Immunology & Cell Biology最新文献

Interleukin-12: Central Roles in Immune Regulation and Disease Therapy 白细胞介素-12：在免疫调节和疾病治疗中的核心作用。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-11-06 Epub Date: 2026-09-30 DOI: 10.1111/imcb.70167

Anthi Psoma, Geert van den Bogaart

{"title":"Interleukin-12: Central Roles in Immune Regulation and Disease Therapy","authors":"Anthi Psoma, Geert van den Bogaart","doi":"10.1111/imcb.70167","DOIUrl":"10.1111/imcb.70167","url":null,"abstract":"Interleukin-12 (IL-12) is a key immunoregulatory cytokine produced primarily by antigen-presenting cells. During infection, IL-12 orchestrates innate immune responses and shapes the nature of subsequent adaptive immunity. Specifically, by promoting interferon-γ (IFN-γ) production in helper and cytolytic T cells and natural killer (NK) cells, it promotes the activation of these cells and drives the differentiation of CD4+ T cells into type 1 T helper (Th1) cells. IL-12 is a heterodimeric cytokine composed of the p35 and p40 subunits, whose coordinated expression is required for formation of the bioactive p70 molecule. The promiscuous use of these subunits within the IL-12 cytokine family, where p40 and p35 also pair with other partners to form IL-23, IL-27, and IL-35, creates structural and functional overlap that enables fine-tuned immune regulation. Given its potent immune functions, it is not surprising that IL-12 availability is regulated at multiple levels, including gene transcription, subunit assembly, and shared receptor signaling components. In this review, we provide an overview of IL-12, how it is produced and secreted and its mechanisms of action. We also discuss the targeting of IL-12 for the treatment of various diseases, including bacterial infections, autoimmune diseases, and cancer.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"104 10","pages":"996-1014"},"PeriodicalIF":3.3,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes 高碳酸血症诱导线粒体适应并改变谷氨酰胺代谢以驱动单核细胞的独特代谢表型。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-11-06 Epub Date: 2026-09-16 DOI: 10.1111/imcb.70162

Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins

{"title":"Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes","authors":"Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins","doi":"10.1111/imcb.70162","DOIUrl":"10.1111/imcb.70162","url":null,"abstract":"Carbon dioxide (CO2) is an ancient and ubiquitous physiological gas generated during aerobic respiration. Historically viewed as a simple metabolic waste product, CO2 has received far less research attention than oxygen (O2), the primary substrate of aerobic respiration. However, emerging evidence has revealed important roles for CO2 in immunometabolism, immunology, muscle physiology, and clinical medicine. While circulating pCO2 levels are tightly regulated, patients with lung diseases such as chronic obstructive pulmonary disease (COPD) frequently develop hypercapnia, pCO2 > 45 mmHg. Hypercapnia is associated with significantly increased mortality, higher risk of ICU admission, and a global prevalence estimated at 13–15 million patients. Its broader clinical consequences remain poorly understood and are inadequately integrated into current therapeutic paradigms. Here, we examined the impact of hypercapnia on the metabolic profile of monocytes. We demonstrate that 24 h of buffered hypercapnia induces a marked reduction in mitochondrial mass. This is accompanied by dysregulation of mitochondrial membrane potential and key bioenergetic substrates (NADH/NAD+ and ATP content). We further show that hypercapnia alters the abundance of metabolites and proteins associated with mitochondrial metabolism, with effects spanning glucose, glutamine, and lipid metabolism. Thus, we provide direct mechanistic evidence that hypercapnia directly alters the glutamine–glutamate–proline synthesis axis. Collectively, these findings establish the foundation for a discrete hypercapnic metabolic phenotype, that is, in several respects, distinct from the metabolic adaptations observed in hypoxia. We propose that hypercapnia triggers a cascade of metabolic adaptations with tissue-dependent consequences on cellular effector functions.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"104 10","pages":"943-963"},"PeriodicalIF":3.3,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.70162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Think BIG, Stay Connected: A Regional Immunology Meeting as a Durable Model for Scientific Community Building 思考大，保持联系：区域免疫学会议作为科学社区建设的持久模式。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-11-06 Epub Date: 2026-09-29 DOI: 10.1111/imcb.70165

