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Highlight of 2023: Tregs in the lungs 2023 年亮点：肺中的集落细胞
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-05-02 DOI: 10.1111/imcb.12771
Ntombizodwa Makuyana, Adrian Liston
{"title":"Highlight of 2023: Tregs in the lungs","authors":"Ntombizodwa Makuyana,&nbsp;Adrian Liston","doi":"10.1111/imcb.12771","DOIUrl":"10.1111/imcb.12771","url":null,"abstract":"<p>In this article for the Highlights of the 2023 Series, we discuss recent discoveries on regulatory T cells in the lungs and their multifaceted roles in various contexts. Key advancements in Treg immunology have broadened our understanding of lung tissue homeostasis and the potential role of Tregs in pathological processes.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"422-424"},"PeriodicalIF":3.2,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12771","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlight of 2023: Unlocking the therapeutic potential of natural killer cells—advances in adaptive functions, cellular engineering and immunotherapy 2023 年的亮点：挖掘自然杀伤细胞的治疗潜力--适应性功能、细胞工程和免疫疗法方面的进展。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-05-02 DOI: 10.1111/imcb.12769
Pui Yeng Lam, Fernando Souza-Fonseca-Guimaraes
{"title":"Highlight of 2023: Unlocking the therapeutic potential of natural killer cells—advances in adaptive functions, cellular engineering and immunotherapy","authors":"Pui Yeng Lam,&nbsp;Fernando Souza-Fonseca-Guimaraes","doi":"10.1111/imcb.12769","DOIUrl":"10.1111/imcb.12769","url":null,"abstract":"<p>Natural killer (NK) cells possess potent cytotoxicity against infected and cancerous cells and hold promise in the development of new immunotherapies. This article for the Highlights of 2023 Series focuses on current advances in NK cell biology in cancerous and infectious settings and highlights opportunities for therapeutic interventions, including engineered NK cell therapies and advancements in feeder cell technologies.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"444-447"},"PeriodicalIF":3.2,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12769","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlight of 2023: CAR T cells driving precision therapy for autoimmune disease 2023 年亮点：CAR T 细胞推动自身免疫性疾病的精准治疗
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-05-01 DOI: 10.1111/imcb.12766
Adrian YS Lee, Joanne H Reed
{"title":"Highlight of 2023: CAR T cells driving precision therapy for autoimmune disease","authors":"Adrian YS Lee,&nbsp;Joanne H Reed","doi":"10.1111/imcb.12766","DOIUrl":"10.1111/imcb.12766","url":null,"abstract":"<p>CAR T cell therapy is showing remarkable results in autoimmune disease with treatment-refractory patients showing durable drug-free remission. Here, we highlight five key papers from 2023 that are driving the development of CAR T cells to improve precision, safety, efficacy and accessibility for the treatment of autoantibody-associated autoimmune diseases.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"437-440"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12766","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140846727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Constitutive Flt3 signaling impacts conventional dendritic cell function 连续的 Flt3 信号影响树突状细胞的常规功能。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-05-01 DOI: 10.1111/imcb.12757
Kayla R Wilson, Christophe Macri, Jose A Villadangos, Justine D Mintern
{"title":"Constitutive Flt3 signaling impacts conventional dendritic cell function","authors":"Kayla R Wilson,&nbsp;Christophe Macri,&nbsp;Jose A Villadangos,&nbsp;Justine D Mintern","doi":"10.1111/imcb.12757","DOIUrl":"10.1111/imcb.12757","url":null,"abstract":"<p>The development of dendritic cells (DCs) depends on signaling via the FMS-like tyrosine kinase 3 (Flt3) receptor. How Flt3 signaling impacts terminally differentiated DC function is unknown. This is important given the increasing interest in exploiting Flt3 for vaccination and tumor immunotherapy. Here, we examined DCs in mice harboring constitutively activated Flt3 (Flt3-ITD). Flt3<sup>ITD/ITD</sup> mice possessed expanded splenic DC subsets including plasmacytoid DC, conventional DC (cDC)1, cDC2, double positive (DP) cDC1 (CD11c<sup>+</sup> CD8<sup>+</sup> CD11b<sup>−</sup> CD103<sup>+</sup> CD86<sup>+</sup>), noncanonical (NC) cDC1 (CD11c<sup>+</sup> CD8<sup>+</sup> CD11b<sup>−</sup> CD103<sup>−</sup> CD86<sup>−</sup>) and