Immunology & Cell Biology最新文献

{"title":"Causal relationship between immune cells, metabolites and polycystic ovary syndrome identified by Mendelian randomization and mediation analyses.","authors":"Lan Li, Yang Mo, Ximing Yu, Bing He, Yue Dai, Longlong Fan, Sijie Yang, Huiping Liu","doi":"10.1111/imcb.70016","DOIUrl":"https://doi.org/10.1111/imcb.70016","url":null,"abstract":"<p><p>Immune cells and blood metabolites play essential roles in the development of polycystic ovary syndrome (PCOS); however, it remains unclear whether blood metabolites mediate the causal relationship between immune cells and PCOS. This study aimed to delineate the causal relationships among immune cells, PCOS and potential blood metabolites through Mendelian randomization (MR). A two-sample MR analysis was conducted using inverse variance weighting as the primary method to determine the causation between immune cells and PCOS risk. This was supplemented by a two-step MR analysis to assess the mediating role of blood metabolites between immune cells and PCOS. In addition, a series of sensitivity analysis methods were employed to test the robustness of the results. We also performed a reverse MR to evaluate the possibility of reverse causal relationships. Our findings identified 22 immune cell phenotypes causally linked to PCOS, with 12 acting as risk factors and 10 as protective factors for PCOS. Furthermore, 45 blood metabolites or ratios were causally related to PCOS. Mediation analysis revealed that X-25519 levels mediated 9.2% of the causal relationship between the absolute count of CD28^-CD25⁺⁺ CD8^br and PCOS. In addition, N-acetylglucosamine/n-acetylgalactosamine levels and adenosine 5'-monophosphate levels mediated 6.7% and -11.1%, respectively, in the causation between naive DN(CD4^- CD8^-) %T cell and PCOS. The aspartate-to-citrate ratio mediated 8.6% of the causal relationship between CD20^- CD38^- %B cells and PCOS. Finally, reverse MR studies did not identify any reverse causation between the 22 immune cell phenotypes and PCOS. This study elucidates the causal links between immune cells and PCOS, highlighting the potential roles of four blood metabolites in mediating the interaction between immune cells and PCOS, thus providing new targets for research and therapeutic interventions.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmodium falciparum and immune phagocytosis: characterization of the process.","authors":"Dia Aldeen Alfaki, Mohamed Mubarak Elbasheir","doi":"10.1111/imcb.70015","DOIUrl":"https://doi.org/10.1111/imcb.70015","url":null,"abstract":"<p><p>Phagocytosis is a critical immunological process that enables the immune system to recognize and eliminate foreign pathogens and self-derived pathogenic molecules. Improving the overall understanding of this immune mechanism during malarial infection is imperative. The mechanisms by which phagocytosis eradicates malaria parasites, particularly Plasmodium falciparum, remain incompletely understood and warrant further investigation. In this context, previous studies have shown that various factors such as phagocyte cell subclasses, plasma protein molecules and Plasmodium evasion tactics influence the phagocytic process differently. However, the mechanisms underlying phagocytic activity during P. falciparum infections are still ambiguous. In this review, we summarize key immunological aspects and current knowledge of phagocytic activity during P. falciparum infection. We highlight the significant involvement of distinct active cells that induce phagocytosis. Additionally, we discuss the implications of phagocytosis and potential therapeutic approaches to enhance its effectiveness.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights of 2024. Broadening anti-cancer immunotherapy modalities with antibody-drug conjugates: emerging insights from clinical studies.","authors":"Jiya Jose, John D Hooper, Fernando Souza-Fonseca-Guimaraes","doi":"10.1111/imcb.70017","DOIUrl":"https://doi.org/10.1111/imcb.70017","url":null,"abstract":"<p><p>In this article for the \"Highlights of 2024\" series, we discuss antibody-drug conjugates (ADCs), which are an emerging class of targeted cancer therapies that harness the specificity of monoclonal antibodies to deliver cytotoxic agents directly to tumor cells. ADCs bind to tumor-associated antigens, undergo internalization via receptor-mediated endocytosis, and release their cytotoxic payload intracellularly, reducing systemic toxicity. This highly selective mechanism has led to significant advancements in oncology, improving treatment efficacy while minimizing adverse effects.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights of 2024: γδ T cells and bad blood.","authors":"Matthias Eberl","doi":"10.1111/imcb.70012","DOIUrl":"https://doi.org/10.1111/imcb.70012","url":null,"abstract":"<p><p>In this manuscript for the \"Highlights of 2024\" series, this is me trying to summarize recent discoveries regarding the emerging regulatory and effector roles of γδ T cells during sepsis, both in human patients and in mouse models. The new findings not only aid our understanding of key immunological and pathophysiological pathways that hit differently during the course of the disease but may also have clinical relevance for a life-threatening condition that requires swift intervention and tailored patient management.