Immunology & Cell Biology最新文献_第4页

4-1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions 4-1BB的表达和信号传导调节MAIT细胞的激活和效应功能。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-08-04 Epub Date: 2026-06-23 DOI: 10.1111/imcb.70142

Lamichhane R, Williams J, Tirand C, Fouillé R, Wedlock LE, Poudel A, Webley MC, Hannaway RF, Ussher JE

{"title":"4-1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions","authors":"Lamichhane R, Williams J, Tirand C, Fouillé R, Wedlock LE, Poudel A, Webley MC, Hannaway RF, Ussher JE","doi":"10.1111/imcb.70142","DOIUrl":"10.1111/imcb.70142","url":null,"abstract":"Mucosal associated invariant T (MAIT) cells are abundant unconventional T cells that recognize microbe-derived riboflavin metabolites presented by MR1. Upon recognition, they become activated, produce proinflammatory cytokines, chemokines, and cytotoxic molecules. MAIT cells are also activated by cytokines independently of T cell receptor (TCR) engagement; however, these two signals can also act in concert to fine-tune MAIT cell functions. Additionally, multiple other co-stimulatory signals have also been reported that can boost MAIT cell effector responses to TCR or cytokine stimulation. However, a comprehensive study exploring the role of surface-bound TNF receptor superfamily (TNFRSF) molecule 4-1BB, well known for its co-stimulatory function during conventional T cell activation, is lacking in the context of MAIT cells. In this study, we show that 4-1BB is the earliest and most highly expressed TNFRSF co-stimulatory molecule on MAIT cells upon activation by Escherichia coli, with expression seen as early as 6 h where it was predominantly MR1 mediated. 4-1BB expression on MAIT cells following late activation was due to both TCR signaling and cytokine signaling. We found marked differences in MAIT cell activation and cytokine expression between 4-1BB+ and 4-1BB- MAIT cells suggesting 4-1BB expression on MAIT cells is associated with functional superiority. By blocking 4-1BB signaling or coculturing with a 4-1BBL overexpressing cell line, we demonstrated an important role of co-stimulation via 4-1BB in MAIT cells during activation. Expression and signaling via 4-1BB also enhanced T-bet and Blimp1 expression. In summary, our study confirms a role for 4-1BB signaling during MAIT cell activation.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"104 7","pages":"686-699"},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.70142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ancestry Matters in Decoding Immunity 祖先在免疫解码中的作用

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-08-04 Epub Date: 2026-06-30 DOI: 10.1111/imcb.70143

Kesong Wu, Amanda J. Oliver, Zewen Kelvin Tuong

引用次数: 0

CD49a expression defines a metabolically robust, cytokine-biased liver NK cell subset in rhesus macaques during lentivirus infection CD49a表达定义了慢病毒感染期间恒河猴代谢稳健，细胞因子偏向的肝脏NK细胞亚群。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-08-04 Epub Date: 2026-05-27 DOI: 10.1111/imcb.70135

Andrew Hudson, Melissa Xin Yu Wong, Michael Verdolin, R Keith Reeves, Cordelia Manickam

{"title":"CD49a expression defines a metabolically robust, cytokine-biased liver NK cell subset in rhesus macaques during lentivirus infection","authors":"Andrew Hudson, Melissa Xin Yu Wong, Michael Verdolin, R Keith Reeves, Cordelia Manickam","doi":"10.1111/imcb.70135","DOIUrl":"10.1111/imcb.70135","url":null,"abstract":"Liver-resident natural killer (LrNK) cells are critical regulators of hepatic immune homeostasis and demonstrate antiviral activity, yet their role in lentivirus infections remains poorly defined. Using a rhesus macaque (RM) model of Simian immunodeficiency virus (SIV) and Simian-human immunodeficiency virus (SHIV) infections, we investigated the phenotypes, metabolic profiles and functional responses of hepatic NK cells across naïve, acutely SIV-infected and chronically SHIV-infected RM. We identified liver-resident (Lr) NK cells as CD3−CD159a/c+CD49a+, whereas CD3−CD159a/c+CD49a− NK cells include circulating NK cell subsets in the liver. Across infection states, CD49a+ LrNK cells exhibited elevated expression of activation markers, including NKG2D, NKp30, NKp46 and CD69, as well as increased expression of metabolic markers, including CD98, Glut1 and MitoTracker. In contrast, Ki-67 expression was reduced in CD49a+ LrNK cells compared with their CD49a− counterparts. Unsupervised clustering revealed that CD49a+ LrNK cells were also marked by high CD69 expression. While total NK cell cytokine secretion was elevated in acute SIV-infected animals, CD49a+ LrNK cells exhibited robust polyfunctional cytokine responses and reduced expression of the cytotoxic marker CD107a upon mitogen stimulation in comparison with CD49a− LrNK cells regardless of infection status. These findings reveal distinct metabolic and functional specialization of hepatic NK cell subsets, underscoring the unique phenotype and functions of CD49a+ LrNK cells in RM, which may offer novel insights and therapeutic opportunities for treating liver inflammation in HIV infection and other chronic liver diseases.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"104 7","pages":"656-666"},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.70135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlight of 2025: From binding prediction to molecular design—computational advances in TCR-pMHC prediction and targeting 2025年亮点：从结合预测到分子设计- TCR-pMHC预测和靶向的计算进展。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-08-04 Epub Date: 2026-06-03 DOI: 10.1111/imcb.70137

