Lipids最新文献_第2页

Expression of Concern 表达关切。

IF 1.8 4区医学

Lipids Pub Date : 2024-08-26 DOI: 10.1002/lipd.12414

引用次数: 0

Expression of Concern 表达关切。

IF 1.8 4区医学

Lipids Pub Date : 2024-08-26 DOI: 10.1002/lipd.12415

引用次数: 0

Expression of Concern 表达关切。

IF 1.8 4区医学

Lipids Pub Date : 2024-08-26 DOI: 10.1002/lipd.12416

引用次数: 0

The predictive value of TyG and lipid ratios on the development of complications and hyperuricemia in patients with type 2 diabetes mellitus TyG和血脂比率对2型糖尿病患者并发症和高尿酸血症发生的预测价值。

IF 1.8 4区医学

Lipids Pub Date : 2024-08-06 DOI: 10.1002/lipd.12411

Jie Yang, Kai-fan Zhou, Guo-dong Tao, Bin Wei, Yu-wei Lu

{"title":"The predictive value of TyG and lipid ratios on the development of complications and hyperuricemia in patients with type 2 diabetes mellitus","authors":"Jie Yang, Kai-fan Zhou, Guo-dong Tao, Bin Wei, Yu-wei Lu","doi":"10.1002/lipd.12411","DOIUrl":"10.1002/lipd.12411","url":null,"abstract":"Investigate the predictive value of TyG and lipid ratios on the development of complications and HUA in patients with T2DM. A retrospective cross-sectional study involving 9488 T2DM patients was conducted. They were divided into HUA and NUA group base on SUA level and divided into with and without complications groups according to the diagnosis of the endocrinologist. Necessary information and biochemical parameters were recorded during outpatient visit. TyG index and lipid ratios were calculated, and statistical analysis was carried out to correlate the calculated values and HUA using SPSS version 26.0 for Windows. TyG and lipid ratios were significantly higher in T2DM with HUA or with complications than those with NUA or without complications (p < 0.05). Regression analysis adjusting for confounding factors found TyG (adjusted OR = 1.54; 95% CI: 1.31–1.82; p < 0.05), TG/HDL-C (adjusted OR = 1.21; 95% CI: 1.04–1.40; p < 0.05) and TC/HDL (adjusted OR = 1.36; 95% CI: 1.17–1.57; p < 0.05) was risk factor of HUA in T2DM patients. TyG (adjusted OR = 1.21; 95% CI: 1.02–1.44; p < 0.05), TG/HDL (adjusted OR = 1.19; 95% CI: 1.03–1.38; p < 0.05) and Apo A/Apo B (adjusted OR = 1.41; 95% CI: 1.26–1.58; p < 0.05) was risk factor of complications in T2DM patients. TyG, TG/HDL-C, and TC/HDL can be used as early sensitive target in the occurrence of HUA in T2DM patients and TyG was the most influential risk factor. TyG, TG/HDL-C, and Apo A/Apo B can be used as early sensitive target in the occurrence of complications in T2DM patients and Apo A/Apo B was the most influential risk factor.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 6","pages":"209-219"},"PeriodicalIF":1.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Nuclear receptors behind the therapeutic effects of plant sterols on metabolism: A review 植物固醇对新陈代谢的治疗作用背后的核受体：综述。

IF 1.8 4区医学

Lipids Pub Date : 2024-07-30 DOI: 10.1002/lipd.12409

María C. Brañes, Raimundo Gillet, Rodrigo Valenzuela

引用次数: 0

Obeticholic acid's effect on HDL function in MASH varies by diabetic status 奥贝胆酸对 MASH 中高密度脂蛋白功能的影响因糖尿病状态而异。

