Concentric-object and equiangular-object methods to perform standardized regional analysis in renal mpMRI.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2024-10-19 DOI:10.1007/s10334-024-01208-0

Luis Carlos Sanmiguel-Serpa, Pieter de Visschere, Pim Pullens

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引用次数: 0

Abstract

Objective: Renal multiparametric magnetic resonance imaging (mpMRI) sequences, including T₁-T₂ mapping, Blood oxygenation level-dependent (BOLD), Renal blood flow (RBF), and Apparent Diffusion Coefficient (ADC) from diffusion-weighted imaging (DWI), provide insights into kidney function. However, consensus on selecting regions of interest (ROIs) is lacking. This study aims to describe and compare the Concentric Objects (CO) and Equiangular Objects (EO) methods for standardized ROI selection and assess their efficacy in capturing regional variations in renal MRI parameters.

Materials and methods: Twelve healthy volunteers underwent mpMRI renal scans. ROIs were selected manually and by applying the CO and EO algorithms to each mpMRI sequence. The methods were tested across various subregion configurations. Regional differences in renal MRI parameters were evaluated.

Results: CO and EO methods demonstrated statistically significant differences in mpMRI parameters across renal regions. ASL-RBF, BOLD-MRI, and T₂-map results indicated substantial variations from the lower to upper kidney areas.

Discussion: This study implemented CO and EO algorithms in renal mpMRI, showing their potential for evaluating cortico-medullary and cranio-caudal profiles. The findings validate the CO method for BOLD and ADC measurements and presented ASL-RBF and T₁-T₂ map profiles. The EO method's utility needs further validation with renal patients.

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在肾脏 mpMRI 中进行标准化区域分析的同心-目标和等边-目标方法。

目的：肾脏多参数磁共振成像（mpMRI）序列，包括 T1-T2 映射、血氧饱和度依赖性（BOLD）、肾脏血流（RBF）和扩散加权成像（DWI）的表观扩散系数（ADC），有助于深入了解肾脏功能。然而，在选择感兴趣区（ROI）方面还缺乏共识。本研究旨在描述和比较用于标准化 ROI 选择的同心圆对象（CO）和等值对象（EO）方法，并评估它们在捕捉肾脏 MRI 参数区域变化方面的功效：12 名健康志愿者接受了 mpMRI 肾脏扫描。在每个 mpMRI 序列中手动选择 ROI，并应用 CO 和 EO 算法。这些方法在不同的子区域配置中进行了测试。评估了肾脏 MRI 参数的区域差异：结果：CO 和 EO 方法在各肾脏区域的 mpMRI 参数中显示出显著的统计学差异。ASL-RBF、BOLD-MRI 和 T2 图谱结果表明，从肾脏下部到肾脏上部区域存在很大差异：本研究在肾脏 mpMRI 中采用了 CO 和 EO 算法，显示了它们在评估肾皮质-髓质和头颅-尾椎轮廓方面的潜力。研究结果验证了BOLD和ADC测量的CO方法，并展示了ASL-RBF和T1-T2图谱。EO 方法的实用性还需要在肾病患者身上进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.