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Emerging mechanisms of ILC2-neuronal crosstalk across the body. ilc2 -神经元跨体串扰的新机制
IF 3 4区 医学
Immunology & Cell Biology Pub Date : 2026-05-01 Epub Date: 2026-03-29 DOI: 10.1111/imcb.70110
David A Posner, Matthew R Hepworth
{"title":"Emerging mechanisms of ILC2-neuronal crosstalk across the body.","authors":"David A Posner, Matthew R Hepworth","doi":"10.1111/imcb.70110","DOIUrl":"10.1111/imcb.70110","url":null,"abstract":"<p><p>Emerging roles of ILC2 in neuronal crosstalk across organs. In a series of studies published in 2025, ILC2 were shown to regulate nervous system function across a range of organs across the body. Within the intestinal tract, ILC2-derived cytokines acted on enteric neurons to orchestrate immunity to helminths (Wang et al). Intestinal ILC2 are triggered to migrate to the pancreas via enteric neuronal-derived norepinephrine (NE), with pancreatic ILC2 mediating key roles in glucose homeostasis (Sestan et al). ILC2-derived cytokines in the dorsal root ganglia of the sciatic nerve controlled neurosensation to regulate gait and locomotor function (Deshpande et al), while in the central nervous system, ILC2 responses modulated neuronal synapse formation in early life to promote learning and memory (Steffen et al). In the context of stroke and neurotrauma, the ILC2 axis promoted tissue repair via actions on local stem cells (Liu et al). Together, these studies highlighted the emerging role of ILC2 neuroimmune crosstalk in health and disease.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"439-442"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in cellular therapy for cancer: vector design and genome editing. 癌症细胞治疗的进展：载体设计和基因组编辑。
IF 3 4区 医学
Immunology & Cell Biology Pub Date : 2026-05-01 Epub Date: 2026-04-07 DOI: 10.1111/imcb.70111
Alexander Donald McLellan, Lachlan James Dobson, Patrick William Marron, Kristine Cate Pe
{"title":"Advances in cellular therapy for cancer: vector design and genome editing.","authors":"Alexander Donald McLellan, Lachlan James Dobson, Patrick William Marron, Kristine Cate Pe","doi":"10.1111/imcb.70111","DOIUrl":"10.1111/imcb.70111","url":null,"abstract":"<p><p>The year 2025 saw continued scientific progress in cell therapy and further commercial expansion of CAR T-cell therapeutics, alongside notable strategic contractions driven largely by manufacturing cost constraints. The field also benefited from the recent transition in T-cell subset nomenclature toward function- and state-based definitions, enabling more precise characterization of CAR T-cell products. We highlight five key advances, including in vivo CAR generation, next-generation genome engineering and the expanding potential of AI-guided antibody discovery platforms for cellular immunotherapy.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"490-493"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAR-NK cell-based therapies: translational and regulatory breakthroughs. CAR-NK细胞疗法：转化和调控的突破。
IF 3 4区 医学
Immunology & Cell Biology Pub Date : 2026-05-01 Epub Date: 2026-04-20 DOI: 10.1111/imcb.70120
Alison Felipe Bordini Biggi, Fernando Souza-Fonseca-Guimaraes
{"title":"CAR-NK cell-based therapies: translational and regulatory breakthroughs.","authors":"Alison Felipe Bordini Biggi, Fernando Souza-Fonseca-Guimaraes","doi":"10.1111/imcb.70120","DOIUrl":"10.1111/imcb.70120","url":null,"abstract":"<p><p>In this article for the \"Highlights of 2025\" series, we discuss advances in chimeric antigen receptor (CAR)-engineered natural killer (NK) cell therapies. We highlight iPSC-derived manufacturing, expansion into autoimmune disease, discovery of intrinsic regulators, and rational antigen targeting, illustrating how discovery-driven biology and engineering are reshaping CAR-NK therapies toward broader clinical applicability. Figure made in ©BioRender-biorender.com.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"528-531"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of metabolically activated macrophages in human adipose tissue and their possible role in preadipocyte differentiation. 人脂肪组织中代谢活化巨噬细胞的鉴定及其在脂肪前细胞分化中的可能作用。
IF 3 4区 医学
Immunology & Cell Biology Pub Date : 2026-05-01 Epub Date: 2026-04-22 DOI: 10.1111/imcb.70115
Elena Berenice Martínez-Shio, Leobardo Emmanuel Álvarez-de León, Silvia Guadalupe Ramírez-Segovia, Ricardo Ramírez-Torres, Rogelio Martínez-Wagner, Claudia Guadalupe Castillo-Martín Del Campo, Othir Gidalti Galicia-Cruz, Adriana Elizabeth Monsiváis-Urenda