single positive (SP) cDC1 (CD11c<sup>+</sup> CD8<sup>+</sup> CD11b<sup>−</sup> CD103<sup>−</sup> CD86<sup>+</sup>). Outcomes of constitutive Flt3 signaling differed depending on the cDC subset examined. In comparison with wild type (WT) DCs, all Flt3<sup>ITD/ITD</sup> cDCs displayed an altered surface phenotype with changes in costimulatory molecules, major histocompatibility complex class I (MHC I) and II (MHC II). Cytokine secretion patterns, antigen uptake, antigen proteolysis and antigen presenting function differed between WT and Flt3<sup>ITD/ITD</sup> subsets, particularly cDC2. In summary, Flt3 signaling impacts the function of terminally differentiated cDCs with important consequences for antigen presentation.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"500-512"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlight of 2023: Unconventional T cells: recent insights on development, trafficking and target cell recognition 2023 年亮点：非常规 T 细胞：关于发育、贩运和靶细胞识别的最新见解。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-05-01 DOI: 10.1111/imcb.12767
Sarah Pasquin
{"title":"Highlight of 2023: Unconventional T cells: recent insights on development, trafficking and target cell recognition","authors":"Sarah Pasquin","doi":"10.1111/imcb.12767","DOIUrl":"10.1111/imcb.12767","url":null,"abstract":"<p>In this article for the Highlights of 2023 Series, we discuss recent research on unconventional T cells with a focus on gamma delta T cell development and cancer cell targeting, as well as the contributions of MAIT cells to wound repair.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"429-431"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12767","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Art, science and inclusion: multisensory Sciart of immunology for blind, low-vision and diverse-needs audiences 艺术、科学与包容：为盲人、低视力和有不同需求的受众提供免疫学的多感官 Sciart。
IF 4 4区 医学
Immunology & Cell Biology Pub Date : 2024-05-01 DOI: 10.1111/imcb.12759
Erica Tandori, Stuart Favilla
{"title":"Art, science and inclusion: multisensory Sciart of immunology for blind, low-vision and diverse-needs audiences","authors":"Erica Tandori,&nbsp;Stuart Favilla","doi":"10.1111/imcb.12759","DOIUrl":"10.1111/imcb.12759","url":null,"abstract":"<p>Art is a powerful tool for conveying scientific discovery. Despite the perceived gap between art and science, as highlighted by CP Snow and others, examples of art communicating science can be found in the ancient world, the Renaissance and contemporary data visualization, demonstrating an enduring and historic connection. However, much of science relies on visual elements, excluding those with blindness, low vision and diverse needs, resulting in their low representation in STEM discourse. This paper introduces a novel science and art collaboration in the form of an exhibition program exploring the concepts of Immunology and Biomedicine to blind and vision-impaired audiences, capitalizing on the lived experience of a legally blind artist. Employing multisensory design, art and co-creation methodologies, it transcends traditional vision-based science communication, showcasing the potential for multisensory art to bridge the gap at the intersection of science and inclusion.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 5","pages":"315-320"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12759","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140846940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlight of 2023: From fundamental studies to clinical trials, the importance of NK cells against cancer 2023 年的亮点：从基础研究到临床试验，NK 细胞对抗癌的重要性。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-04-26 DOI: 10.1111/imcb.12763
Capucine Bourel, Sylvie Lesage
{"title":"Highlight of 2023: From fundamental studies to clinical trials, the importance of NK cells against cancer","authors":"Capucine Bourel,&nbsp;Sylvie Lesage","doi":"10.1111/imcb.12763","DOIUrl":"10.1111/imcb.12763","url":null,"abstract":"<p>In this article for the Highlights of 2023 Series, we discuss how various factors affect the ability of natural killer (NK) cells to fight tumors. For instance, tumor cells can hinder NK cell function by reducing surface protrusions or increasing HLA-E expression via platelets. Lower UTX protein levels in male NK cells also decrease their cytotoxicity compared with females. Fortunately, recent advancements in therapeutic approaches have emerged, including the development of a comprehensive atlas of NK cell heterogeneity within the tumor microenvironment, as well as a trispecific engager molecule that has shown promise in enhancing the anti-tumor functions of NK cells.