Magnetic Resonance Materials in Physics, Biology and Medicine最新文献

{"title":"Reproducibility and quality assurance in MRI.","authors":"Tony Stöcker, Kathryn E Keenan, Florian Knoll, Nikos Priovoulos, Martin Uecker, Maxim Zaitsev","doi":"10.1007/s10334-025-01271-1","DOIUrl":"10.1007/s10334-025-01271-1","url":null,"abstract":"","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"347-352"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeatability of 3D MR fingerprinting during scanner software upgrades.","authors":"Andrew Dupuis, Yong Chen, Kelvin Chow, Mark A Griswold, Rasim Boyacioglu","doi":"10.1007/s10334-024-01211-5","DOIUrl":"10.1007/s10334-024-01211-5","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to quantify the repeatability of a 3D Magnetic Resonance Fingerprinting (MRF) research protocol in the context of a scanner software upgrade. All of MRI assumes consistent hardware performance and raw data pre-processing on the acquisition side. Software upgrades can affect hardware specifications and reconstruction chain parameters. Understanding how vendor-provided software upgrades vary MRF-derived T1 and T2 values is crucial for its application in different settings.</p><p><strong>Materials and methods: </strong>Eight healthy volunteers were imaged with an in-house developed 3D MRF pulse sequence using a 3T scanner before and after a software upgrade (VA31A to VA50A, MAGNETOM Vida, Siemens Healthineers). Online MRF reconstruction using Singular Value Decomposition (SVD) timeseries compression and B1+ correction was performed. The study involved test-retest repeatability assessment and a comparison of pre- and post-upgrade data based on automatically extracted T1 and T2 values from MNI-152 Harvard-Oxford Subcortical Structural Atlas regions.</p><p><strong>Results: </strong>Significant mismatches were found directly after the upgrade. However, after an information exchange with the vendor, the 3D-MRF sequence showed consistent repeatability in both intra-version test-retest scenarios and cross-version comparisons: <math><mo>-</mo></math> 1.16 ± 3.18% variability in T1 and <math><mo>-</mo></math> 0.54 ± 4.84% in T2 for intra-version tests, and <math><mo>-</mo></math> 0.83 ± 3.68% (T1) and <math><mo>-</mo></math> 0.05 ± 5.81% (T2) variability for cross-version comparisons.</p><p><strong>Discussion: </strong>The study shows the reliable performance of 3D MRF protocols across software upgrades is possible, but it also highlights the importance of detailed evaluation and vendor collaboration in ensuring consistency. These findings support the application of MRF in longitudinal studies and emphasize the need for systematic assessments following hardware or software modifications.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"441-448"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quality assurance protocol for reliable and reproducible multi-TI arterial spin labeling perfusion imaging in rat livers.","authors":"Wan-Ting Zhao, Karl-Heinz Herrmann, Weiwei Wei, Martin Krämer, Uta Dahmen, Jürgen R Reichenbach","doi":"10.1007/s10334-024-01223-1","DOIUrl":"10.1007/s10334-024-01223-1","url":null,"abstract":"<p><strong>Objective: </strong>To establish an arterial spin labeling (ASL) protocol for rat livers that improves data reliability and reproducibility for perfusion quantification.</p><p><strong>Methods: </strong>This study used respiratory-gated, single-slice, FAIR-based ASL imaging with multiple inversion times (TI) in rat livers. Quality assurance measures included: (1) introduction of mechanical ventilation to ensure consistent respiratory cycles by controlling the respiratory rate (45 bpm), tidal volume (10 ml/kg), and inspiration: expiration ratio (I:E ratio, 1:2), (2) optimization of the trigger window for consistent trigger points, and (3) use of fit residual map and coefficient of variance as metrics to assess data quality. We compared image quality, perfusion maps, and fit residual maps between mechanically ventilated and non-ventilated animals, as well as repeated ASL measurements (session = 4 per animal) in two mechanically ventilated animals.</p><p><strong>Results: </strong>Perfusion measurements over multiple sessions in mechanically ventilated rats exhibited low perfusion data variability and high reproducibility both within and between liver lobes. Image quality and perfusion maps were significantly improved in mechanically ventilated animals compared to non-ventilated animals.