Danielle I. Stanisic, Rajiv Khanna, Severine Navarro, J. Alejandro Lopez

{"title":"Think BIG, Stay Connected: A Regional Immunology Meeting as a Durable Model for Scientific Community Building","authors":"Danielle I. Stanisic, Rajiv Khanna, Severine Navarro, J. Alejandro Lopez","doi":"10.1111/imcb.70165","DOIUrl":"10.1111/imcb.70165","url":null,"abstract":"Regional scientific meetings occupy a distinctive but underexamined position within the research ecosystem. Smaller and more accessible than national congresses, yet broader in scope than institutional seminar programm, they provide opportunities for repeated interactions across institutions, career stages, and research domains. The Brisbane Immunology Group (BIG) meeting is one of the longest-running and most influential regional meetings associated with the Australian and New Zealand Society for Immunology (ASI), providing a focal point for immunology researchers across Queensland, Australia, and beyond. This article examines the BIG meeting as a case study of a regional immunology community that has sustained scientific engagement, mentoring, and collaboration for 25 years. Drawing on historical records and thematic analysis of interviews with organizers, senior contributors, and recent attendees, we identify six characteristics that have contributed to the longevity and impact of the meeting: accessibility, cross-institutional ownership, intergenerational participation, social integration, programmatic continuity with adaptive innovation, and deliberate recognition of community contributions. We argue that BIG functions not merely as an annual scientific meeting but as a regional community of practice that supports scientific collaboration, professional identity formation, and leadership development. The BIG experience provides broader lessons regarding the role of regional meetings in strengthening scientific communities, supporting future scientific leaders and sustaining disciplinary vitality.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"104 10","pages":"987-995"},"PeriodicalIF":3.3,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.70165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Antibody Evolution: Germline-Targeting HIV Vaccines Reach a Turning Point 工程抗体进化：生殖系靶向HIV疫苗达到转折点。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-11-06 Epub Date: 2026-10-06 DOI: 10.1111/imcb.70169

Rowena A. Bull, Deborah L. Burnett

引用次数: 0

Role of T Cells in Chronic Pain: Mechanisms, Regulation, and Therapeutic Implications T细胞在慢性疼痛中的作用：机制、调节和治疗意义。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-11-06 Epub Date: 2026-09-06 DOI: 10.1111/imcb.70160

Yuanyuan Li, Ruihan Yang, Shipeng Wei, Jing Wang, Haoyu Ke, Wenguo Fan

引用次数: 0

Unmasking the Influence of Viral Micro-RNAs on Host Immunity 揭示病毒微rna对宿主免疫的影响。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-11-06 Epub Date: 2026-09-22 DOI: 10.1111/imcb.70164

Riley J. K. Easton, Bernadette M. Saunders

{"title":"Unmasking the Influence of Viral Micro-RNAs on Host Immunity","authors":"Riley J. K. Easton, Bernadette M. Saunders","doi":"10.1111/imcb.70164","DOIUrl":"10.1111/imcb.70164","url":null,"abstract":"Micro-RNAs (miRNAs) are key regulators of human immunity, controlling critical cellular programmes including proliferation, differentiation, apoptosis, and immune activation to shape the host response to infection. Multiple human-infecting viruses encode their own miRNA (v-miRNA), enabling them to co-opt host gene regulatory machinery to subvert immunity, establish persistence and evade immune-mediated killing. This review synthesizes the current evidence on viral miRNAs and their roles in host–virus interactions, with an explicit focus on immune regulation. We examine how different viruses use v-miRNAs to modulate core immune functions, including antigen presentation, cytokine signaling, NK and CD8 T-cell activation, and apoptosis. We also examine how v-miRNAs manipulate viral gene expression to aid immune evasion and promote persistence. Particular emphasis is placed on experimentally validated immune targets and their clinical consequences. Collectively, these examples illustrate the convergent evolution of v-miRNA-mediated immune evasion across diverse viral families. Understanding this class of molecules will provide insight into critical immune evasion strategies employed by clinically important viruses and may identify novel targets for diagnostic and antiviral therapeutics, including antagomir-based and RNA silencing approaches.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"104 10","pages":"964-974"},"PeriodicalIF":3.3,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.70164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149014927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Leukocyte Landscape Across Mouse Strains and Tissues 跨小鼠品系和组织的白细胞景观。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-11-06 Epub Date: 2026-10-08 DOI: 10.1111/imcb.70168

