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The journey of young scientists in Brazil: challenges and perspectives. 巴西青年科学家的历程：挑战与展望。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-11-09 DOI: 10.1111/imcb.12835
Fabiana Corsi-Zuelli
{"title":"The journey of young scientists in Brazil: challenges and perspectives.","authors":"Fabiana Corsi-Zuelli","doi":"10.1111/imcb.12835","DOIUrl":"10.1111/imcb.12835","url":null,"abstract":"<p><p>As a young scientist in Brazil, my journey began with a modest education in a public school system that often lacked the resources needed to provide students with comprehensive support. However, with persistence and determination, I successfully gained admission to the University of São Paulo, a prestigious institution and one of the top universities in Latin America. My research focuses on the relationship between the nervous and immune systems in psychosis, a topic I am deeply passionate about. In this piece, I will discuss the systemic issues within the Brazilian education and research systems and delve deeper into my own challenges and achievements as a young scientist in Brazil, sharing insights that can inspire others in similar situations.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"22-26"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From the bench to the farm and back again. 从长椅到农场，再从农场到长椅。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-07-11 DOI: 10.1111/imcb.12810
Johnathan Canton
{"title":"From the bench to the farm and back again.","authors":"Johnathan Canton","doi":"10.1111/imcb.12810","DOIUrl":"10.1111/imcb.12810","url":null,"abstract":"<p><p>My path to becoming a scientist has taken many twists and turns. This is perhaps not unusual to hear. Indeed, in discussions with my colleagues it seems that for many of us the path was never a straight one. Certainly, for me there have been moments when my whole world was encompassed by science and at other times, I have felt strongly that my time in science was up. I like to think that as scientists we ask a lot of questions and, for many of us, those questions extend to our very purpose as a scientist. My intention with this article is not to document my career path in detail or to provide very specific advice. Rather, I hope to describe how questions have defined my journey and to inspire others to occasionally pause and ask themselves what a career in science means to them. Today, I am an Assistant Professor at a major Canadian university, and here are the questions I asked along the way.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"15-18"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strive, Thrive & Survive: embracing challenges in pursuit of passion. 努力、成长和生存：迎接挑战，追求激情。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-10-23 DOI: 10.1111/imcb.12827
Abolaji Samson Olagunju
{"title":"Strive, Thrive & Survive: embracing challenges in pursuit of passion.","authors":"Abolaji Samson Olagunju","doi":"10.1111/imcb.12827","DOIUrl":"10.1111/imcb.12827","url":null,"abstract":"<p><p>Challenges don't last; embracing them is crucial to growth and success. Knowing and absorbing this is very important for students in any program and at any level in the academic world. I have my bachelor's and master's degrees from Ladoke Akintola University of Technology and University of Ibadan, Nigeria, respectively. Currently, I am a doctorate student at the Department of Immunology, University of Sao Paulo, Brazil. This article discusses my adaptation to a new environment, overcoming challenges, and the importance of support systems.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"19-21"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The multiple roles of macrophages in peritoneal adhesion. 巨噬细胞在腹膜粘连中的多重作用
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.1111/imcb.12831
Shangwei Yang, Yanhe Zheng, Zhenjun Pu, Hongyu Nian, Junliang Li
{"title":"The multiple roles of macrophages in peritoneal adhesion.","authors":"Shangwei Yang, Yanhe Zheng, Zhenjun Pu, Hongyu Nian, Junliang Li","doi":"10.1111/imcb.12831","DOIUrl":"10.1111/imcb.12831","url":null,"abstract":"<p><p>Peritoneal adhesion (PA) refers to the abnormal adhesion of the peritoneum either with the peritoneum itself or with tissues and organs that is caused by abdominopelvic surgery, abdominal infection or peritoneal inflammation. PA is associated with various clinical complications, such as abdominal pain and distension, intestinal obstruction, gastrointestinal disorders and female infertility, and adversely affects the quality of life of patients. Macrophages are essential for PA formation and can undergo polarization into classically activated macrophages (M1) and alternatively activated macrophages (M2), which are influenced by the peritoneal microenvironment. By releasing proinflammatory cytokines and reactive oxygen species, M1 macrophages promote peritoneal inflammatory reactions and the resultant formation of adhesion. In contrast, M2 macrophages secrete anti-inflammatory cytokines and growth factors to inhibit PA formation and to promote repair and healing of peritoneal tissues, and thereby play a significant anti-inflammatory role. This review comprehensively explores the function and mechanism of macrophages and their subtypes in PA formation to gain insight into the prevention and treatment of PA based on the modulation of macrophages.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"31-44"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of clonally expanded γδ T-cell populations during CAR-T cell therapy. 识别 CAR-T 细胞疗法中克隆扩增的 γδ T 细胞群。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-11-05 DOI: 10.1111/imcb.12834
