Immunology & Cell Biology最新文献_第4页

Chemokines in neurodegenerative diseases 趋化因子在神经退行性疾病中的作用。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-12-26 DOI: 10.1111/imcb.12843

Hashemi Vida, Mehranfar Sahar, Amin Nikdouz, Hosseini Arezoo

{"title":"Chemokines in neurodegenerative diseases","authors":"Hashemi Vida, Mehranfar Sahar, Amin Nikdouz, Hosseini Arezoo","doi":"10.1111/imcb.12843","DOIUrl":"10.1111/imcb.12843","url":null,"abstract":"Neurodegeneration and neuroinflammation disorders are mainly the result of the deposition of various proteins, such as α-synuclein, amyloid-β and prions, which lead to the initiation and activation of inflammatory responses. Different chemokines are involved in the infiltration and movement of inflammatory leukocytes into the central nervous system (CNS) that express chemokine receptors. Dysregulation of several members of chemokines has been shown in the CNS, cerebrospinal fluid and peripheral blood of patients who have neurodegenerative disorders. Upon infiltration of various cells, they produce many inflammatory mediators such as cytokines. Besides them, some CNS-resident cells, such as neurons and astrocytes, are also involved in the pathogenesis of neurodegeneration by producing chemokines. In this review, we summarize the role of chemokines and their related receptors in the pathogenesis of neurodegeneration and neuroinflammation disorders, including multiple sclerosis, Parkinson's disease and Alzheimer's disease. Therapeutic strategies targeting chemokines or their related receptors are also discussed in this article.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"103 3","pages":"275-292"},"PeriodicalIF":3.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12843","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovations in Immunology Education: bridging theory, practice and professional development 免疫学教育的创新：衔接理论、实践和专业发展。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-12-23 DOI: 10.1111/imcb.12846

Samy Sakkal, Maurizio Costabile

引用次数: 0

ILC1 as critical gatekeepers in autoimmune kidney damage ILC1是自身免疫性肾损伤的关键看门人。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-12-06 DOI: 10.1111/imcb.12842

Cyril Seillet, Le Xiong

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RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration RNAi 文库筛选发现 Gβ1、酪蛋白激酶 2 和 ICAP-1 是 LFA-1 介导的 T 细胞极性和迁移的新型调控因子。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-11-28 DOI: 10.1111/imcb.12838

Antje Haap-Hoff, Michael Freeley, Eugene Dempsey, Dara Dunican, Emily Bennett, Denise Triglia, Joanna Skubis-Zegadlo, Anthony Mitchell Davies, Dermot Kelleher, Aideen Long

{"title":"RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration","authors":"Antje Haap-Hoff, Michael Freeley, Eugene Dempsey, Dara Dunican, Emily Bennett, Denise Triglia, Joanna Skubis-Zegadlo, Anthony Mitchell Davies, Dermot Kelleher, Aideen Long","doi":"10.1111/imcb.12838","DOIUrl":"10.1111/imcb.12838","url":null,"abstract":"The αLβ2 integrin LFA-1 plays a key role in T-cell adhesion to the endothelial vasculature and migration into both secondary lymphoid organs and peripheral tissues via interactions with its target protein ICAM-1, but the pathways that regulate LFA-1-mediated T-cell polarity and migration are not fully understood. In this study we screened two RNAi libraries targeting G protein-coupled receptors (GPCR)/GPCR-associated proteins and kinases in a HuT 78 T cell line model of LFA-1-stimulated T-cell migration. Based on staining of the actin cytoskeleton, multiple parameters to measure cell morphology were used to assess the contribution of 1109 genes to LFA-1-mediated T-cell polarity and migration. These RNAi screens identified a number of both novel and previously identified genes that either increased or decreased the polarity and migratory capacity of these cells. Following multiparametric analysis, hierarchical clustering and pathway analysis, three of these genes were characterized in further detail using primary human T cells, revealing novel roles for the heterotrimeric G protein subunit Gβ1 and Casein Kinase 2 in LFA-1-mediated T-cell polarity and migration in vitro. Our studies also highlighted a new role for ICAP-1, an adaptor protein previously described to be associated with β1 integrins, in β2 integrin LFA-1-directed migration in T cells. Knockdown of ICAP-1 expression in primary T cells revealed a role in cell polarity, cell velocity and transmigration towards SDF-1 for this adaptor protein. This study therefore uncovers new roles for GPCR/GPCR-associated proteins and kinases in T-cell migration and provides potential novel targets for modulation of the T-cell immune response.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"103 1","pages":"73-92"},"PeriodicalIF":3.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antigen presentation of post-translationally modified peptides in major histocompatibility complexes 翻译后修饰肽在主要组织相容性复合体中的抗原呈递。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-11-28 DOI: 10.1111/imcb.12839

Alexine S de Wit, Frans Bianchi, Geert van den Bogaart

{"title":"Antigen presentation of post-translationally modified peptides in major histocompatibility complexes","authors":"Alexine S de Wit, Frans Bianchi, Geert van den Bogaart","doi":"10.1111/imcb.12839","DOIUrl":"10.1111/imcb.12839","url":null,"abstract":"T cells of the adaptive immune system recognize pathogens and malignantly transformed cells through a process called antigen presentation. During this process, peptides are displayed on major histocompatibility complex (MHC) class I and II molecules. Self-reactive T cells are typically removed or suppressed during T-cell development and through peripheral tolerance mechanisms, ensuring that only T cells recognizing peptides that are either absent or present in low abundance under normal conditions remain. This selective process allows T cells to respond to peptides derived from foreign proteins while ignoring those from self-proteins. However, T cells can also respond to peptides derived from proteins that have undergone post-translational modifications (PTMs). Over 200 different PTMs have been described, and while they are essential for protein function, localization and stability, their dysregulation is often associated with disease conditions. PTMs can affect the proteolytic processing of proteins and prevent MHC binding, thereby changing the repertoire of peptides presented on MHC molecules. However, it is also increasingly evident that many peptides presented on MHC molecules carry PTMs, which can alter their immunogenicity. As a result, the presentation of post-translationally modified peptides by MHC molecules plays a significant role in various diseases, as well as autoimmune disorders and allergies. This review will provide an overview of the impact of PTMs on antigen presentation and their implications for immune recognition and disease.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"103 2","pages":"161-177"},"PeriodicalIF":3.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anyone can cook, but only the fearless can be a great chef 人人都会烹饪，但只有无所畏惧的人才能成为大厨。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-11-28 DOI: 10.1111/imcb.12841

Eduardo J Villablanca

引用次数: 0

The future of scientific labs: how we are making our research more sustainable 科学实验室的未来：我们如何使我们的研究更具可持续性。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-11-27 DOI: 10.1111/imcb.12840

Ebony A Monson, Stephanie Rutter, Christopher C Reimann, Andrea Bueno-Pedraz, Caitlin Vella, Xavier G Pearce, Jennifer L Wood, Kerry V Fanson

引用次数: 0

Prenatal Skin Cell Atlas reveals macrophages’ role beyond immunity 产前皮肤细胞图谱揭示了巨噬细胞在免疫之外的作用。