</p><p><strong>Discussion: </strong>The implementation of mechanical ventilation and optimized quality assurance protocols enhanced the reliability and reproducibility of FAIR-based multi-TI-ASL imaging in rat livers. Our findings demonstrate these measures as a robust approach for achieving consistent liver perfusion quantification in preclinical settings.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"503-517"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical zone and tissue type impacts the repeatability of quantitative MRI parameters and radiomic features for longitudinal monitoring of treatment response in the prostate.","authors":"Yu-Feng Wang, Sirisha Tadimalla, Lois Holloway, Niluja Thiruthaneeswaran, Annette Haworth","doi":"10.1007/s10334-025-01231-9","DOIUrl":"10.1007/s10334-025-01231-9","url":null,"abstract":"<p><strong>Objective: </strong>To (1) establish the repeatability coefficient (%RC) of region of interest (ROI) and voxel-wise measurements of a comprehensive range of quantitative MRI (qMRI) parameters and radiomic features in the prostate, and (2) assess the impact of different tissue types (benign vs tumor) and anatomical zones (peripheral, PZ, and non-peripheral, nPZ) on the %RCs.</p><p><strong>Methods: </strong>Test-retest qMRI was acquired in ten prostate cancer patients and six healthy volunteers. Parametric maps of apparent diffusion coefficient (ADC), diffusion coefficient (D), perfusion fraction (f), hypoxia score (HS), longitudinal relaxation time (T1), and observed transverse relaxation rate (R2*) were calculated. Fifty-nine radiomic feature maps were calculated from each of the parametric maps and T2-weighted images. The %RCs between tissue type and anatomical zones were compared using the Student's t test at 95% significance level.</p><p><strong>Results: </strong>The %RC of ADC, D and HS, and up to 118 (out of all 413) radiomic features was significantly different between either anatomical zones, or between tumor and benign tissue, or both.</p><p><strong>Conclusions: </strong>DWI-derived parameters and a portion of their radiomic features require %RCs to be established specifically for anatomical zones, tumor and benign tissues. The remaining qMRI parameters and features can have a single threshold for the whole prostate.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"475-490"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Pulseq-CEST Library: definition of preparations and simulations, example data, and example evaluations.","authors":"Alexander Liebeskind, Jan Rüdiger Schüre, Moritz Simon Fabian, Simon Weinmüller, Patrick Schünke, Vladimir Golkov, Daniel Cremers, Moritz Zaiss","doi":"10.1007/s10334-025-01242-6","DOIUrl":"10.1007/s10334-025-01242-6","url":null,"abstract":"<p><strong>Objectives: </strong>Despite prevalent use of chemical exchange saturation transfer (CEST) MRI, standardization remains elusive. Imaging depends heavily on parameters dictating radiofrequency (RF) events, gradients, and apparent diffusion coefficient (ADC). We present the Pulseq-CEST Library, a repository of CEST preparation and simulation definitions, including example data and evaluations, that provides a common basis for reproducible research, rapid prototyping, and in silico deep learning training data generation.</p><p><strong>Materials and methods: </strong>A Pulseq-CEST experiment requires (i) a CEST preparation sequence, (ii) a Bloch-McConnell parameter set, (iii) a Bloch-McConnell simulation, and (iv) an evaluation script. Pulseq-CEST utilizes the Bloch-McConnell equations to model in vitro and in vivo conditions. Using this model, a candidate sequence or environment can be held constant while varying other inputs, enabling robust testing.</p><p><strong>Results: </strong>Data were compared for amide proton transfer weighted (APTw) and water shift and B1 (WASABI) protocols using a five-tube phantom and simulated environments. Real and simulated data matched anticipated spectral shapes and local peak characteristics. The Pulseq-CEST Library supports similar experiments with common sequences and environments to assess new protocols and sample data.</p><p><strong>Discussion: </strong>The Pulseq-CEST Library provides a flexible mechanism for standardizing and prototyping CEST sequences, facilitating collaborative development. With the capability for expansion, including open-source incorporation of new sequences and environments, the library accelerates the invention and spread of novel CEST and other saturation transfer approaches, such as relayed NOEs (rNOEs) and semisolid magnetization transfer contrast (MTC) methods.