Jamie Small, David Price, Joe Martin, Alan Wright, Anthony Price, Marco Borri, Jane Ansell, Elizabeth Stamou, Ariona Kruezi, Ioana Pinzaru, Elizabeth Gabriel, Laurence Jackson, Caitlin O'Brien, Harriet Rogers, Francesco Padormo, Geoff Charles-Edwards
{"title":"MRI faraday cage performance during the lifetime of clinical MRI systems.","authors":"Jamie Small, David Price, Joe Martin, Alan Wright, Anthony Price, Marco Borri, Jane Ansell, Elizabeth Stamou, Ariona Kruezi, Ioana Pinzaru, Elizabeth Gabriel, Laurence Jackson, Caitlin O'Brien, Harriet Rogers, Francesco Padormo, Geoff Charles-Edwards","doi":"10.1007/s10334-025-01321-8","DOIUrl":"10.1007/s10334-025-01321-8","url":null,"abstract":"<p><strong>Objective: </strong>This work investigated the performance of MRI Faraday cages (FCs) over the lifetime of clinical MRI systems, aiming to better inform an option to repurpose an existing FC when an MRI scanner is replaced.</p><p><strong>Materials and methods: </strong>FC performance was measured at acceptance testing for 40 MRI systems and for a further 11 MRI systems of various ages. Results were compared with the MRI vendor's FC specification and with measurements made when the FCs were initially built.</p><p><strong>Results: </strong>The majority of FCs, 63% (n = 25), had at least one measurement below specification at acceptance testing. However, no RF artefacts were observed on MR images. There were significant negative relationships between FC performance and age at the locations of the door and window (p < 0.001).</p><p><strong>Discussion: </strong>FC performance can degrade between the time of FC manufacture and initial clinical MRI scanning. However, FC attenuation levels may need to be considerably less than specification values before external RF artefacts start appearing on MR images in practice. Further degradation of FC performance may occur over time, but this may be better addressed by maintenance on the MR exam room door rather than a much more costly and time-consuming replacement of the FC.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"585-592"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yongha Gi, A Hyun Jung, Hyungjin Lim, Sangyoon Park, Jeongwon Lee, Jong Hyun Kim, Byung-Jo Kim, Seol-Hee Baek, Myonggeun Yoon
{"title":"Inclusion of intracranial volume as a covariate feature improves MRI-based Alzheimer's disease classification.","authors":"Yongha Gi, A Hyun Jung, Hyungjin Lim, Sangyoon Park, Jeongwon Lee, Jong Hyun Kim, Byung-Jo Kim, Seol-Hee Baek, Myonggeun Yoon","doi":"10.1007/s10334-025-01318-3","DOIUrl":"10.1007/s10334-025-01318-3","url":null,"abstract":"<p><strong>Objective: </strong>Structural MRI-based regional volumes are widely used for Alzheimer's disease (AD) classification, but inter-individual variability in intracranial volume (ICV) introduces confounding. Traditional adjustment methods use region-of-interest (ROI)/ICV ratios or residual adjustment during pre-processing, yet no consensus exists on the optimal method. This study tests whether explicitly including ICV as a covariate (ROI + ICV) improves classification compared with ratio, residual adjustment, and the unadjusted baseline.</p><p><strong>Materials and methods: </strong>T1-weighted MRIs from ADNI1 (n = 1423) and MIRIAD (n = 69) were processed with FreeSurfer to extract eight AD-related ROI volumes and ICV. Four feature configurations (ROI-only, ROI/ICV, Residual ROI, ROI + ICV) were benchmarked across six classifiers for cognitive normal (CN)-AD, CN-mild cognitive impairment (MCI), and MCI-AD. Performance was assessed with AUROC and F1 using Friedman and post hoc tests. In addition, feature attribution was examined with permutation importance and SHAP.</p><p><strong>Results: </strong>ROI + ICV consistently produced the largest performance gains over ROI-only in CN-AD and CN-MCI, outperforming ratio and residual adjustment across most classifiers. These improvements generalized to the independent MIRIAD dataset. SHAP analyses showed that the directional effect of ICV reversed across strategies: under ratio or residual adjustment, larger ICV decreased AD probability, whereas in ROI + ICV, larger ICV increased it. This highlights ICV's contextual influence on model decisions.</p><p><strong>Discussion: </strong>Pre-processing-based adjustments do not fully remove ICV effects and can distort ROI-ICV relationships. Explicit covariate inclusion avoids these issues and yields more consistent, generalizable improvements. Thus, ICV should be modeled rather than removed, making ROI + ICV the preferred default ICV-handling strategy for MRI-based AD classification.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"671-685"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Petr Bulanov, Petr Menshchikov, Johannes A Grimm, Niklas Himburg, Simon Schmidt, Stephan Orzada, Mark E Ladd, Sebastian Schmitter