Ella Trolio, Sarah Dart, Liu Liu, Michaela Lucas, Amy Prosser

{"title":"The Leukocyte Landscape Across Mouse Strains and Tissues","authors":"Ella Trolio, Sarah Dart, Liu Liu, Michaela Lucas, Amy Prosser","doi":"10.1111/imcb.70168","DOIUrl":"10.1111/imcb.70168","url":null,"abstract":"With widespread use of mice (Mus musculus) in immunological research, understanding baseline immune variation between mouse models is critical. While peripheral blood immune profiles have been well-defined, strain- and sex-specific differences in leukocyte composition across other tissues remain poorly characterized. Here, we performed flow cytometric immunophenotyping of 19 leukocyte subsets and 3 T cell memory phenotypes in the blood, bone marrow, liver, spleen, and lymph nodes of seven strains of naïve adult male mice: Balb.b, BALB/c, BALB/c Ly5.1, C57BL/6J, C57BL/6J Ly5.1, BALB/c:B6J (F1), and DBA/2 J. Parallel analyses were conducted in female BALB/c and C57BL/6J mice. Each tissue contained a unique immunobiome, with conventional T and B cells enriched in the lymph nodes and spleen, unconventional T cells and innate lymphoid cells (ILCs) in the liver, and myeloid cells in the bone marrow. Generally, BALB-derived strains displayed a helper T cell- and innate-skewed profile, enriched for CD4 and regulatory T cells, neutrophils, and natural killer cells. C57BL/6J-derived strains were typically enriched for CD8 T cells, ILC1s, and conventional dendritic cells, consistent with a cytotoxic immune bias. Small differences were detected between congenic and parental strains. F1's exhibited a mix of C57BL/6J-biased and intermediate parental phenotypes. DBA/2 J mice were immunologically distinct, notably enriched for γδ T cells. Sex-associated differences were minor compared to strain effects. These findings provide tissue-specific benchmarks for leukocyte composition across commonly used mouse strains. They also highlight the importance of strain and sex selection and baseline immunophenotyping to support accurate interpretation of observed immune phenotypes in experimental contexts.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"104 10","pages":"1019-1034"},"PeriodicalIF":3.3,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.70168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Cytosolic dsRNA Sensing of Viral Infections 病毒感染细胞质dsRNA检测的研究进展。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-11-06 Epub Date: 2026-09-27 DOI: 10.1111/imcb.70163

Sofia Maceratessi, Natalia G. Sampaio

引用次数: 0

STAG Priming Preserves Paneth Cells and Limits Parasite-Triggered Ileitis. STAG启动保存平板细胞和限制寄生虫引发的回肠炎。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-11-04 DOI: 10.1111/imcb.70173

Ester Cristina Borges Araujo, Luciana Alves Sousa, Marisol Pallete Briceno, Loyane Bertagnolli Coutinho, Alexsandra Alves Bezerra Martins, Anne Fenton, Sumathi Sankaran-Walters, Paulo Czarnewski, Neide Maria Silva

{"title":"STAG Priming Preserves Paneth Cells and Limits Parasite-Triggered Ileitis.","authors":"Ester Cristina Borges Araujo, Luciana Alves Sousa, Marisol Pallete Briceno, Loyane Bertagnolli Coutinho, Alexsandra Alves Bezerra Martins, Anne Fenton, Sumathi Sankaran-Walters, Paulo Czarnewski, Neide Maria Silva","doi":"10.1111/imcb.70173","DOIUrl":"https://doi.org/10.1111/imcb.70173","url":null,"abstract":"Toxoplasma gondii triggered ileitis is a commonly used model for diseases affecting the small intestine, such as Crohn's Disease. Inflammation is primarily dependent on Th1-mediated killing of Paneth cells, which consequently promotes intestinal dysbiosis and boosts inflammation and pathology in the organs. Priming of the immune system with soluble Toxoplasma antigen (STAG) has been shown to induce immune regulation in several inflammatory diseases. Herein, we describe how protection of Paneth cells by priming with STAG is associated with protection against T. gondii triggered ileitis. We observed that STAG priming diminished intestinal pathology and modulated cytokine profile, and specifically downregulates interferon expression. Consequently, priming with STAG sustained Paneth-cell numbers during infection, unlike non-immunized controls, and thus also retained antimicrobial protein expression. Interestingly, we show that naturally resistant BALB/c mice did not undergo total Paneth-cell ablation, but upon additional Paneth-cell depletion, presented intestinal pathology and tissue parasitism levels similar to susceptible C57BL/6. Finally, we show that the STAG-primed groups presented a different intestinal microbiota, primarily through promotion of a protective microbiota enriched in Firmicutes and depleted of Enterobacteriaceae. Thus, the results suggest that priming with STAG is able to prevent Paneth-cell depletion and is associated with resistance to T. gondii triggered ileitis.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Milk-Derived Signals Guide Neonatal Hematopoiesis and Respiratory Defense. 乳源性信号引导新生儿造血和呼吸防御。

IF 3.3 4区医学

Immunology & Cell Biology Pub Date : 2026-11-02 DOI: 10.1111/imcb.70175

Jonatan Leffler, Nivedithaa Divakara, Valerie Verhasselt

引用次数: 0