{"title":"Identification of metabolically activated macrophages in human adipose tissue and their possible role in preadipocyte differentiation.","authors":"Elena Berenice Martínez-Shio, Leobardo Emmanuel Álvarez-de León, Silvia Guadalupe Ramírez-Segovia, Ricardo Ramírez-Torres, Rogelio Martínez-Wagner, Claudia Guadalupe Castillo-Martín Del Campo, Othir Gidalti Galicia-Cruz, Adriana Elizabeth Monsiváis-Urenda","doi":"10.1111/imcb.70115","DOIUrl":"10.1111/imcb.70115","url":null,"abstract":"<p><p>Dyslipidemia can modify the function and phenotype of adipose tissue macrophages. Accumulated evidence suggests that metabolically activated (MMe) macrophages perform both detrimental and beneficial functions in adipose tissue. However, no studies evaluating their role in adipogenesis have been performed. Here, we combine in vitro assays with flow cytometry to characterize the adipose tissue macrophage populations of 32 specimens from patients with dyslipidemia and control subjects, and determine the role of MMe macrophages in the differentiation of primary human preadipocytes. We observed that the increase of MMe macrophages from adipose tissue is influenced by dyslipidemia, but the frequency of M1 and M2 macrophages did not differ when comparing both study groups. We found that MMe macrophages from dyslipidemic patients promote more adipogenic differentiation of preadipocytes compared with those from control subjects; this effect can be attributed to a mechanism governed by soluble factors and cell contact. We also observed that CD38 is expressed on CD14<sup>+</sup>CD80<sup>+</sup>CD68<sup>+</sup> (M1), CD14<sup>+</sup>CD206<sup>+</sup>CD163<sup>+</sup> (M2) and MMe macrophages from adipose tissue, but a higher frequency of CD38<sup>+</sup> macrophages with MMe phenotype was found compared with M2. In addition, we observed a positive trend between the frequency of CD38<sup>+</sup> MMe macrophages and age of dyslipidemic patients. This study demonstrates that MMe macrophages promote the differentiation of preadipocytes and this effect is favored in dyslipidemia conditions.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"532-544"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-1β and IL-6 synergistically drive murine TFH cell differentiation and maintenance in vitro. IL-1β和IL-6协同驱动小鼠TFH细胞的体外分化和维持。
IF 3 4区 医学
Immunology & Cell Biology Pub Date : 2026-05-01 Epub Date: 2026-03-31 DOI: 10.1111/imcb.70104
Juliana Restrepo Munera, S Rameeza Allie
{"title":"IL-1β and IL-6 synergistically drive murine TFH cell differentiation and maintenance in vitro.","authors":"Juliana Restrepo Munera, S Rameeza Allie","doi":"10.1111/imcb.70104","DOIUrl":"10.1111/imcb.70104","url":null,"abstract":"<p><p>T follicular helper (TFH) cells are critical in supporting B-cell responses, which ultimately establish long-term protective immunity against infection and some cancers by producing protective B cells, including antibody-secreting cells and memory cells. However, this same GC output can also promote autoimmune pathology. Therefore, TFH cells are at the core of humoral immunity, underscoring TFH cells as targets for long-term protective and/or pathologic immune responses. Here we define conditions that promote physiologically relevant TFH cell differentiation in vitro. We demonstrate that in addition to T-cell receptor (TCR) signaling, IL-6 and IL-1β individually and jointly promote TFH cell differentiation. These findings highlight key requirements for generating functional TFH cells, providing a model to study therapeutic impacts on TFH cells across diverse disease settings.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"457-472"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal ILC-epithelial cell circuits shaping barrier immunity. 肠道ilc -上皮细胞回路形成屏障免疫。
IF 3 4区 医学
Immunology & Cell Biology Pub Date : 2026-05-01 Epub Date: 2026-03-31 DOI: 10.1111/imcb.70109
Huiyang Yu, Evelyn Chen, Gabrielle T Belz
{"title":"Intestinal ILC-epithelial cell circuits shaping barrier immunity.","authors":"Huiyang Yu, Evelyn Chen, Gabrielle T Belz","doi":"10.1111/imcb.70109","DOIUrl":"10.1111/imcb.70109","url":null,"abstract":"<p><p>Recent studies in 2025 uncovered the crosstalk between intestinal innate lymphoid cells (ILCs) and epithelial cells, highlighting a previously unappreciated role of intestinal ILC-epithelial cell circuit in shaping intestinal barrier immunity.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"452-456"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147579928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine armored CAR T cells for cancer immunotherapy. 细胞因子装甲CAR - T细胞用于癌症免疫治疗。
