Immunology & Cell Biology最新文献_第5页

From dentistry to immunology: navigating challenges and building a career in neuroimmunology. 从牙科到免疫学：迎接挑战，开创神经免疫学事业。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-06-27 DOI: 10.1111/imcb.12797

Lidia Yshii

引用次数: 0

Striking an alliance between T cells and macrophages for enhanced cancer immunotherapy 在 T 细胞和巨噬细胞之间建立联盟，增强癌症免疫疗法。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-06-27 DOI: 10.1111/imcb.12799

Tessa Gargett, Lisa M Ebert

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Helminth infection induces a distinct subset of CD101hi lung tissue–infiltrating eosinophils that are differentially regulated by type 2 cytokines 螺旋体感染会诱导不同的 CD101hi 肺组织浸润性嗜酸性粒细胞亚群，这些亚群受 2 型细胞因子的不同调节。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-06-26 DOI: 10.1111/imcb.12796

Sophia-Louise Noble, Francesco Vacca, Kerry L Hilligan, Thomas C Mules, Graham Le Gros, Stephen Inns

{"title":"Helminth infection induces a distinct subset of CD101hi lung tissue–infiltrating eosinophils that are differentially regulated by type 2 cytokines","authors":"Sophia-Louise Noble, Francesco Vacca, Kerry L Hilligan, Thomas C Mules, Graham Le Gros, Stephen Inns","doi":"10.1111/imcb.12796","DOIUrl":"10.1111/imcb.12796","url":null,"abstract":"Eosinophils play divergent roles in health and disease, contributing to both immunoregulatory and proinflammatory responses. Helminth infection is strongly associated with eosinophilia and the induction of the type 2 cytokines interleukin (IL)-5, IL-4 and IL-13. This study aimed to elucidate the heterogeneity of pulmonary eosinophils in response to helminth infection and the roles of IL-5, IL-4 and IL-13 in driving pulmonary eosinophil responses. Using the murine helminth model Nippostrongylus brasiliensis (Nb), we characterize a subtype of eosinophils, defined by high expression of CD101, that is induced in the lungs of Nb-infected mice and are phenotypically distinct from lung eosinophils that express low levels of CD101. Strikingly, we show that the two eosinophil subtypes have distinct anatomical localization within the lung: CD101low eosinophils are predominantly localized in the lung vasculature, whereas Nb-induced CD101hi eosinophils are predominantly localized in the extravascular lung niche. We show that CD101hi eosinophils are also induced across other models of pulmonary infection and inflammation, including a nonlung-migrating helminth infection, house dust mite–induced allergic inflammation and influenza infection. Furthermore, we demonstrate that the induction of CD101hi tissue eosinophils is independent of IL-5 and IL-4 signaling, but is dependent on intact IL-13 signaling. These results suggest that IL-13 produced during helminth infection and other disease states promotes a pulmonary tissue-infiltrating program in eosinophils defined by high expression of CD101.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 8","pages":"734-746"},"PeriodicalIF":3.2,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12796","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy 在细菌感染过程中，免疫检查点 TIGIT 在 T 细胞中上调，是免疫疗法的潜在靶点。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-06-14 DOI: 10.1111/imcb.12794

Timothy R McCulloch, Gustavo R Rossi, Socorro Miranda-Hernandez, Ana Maria Valencia-Hernandez, Louisa Alim, Clemence J Belle, Andrew Krause, Lucia F Zacchi, Pui Yeng Lam, Kyohei Nakamura, Andreas Kupz, Timothy J Wells, Fernando Souza-Fonseca-Guimaraes