{"title":"Abdominal T<sub>1</sub> relaxation times at 7T.","authors":"Petr Bulanov, Petr Menshchikov, Johannes A Grimm, Niklas Himburg, Simon Schmidt, Stephan Orzada, Mark E Ladd, Sebastian Schmitter","doi":"10.1007/s10334-025-01317-4","DOIUrl":"10.1007/s10334-025-01317-4","url":null,"abstract":"<p><strong>Objective: </strong>To quantify the T<sub>1</sub> relaxation times at 7T for key abdominal organs and tissues, including the liver, kidney, spleen, and skeletal paraspinal muscles.</p><p><strong>Materials and methods: </strong>T<sub>1</sub> mapping was performed on a 7T whole-body scanner with a parallel transmission (pTx) system in five healthy volunteers. Static pTx (B<sub>1</sub><sup>+</sup> shimming) was applied to maximize B<sub>1</sub><sup>+</sup> magnitude in the target region. For each T<sub>1</sub> map, data were collected using eight snapshot gradient-echo inversion recovery sequences during breath holding. Voxel-wise T<sub>1</sub> values were calculated based on DICOM data using exponential model fitting.</p><p><strong>Results: </strong>Mean abdomen T<sub>1</sub> values and corresponding coefficients of variation across the group were: 1829 ± 60 ms, 3.3% for the kidney cortex; 2619 ± 83 ms, 3.2% for the kidney medulla; 1378 ± 48 ms, 3.5% for the liver; 1954 ± 28 ms, 1.4% for the skeletal paraspinal muscle; 1770 ± 36 ms, 2.0% for the spleen.</p><p><strong>Conclusion: </strong>In this study, we quantified the T<sub>1</sub> relaxation times at 7T for key abdominal organs and tissues, including the liver, kidney, spleen, and skeletal paraspinal muscle. To achieve this, pTx was applied to mitigate B<sub>1</sub><sup>+</sup> dropouts in the target regions. The B<sub>1</sub><sup>+</sup> insensitive snapshot gradient-echo inversion recovery method was utilized to acquire accurate and reproducible T<sub>1</sub> maps.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"605-617"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julian Schüle, Christoph A Müller, Sebastian Lucas, Leonard Schraff, Stefan Menzel, Tobias Speidel, Ilai Schwartz, Volker Rasche
{"title":"Design and chemical composition of a reference phantom for <sup>13</sup>C metabolic MRSI.","authors":"Julian Schüle, Christoph A Müller, Sebastian Lucas, Leonard Schraff, Stefan Menzel, Tobias Speidel, Ilai Schwartz, Volker Rasche","doi":"10.1007/s10334-026-01330-1","DOIUrl":"10.1007/s10334-026-01330-1","url":null,"abstract":"<p><strong>Object: </strong>Development of a reproducible and long-term stable reference phantom for <sup>13</sup>C metabolic MRSI, addressing the need for accessible calibration and quality assurance tools across sites and platforms.</p><p><strong>Materials and methods: </strong>The phantom was built from readily available labware (50 mL centrifuge tubes, NMR glass vials) and 3D-printed holders, designed to ensure sufficient coil loading and excellent B<sub>0</sub> homogeneity. <sup>13</sup>C-labeled reference solutions were stabilized by argon degassing, sodium azide addition, and airtight flame sealing, with optional gadolinium doping to tune T<sub>1</sub>/T<sub>2</sub> relaxation. Performance was tested at 1.4 T, 3 T, and 11.7 T using <sup>1</sup>H MRI, <sup>13</sup>C spectroscopy, and <sup>13</sup>C MRSI.</p><p><strong>Results: </strong>The reference solutions remained chemically and spectrally stable for up to 20 months under cooled, light-protected storage. Ethyl acetate provided a stable alternative to pyruvate, while gadolinium enabled the control of relaxation properties. Spectral assessment confirmed narrow linewidths, strong SNR, and reproducible peak separation across field strengths, validating the phantom's suitability for calibration and method development.</p><p><strong>Discussion: </strong>This low-cost, open-source design provides a durable and reproducible <sup>13</sup>C phantom that complements existing dynamic and metabolite-specific models. It enables long-term standardization, supports multi-center studies, and facilitates robust quality assurance in hyperpolarized and thermal <sup>13</sup>C MRSI.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"559-570"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johanna Thomä, Lionel Butry, Martijn Froeling, Marco Meixner, Johannes Forsting, Lara Schlaffke
