Type I interferon: it's all about intracellular TLR4

IF 3 4区医学 Q3 CELL BIOLOGY

Immunology & Cell Biology Pub Date : 2025-07-10 DOI:10.1111/imcb.70048

Harald Husebye

引用次数: 0

Abstract

A recent extensive study from the Blumenthal research group has demonstrated that Toll-like receptor 4 (TLR4) signaling from the endosomes can be uncoupled from CD14-mediated endocytosis, revealing two distinct TLR4 signaling pathways. TLR4 was the first of the toll-like receptors to be discovered and one of the most studied.

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I型干扰素，主要是细胞内TLR4。

Blumenthal研究小组最近的一项广泛研究表明，来自核内体的toll样受体4 （TLR4）信号可以与cd14介导的内吞作用解耦，揭示了两种不同的TLR4信号通路。TLR4是最早发现的toll样受体，也是研究最多的受体之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology & Cell Biology 医学-免疫学

CiteScore

7.50

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.