Immunology & Cell Biology最新文献_第10页

Not an immune cell, but they may act like one—cells with immune properties outside the immune system 不是免疫细胞，但它们可能像免疫细胞--在免疫系统外具有免疫特性的细胞。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-04-22 DOI: 10.1111/imcb.12752

Marlena Typiak, Dorota Żurawa-Janicka

{"title":"Not an immune cell, but they may act like one—cells with immune properties outside the immune system","authors":"Marlena Typiak, Dorota Żurawa-Janicka","doi":"10.1111/imcb.12752","DOIUrl":"10.1111/imcb.12752","url":null,"abstract":"The cells presented in this work are not classified as cells that make up the immune system. They, however, present functions and molecules, which are characteristic of immune cells. These characteristic functions are, for example, sensing threat, performing phagocytosis, presentation of foreign antigens, cytokine release or enhancing immune memory. The enlisted immune response mechanisms are carried out by the possession of molecules such as Toll-like receptors, receptors for the Fc fragment of IgG, major histocompatibility complex class II molecules, costimulatory CD80/CD86 proteins and molecules needed for NLRP3 (NOD-like family pyrin domain containing 3) inflammasome activation. Thanks to these properties, the described nonimmune cells play an important role in the local immune response and support of the entire body in the fight against pathogens. They constitute the first line of defense of tissues and organs against pathogens and molecules recognized as harmful. The cells described in this article are particularly important in immunologically privileged places (e.g. the Bowman's capsule in the kidney), where “typical” immune cells normally do not have access. In this paper, we present immune-like functions and molecule suites of resident kidney cells (podocytes and mesangial cells), cochlear resident cells, fibrocytes and fibroblasts, as well as some stem cells (mesenchymal stem cells and umbilical cord Wharton's jelly–derived cells).","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"487-499"},"PeriodicalIF":3.2,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12752","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlight of 2023: Thymic B cells—important players in the establishment of T-cell tolerance 2023 年亮点：胸腺 B 细胞--建立 T 细胞耐受性的重要参与者

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-04-22 DOI: 10.1111/imcb.12761

Félix Lombard-Vadnais, Sylvie Lesage

引用次数: 0

Mimicking the cellular environment does not cause monocyte-derived macrophages to become phenotypically similar to Kupffer cells 模拟细胞环境并不会使单核细胞衍生的巨噬细胞在表型上与 Kupffer 细胞相似。

IF 4 4区医学

Immunology & Cell Biology Pub Date : 2024-04-17 DOI: 10.1111/imcb.12746

Andrey Elchaninov, Polina Vishnyakova, Maria Kuznetsova, Anastasiya Lokhonina, Anna Soboleva, Dmitry Trofimov, Timur Fatkhudinov, Gennady Sukhikh

{"title":"Mimicking the cellular environment does not cause monocyte-derived macrophages to become phenotypically similar to Kupffer cells","authors":"Andrey Elchaninov, Polina Vishnyakova, Maria Kuznetsova, Anastasiya Lokhonina, Anna Soboleva, Dmitry Trofimov, Timur Fatkhudinov, Gennady Sukhikh","doi":"10.1111/imcb.12746","DOIUrl":"10.1111/imcb.12746","url":null,"abstract":"Resident macrophages of various mammalian organs are characterized by several distinctive features in their gene expression profile and phenotype, including involvement in the regulation of organ functions, as well as reduced sensitivity to proinflammatory activation factors. The reasons for the formation of such a specific phenotype remain the subject of intensive research. Some papers emphasize the role of the origin of organ macrophages. Other studies indicate that monocytes that develop in the red bone marrow are also able to form resident macrophages with a phenotype characteristic of a particular organ, but this requires appropriate microenvironmental conditions. In this article, we studied the possibility of differentiation of monocyte-derived macrophages into cells with a Kupffer-like phenotype under the influence of the main stromal components of Kupffer cells macrophage niche: Ito cells, liver sinusoid endotheliocytes and hepatocyte growth factor (HGF). It was found that Kupffer cells are characterized by several features, including increased expression of transcription factors Spic and Id3, as well as MUP family genes, Clusterin and Ngp genes. In addition, Kupffer cells were characterized by a higher proliferative activity. The expression of marker genes of Kupffer cells (i.e. Id3, Spic, Marco and Timd4) increased in monocyte-derived macrophages during coculture with Ito cells, liver sinusoid endothelial cells, macrophage colony–stimulating factor and HGF cells only by 3 days. However, the expression level of these genes was always higher in Kupffer cells. In addition, a complete coincidence of the expressed gene profile in monocyte-derived macrophages and Kupffer cells did not occur even after 3 days of culturing.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 5","pages":"381-395"},"PeriodicalIF":4.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlight of 2023: The metabolic symphony – orchestrating T-cell immunity 2023 年亮点：新陈代谢交响乐--协调 T 细胞免疫。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-04-17 DOI: 10.1111/imcb.12750