{"title":"Standardizing quantitative muscle MRI: an inter-vendor evaluation in healthy adults.","authors":"Johanna Thomä, Lionel Butry, Martijn Froeling, Marco Meixner, Johannes Forsting, Lara Schlaffke","doi":"10.1007/s10334-026-01328-9","DOIUrl":"10.1007/s10334-026-01328-9","url":null,"abstract":"<p><strong>Objectives: </strong>Quantitative muscle MRI (qMRI) is applied to detect muscular alterations, particularly in neuromuscular diseases (NMDs). As studies on rare NMDs benefit from multi-center designs, inter-vendor reproducibility must be assessed to ensure data comparability. However, manufacturer-related variability has been limited investigated. This study evaluates inter-vendor reproducibility of qMRI parameters in healthy subjects.</p><p><strong>Methods: </strong>Ten healthy volunteers were investigated within 1 week on two 3T MRI systems (Siemens, Philips). Twelve leg muscles were analyzed using Dixon (fat fraction, FF), T2 mapping (water T2, wT2), and diffusion-weighted-sequence (diffusion parameters: fractional anisotropy (FA), mean, radial, axial diffusivity [MD, RD, λ<sub>1</sub>]). Reproducibility was assessed using intraclass correlation coefficient (ICC), within-subject coefficients of variation, t tests, and Bland-Altman analysis.</p><p><strong>Results: </strong>ICCs demonstrated moderate to excellent reproducibility for most parameters (ICC<sub>FF</sub> = 0.923, ICC<sub>wT2</sub> = 0.792, ICC<sub>FA</sub> = 0.777, ICC<sub>MD</sub> = 0.708, ICC<sub>RD</sub> = 0.850), except for λ<sub>1</sub> (ICC = 0.361). Significant inter-vendor differences were observed for all parameters (p < 0.05), with systematic biases ranging from 44.2% for FF to 3.6% for FA.</p><p><strong>Discussion: </strong>qMRI parameters were generally reproducible in healthy volunteers. However, absolute values differed between manufacturers and require correction. These differences should be considered to minimize manufacturer-related discrepancies and to facilitate data pooling in multi-center and longitudinal studies.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"631-643"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of contrast transit time on late arterial phase timing in Gd-EOB-DTPA-enhanced MRI.","authors":"Tomokazu Takeuchi, Soma Kumasaka, Yasuhiro Fukushima, Daisuke Ozaki, Yusuke Sato, Yuka Kumasaka, Kouichi Ujita, Takayuki Suto, Yoshito Tsushima","doi":"10.1007/s10334-025-01316-5","DOIUrl":"10.1007/s10334-025-01316-5","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the physiological factors affecting the timing of late arterial phase imaging in gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid-enhanced MRI (EOB-MRI), with a focus on contrast transit times.</p><p><strong>Methods: </strong>This retrospective study included 122 patients who underwent EOB-MRI between April and September 2024. Contrast transit times from the right atrium to the left ventricle (RA-LV time) and to the celiac artery (RA-CeA time) were measured using real-time bolus-tracking images. Using vascular enhancement patterns, the late arterial phase timing was visually assessed and categorized as Early, Appropriate, or Delayed. Differences among the imaging timing groups were analyzed using analysis of variance (ANOVA) and post hoc Welch's t tests with Holm correction, with a significance threshold of p < 0.05.</p><p><strong>Results: </strong>Mean RA-LV times (mean ± SD, range) were 7.0 ± 1.1 s (5.0-9.0 s), 5.2 ± 0.9 s (4.0-8.0 s), and 4.7 ± 0.6 s (4.0-6.0 s) for the Early, Appropriate, and Delayed groups, respectively; significant differences were observed between Early vs. Appropriate (p < 0.001) and Appropriate vs. Delayed (p = 0.02). Correspondingly, RA-CeA times were 12.4 ± 2.0 s (10.0-15.0 s), 8.9 ± 1.8 s (5.0-14.0 s), and 7.7 ± 1.1 s (6.0-10.0 s), respectively, with significant differences between Early vs. Appropriate (p < 0.001) and Appropriate vs. Delayed (p = 0.001). Additionally, significant differences in sex and height were observed between the Early and Appropriate groups (p < 0.01). No other variables showed significant differences.