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"441-443"},"PeriodicalIF":3.2,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12763","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140846516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional and biological implications of clonotypic diversity among human donor-unrestricted T cells 人类供体无限制 T 细胞克隆型多样性的功能和生物学意义。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-04-24 DOI: 10.1111/imcb.12751
Megan D Maerz, Deborah L Cross, Chetan Seshadri
{"title":"Functional and biological implications of clonotypic diversity among human donor-unrestricted T cells","authors":"Megan D Maerz,&nbsp;Deborah L Cross,&nbsp;Chetan Seshadri","doi":"10.1111/imcb.12751","DOIUrl":"10.1111/imcb.12751","url":null,"abstract":"<p>T cells express a T-cell receptor (TCR) heterodimer that is the product of germline rearrangement and junctional editing resulting in immense clonotypic diversity. The generation of diverse TCR repertoires enables the recognition of pathogen-derived peptide antigens presented by polymorphic major histocompatibility complex (MHC) molecules. However, T cells also recognize nonpeptide antigens through nearly monomorphic antigen-presenting systems, such as cluster of differentiation 1 (CD1), MHC-related protein 1 (MR1) and butyrophilins (BTNs). This potential for shared immune responses across genetically diverse populations led to their designation as donor-unrestricted T cells (DURTs). As might be expected, some CD1-, MR1- and BTN-restricted T cells express a TCR that is conserved across unrelated individuals. However, several recent studies have reported unexpected diversity among DURT TCRs, and increasing evidence suggests that this diversity has functional consequences. Recent reports also challenge the dogma that immune cells are either innate or adaptive and suggest that DURT TCRs may act in both capacities. Here, we review this evidence and propose an expanded view of the role for clonotypic diversity among DURTs in humans, including new perspectives on how DURT TCRs may integrate their adaptive and innate immune functions.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"474-486"},"PeriodicalIF":3.2,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12751","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlight of 2023: Virtues and vices of CD4 CAR T cells 2023 年的亮点：CD4 CAR T 细胞的优点和缺点。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-04-24 DOI: 10.1111/imcb.12764
Shivali Savita Chinni, Megan F Taylor, Jessica G Borger, Kylie M Quinn
{"title":"Highlight of 2023: Virtues and vices of CD4 CAR T cells","authors":"Shivali Savita Chinni,&nbsp;Megan F Taylor,&nbsp;Jessica G Borger,&nbsp;Kylie M Quinn","doi":"10.1111/imcb.12764","DOIUrl":"10.1111/imcb.12764","url":null,"abstract":"<p>This article for the Highlights of 2023 Series explores recent work that suggests that targeting CD4 CAR T cells may be critical for both of these challenges.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"432-436"},"PeriodicalIF":3.2,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlight of 2023: Microglia biology 2023 年亮点：小胶质细胞生物学
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-04-23 DOI: 10.1111/imcb.12754
Amy Dashwood, Adrian Liston
{"title":"Highlight of 2023: Microglia biology","authors":"Amy Dashwood,&nbsp;Adrian Liston","doi":"10.1111/imcb.12754","DOIUrl":"10.1111/imcb.12754","url":null,"abstract":"<p>The field of neuroimmunology is quickly expanding and, as the primary immune cell of the brain, microglia are truly in the spotlight. In 2023, the number of microglia related articles published on PubMed rose to 5152. This number has consistently increased year on year and has more than doubled since 2013, as we begin to appreciate the role of microglia in brain development, health and disease. The year 2023 continued to bring new important discoveries, extending our knowledge of microglia biology. This image was created in BioRender.com.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"456-459"},"PeriodicalIF":3.2,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140671085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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