IF 1.8 4区医学

Lipids Pub Date : 2024-07-16 DOI: 10.1002/lipd.12408

Chunki Kim, Tsung-Heng Tsai, Rocio Lopez, Arthur McCullough, Takhar Kasumov

{"title":"Obeticholic acid's effect on HDL function in MASH varies by diabetic status","authors":"Chunki Kim, Tsung-Heng Tsai, Rocio Lopez, Arthur McCullough, Takhar Kasumov","doi":"10.1002/lipd.12408","DOIUrl":"10.1002/lipd.12408","url":null,"abstract":"Inflammation and oxidative stress are the key factors in the pathogenesis of both metabolic dysfunction-associated steatohepatitis (MASH) and atherosclerosis. Obeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, improves hepatic inflammation and fibrosis in patients with MASH. However, it also reduces HDL cholesterol, suggesting that OCA may increase cardiovascular disease (CVD) risk in patients with MASH. We assessed HDL cholesterol efflux function, antioxidant (paraoxonase and ceruloplasmin activity), pro-inflammatory index, and particle sizes in a small group of patients with and without diabetes (n = 10/group) at baseline and after 18 months of OCA treatment. Patients on lipid-lowering medications (statins, fibrates) were excluded. At baseline, ferritin levels were higher in patients with MASH without diabetes (336.5 [157.0, 451.0] vs. 83 [36.0, 151.0] ng/mL, p < 0.005). Markers of HDL functions were similar in both groups. OCA therapy significantly improved liver histology and liver enzymes but increased alkaline phosphatase levels in nondiabetic patients with MASH (p < 0.05). However, it did not have any significant effect on cholesterol efflux and the antioxidant paraoxonase functions. In nondiabetics, ceruloplasmin (CP) antioxidant activity decreased (p < 0.005) and the pro-inflammatory index of HDL increased (p < 0.005) due to OCA therapy. In contrast, in diabetics, OCA increased levels of pre-β-HDL—the HDL particles enhanced protective capacity (p = 0.005) with no alteration in HDL functionality. In all patients, serum glucose levels were negatively correlated with OCA-induced change in pro-inflammatory function in HDL (p < 0.001), which was primarily due to diabetes (p = 0.05). These preliminary results suggest a distinct effect of OCA therapy on diabetic and nondiabetic patients with MASH and warrant a future large-scale study.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 6","pages":"221-231"},"PeriodicalIF":1.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute ultraviolet B irradiation increases cholesterol and decreases Cyp7a1 expression in the liver of female mice 急性紫外线 B 照射会增加雌性小鼠肝脏中的胆固醇并降低 Cyp7a1 的表达。

IF 1.8 4区医学

Lipids Pub Date : 2024-07-03 DOI: 10.1002/lipd.12407

Takumi Yamane, Takahiro Okumoto, Tomoko Tamura, Yuichi Oishi

引用次数: 0

Efficacy and safety of omega-3-acid ethyl acetate 90 capsules in severe hypertriglyceridemia: A randomized, controlled, multicenter study 欧米伽-3 酸乙酯 90 粒胶囊对严重高甘油三酯血症的疗效和安全性：一项随机对照多中心研究。

IF 1.8 4区医学

Lipids Pub Date : 2024-06-03 DOI: 10.1002/lipd.12406

Wang Zhao, Yangang Wang, Jin Li, Tao Chen, Delu Yin, Hailong Dai, Zhuhua Yao, Shuiping Zhao

{"title":"Efficacy and safety of omega-3-acid ethyl acetate 90 capsules in severe hypertriglyceridemia: A randomized, controlled, multicenter study","authors":"Wang Zhao, Yangang Wang, Jin Li, Tao Chen, Delu Yin, Hailong Dai, Zhuhua Yao, Shuiping Zhao","doi":"10.1002/lipd.12406","DOIUrl":"10.1002/lipd.12406","url":null,"abstract":"Omega-3-acid ethyl acetate 90 capsules (containing 465 mg of eicosapentaenoic acid and 375 mg docosahexaenoic acid) is composed of highly purified omega-3 polyunsaturated fatty acid (PUFA) ethyl esters, whose lipid-lowering effect for severe hypertriglyceridemia (HTG) treatment is unclear. This study aimed to evaluate the efficacy and safety of omega-3-acid ethyl acetate 90 capsules in patients with severe HTG. In this randomized, double-blind, placebo-controlled, multicenter study, 239 patients with severe HTG were enrolled and randomized (1:1) into omega-3 group (N = 122) and placebo group (N = 117) to receive 12-week corresponding treatments. Lipid-related indexes were obtained at treatment initiation (W0), 4 weeks (W4), W8, and W12 after treatment. Adverse events and adverse drug reactions were recorded. Triacylglycerols (TAG), total cholesterol (TC), non-high-density lipoprotein cholesterol (non-HDL-C), very-low-density lipoprotein cholesterol (VLDL-C), and apolipoprotein C-III (Apo C-III) at W4, W8, and W12 were decreased in the omega-3 group versus the placebo group (all p < 0.05). Moreover, the percentage changes of TAG, TC, non-HDL-C, and VLDL-C from W0 to W4, W8, and W12, and the percentage change of Apo C-III from W0 to W4 and W8, were more obvious in the omega-3 group compared with the placebo group (all p < 0.05). However, no difference was observed in the percentage changes of HDL-C, low-density lipoprotein cholesterol (LDL-C), and LDL-C/HDL-C ratio during follow-up between groups (all p > 0.05). Additionally, there was no discrepancy in adverse events and adverse drug reactions between groups (all p > 0.05). Omega-3-acid ethyl acetate 90 capsules exhibit satisfied lipid-lowering effect with tolerable safety profile in patients with severe HTG.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 5","pages":"145-157"},"PeriodicalIF":1.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of different lipid sources with or without a probiotic on gastrointestinal tract, immune system and blood parameters of chickens: An animal model 添加或不添加益生菌的不同脂质来源对鸡胃肠道、免疫系统和血液参数的影响：动物模型。