</p><p><strong>Conclusion: </strong>Contrast transit times significantly affect the appropriateness of late arterial phase imaging in EOB-MRI. Incorporating individualized transit time assessment alongside conventional bolus tracking may improve the consistency of late arterial phase acquisition and enhance the performance for diagnosing hepatic tumors.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"663-670"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Wenz, Jules Vliem, Elizaveta Shegurova, Mark Widmaier, Lijing Xin, Dimitrios C Karampinos, Irena Zivkovic
{"title":"Enhancing SNR in MRI at 7T using wearable coils, dielectric resonators, and dipole antennas.","authors":"Daniel Wenz, Jules Vliem, Elizaveta Shegurova, Mark Widmaier, Lijing Xin, Dimitrios C Karampinos, Irena Zivkovic","doi":"10.1007/s10334-026-01323-0","DOIUrl":"10.1007/s10334-026-01323-0","url":null,"abstract":"<p><strong>Motivation: </strong>The twisted-pair (TP) coil design is a promising strategy for developing novel, flexible, wearable MRI detectors that can provide SNR gains in various clinical applications of high-field MRI. We hypothesize that the TP coil's receive (Rx) sensitivity can be significantly increased by combining it with two complementary elements, such as dielectric resonators (DRs) and dipole antennas.</p><p><strong>Methods: </strong>TP coils were combined with DRs made of high-permittivity material (ε<sub>r</sub> = 1070) and transceiver (TxRx) dipole antennas. The Tx and Rx performance of six different types of arrays (TP-only, dipole-only, TP with DRs, dipole with DRs, dipole with TPs, and dipole with TPs and DRs) was investigated through numerical simulations involving a cylindrical phantom suitable for lower extremity applications and two human voxel models. MR phantom experiments were conducted using a 7 Tesla whole-body MRI scanner to validate the Tx and Rx performance of all six array types.</p><p><strong>Results: </strong>The array combining all three types of elements (TP coils, DRs, and dipole antennas) provided the highest overall Rx performance; MR phantom experiments showed that integrating DRs with TP coils increased peripheral SNR by 250% and central SNR by 23% (for a total 38% gain in the center when also using dipole antennas in Rx). Human voxel model simulations confirmed that similar SNR gains can be achieved in vivo. Integrating DRs into TP coils also increased central Tx field efficiency by 4.6% and reduced the peak SAR<sub>10g</sub> by 25.8% in the human voxel model Hugo.</p><p><strong>Conclusion: </strong>DRs and dipole antennas can significantly improve the overall Rx performance of TP coils. This concept can benefit MRI of the human lower extremity at 7 Tesla and encourage exploration of its utility for other clinical applications.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"571-582"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In-cell NMR spectroscopy: advancements, applications, challenges, and future directions in structural biology.","authors":"Omar Eladl","doi":"10.1007/s10334-025-01313-8","DOIUrl":"10.1007/s10334-025-01313-8","url":null,"abstract":"<p><p>In-cell nuclear magnetic resonance (NMR) spectroscopy has emerged as a leading technique in structural biology, providing atomic-level insights into the structures, dynamics, and interactions of biomolecules within their native cellular environments. By bridging the gap between conventional in vitro studies and the complexity of living systems, in-cell NMR enables direct observation of biomolecular behavior under near-physiological conditions. This review highlights recent methodological advances that have expanded the scope and feasibility of in-cell NMR. Innovations in isotopic labeling, including selective incorporation strategies, have enhanced spectral resolution and sensitivity. Optimized delivery approaches, such as microinjection and electroporation, facilitate efficient introduction of labeled biomolecules