Kilian J. Maire, Jonathan M. Coquet

引用次数: 0

The Role of the IL-33/ST2 Axis in Nervous System Development and Diseases IL-33/ST2轴在神经系统发育和疾病中的作用

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-08-04 Epub Date: 2026-06-11 DOI: 10.1111/imcb.70138

Zhoutong Luo, Junhua Yang

{"title":"The Role of the IL-33/ST2 Axis in Nervous System Development and Diseases","authors":"Zhoutong Luo, Junhua Yang","doi":"10.1111/imcb.70138","DOIUrl":"10.1111/imcb.70138","url":null,"abstract":"Interleukin (IL)-33, a cytokine belonging to the IL-1 family, is produced in various tissues, including the nervous system. As a nuclear-stored alarmin protein, IL-33 is released under cell stress or damage, triggering immune responses through its receptor complex, composed of ST2L and the IL-1 receptor accessory protein (IL-1RAcP). The receptors for IL-33 are expressed in various cell types within the nervous system, including neurons, astrocytes, and microglia, and play a crucial role in neurodevelopment and the pathogenesis of neurological diseases. In neurodevelopment, IL-33 promotes microglial metabolic adaptation and phagocytosis via the IL-33/ST2/Akt axis, modulates glial function to affect neural circuit maturation, and influences oligodendrocyte differentiation. In neurological disorders, IL-33 exerts context-dependent regulatory effects in the nervous system through modulation of myeloid and T-cell responses, maintenance of barrier integrity, promotion of tissue repair, and regulation of neuroimmune homeostasis. In acute CNS injuries such as ischemic stroke and traumatic brain injury, IL-33 is generally associated with anti-inflammatory polarization and enhanced repair, although circulating levels may also reflect injury severity. In chronic neurodegenerative diseases including Alzheimer's and Parkinson's disease, IL-33 is implicated in amyloid-β clearance, remyelination, glymphatic function, and neuroprotection, while dysregulation of the IL-33/sST2 axis correlates with disease progression. In contrast, IL-33 may facilitate tumor progression in glioma. Emerging evidence also supports IL-33 and sST2 as potential biomarkers for diagnosis and prognosis in CNS disorders.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"104 7","pages":"671-681"},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.70138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving COVID-19 Vaccine Uptake Among Ethnic Minority Communities in Wales: A Community-Based Approach 提高威尔士少数民族社区COVID-19疫苗的吸收率：基于社区的方法

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-08-04 Epub Date: 2026-06-30 DOI: 10.1111/imcb.70140

Bnar Talabani, Sayma Hanif, Kasim Ramzan, Farzana Mohammed, Amara Naseem, Emaad Alauddin

{"title":"Improving COVID-19 Vaccine Uptake Among Ethnic Minority Communities in Wales: A Community-Based Approach","authors":"Bnar Talabani, Sayma Hanif, Kasim Ramzan, Farzana Mohammed, Amara Naseem, Emaad Alauddin","doi":"10.1111/imcb.70140","DOIUrl":"10.1111/imcb.70140","url":null,"abstract":"During the COVID-19 pandemic, misinformation and vaccine hesitancy disproportionately affected ethnic minority communities across the United Kingdom, including in Wales. Muslim Doctors Cymru (MDC), a grassroots coalition of Muslim healthcare professionals, played a pivotal role in countering this challenge. This paper describes the strategies and impact of MDC's work in addressing health misinformation, building trust, and promoting vaccine uptake among ethnic minority communities in Wales. Through culturally sensitive engagement, multilingual public health messaging, and close collaboration with mosques, community leaders, and local media, MDC delivered targeted outreach that bridged gaps between public health authorities and underserved populations. This case study draws on a grassroots-efforts approach to tackling vaccine inequity using community-based approaches. Findings highlight the importance of culturally competent healthcare communication and the value of community-led initiatives in improving public health outcomes during crises. MDC's model offers a replicable framework for addressing health inequalities and misinformation in diverse populations.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"104 7","pages":"700-707"},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.70140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The EBV-autoimmunity axis: mechanistic insights in SLE, MS and PSC ebv -自身免疫轴：SLE， MS和PSC的机制见解。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-07-03 Epub Date: 2026-05-05 DOI: 10.1111/imcb.70127

Seyhan Yazar, Nicholas Schwab, Nicholas S. R. Sanderson, Jennifer Massey

引用次数: 0

Decoding immunity: AI-driven insights into T-cell receptor antigen recognition and immune function 解码免疫：人工智能驱动的t细胞受体抗原识别和免疫功能的见解。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-07-03 Epub Date: 2026-05-23 DOI: 10.1111/imcb.70134

Martina Bonomi, Tom Donaldson, Fabio Luciani

引用次数: 0

Reprogramming the gut immune system: featured advances in intestinal immunity in 2025 重编程肠道免疫系统：2025年肠道免疫的主要进展。