Immunology & Cell Biology最新文献

Building a thriving immunology community in Chile. 在智利建立一个繁荣的免疫学社区。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-05-15 DOI: 10.1111/imcb.70033

Maria Rosa Bono, Fabiola Osorio

引用次数: 0

Highlights of 2024: Tregs immunometabolism and how to counter inflammatory niches. 2024年的亮点：Tregs免疫代谢和如何对抗炎症利基。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-05-04 DOI: 10.1111/imcb.70027

Nicolas Valentini, Christopher J Requejo Cier, Caroline Lamarche

引用次数: 0

Are single nucleotide polymorphisms underutilized for guiding treatment of inflammatory bowel disease? 单核苷酸多态性在炎性肠病指导治疗中的应用是否不足？

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-05-02 DOI: 10.1111/imcb.70029

Jildou van der Werf, Nicholas Ian Fleming

{"title":"Are single nucleotide polymorphisms underutilized for guiding treatment of inflammatory bowel disease?","authors":"Jildou van der Werf, Nicholas Ian Fleming","doi":"10.1111/imcb.70029","DOIUrl":"https://doi.org/10.1111/imcb.70029","url":null,"abstract":"Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD), ulcerative colitis (UC) and IBD unclassified (IBDU), significantly impacts quality of life. Despite significant advances in the management of the conditions, responses to treatments vary greatly, and this is due partly to our natural genetic variation. Here we will review the evidence for whether single nucleotide polymorphisms (SNPs) have the potential to guide treatment decisions for people with IBD. We will first consider SNPs that exhibit strong associations with IBD pathogenesis and their relevance to epithelial barrier integrity, cytokine production, and immune system function. Then, we will cover those SNPs implicated in altering response to our various current IBD therapeutics, including the recently implemented drugs ustekinumab and tofacitinib. Finally, we will explore lesser-known SNPs that exhibit complex relationships with the disease and which may be undervalued as pharmacogenetic tools. Overall, it will be demonstrated that SNPs associated with IBD pathology are largely distinct from those predicting response to treatments and that new discoveries of clinically useful tools can be expected from therapy-focused investigations. Given the growing list of treatments available, we argue that beneficial personalization of treatments based on SNPs is still underutilized.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlights of 2024: Beyond lipids: immune dysfunction in APOE4-associated Alzheimer's disease. 2024年的亮点：超越脂质：apoe4相关阿尔茨海默病的免疫功能障碍

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-04-30 DOI: 10.1111/imcb.70025

Isabella McEwan, Shannon Thomson, Jasmeen K Issar, Caitlin A Finney

引用次数: 0

Highlights of 2024: The rising role of age-associated B cells in autoimmune diseases. 2024年的亮点：年龄相关B细胞在自身免疫性疾病中的作用日益增强。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-04-27 DOI: 10.1111/imcb.70023

Adrian Ys Lee, Joanne H Reed

引用次数: 0

The tall tale of research and success. 研究和成功的荒诞故事。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-04-23 DOI: 10.1111/imcb.70028

Ajitha Thanabalasuriar

引用次数: 0

Highlights of 2024: New insights into the molecular regulation of antibody-secreting cells and their subsets. 2024年的亮点：抗体分泌细胞及其亚群分子调控的新见解。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-04-23 DOI: 10.1111/imcb.70024

Michael James Flaman, KimAnh Trang Pioli, Peter Dion Pioli

引用次数: 0

A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells. 一种测量体内稀有细胞代谢的新方法揭示了肺T细胞对氧化磷酸化的高度依赖性。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-04-23 DOI: 10.1111/imcb.70018

Aristeidis Roubanis, Morgane Hilaire, Morgane Le Teuff, Odile Devergne, Tim Sparwasser, Luciana Berod, Benoît L Salomon

{"title":"A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells.","authors":"Aristeidis Roubanis, Morgane Hilaire, Morgane Le Teuff, Odile Devergne, Tim Sparwasser, Luciana Berod, Benoît L Salomon","doi":"10.1111/imcb.70018","DOIUrl":"https://doi.org/10.1111/imcb.70018","url":null,"abstract":"Regulation of cellular metabolism is a central element governing the fate and function of T cells. However, the in vivo metabolic characteristics of rare cells, such as nonlymphoid tissue T cells, are poorly understood because of experimental limitations. Most techniques measuring cell metabolism require large cell numbers. The recent SCENITH method allows for studying the metabolism of rare cells by flow cytometry. However, this technique requires cells to be isolated and cultured ex vivo, which may alter their metabolism. Here, we propose a new experimental approach, called in vivo SCENITH, to investigate the cellular metabolism of T cells in vivo at a steady state in the spleen and lungs. For this purpose, we administered the metabolic modulators directly in mice, instead of applying these reagents ex vivo, as in the classical SCENITH method. Whereas ex vivo manipulation impacted the viability and phenotype of T cells, this toxic effect was not observed in the in vivo SCENITH. We observed that conventional and regulatory T cells shared similar metabolic profiles. Importantly, whereas spleen T cells used both oxidative phosphorylation and glycolysis, the metabolism of T cells in the lungs was mainly based on oxidative phosphorylation. Finally, metabolic inhibitors that interfere with protein translation and energy availability downregulated Foxp3 expression in regulatory T cells. These results describe an expansion of SCENITH that allows to measure the metabolic profile of rare cells in vivo, revealing a high dependence on oxidative phosphorylation of lung T cells.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Touching the invisible: exploring intracellular host-pathogen interactions through multisensory art. 触摸无形：通过多感官艺术探索细胞内宿主-病原体相互作用。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-04-23 DOI: 10.1111/imcb.70019

Rachel Elizabeth Jackson, Georgia Miller, Rachel Weild, Svetlana Atlavina, Frances Aylward, Elizabeth Harris, Richard Hayward, Camilla Godlee

{"title":"Touching the invisible: exploring intracellular host-pathogen interactions through multisensory art.","authors":"Rachel Elizabeth Jackson, Georgia Miller, Rachel Weild, Svetlana Atlavina, Frances Aylward, Elizabeth Harris, Richard Hayward, Camilla Godlee","doi":"10.1111/imcb.70019","DOIUrl":"https://doi.org/10.1111/imcb.70019","url":null,"abstract":"The microscopic world of intracellular bacteria is rarely communicated to non-scientists. By participating in the Sensory Science Exhibition, held at St Catharine's College, University of Cambridge as part of the Cambridge Festival, we sought to address this problem by creating a 3D mammalian cell with model bacteria, including Salmonella enterica, Chlamydia trachomatis and Orientia tsutsugamushi. By hijacking eukaryotic host cellular machinery and avoiding detection, these bacteria orchestrate their survival and replication within host cells. This tactile display aimed to guide participants through key aspects of intracellular bacterial life cycles such as host cell entry, Salmonella type three secretion system (T3SS) protein secretion, O. tsutsugamushi trafficking along microtubules, and C. trachomatis replication within an inclusion. We summarize our experiences in this report. We hope our multisensory conceptualization of intracellular bacteria provided inclusive and easy-to-understand communication of complex science concepts to the general public with modalities also accessible to the low-vision and blind communities.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlights of 2024: The multifaceted roles of ILC3s in mucosal immunity and inflammation. 2024年的亮点：ILC3s在粘膜免疫和炎症中的多方面作用。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2025-04-19 DOI: 10.1111/imcb.70021

Xin Shen, Xianzhi Gao, Lie Wang

引用次数: 0