IF 3 4区 医学
Immunology & Cell Biology Pub Date : 2026-05-01 Epub Date: 2026-04-05 DOI: 10.1111/imcb.70112
Kevin Sek, Kah Min Yap, Woon Xuan Hong, Phillip K Darcy
{"title":"Cytokine armored CAR T cells for cancer immunotherapy.","authors":"Kevin Sek, Kah Min Yap, Woon Xuan Hong, Phillip K Darcy","doi":"10.1111/imcb.70112","DOIUrl":"10.1111/imcb.70112","url":null,"abstract":"<p><p>Cytokine armoring of CAR T cells for enhancing the immunotherapy of cancer. Reprogramming of CAR T-cell phenotypes through (a) IL-15<sup>8</sup> or (b) IL-9Rα<sup>9</sup> engineering. Reprogramming of the tumor microenvironment and recruitment of host antitumor immunity through (c) IL-36γ<sup>10</sup> or (d) IL-12<sup>11,12</sup> engineering. (e) Tumor-inducible cytokine expression utilizing synthetic NFAT or endogenous NR4A2 promoter systems to restrict systemic expression of potent cytokines for improved safety.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"485-489"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroinflammation as a result of non-neurotropic herpesvirus infection. 非嗜神经性疱疹病毒感染引起的神经炎症。
IF 3 4区 医学
Immunology & Cell Biology Pub Date : 2026-05-01 Epub Date: 2026-03-31 DOI: 10.1111/imcb.70108
Christian Münz
{"title":"Neuroinflammation as a result of non-neurotropic herpesvirus infection.","authors":"Christian Münz","doi":"10.1111/imcb.70108","DOIUrl":"10.1111/imcb.70108","url":null,"abstract":"<p><p>The non-neurotropic Epstein Barr virus (EBV) has been suggested to initiate the prodromal phase of multiple sclerosis (MS), often years before the first clinical symptoms. This review discusses mechanisms by which EBV might cause neuroinflammatory B-cell migration to the central nervous system (CNS), as observed during primary CNS lymphomas and MS. Furthermore, mechanisms of molecular mimicry and autoreactive B-cell expansion by EBV will also be summarized. Finally, approaches to target EBV-mediated neuroinflammation for therapeutic interventions in people with MS (pwMS) will be explored. The recently provided information on EBV's association with MS gives exciting insights into the initiation of this autoimmune disease. Successful therapeutic interventions on the basis of this knowledge might provide evidence that EBV contributes also to the clinical phase of this autoimmune disease.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"443-451"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147579930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Origins and drivers of self-reactive B cells in autoimmune disease. 自身免疫性疾病中自身反应性B细胞的起源和驱动因素。
IF 3 4区 医学
Immunology & Cell Biology Pub Date : 2026-05-01 DOI: 10.1111/imcb.70128
Adrian Y S Lee, Qian Shen, Joanne H Reed
{"title":"Origins and drivers of self-reactive B cells in autoimmune disease.","authors":"Adrian Y S Lee, Qian Shen, Joanne H Reed","doi":"10.1111/imcb.70128","DOIUrl":"https://doi.org/10.1111/imcb.70128","url":null,"abstract":"<p><p>Self-reactive B cells are a hallmark of autoimmune disease and may directly contribute to disease pathogenesis. This Research Highlight article reviews four articles published in 2025 that offer new insights into the origins and drivers of self-reactive B cells. These studies investigate self-reactive B cells in human peripheral blood, murine models, and the role of viral and genetic drivers.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular gatekeepers of central nervous system immunity. 中枢神经系统免疫的血管看门人。
IF 3 4区 医学
Immunology & Cell Biology Pub Date : 2026-05-01 Epub Date: 2026-04-17 DOI: 10.1111/imcb.70116
Luca Vinnell, Kate Hitpass Romero, Taylor J Stevenson, Justin Rustenhoven
{"title":"Vascular gatekeepers of central nervous system immunity.","authors":"Luca Vinnell, Kate Hitpass Romero, Taylor J Stevenson, Justin Rustenhoven","doi":"10.1111/imcb.70116","DOIUrl":"10.1111/imcb.70116","url":null,"abstract":"<p><p>In this article for the Highlights of 2025 series, we review recent advances in the vascular biology of CNS border tissues. These studies reveal how blood and lymphatic networks at the meninges, nasal regions, and skull coordinate fluid flow and immune surveillance, uncovering new opportunities for therapeutic intervention in neurological disease.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":"519-523"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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