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"413-422"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESMRMB 2025 focus topic: cycle of quality-from concept to clinical and scientific impact.","authors":"Thomas Küstner, Roy Haast, Nikos Priovoulos, Patricia Clement, Daniel Pinto Dos Santos","doi":"10.1007/s10334-025-01272-0","DOIUrl":"10.1007/s10334-025-01272-0","url":null,"abstract":"","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"631-633"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a cost-effective 3D-printed MRI phantom for enhanced teaching of system performance and image quality concepts.","authors":"Habeeb Yusuff, Pierre-Emmanuel Zorn, Céline Giraudeau, Benoît Wach, Philippe Choquet, Simon Chatelin, Jean-Philippe Dillenseger","doi":"10.1007/s10334-024-01217-z","DOIUrl":"10.1007/s10334-024-01217-z","url":null,"abstract":"<p><strong>Purposes: </strong>This research highlights the need for affordable phantoms for MRI education. Current options are either expensive or limited. A phantom, easy to manufacture and distribute, is proposed to demonstrate various pedagogical concepts, aiding students in understanding MRI image quality concepts.</p><p><strong>Methods: </strong>We designed a cylindrical MRI phantom that comprises sections that can be filled with chosen liquids and gels. The dimensions were chosen to fit most consumer-grade 3D printers, facilitating widespread dissemination. It includes five modular sections for evaluating spatial resolution, geometrical accuracy, slice thickness accuracy, homogeneity, and contrast.</p><p><strong>Results: </strong>The modular cylindrical MRI phantom was successfully fabricated. Each section of the phantom was tested to ensure it met the specified pedagogical needs. The spatial resolution section provided clear images for evaluating fine details. The geometrical accuracy section allowed for precise measurement of distortions. The slice thickness accuracy section confirmed the consistency of slice thickness across different MRI sequences. The homogeneity section demonstrated uniform signal distribution, and the contrast section effectively displayed varying contrast levels.</p><p><strong>Conclusions: </strong>This modular MRI phantom offers a cost-effective tool for educational purposes in MRI. Its design enables educators to demonstrate multiple pedagogical scenarios with a single object. The phantom's compatibility with consumer-grade 3D printers and its modularity makes it accessible and adaptable to various educational settings. Future work could explore further customization and enhancement of the phantom to cover additional educational needs. This tool represents a significant step toward improving MRI education and training by providing a practical, hands-on learning experience.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"561-574"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-center and multi-vendor evaluation study across 1.5 T and 3 T scanners (part 1): apparent diffusion coefficient standardization in a diffusion MRI phantom.","authors":"Siria Pasini, Steffen Ringgaard, Tau Vendelboe, Leyre Garcia-Ruiz, Anika Strittmatter, Giulia Villa, Anish Raj, Rebeca Echeverria-Chasco, Michela Bozzetto, Paolo Brambilla, Malene Aastrup, Esben S S Hansen, Luisa Pierotti, Matteo Renzulli, Susan T Francis, Frank G Zoellner, Christoffer Laustsen, Maria A Fernandez-Seara, Anna Caroli","doi":"10.1007/s10334-025-01256-0","DOIUrl":"10.1007/s10334-025-01256-0","url":null,"abstract":"<p><strong>Objective: </strong>To validate multi-site and multi-vendor ADC measurements using the QIBA/NIST diffusion MRI phantom at room temperature.</p><p><strong>Materials and methods: </strong>ADC measurements were performed on 12 scanners (evenly split between 1.5 and 3 T) from three vendors at five sites and compared with reference values at room temperature. We adopted Pearson's correlation (r) and accuracy error for comparison with reference values; within scanner coefficient of variation (CV_intra%) for intra-session repeatability and inter-scanner for agreement (CV_inter%); Bland-Altman plots and precision error for short-term reproducibility; generalized linear mixed models and post-hoc tests ( <math><mi>α</mi></math> =0.05) to compare accuracy, repeatability and precision across field strengths, vendors, and scanners.