Arman Safavi, Jerome Samir, Mandeep Singh, Martina Bonomi, Raymond Yip Louie, Kenneth Micklethwaite, Fabio Luciani
{"title":"Identification of clonally expanded γδ T-cell populations during CAR-T cell therapy.","authors":"Arman Safavi, Jerome Samir, Mandeep Singh, Martina Bonomi, Raymond Yip Louie, Kenneth Micklethwaite, Fabio Luciani","doi":"10.1111/imcb.12834","DOIUrl":"10.1111/imcb.12834","url":null,"abstract":"<p><p>Anti-CD19 Chimeric Antigen Receptor (CAR)-T cell therapies have shown promise for treating B cell malignancies, but the clinical outcome is influenced by both the CAR-T product and the patient's immune system. The role of γδ T cells in the context of CAR-T cell therapy remains poorly understood. This study investigates the transcriptional heterogeneity, clonal expansion and dynamics of γδ T cells in patients undergoing anti-CD19 CAR-T cell therapy. Longitudinal single cell multi-omics analysis was performed on γδ T cells from four patients receiving anti-CD19 CAR-T cell therapy. Single cell RNA-seq, antibody-based protein profiling (AbSeq) and full-length TCRγδ sequences revealed clonally expanded populations displaying plasticity in T cell differentiation, and temporal dynamics of large clones, suggesting ongoing expansion and differentiation. Clonally expanded γδ T cells had heterogeneous gene expression profiles, occupying seven transcriptionally distinct clusters. Analysis of chemokine markers indicated cluster-specific homing tendencies of circulating γδ T cells to peripheral tissues. We found unexpectedly high frequencies of Vδ1 and Vδ3 cells in the blood with distinct gene and protein expression profiles. This analysis provides insights into the dynamic and heterogeneous nature of γδ T cells following anti-CD19 CAR-T cell therapy, contributing valuable information for optimizing CAR-T cell therapies in B cell malignancies.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"60-72"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of cellular and molecular immune components of the painted white sea urchin Lytechinus pictus in response to bacterial infection. 绘白海胆（Lytechinus pictus）对细菌感染的细胞和分子免疫成分的特征。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-10-22 DOI: 10.1111/imcb.12828
Katherine T Nesbit, Alexis Cody Hargadon, Gloria D Renaudin, Nicholas D Kraieski, Katherine M Buckley, Emily Darin, Yoon Lee, Amro Hamdoun, Catherine S Schrankel
{"title":"Characterization of cellular and molecular immune components of the painted white sea urchin Lytechinus pictus in response to bacterial infection.","authors":"Katherine T Nesbit, Alexis Cody Hargadon, Gloria D Renaudin, Nicholas D Kraieski, Katherine M Buckley, Emily Darin, Yoon Lee, Amro Hamdoun, Catherine S Schrankel","doi":"10.1111/imcb.12828","DOIUrl":"10.1111/imcb.12828","url":null,"abstract":"<p><p>Sea urchins are basal deuterostomes that share key molecular components of innate immunity with vertebrates. They are a powerful model for the study of innate immune system evolution and function, especially during early development. Here we characterize the morphology and associated molecular markers of larval immune cell types in a newly developed model sea urchin, Lytechinus pictus. We then challenge larvae through infection with an established pathogenic Vibrio and characterize phenotypic and molecular responses. We contrast these to the previously described immune responses of the purple sea urchin Strongylocentrotus purpuratus. The results revealed shared cellular morphologies and homologs of known pigment cell immunocyte markers (PKS, srcr142) but a striking absence of subsets of perforin-like macpf genes in blastocoelar cell immunocytes. We also identified novel patterning of cells expressing a scavenger receptor cysteine rich (SRCR) gene in the coelomic pouches of the larva (the embryonic stem cell niche). The SRCR signal becomes further enriched in both pouches in response to bacterial infection. Collectively, these results provide a foundation for the study of immune responses in L. pictus. The characterization of the larval immune system of this rapidly developing and genetically enabled sea urchin species will facilitate more sophisticated studies of innate immunity and the crosstalk between the immune system and development.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"45-59"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anyone can cook, but only the fearless can be a great chef. 人人都会烹饪，但只有无所畏惧的人才能成为大厨。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-11-28 DOI: 10.1111/imcb.12841
Eduardo J Villablanca