Lee M Booty

引用次数: 0

Highlight of 2023: big impacts of microRNAs in T cells 2023 年亮点：T 细胞中 microRNA 的巨大影响

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-04-16 DOI: 10.1111/imcb.12753

Yangnan Zhang, Mark MW Chong

引用次数: 0

Unlocking adult T-cell leukemia/lymphoma's epigenetic secrets: delving into the mechanism and impact of EZH1/2 inhibition 揭开成人 T 细胞白血病/淋巴瘤的表观遗传学秘密：探究 EZH1/2 抑制的机制和影响

IF 4 4区医学

Immunology & Cell Biology Pub Date : 2024-04-12 DOI: 10.1111/imcb.12748

Paniz Tavakoli Shirazi, Megan J Bywater

{"title":"Unlocking adult T-cell leukemia/lymphoma's epigenetic secrets: delving into the mechanism and impact of EZH1/2 inhibition","authors":"Paniz Tavakoli Shirazi, Megan J Bywater","doi":"10.1111/imcb.12748","DOIUrl":"10.1111/imcb.12748","url":null,"abstract":"Epigenetic modifications, particularly through methylation of DNA packaging histones, play a pivotal role in controlling gene expression. Aberrant patterns of histone methylation have been associated with the development and progression of hematological malignancies. Unraveling the impact of aberrant histone marks on gene expression and leukemogenesis has spurred a concerted effort to develop clinically effective epigenetic therapies. In malignancies associated with the accumulation of histone H3 lysine trimethylation (H3K27me3), one such intervention involves preventing the deposition of this repressive histone mark by inhibiting the histone-modifying enzymes EZH1 and EZH2. While inhibition of EZH1/2 has demonstrated efficacy in both preclinical studies and clinical trials in various cancers, studies delineating the dynamic effect of EZH1/2 inhibition on H3K27me3 and disease relapse in clinical samples are lacking. In a recent publication, Yamagishi et al. explore how responses of a patient with adult T-cell leukemia/lymphoma to valemetostat, an EZH1/2 inhibitor, are associated with changes in H3K27me3, chromatin accessibility and gene expression, and how these changes can be circumvented in relapsed disease.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 5","pages":"298-301"},"PeriodicalIF":4.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12748","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing a mentoring program to support the next generation of immunologists 制定指导计划，为下一代免疫学家提供支持

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-04-12 DOI: 10.1111/imcb.12747

Alexandra R Dvorscek

{"title":"Developing a mentoring program to support the next generation of immunologists","authors":"Alexandra R Dvorscek","doi":"10.1111/imcb.12747","DOIUrl":"10.1111/imcb.12747","url":null,"abstract":"Mentorship refers to the guidance given by a mentor to a less experienced individual to enhance their professional and personal development. For graduate research students, seeking independent mentors external to their institution offers the rewarding opportunity to obtain objective guidance on a variety of work, study and life matters. This article outlines the steps taken to develop a professional society-based, international mentoring program of over 70 participants. This 6-month program aimed to connect graduate research students with more senior academic scientists in response to the limited networking opportunities imposed by the coronavirus disease 2019 (COVID-19) pandemic in Australia. Outlined here are the resources used to maximize the potential of this successful program, which include (1) an ‘Introduction to Mentoring’ workshop, (2) the use of a mentoring software or communication strategy to maintain program momentum and (3) the integration of in-person networking events. Overall, the program was a great success, with a high satisfaction rating (8.7/10) and a large number of participants reported that they would maintain their mentoring relationship. All participants stated that they would recommend the program to a peer, and thus reiterations of the program would likely be similarly well-received and beneficial to the Australasian immunology community.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"467-473"},"PeriodicalIF":3.2,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility of using a combination of staphylococcal superantigen-like proteins 3, 7 and 11 in a fusion vaccine for Staphylococcus aureus 在金黄色葡萄球菌融合疫苗中使用葡萄球菌超抗原样蛋白 3、7 和 11 组合的可行性