into diverse cell types. The use of cryogenically cooled probes and high-field magnets further improves signal detection, enabling the study of low-abundance targets. We discuss key applications, including protein folding, conformational dynamics, biomolecular interaction networks, and nucleic acid structural rearrangements. In addition, in-cell NMR has proven invaluable for drug discovery, providing mechanistic insights into intracellular drug-target interactions. Despite these advances, challenges remain, including spectral overlap from endogenous components, low intracellular concentrations, and maintaining cell viability during extended experiments. Future developments integrating cryo-electron microscopy (cryo-EM), mass spectrometry (MS), hyperpolarization techniques, and advanced labeling strategies promise to enhance sensitivity, resolution, and applicability, solidifying in-cell NMR as an indispensable tool for probing biomolecular function in living cells.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"545-558"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luise Brock, Andrzej Liebert, Hannes Schreiter, Dominika Skwierawska, Chris Ehring, Jessica Eberle, Shirin Heidarikahkesh, Frederik Bernd Laun, Michael Uder, Lorenz Kapsner, Judith Lach, Evelyn Wenkel, Sabine Ohlmeyer, Dominique Hadler, Florian Knoll, Sebastian Bickelhaupt
{"title":"Influence of co-registration on lesion characterization in diffusion-weighted breast MRI.","authors":"Luise Brock, Andrzej Liebert, Hannes Schreiter, Dominika Skwierawska, Chris Ehring, Jessica Eberle, Shirin Heidarikahkesh, Frederik Bernd Laun, Michael Uder, Lorenz Kapsner, Judith Lach, Evelyn Wenkel, Sabine Ohlmeyer, Dominique Hadler, Florian Knoll, Sebastian Bickelhaupt","doi":"10.1007/s10334-026-01324-z","DOIUrl":"10.1007/s10334-026-01324-z","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate if co-registering Diffusion-Weighted Imaging (DWI) before generating Apparent Diffusion Coefficient (ADC) maps can improve differentiating benign and malignant breast lesions in MRI based on the A6702 thresholds.</p><p><strong>Materials and methods: </strong>This IRB-approved study involved an in-house dataset and the publicly available ACRIN-6698 dataset, both including multi b-value DWI. In phase one, 16 ANTs library-based co-registration methods were evaluated on a subset of n = 138 cases from our in-house cohort. The quantitative assessment included mean ADC values of manually segmented lesions (diagnostic metrics using individual and A6702-defined thresholds) and coefficient of Variation. In the second phase, the best-performing methods were tested for generalizability on an unseen set of 40 cases (20 from in-house and 20 from external dataset). Three blinded readers segmented lesions on co-registered and non-co-registered ADC maps. Agreement and consistency were evaluated via Bland-Altman, segmentation distance, and intraclass correlation coefficient.</p><p><strong>Results: </strong>Rigid co-registration using DWI at b = 750 s/mm<sup>2</sup> as reference (b750-Rigid) improved accuracy of both optimal/conservative A6702 trial thresholds with sensitivity/specificity increasing from 93%/10% to 97%/30% and 100%/30% respectively. Mean ADC values were not significantly different after co-registration (p > 0.05).</p><p><strong>Discussion: </strong>Co-registration of DWI images before ADC map generation, particularly using b750-Rigid registration, seems promising for improving lesion classification in breast MRI. Further validation is warranted.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"645-662"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niklas Wehkamp, Patrick Hucker, Johannes Fischer, Andreas Greiner, Jon-Fredrik Nielsen, Maxim Zaitsev, Robert Dehnert
{"title":"Correction: Naming convention for gradient system transfer function and gradient system frequency response for magnetic resonance imaging encoding field characterization.","authors":"Niklas Wehkamp, Patrick Hucker, Johannes Fischer, Andreas Greiner, Jon-Fredrik Nielsen, Maxim Zaitsev, Robert Dehnert","doi":"10.1007/s10334-026-01336-9","DOIUrl":"10.1007/s10334-026-01336-9","url":null,"abstract":"","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"705"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}