Immunology & Cell Biology最新文献

The cyclin-dependent kinase inhibitor AT7519 is a human RORγt agonist.

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-01-23 DOI: 10.1111/imcb.12851

Kaja Karaś, Joanna Pastwińska, Anna Sałkowska, Iwona Karwaciak, Rafał A Bachorz, Marcin Ratajewski

{"title":"The cyclin-dependent kinase inhibitor AT7519 is a human RORγt agonist.","authors":"Kaja Karaś, Joanna Pastwińska, Anna Sałkowska, Iwona Karwaciak, Rafał A Bachorz, Marcin Ratajewski","doi":"10.1111/imcb.12851","DOIUrl":"https://doi.org/10.1111/imcb.12851","url":null,"abstract":"AT7519, which inhibits multiple cyclin-dependent kinases, has been extensively investigated in various types of cancer cells. Previous studies have demonstrated the ability of this molecule to suppress the expression of the nuclear receptor retinoic acid-related orphan receptor gamma (RORγ) and several genes involved in hepatocellular carcinoma progression. In this study, we identified a distinct agonistic effect of AT7519 on RORγt, an isoform expressed by various immune cells, including T helper 17 lymphocytes. These immune cells play pivotal roles in shaping the tumor microenvironment and promoting the anticancer response of the immune system. After exposure to AT7519 during differentiation, primary human CD4+ T cells presented increased expression of IL17A/F, IFNG and GZMB and decreased expression of PDCD1 and CTLA4. These findings elucidate a previously unrecognized facet of AT7519 activity and suggest the potential incorporation of this molecule into immune therapies to augment the effectiveness of diverse anticancer strategies involving anti-programmed cell death protein 1 (anti-PD-1) and anti-cytotoxic T-lymphocyte antigen 4 (anti-CTLA4) regimens.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ADAM10 modulates the efficacy of T-cell mediated therapy in solid tumors. ADAM10调节实体瘤中t细胞介导治疗的疗效。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-01-20 DOI: 10.1111/imcb.12855

Ahmed Me Abdalla, Yu Miao, Ning Meng, Chenxi Ouyang

引用次数: 0

An X-tra role for NFκB in gene regulation? NFκB在基因调控中的X-tra作用？

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-01-10 DOI: 10.1111/imcb.12850

Sara Berent, Rhys S Allan

引用次数: 0

Refining bone marrow ablation and reconstitution in mice. 改良小鼠骨髓消融和重建。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-01-09 DOI: 10.1111/imcb.12847

Penny Hawkins, James Dooley, Jessica Rodda, Colin Gilbert

引用次数: 0

Learnings from ten years away from "home" as a South American immunologist in Ireland. 作为一名南美免疫学家，在爱尔兰远离“家乡”十年的学习。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-01-07 DOI: 10.1111/imcb.12849

Natalia Muñoz-Wolf

{"title":"Learnings from ten years away from \"home\" as a South American immunologist in Ireland.","authors":"Natalia Muñoz-Wolf","doi":"10.1111/imcb.12849","DOIUrl":"https://doi.org/10.1111/imcb.12849","url":null,"abstract":"Pursuing an international scientific career is a fantastic opportunity for personal and professional growth, but it also poses unique challenges, which can be particularly daunting for researchers coming from resource-limited countries. Drawing from personal experience, this article provides insights into navigating the transition to working abroad in academia and developing a sustainable career while integrating into a new culture. From predeparture preparations to achieving career independence, I discuss practical aspects of crafting tailored applications to contact potential advisers, contemplating visa-related challenges, establishing collaborations and emphasizing the value of finding appropriate mentorship to help you adapt to new cultural and professional environments. The article also underscores the importance of resilience, adaptability and redefining career success as a dynamic, nonlinear process. I present an original perspective on career planning, inspired by maritime voyage planning, to address the complexities of balancing personal and professional life, particularly during transitional periods. This approach, which combines four key stages of planning, namely, appraisal, planning, execution and monitoring, serves as a model for early-career researchers to navigate the unpredictable tides of academic work and personal life abroad with the goal of sustaining progress and well-being. These reflections aim to empower scientists preparing for or adapting to international research environments, fostering resilience and adaptability for long-term success abroad.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-seeking bacterial missiles. 寻找肿瘤的细菌导弹。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-01-05 DOI: 10.1111/imcb.12844

George Cavic, Aude M Fahrer

引用次数: 0

From dentistry to immunology: navigating challenges and building a career in neuroimmunology. 从牙科到免疫学：迎接挑战，开创神经免疫学事业。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-06-27 DOI: 10.1111/imcb.12797

Lidia Yshii

引用次数: 0

ILC1 as critical gatekeepers in autoimmune kidney damage. ILC1是自身免疫性肾损伤的关键看门人。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1111/imcb.12842

Cyril Seillet, Le Xiong

引用次数: 0

Prenatal Skin Cell Atlas reveals macrophages' role beyond immunity. 产前皮肤细胞图谱揭示了巨噬细胞在免疫之外的作用。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-11-17 DOI: 10.1111/imcb.12837

Céline Pattaroni

引用次数: 0

RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration. RNAi 文库筛选发现 Gβ1、酪蛋白激酶 2 和 ICAP-1 是 LFA-1 介导的 T 细胞极性和迁移的新型调控因子。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-11-28 DOI: 10.1111/imcb.12838

Antje Haap-Hoff, Michael Freeley, Eugene Dempsey, Dara Dunican, Emily Bennett, Denise Triglia, Joanna Skubis-Zegadlo, Anthony Mitchell Davies, Dermot Kelleher, Aideen Long

{"title":"RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration.","authors":"Antje Haap-Hoff, Michael Freeley, Eugene Dempsey, Dara Dunican, Emily Bennett, Denise Triglia, Joanna Skubis-Zegadlo, Anthony Mitchell Davies, Dermot Kelleher, Aideen Long","doi":"10.1111/imcb.12838","DOIUrl":"10.1111/imcb.12838","url":null,"abstract":"The αLβ2 integrin LFA-1 plays a key role in T-cell adhesion to the endothelial vasculature and migration into both secondary lymphoid organs and peripheral tissues via interactions with its target protein ICAM-1, but the pathways that regulate LFA-1-mediated T-cell polarity and migration are not fully understood. In this study we screened two RNAi libraries targeting G protein-coupled receptors (GPCR)/GPCR-associated proteins and kinases in a HuT 78 T cell line model of LFA-1-stimulated T-cell migration. Based on staining of the actin cytoskeleton, multiple parameters to measure cell morphology were used to assess the contribution of 1109 genes to LFA-1-mediated T-cell polarity and migration. These RNAi screens identified a number of both novel and previously identified genes that either increased or decreased the polarity and migratory capacity of these cells. Following multiparametric analysis, hierarchical clustering and pathway analysis, three of these genes were characterized in further detail using primary human T cells, revealing novel roles for the heterotrimeric G protein subunit Gβ1 and Casein Kinase 2 in LFA-1-mediated T-cell polarity and migration in vitro. Our studies also highlighted a new role for ICAP-1, an adaptor protein previously described to be associated with β1 integrins, in β2 integrin LFA-1-directed migration in T cells. Knockdown of ICAP-1 expression in primary T cells revealed a role in cell polarity, cell velocity and transmigration towards SDF-1 for this adaptor protein. This study therefore uncovers new roles for GPCR/GPCR-associated proteins and kinases in T-cell migration and provides potential novel targets for modulation of the T-cell immune response.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"73-92"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0