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing equity and inclusion in healthcare and STEMM: an immunological call to action","authors":"Jessica G Borger","doi":"10.1111/imcb.70009","DOIUrl":"https://doi.org/10.1111/imcb.70009","url":null,"abstract":"<p>Scientists and researchers represent a broad diversity of genders, races, and abilities, emphasising the importance of intersectionality in healthcare and STEMM. However, with diversity come systemic barriers that must be addressed to achieve equity and inclusion. Overcoming these challenges is essential to enrich scientific discovery and drive medical progress. This Special Feature of <i>Immunology &amp; Cell Biology</i> on “Advancing Equity and Inclusion in Healthcare: an immunological call to action” highlights key barriers to the entry and retention of underrepresented minorities in healthcare and STEMM. We also examine the individual, institutional and systemic changes needed to ensure that intersectionality fuels innovation and that solutions are as dynamic and inclusive as the challenges they seek to address.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"103 3","pages":"228-233"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights of 2024: Cytokines and ligands modulating NK cell effector functions.","authors":"Aneena Mary Shajan, Louisa Alim, Fernando Souza-Fonseca-Guimaraes","doi":"10.1111/imcb.70014","DOIUrl":"https://doi.org/10.1111/imcb.70014","url":null,"abstract":"<p><p>In this article for the \"Highlights of 2024\" Series, we discuss natural killer cells, which are essential players in immune defense, with their function tightly regulated by cytokines and ligand-receptor interactions. We discuss important recent findings that have uncovered critical regulatory pathways shaping NK cell activity.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining success: a scientist's transition from researcher to research advisor.","authors":"Amy L Wilson","doi":"10.1111/imcb.70013","DOIUrl":"https://doi.org/10.1111/imcb.70013","url":null,"abstract":"<p><p>I never imagined my career would take me beyond the laboratory bench. As a postdoctoral researcher at the Hudson Institute of Medical Research, I was deeply invested in understanding the mechanisms behind ovarian cancer progression, driven by curiosity and the hope that my work might one day improve outcomes for patients. But science isn't just about discovery-it's also about impact. And somewhere along the way, I realized that my passion extended beyond experiments and data-I wanted to help shape the research landscape itself. That realisation led me to my current role as a Research Advisor for the Ovarian Cancer Research Foundation (OCRF), where I now work to bridge the gap between research and funding, ensuring that the needs of those with a lived experience of ovarian cancer align with the research. The transition from academic research to the not-for-profit sector wasn't without its challenges. I had to navigate uncertainty, redefine my professional identity and learn to recognise the value of my transferable skills-critical thinking, science communication and strategic planning. This journey has reinforced what I haven't always realized: science isn't confined to the laboratory. It's in the conversations we have, the policies we influence and the way we shape the future of research. My career continues to evolve, and while I don't know exactly what the future holds, one thing remains certain: I am committed to making a difference, in whatever form that takes.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The macrophage galactose-type C-type lectin 1 receptor plays a major role in mediating colitis-associated colorectal cancer malignancy.","authors":"Oscar Nieto-Yañez, Sonia H Navia, Imelda Juárez-Avelar, Tonathiu Rodríguez, Antonio Andrade-Meza, Betsaida J Ortiz-Sánchez, Mónica G Mendoza-Rodríguez, Jonadab E Olguín, José L Reyes, Daniel Montes de Oca-Samperio, Citlaltepetl Salinas Lara, Luis I Terrazas, Miriam Rodriguez-Sosa","doi":"10.1111/imcb.70011","DOIUrl":"https://doi.org/10.1111/imcb.70011","url":null,"abstract":"<p><p>Cancer-associated aberrant glycosylation can be detected by the macrophage galactose-type C-type lectin (MGL) receptor; however, whether this interaction enhances or deadens cancer development along with the associated immune response has not been well established. To determine the role of mouse MGL1 in colitis-associated colon cancer (CAC), azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced tumor development was compared between Mgl1 knockout (Mgl1^-/-) mice and their wild-type (WT) littermates. At 75 days post-CAC induction, colon tumor tissue contained more highly glycosylated proteins, representing potential ligands for the mMGL1 receptor, than did healthy colon tissue. The Mgl1^-/- CAC mice scored lower in disease activity indices and had fewer colonic tumors. In addition, the colonic crypt architecture was less damaged, and mucin production was more significant than in the WT CAC mice. Furthermore, Mgl1^-/- CAC mice displayed higher percentages of CD4⁺ and CD8⁺ T cells in the peripheral blood, and colonic lamina propria; and lower percentages of myeloid-derived suppressor cells (MDSCs). Additionally, less macrophage (Mφ) and natural killer (NK) cell infiltration and lower levels of iNOS and arginase were found in the tumor microenvironment of Mgl1^-/- CAC mice compared with WT mice. These results suggest that the mMGL1 receptor may recognize aberrant glycosylation in colon cancer, which may trigger an inflammatory microenvironment and favor colon tumorigenesis.