</p><p><strong>Results: </strong>Temperature adjusted ADCs were well correlated with NIST reference values (r <math><mo>≥</mo></math> 0.997 for 1.5 T, r <math><mo>≥</mo></math> 0.996 for 3 T). Median accuracy error was lower than 5% for all scanners. In the renal physiologic range (ADC > 0.83 <math><mo>×</mo></math> 10^-3 mm²/s), accuracy error was < 10% and CV_intra < 2%. Across all scanners, good short-term reproducibility with limits of agreement < 10% and excellent agreement (median CV_inter < 2%) were found.</p><p><strong>Discussion: </strong>Despite using abdominal receive coils and room temperature measurements, all quantitative parameters were within literature findings. High accuracy, repeatability and precision within the renal physiologic range support the feasibility of scanner evaluation using QIBA standardization process for diffusion measurements in renal studies.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"593-609"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-supervised learning for MRI reconstruction: a review and new perspective.","authors":"Xinzhen Li, Jinhong Huang, Guanglong Sun, Zihan Yang","doi":"10.1007/s10334-025-01274-y","DOIUrl":"https://doi.org/10.1007/s10334-025-01274-y","url":null,"abstract":"<p><strong>Objective: </strong>To review the latest developments in self-supervised deep learning (DL) techniques for magnetic resonance imaging (MRI) reconstruction, emphasizing their potential to overcome the limitations of supervised methods dependent on fully sampled k-space data.</p><p><strong>Background: </strong>While DL has significantly advanced MRI, supervised approaches require large amounts of fully sampled k-space data for training-a major limitation given the impracticality and expense of acquiring such data clinically. Self-supervised learning has emerged as a promising alternative, enabling model training using only undersampled k-space data, thereby enhancing feasibility and driving research interest.</p><p><strong>Methods: </strong>We conducted a comprehensive literature review to synthesize recent progress in self-supervised DL for MRI reconstruction. The analysis focused on methods and architectures designed to improve image quality, reduce scanning time, and address data scarcity challenges, drawing from peer-reviewed publications and technical innovations in the field.</p><p><strong>Conclusions: </strong>Self-supervised DL holds transformative potential for MRI reconstruction, offering solutions to data limitations while maintaining image quality and accelerating scans. Key challenges include robustness across diverse anatomies, standardization of validation, and clinical integration. Future research should prioritize hybrid methodologies, domain-specific adaptations, and rigorous clinical validation. This review consolidates advancements and unresolved issues, providing a foundation for next-generation medical imaging technologies.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open-source, customizable phantom for low-field magnetic resonance imaging.","authors":"Kalina V Jordanova, Stephen E Russek, Kathryn E Keenan","doi":"10.1007/s10334-025-01270-2","DOIUrl":"https://doi.org/10.1007/s10334-025-01270-2","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to describe important criteria for phantom design, while designing an open-source phantom that uses accessible materials and fabrication processes, and that can be easily reproduced and modified by others in the MRI research community.</p><p><strong>Materials and methods: </strong>We enumerate considerations related to designing a phantom based on literature and previous experience. We design and use an open-source phantom on a low-field MRI system. The phantom was 3D printed and assembled, and the imaged samples were made from commonly available materials. T1-weighted and T2-weighted axial and coronal images were acquired at 64 mT, and signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and geometric distortion along one dimension were assessed for each image.</p><p><strong>Results: </strong>Two iterations of the phantom design were made to improve the construction materials and overall form factor for imaging. T1-weighted and T2-weighted images showed contrast between samples and background. T2-weighted images had an 8-10× increase in SNR and CNR compared to T1-weighted images. Geometric distortion measurements were within one-pixel spacing for all scans.</p><p><strong>Discussion: </strong>An open-source phantom was created to assess MRI scans at low-field. Future users may modify the phantom to suit their needs. User-designed inserts can be added, allowing for validation of many MRI-related measurements.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}