IF 4 4区医学

Immunology & Cell Biology Pub Date : 2024-04-04 DOI: 10.1111/imcb.12745

Janlin Ying Hui Chan, Fiona Clow, Victoria Pearson, Ries J Langley, John D Fraser, Fiona J Radcliff

{"title":"Feasibility of using a combination of staphylococcal superantigen-like proteins 3, 7 and 11 in a fusion vaccine for Staphylococcus aureus","authors":"Janlin Ying Hui Chan, Fiona Clow, Victoria Pearson, Ries J Langley, John D Fraser, Fiona J Radcliff","doi":"10.1111/imcb.12745","DOIUrl":"10.1111/imcb.12745","url":null,"abstract":"Staphylococcus aureus is a significant bacterial pathogen in both community and hospital settings, and the escalation of antimicrobial-resistant strains is of immense global concern. Vaccination is an inviting long-term strategy to curb staphylococcal disease, but identification of an effective vaccine has proved to be challenging. Three well-characterized, ubiquitous, secreted immune evasion factors from the staphylococcal superantigen-like (SSL) protein family were selected for the development of a vaccine. Wild-type SSL3, 7 and 11, which inhibit signaling through Toll-like receptor 2, cleavage of complement component 5 and neutrophil function, respectively, were successfully combined into a stable, active fusion protein (PolySSL7311). Vaccination of mice with an attenuated form of the PolySSL7311 protein stimulated significantly elevated specific immunoglobulin G and splenocyte proliferation responses to each component relative to adjuvant-only controls. Vaccination with PolySSL7311, but not a mixture of the individual proteins, led to a > 102 reduction in S. aureus tissue burden compared with controls after peritoneal challenge. Comparable antibody responses were elicited after coadministration of the vaccine in either AddaVax (an analog of MF59) or an Alum-based adjuvant; but only AddaVax conferred a significant reduction in bacterial load, aligning with other studies that suggest both cellular and humoral immune responses are necessary for protective immunity to S. aureus. Anti-sera from mice immunized with PolySSL7311, but not individual proteins, partially neutralized the functional activities of SSL7. This study confirms the importance of these SSLs for the survival of S. aureus in vivo and suggests that PolySSL7311 is a promising vaccine candidate.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 5","pages":"365-380"},"PeriodicalIF":4.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12745","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ABCs begin with ZEB2 ABC 以 ZEB2 开始。

IF 4 4区医学

Immunology & Cell Biology Pub Date : 2024-03-25 DOI: 10.1111/imcb.12744

James J Knox, Michael P Cancro

引用次数: 0

It feels like lupus: accessible science for the low-vision community on immune system dysfunction in lupus 感觉就像狼疮：低视力群体可获得的关于狼疮免疫系统功能障碍的科学知识。

IF 4 4区医学

Immunology & Cell Biology Pub Date : 2024-03-18 DOI: 10.1111/imcb.12743

Taylah Jane Bennett

{"title":"It feels like lupus: accessible science for the low-vision community on immune system dysfunction in lupus","authors":"Taylah Jane Bennett","doi":"10.1111/imcb.12743","DOIUrl":"10.1111/imcb.12743","url":null,"abstract":"Science communication is often confined to spoken, written or graphical form, neglecting the integration of other tools that would open inclusive scientific dialog to the low-vision community. To address this barrier, members from the Monash Rheumatology clinical and laboratory research groups formed a Lupus Sensory Science team to create a breakout room at the 2023 Monash Sensory Science Exhibit on Autoimmunity. Our goal was to develop multimodal displays and artworks to engage participants with blindness and low vision with the immunological underpinnings of systemic lupus erythematosus (SLE). Here I describe how we created several stations using a combination of tactile posters and models to communicate disease manifestations and immune system dysregulation in SLE. I reflect on how participants keenly engaged with our artworks, asking thoughtful questions that stimulated interesting discussions about treatment options in SLE. In addition, I analyze how our exhibit could be improved to further increase accessibility for the low-vision community. Overall, we learned a lot about how to be inclusive in scientific communication methods and we will strive to continue to engage all members of our community in scientific discussion.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 5","pages":"347-352"},"PeriodicalIF":4.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12743","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140142376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0