{"title":"Anyone can cook, but only the fearless can be a great chef.","authors":"Eduardo J Villablanca","doi":"10.1111/imcb.12841","DOIUrl":"10.1111/imcb.12841","url":null,"abstract":"<p><p>Role models play a crucial role in inspiring and guiding careers in science, offering tangible examples of success and resilience. Reflecting on my journey from a small town in southern Chile to leading a lab at Karolinska Institutet, I've learned that relatable role models are particularly impactful for overcoming imposter syndrome and fostering a sense of belonging in academia. Early in my career, I drew inspiration from peers and mentors, gradually building my confidence and embracing my strengths. Later, exposure to interdisciplinary role models expanded my horizons and shaped my approach to science. Now, as a PI, I see my role as both a coach and mentor, fostering a team dynamic that amplifies individual strengths. Success in science often stems from fearlessness, adaptability and a willingness to seize opportunities, even when the outcome is uncertain. My journey demonstrates that good scientists can come from anywhere, including a small town in southern Chile.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"27-30"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the dynamics of T-cell responses: a combined approach using EdU incorporation and proliferation dye dilution assay. 探索t细胞反应的动力学：使用EdU掺入和增殖染料稀释试验的联合方法。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-12-30 DOI: 10.1111/imcb.12845
Hilde Raaphorst, Sinéad Lougheed, Latifa Saou, Nadine D van Kleef, Irma Rensink, Anja Ten Brinke, Julian J Freen-van Heeren, Annelies W Turksma
{"title":"Exploring the dynamics of T-cell responses: a combined approach using EdU incorporation and proliferation dye dilution assay.","authors":"Hilde Raaphorst, Sinéad Lougheed, Latifa Saou, Nadine D van Kleef, Irma Rensink, Anja Ten Brinke, Julian J Freen-van Heeren, Annelies W Turksma","doi":"10.1111/imcb.12845","DOIUrl":"https://doi.org/10.1111/imcb.12845","url":null,"abstract":"<p><p>Understanding antigen-specific T-cell responses is crucial for advancing immunotherapies and vaccine development. This study proposes a novel approach combining two complementary assays: the 5-ethynyl-2'-deoxyuridine (EdU) incorporation assay (tracking proliferation over 0-48 h) and the VPD450 dye dilution assay (tracking proliferation over 4-6 days). Integrating these techniques provides additional insights into T-cell proliferation kinetics. Both assays were independently optimized using anti-CD3 and anti-CD28 polyclonal T cell stimulation. 1 μM VPD450 is suitable for assessing T-cell proliferation. The EdU concentration should match the stimulation strength, requiring higher concentrations to efficiently track DNA replication detection during increased cellular division. Day 5 was the optimal read-out day for the EdU incorporation assay. We then combined the VPD450 dye dilution and EdU incorporation assays. As a proof of principle, we stimulated PBMCs from healthy donors with tetanus toxoid to assess antigen-specific T-cell responses. Additionally, we demonstrated the assay's application in drug research by evaluating proliferation in a mixed lymphocyte reaction with abatacept, an agonistic anti-CTLA-4 antibody. This combined approach offers qualitative insights into T-cell proliferation kinetics, beneficial for assessing novel vaccine efficiency or for designing new treatments targeting T cell proliferation, such as in autoimmune settings.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemokines in neurodegenerative diseases. 趋化因子在神经退行性疾病中的作用。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-12-26 DOI: 10.1111/imcb.12843
Hashemi Vida, Mehranfar Sahar, Amin Nikdouz, Hosseini Arezoo
{"title":"Chemokines in neurodegenerative diseases.","authors":"Hashemi Vida, Mehranfar Sahar, Amin Nikdouz, Hosseini Arezoo","doi":"10.1111/imcb.12843","DOIUrl":"https://doi.org/10.1111/imcb.12843","url":null,"abstract":"<p><p>Neurodegeneration and neuroinflammation disorders are mainly the result of the deposition of various proteins, such as α-synuclein, amyloid-β and prions, which lead to the initiation and activation of inflammatory responses. Different chemokines are involved in the infiltration and movement of inflammatory leukocytes into the central nervous system (CNS) that express chemokine receptors. Dysregulation of several members of chemokines has been shown in the CNS, cerebrospinal fluid and peripheral blood of patients who have neurodegenerative disorders. Upon infiltration of various cells, they produce many inflammatory mediators such as cytokines. Besides them, some CNS-resident cells, such as neurons and astrocytes, are also involved in the pathogenesis of neurodegeneration by producing chemokines. In this review, we summarize the role of chemokines and their related receptors in the pathogenesis of neurodegeneration and neuroinflammation disorders, including multiple sclerosis, Parkinson's disease and Alzheimer's disease. Therapeutic strategies targeting chemokines or their related receptors are also discussed in this article.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovations in Immunology Education: bridging theory, practice and professional development. 免疫学教育的创新：衔接理论、实践和专业发展。
IF 3.2 4区 医学
Immunology & Cell Biology Pub Date : 2024-12-23 DOI: 10.1111/imcb.12846
Samy Sakkal, Maurizio Costabile
{"title":"Innovations in Immunology Education: bridging theory, practice and professional development.","authors":"Samy Sakkal, Maurizio Costabile","doi":"10.1111/imcb.12846","DOIUrl":"https://doi.org/10.1111/imcb.12846","url":null,"abstract":"","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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