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From science to sensory art: an inclusive pedagogical tool for the UK blind, low-vision and diverse-needs community to increase cervical cancer awareness.","authors":"Jhagavan Arunthavalingam, Caroline Walker, Arman Ghodsinia, Konstanze Schichl, Stuart Favilla, Erica Tandori, Adrian Liston","doi":"10.1111/imcb.70010","DOIUrl":"https://doi.org/10.1111/imcb.70010","url":null,"abstract":"<p><p>Effective scientific communication fosters public support and trust in research, establishing a stronger understanding of health and disease. Making STEM education more accessible is crucial for blind, low-vision and diverse-needs (BLVDN) communities, where grasping complex biomedical concepts can be challenging. Such accessibility promotes equal opportunities and encourages innovation through diverse perspectives. This paper examines the Sensory Science Cambridge exhibition, held at the Cambridge Festival in March 2024, aiming to enhance the accessibility of biomedical concepts for BLVDN communities, inspired by Monash Sensory Science in Australia. The exhibition included several tactile exhibits, including one designed to educate on the nature of human papillomavirus (HPV) infections and their link to cervical cancer through a diorama art piece. We were guided by the question: How can tactile and sensory materials convey HPV infection and its progression to cervical cancer? To achieve this, we developed a tactile diorama for independent navigation, featuring braille keys, explanatory panels and verbal descriptions. The diorama was created through collaboration between scientists and artists, and its effectiveness was evaluated through participant feedback and observational studies during the exhibition. The diorama significantly improved the participants' understanding of HPV and cervical cancer, providing new or building on existing knowledge. The success of this exhibition project provides a model for using tactile and sensory materials in biomedical education. It highlights the potential of sensory science approaches in making STEM education more accessible and underscores the importance of interdisciplinary collaboration in creating accessible, scientifically rigorous communication tools, offering insights for future inclusive science outreach.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory analyses of leukocyte responses in hospitalized patients treated with ozanimod following a severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection.","authors":"Olivier Courtemanche, Pascale Blais-Lecours, Sylvie Lesage, Geneviève Chabot-Roy, Lise Coderre, Marie-Renée Blanchet, Nathalie Châteauvert, François Lellouche, David Marsolais","doi":"10.1111/imcb.70006","DOIUrl":"https://doi.org/10.1111/imcb.70006","url":null,"abstract":"<p><p>Sphingosine-1-phosphate receptor 1 (S1P₁) ligands effectively reduce immunopathological damage in viral pneumonia models. Specifically, S1P₁ ligands inhibit cytokine storm and help preserve lung endothelial barrier integrity. We recently showed that the S1P receptor ligand ozanimod can be safely administered to hospitalized patients with coronavirus disease 2019 (COVID-19) exhibiting severe symptoms of viral pneumonia, with potential clinical benefits. Here, we extend on this study and investigate the impact of ozanimod on key features of the immune response in patients with severe COVID-19. We quantified circulating cytokine levels, peripheral immune cell numbers, proportions and activation status; we also monitored the quality of the humoral response by assessing anti-severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) antibodies. Our findings reveal that patients receiving ozanimod during acute SARS-CoV-2 infection exhibit significantly reduced numbers of circulating monocytes compared with those receiving standard care. Correspondingly, in the ozanimod-treated group, circulating levels of C-C motif ligand 2 (CCL2) were decreased. While treatment with ozanimod negatively impacted the humoral response to COVID-19 in unvaccinated patients, it did not impair the development of a robust anti-SARS-CoV-2 antibody response in vaccinated patients. These findings suggest that ozanimod influences key immune mechanisms during the acute phase of SARS-CoV-2 infection.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}