IF 1.8 4区医学

Lipids Pub Date : 2024-05-21 DOI: 10.1002/lipd.12397

Mohammadreza Poorghasemi, Mohammad Chamani, Seyed Ziaeddin Mirhosseini, Ali Saravy, Ali-Asghar Sadeghi, Alireza Seidavi, Heder José D'Avila Lima

{"title":"Effects of different lipid sources with or without a probiotic on gastrointestinal tract, immune system and blood parameters of chickens: An animal model","authors":"Mohammadreza Poorghasemi, Mohammad Chamani, Seyed Ziaeddin Mirhosseini, Ali Saravy, Ali-Asghar Sadeghi, Alireza Seidavi, Heder José D'Avila Lima","doi":"10.1002/lipd.12397","DOIUrl":"10.1002/lipd.12397","url":null,"abstract":"The objective of this study was to determine the effects of different lipid sources, with or without a probiotic, on the gastrointestinal tract, immune system and blood parameters of Ross 308 male chickens. In this study, 360 one-day-old chickens were randomly allotted to six treatments with six replicates. Experimental diets were: (1) control (CTL); (2) a diet containing 30 g/kg lipid from tallow (CTL+TLW); (3) a diet containing 30 g/kg lipid from soybean oil (CTL+SO); (4) the basal diet plus a probiotic (CTL+PRO), (5) a diet containing 30 g/kg tallow plus probiotic (TLW+PRO); and (6) a diet containing 30 g/kg soybean oil plus probiotic (SO+PRO). The percentage of liver and jejunum in the treatments that used tallow alone or tallow with probiotics had a significant increase as compared to the control. The villus height and crypt depth of the ileum and villus height/crypt depth in the treatments that used soybean oil and probiotic alone had a significant increase compared to the control. The weight of the spleen, bursa of Fabricius, and thymus in the treatments that used probiotics had a significant increase compared to the control. The amount of alkaline phosphatase and alanine aminotransferase as well as triacylglycerol in the treatment containing probiotic and its mixture with soybean oil had the least significant difference with the control. The results showed that the use of soybean oil, probiotics, and their mixture can improve intestinal morphology, strengthen the immune system, and reduce liver enzymes in chickens.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 5","pages":"113-122"},"PeriodicalIF":1.8,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of high-intensity statin therapy on steroid hormones and vitamin D in type 2 diabetic men: A prospective self-controlled study 高强度他汀治疗对 2 型糖尿病男性体内类固醇激素和维生素 D 的影响：前瞻性自我对照研究

IF 1.8 4区医学

Lipids Pub Date : 2024-05-20 DOI: 10.1002/lipd.12399

Melika Chihaoui, Amani Terzi, Bessam Hammami, Ibtissem Oueslati, Nadia Khessairi, Fatma Chaker, Meriem Yazidi, Moncef Feki

{"title":"Effects of high-intensity statin therapy on steroid hormones and vitamin D in type 2 diabetic men: A prospective self-controlled study","authors":"Melika Chihaoui, Amani Terzi, Bessam Hammami, Ibtissem Oueslati, Nadia Khessairi, Fatma Chaker, Meriem Yazidi, Moncef Feki","doi":"10.1002/lipd.12399","DOIUrl":"10.1002/lipd.12399","url":null,"abstract":"The study aimed to assess the effect of high-intensity statin therapy on testicular and adrenal steroids and vitamin D levels in type 2 diabetic men. A prospective study, conducted between March 2021 and July 2022, including 60 men with type 2 diabetes, aged 40–65 years, statin-free, and in whom treatment with high-intensity statin was indicated. The patients had two visits, before and 6 months after a daily intake of 40 mg of atorvastatin. During each visit, they underwent a clinical examination, and a fasting blood sample was collected for biological and hormonal measurements. There was a significant increase in the prevalence of decreased libido (from 22% to 47%, p = 0.001) and a significant decrease in the frequency of sexual intercourse (from 4 [1–8] to 3 [0–4] per month, p = 0.005). The median ADAM's score significantly increased (from 4 [2–7] to 6 [3–8], p = 0.000). Twenty-two percent of the patients developed gynecomastia. The median total, bioavailable and free testosterone significantly decreased from 15.1 (11.4–17.4), 6.3 (5.0–7.8), and 0.27 (0.22–0.33) nmol/L to 12.7 (10.7–15.9), 5.7 (4.4–7.0), and 0.24 (0.19–0.30) nmol/L, respectively, with no change in FSH and LH levels. Three patients (5%) developed hypogonadism (testosterone <8 nmol/L). There was a significant decrease in DHEAS from 4.5 (2.8–6.1) to 3.8 μmol/L (2.6–5.6) and no change in cortisol and vitamin D levels. High-intensity statin therapy decreased androgen levels in type 2 diabetic men with significant clinical impact.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"59 5","pages":"135-144"},"PeriodicalIF":1.8,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0