups such as truck drivers. In Brazil, the Mission® test uniquely offers test strips for simultaneous measurement of total cholesterol (TC), high-density lipoprotein (HDL), triglycerides (TG), and low-density lipoprotein (LDL). This study evaluates the accuracy of the Mission® analyzer compared to laboratory testing for HDL-C, TG, and TC in truck drivers. A blinded cross-sectional study was conducted among truck drivers aged 30–64 in Campo Grande, Mato Grosso do Sul, Brazil. Spearman correlation, linear regression, and the Bland–Altman analyses were employed to compare lipid profile results between the Mission® analyzer and laboratory methods. A total of 108 samples were analyzed. For HDL, the Mission® analyzer showed a sensitivity of 0.88, a specificity of 0.67, and an area under the curve (AUC) of 0.77 (95% CI: 0.68–0.86). For TG, sensitivity and specificity were 0.96 and 0.98, respectively, with an AUC of 0.97 (95% CI: 0.93–1.0). For TC, the AUC was 0.87 (95% CI: 0.79–0.95). Bland–Altman analysis revealed biases of −4.5 for HDL, 12.4 for TC, and −42.8 for TG between Mission® and laboratory results. The Mission® analyzer demonstrates good accuracy for rapid dyslipidemia diagnosis and Framingham Global Risk Score calculation. It is a valuable tool for initial screening and risk assessment, confirmation with laboratory testing is recommended for definitive diagnosis and treatment planning.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"60 2","pages":"101-111"},"PeriodicalIF":1.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of enrichment of live prey with soy lecithin on growth, stress resistance, digestive enzymes activity, and antioxidant capacity in yellowfin seabream (Acanthopagrus latus) larvae","authors":"Vahid Morshedi,&nbsp;Mansour Torfi Mozanzadeh,&nbsp;Farzaneh Noori,&nbsp;Naser Agh,&nbsp;Fatemeh Jafari,&nbsp;Shirin Hamedi,&nbsp;Maryam Azodi,&nbsp;Reza Afshar Moghadam,&nbsp;Kamil Mert Eryalçın","doi":"10.1002/lipd.12424","DOIUrl":"10.1002/lipd.12424","url":null,"abstract":"<p>Phospholipid (PL) is an essential nutrient that has vital effects on growth, stress resistance, and early development in marine fish larvae. In this regard, a 30-day feeding experiment was conducted in order to examine the effects of live prey enrichment with graded levels of soy lecithin (SL) on some physiological responses of <i>Acanthopagrus latus</i> larvae. Four experimental emulsion levels of SL were used to enrich rotifer and Artemia including very low (2%, N-Nil), low (4%, L), medium (8%, M), and high (12%, H). Newly hatched larvae were distributed into 12,250-L cylindrical tanks with an initial density of 15,000 larvae in each tank that was supplied with natural seawater (23 ± 1°C; 40.0 ± 1.0 g L⁻¹). Larvae fed live prey enriched with 4% SL significantly had higher wet weight gain than other treatments. Air exposure and osmotic activity tests were also performed to detect larval resistance to stress. Larvae fed live prey enriched with 8% and 12% SL had higher survival compared to the other two groups. The accumulation of arachidonic (ARA) and docosahexaenoic acid (DHA) was increased in the whole body of larvae fed high SL-supplemented live prey. Alkaline phosphatase and aminopeptidase N activities in the guts brush border membrane of larvae in M and H groups were higher than other treatments. The trypsin and chymotrypsin activities in the N group were lower than in other groups. The highest and lowest amylase activities were in the H and N groups, respectively. The activity of catalase in the whole body of the M group was higher than the N group and the glutathione reductase activity was significantly increased in the M and L groups compared to the N and H groups. Total antioxidant capacity in the whole body of larvae in the N group was lower than in the other treatments. In summary, moderate levels of SL (4%–8%) are suggested for the enrichment of live prey in <i>A. latus</i>.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"60 2","pages":"85-99"},"PeriodicalIF":1.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-density lipoprotein cholesterol to c-reactive protein ratio predicts atrial fibrillation recurrence after electrical cardioversion","authors":"Mehmet Rasih Sonsöz MD,&nbsp;İhsan Demirtaş MD,&nbsp;Orkun Canbolat MD,&nbsp;Nazime Karadamar RN,&nbsp;Eyüp Özkan MD,&nbsp;Yelda Saltan Özateş MD","doi":"10.1002/lipd.12423","DOIUrl":"10.1002/lipd.12423","url":null,"abstract":"<p>Atrial fibrillation (AF) recurrence after cardioversion is common, and inflammation plays a critical role in its pathophysiology. We aimed to elucidate the predictive role of the ratio of high-density lipoprotein cholesterol to c-reactive protein (HDL-C/CRP) as an inflammatory marker in AF recurrence after electrical cardioversion (ECV). We analyzed patients who underwent elective ECV for atrial fibrillation between June 2020 and December 2023. Baseline levels of HDL-C and CRP were obtained. Ninety-six patients were included. The median age was 59 years, and 48% were female. Atrial fibrillation recurred after ECV in 56 patients (58%). In the AF recurrence group, CHA₂DS₂-VASc score was higher (2 [1–3] vs. 1[0–2]; <i>p</i> = 0.013), left atrial diameter was larger (43 ± 5 vs. 40 ± 6 mm; <i>p</i> = 0.015), and HDL-C/CRP ratio was lower (5.6 [2.7–13.0] vs. 14.0 [4.8–38.0]; <i>p</i> = 0.003) compared with the sinus rhythm group. Cox regression analysis showed that HDL-C/CRP was a predictor of AF recurrence at follow-up (unadjusted HR = 0.97; CI 95%: 0.95–0.99; <i>p</i> = 0.004; adjusted HR = 0.98; CI 95%: 0.96–0.99; <i>p</i> = 0.030). ROC curve showed that HDL-C/CRP ratio was able to predict AF recurrence after ECV (AUC = 0.68; <i>p</i> = 0.003). Kaplan–Meier analysis showed that patients with baseline HDL-C/CRP &lt;7.4 had higher AF recurrence (log-rank test <i>p</i> = 0.013). Our research demonstrated that the lower HDL-C/CRP ratio predicted AF recurrence after ECV during follow-up.</p>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"60 2","pages":"77-84"},"PeriodicalIF":1.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}