{"title":"The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy","authors":"Timothy R McCulloch, Gustavo R Rossi, Socorro Miranda-Hernandez, Ana Maria Valencia-Hernandez, Louisa Alim, Clemence J Belle, Andrew Krause, Lucia F Zacchi, Pui Yeng Lam, Kyohei Nakamura, Andreas Kupz, Timothy J Wells, Fernando Souza-Fonseca-Guimaraes","doi":"10.1111/imcb.12794","DOIUrl":"10.1111/imcb.12794","url":null,"abstract":"Antibiotic resistance is a major public health threat, and alternatives to antibiotic therapy are urgently needed. Immunotherapy, particularly the blockade of inhibitory immune checkpoints, is a leading treatment option in cancer and autoimmunity. In this study, we used a murine model of Salmonella Typhimurium infection to investigate whether immune checkpoint blockade could be applied to bacterial infection. We found that the immune checkpoint T-cell immunoglobulin and ITIM domain (TIGIT) was significantly upregulated on lymphocytes during infection, particularly on CD4+ T cells, drastically limiting their proinflammatory function. Blockade of TIGIT in vivo using monoclonal antibodies was able to enhance immunity and improve bacterial clearance. The efficacy of anti-TIGIT was dependent on the capacity of the antibody to bind to Fc (fragment crystallizable) receptors, giving important insights into the mechanism of anti-TIGIT therapy. This research suggests that targeting immune checkpoints, such as TIGIT, has the potential to enhance immune responses toward bacteria and restore antibacterial treatment options in the face of antibiotic resistance.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 8","pages":"721-733"},"PeriodicalIF":3.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional network analysis of peripheral blood leukocyte subsets in multiple sclerosis identifies a pathogenic role for a cytotoxicity-associated gene network in myeloid cells 多发性硬化症外周血白细胞亚群的转录网络分析确定了骨髓细胞中细胞毒性相关基因网络的致病作用。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-06-14 DOI: 10.1111/imcb.12793

Margaret A Jordan, Melissa M Gresle, Adrian T Gemiarto, Dragana Stanley, Letitia D Smith, Louise Laverick, Tim Spelman, Jim Stankovich, Annie ML Willson, Xuyen T Dinh, Laura Johnson, Kylie Robertson, Christopher AR Reid, Judith Field, Helmut Butzkueven, Alan G Baxter

{"title":"Transcriptional network analysis of peripheral blood leukocyte subsets in multiple sclerosis identifies a pathogenic role for a cytotoxicity-associated gene network in myeloid cells","authors":"Margaret A Jordan, Melissa M Gresle, Adrian T Gemiarto, Dragana Stanley, Letitia D Smith, Louise Laverick, Tim Spelman, Jim Stankovich, Annie ML Willson, Xuyen T Dinh, Laura Johnson, Kylie Robertson, Christopher AR Reid, Judith Field, Helmut Butzkueven, Alan G Baxter","doi":"10.1111/imcb.12793","DOIUrl":"10.1111/imcb.12793","url":null,"abstract":"Multiple sclerosis (MS) is an autoimmune disease of the central nervous system affecting predominantly adults. It is a complex disease associated with both environmental and genetic risk factors. Although over 230 risk single-nucleotide polymorphisms have been associated with MS, all are common human variants. The mechanisms by which they increase the risk of MS, however, remain elusive. We hypothesized that a complex genetic phenotype such as MS could be driven by coordinated expression of genes controlled by transcriptional regulatory networks. We, therefore, constructed a gene coexpression network from microarray expression analyses of five purified peripheral blood leukocyte subsets of 76 patients with relapsing remitting MS and 104 healthy controls. These analyses identified a major network (or module) of expressed genes associated with MS that play key roles in cell-mediated cytotoxicity which was downregulated in monocytes of patients with MS. Manipulation of the module gene expression was achieved in vitro through small interfering RNA gene knockdown of identified drivers. In a mouse model, network gene knockdown modulated the autoimmune inflammatory MS model disease—experimental autoimmune encephalomyelitis. This research implicates a cytotoxicity-associated gene network in myeloid cells in the pathogenesis of MS.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 8","pages":"702-720"},"PeriodicalIF":3.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12793","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nurturing a positive research culture within your organization 在组织内部培养积极的科研文化。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-06-13 DOI: 10.1111/imcb.12795

Adrian Liston, Denise C Fitzgerald

引用次数: 0

Impact of socioeconomic status on healthy immune responses in humans 社会经济地位对人类健康免疫反应的影响。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-06-11 DOI: 10.1111/imcb.12789

Anthony Bertrand, Jamie Sugrue, Tianai Lou, Nollaig M Bourke, Lluis Quintana-Murci, Violaine Saint-André, Cliona O'Farrelly, Darragh Duffy, the Milieu Intérieur Consortium

{"title":"Impact of socioeconomic status on healthy immune responses in humans","authors":"Anthony Bertrand, Jamie Sugrue, Tianai Lou, Nollaig M Bourke, Lluis Quintana-Murci, Violaine Saint-André, Cliona O'Farrelly, Darragh Duffy, the Milieu Intérieur Consortium","doi":"10.1111/imcb.12789","DOIUrl":"10.1111/imcb.12789","url":null,"abstract":"Individuals with low socioeconomic status (SES) are at greater risk of contracting and developing severe disease compared with people with higher SES. Age, sex, host genetics, smoking and cytomegalovirus (CMV) serostatus are known to have a major impact on human immune responses and thus susceptibility to infection. However, the impact of SES on immune variability is not well understood or explored. Here, we used data from the Milieu Intérieur project, a study of 1000 healthy volunteers with extensive demographic and biological data, to examine the effect of SES on immune variability. We developed an Elo-rating system using socioeconomic features such as education, income and home ownership status to objectively rank SES in the 1000 donors. We observed sex-specific SES associations, such as females with a low SES having a significantly higher frequency of CMV seropositivity compared with females with high SES, and males with a low SES having a significantly higher frequency of active smoking compared with males with a high SES. Using random forest models, we identified specific immune genes which were significantly associated with SES in both baseline and immune challenge conditions. Interestingly, many of the SES associations were sex stimuli specific, highlighting the complexity of these interactions. Our study provides a new way of computing SES in human populations that can help identify novel SES associations and reinforces biological evidence for SES-dependent susceptibility to infection. This should serve as a basis for further understanding the molecular mechanisms behind SES effects on immune responses and ultimately disease.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 7","pages":"618-629"},"PeriodicalIF":3.2,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12789","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding changes in tumor-infiltrating leukocytes through dynamic experimental models and single-cell technologies 通过动态实验模型和单细胞技术解码肿瘤浸润白细胞的变化。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-06-10 DOI: 10.1111/imcb.12787

Colin YC Lee, Menna R Clatworthy, David R Withers

引用次数: 0

Discovery of a monoclonal, high-affinity CD8+ T-cell clone following natural hepatitis C virus infection 发现自然感染丙型肝炎病毒后的单克隆高亲和性 CD8+ T 细胞克隆。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-06-10 DOI: 10.1111/imcb.12791

Curtis Cai, Elizabeth Keoshkerian, Kristof Wing, Jerome Samir, Manuel Effenberger, Kilian Schober, Rowena A Bull, Andrew R Lloyd, Dirk H Busch, Fabio Luciani

{"title":"Discovery of a monoclonal, high-affinity CD8+ T-cell clone following natural hepatitis C virus infection","authors":"Curtis Cai, Elizabeth Keoshkerian, Kristof Wing, Jerome Samir, Manuel Effenberger, Kilian Schober, Rowena A Bull, Andrew R Lloyd, Dirk H Busch, Fabio Luciani","doi":"10.1111/imcb.12791","DOIUrl":"10.1111/imcb.12791","url":null,"abstract":"CD8+ T cells recognizing their cognate antigen are typically recruited as a polyclonal population consisting of multiple clonotypes with varying T-cell receptor (TCR) affinity to the target peptide–major histocompatibility complex (pMHC) complex. Advances in single-cell sequencing have increased accessibility toward identifying TCRs with matched antigens. Here we present the discovery of a monoclonal CD8+ T-cell population with specificity for a hepatitis C virus (HCV)–derived human leukocyte antigen (HLA) class I epitope (HLA-B*07:02 GPRLGVRAT) which was isolated directly ex vivo from an individual with an episode of acutely resolved HCV infection. This population was absent before infection and underwent expansion and stable maintenance for at least 2 years after infection as measured by HLA-multimer staining. Furthermore, the monoclonal clonotype was characterized by an unusually long dissociation time (half-life = 794 s and koff = 5.73 × 10−4) for its target antigen when compared with previously published results. A comparison with related populations of HCV-specific populations derived from the same individual and a second individual suggested that high-affinity TCR–pMHC interactions may be inherent to epitope identity and shape the phenotype of responses which has implications for rational TCR selection and design in the age of personalized immunotherapies.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 7","pages":"630-641"},"PeriodicalIF":3.2,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12791","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Highlight of 2023: Advances in pediatric immunology 2023 年的亮点：儿科免疫学的进步

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-06-07 DOI: 10.1111/imcb.12790

Erika Van Nieuwenhove

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