Journal of VitreoRetinal Diseases最新文献

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Carbon Footprint of Pars Plana Vitrectomy, Pneumatic Retinopexy, and Scleral Buckle Procedures for Rhegmatogenous Retinal Detachment Repair. 玻璃体切除、充气视网膜固定术和巩膜扣术对孔源性视网膜脱离修复的碳足迹。
IF 0.8
Journal of VitreoRetinal Diseases Pub Date : 2025-09-03 DOI: 10.1177/24741264251367120
Rahul Moorjani, Graeme Kenneth Loh, Matthew T S Tennant, Peter J Kertes, Parampal S Grewal
{"title":"Carbon Footprint of Pars Plana Vitrectomy, Pneumatic Retinopexy, and Scleral Buckle Procedures for Rhegmatogenous Retinal Detachment Repair.","authors":"Rahul Moorjani, Graeme Kenneth Loh, Matthew T S Tennant, Peter J Kertes, Parampal S Grewal","doi":"10.1177/24741264251367120","DOIUrl":"10.1177/24741264251367120","url":null,"abstract":"<p><p><b>Purpose:</b> To quantify the environmental impact of pars plana vitrectomy (PPV), pneumatic retinopexy, and scleral buckle procedures used in rhegmatogenous retinal detachment (RRD) repair. <b>Methods:</b> We conducted a life cycle assessment of PPV, pneumatic retinopexy, and scleral buckle procedures. The primary outcome measure was the greenhouse gas emissions associated with each procedure measured in carbon dioxide equivalents. <b>Results:</b> The total greenhouse gas emissions produced were 51.10 kg carbon dioxide equivalents for PPV, 2.09 kg carbon dioxide equivalents for pneumatic retinopexy, and 12.57 kg carbon dioxide equivalents for scleral buckle. Emissions related to equipment use (30.07 kg carbon dioxide equivalents) followed by equipment manufacturing (21.00 kg carbon dioxide equivalents) were the main contributors of greenhouse gases in PPV. Emissions related to equipment manufacturing (1.60 kg and 8.51 kg of carbon dioxide equivalents for pneumatic retinopexy and scleral buckle, respectively), followed by equipment use (0.49 kg and 4.05 kg of carbon dioxide equivalents for pneumatic retinopexy and scleral buckle, respectively), were the greatest contributors of greenhouse gases in pneumatic retinopexy and scleral buckle. <b>Conclusions:</b> There is a substantial difference in greenhouse gas emissions among PPV, pneumatic retinopexy, and scleral buckle. Quantifying and understanding these differences can inform surgical decision-making.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251367120"},"PeriodicalIF":0.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-World Experience of Geographic Atrophy Treatment With Avacincaptad Pegol. 用无脑Pegol治疗地理萎缩的现实经验。
IF 0.8
Journal of VitreoRetinal Diseases Pub Date : 2025-09-03 DOI: 10.1177/24741264251367100
Abdullah Abou-Samra, Muhi Dean Barazi, Amira Abbas, Omar Sabbagh, Yusuf Bade, Brian K Do, Jeanette Du, Jared Ebert, Jordana Fein, Joshua D Levinson, Alexander Melamud, Osama Sabbagh, Mohsin H Ali
{"title":"Real-World Experience of Geographic Atrophy Treatment With Avacincaptad Pegol.","authors":"Abdullah Abou-Samra, Muhi Dean Barazi, Amira Abbas, Omar Sabbagh, Yusuf Bade, Brian K Do, Jeanette Du, Jared Ebert, Jordana Fein, Joshua D Levinson, Alexander Melamud, Osama Sabbagh, Mohsin H Ali","doi":"10.1177/24741264251367100","DOIUrl":"10.1177/24741264251367100","url":null,"abstract":"<p><p><b>Purpose:</b>To present the first real-world safety data describing the clinical experience of geographic atrophy (GA) treatment with avacincaptad pegol in a large cohort. <b>Methods:</b> A retrospective, observational cohort study was conducted within the PRISM Vision Group by filtering for J codes for avacincaptad pegol from August 3, 2023, to October 10, 2024. <b>Results:</b> The study included 461 eyes of 335 patients with GA who were treated with intravitreal avacincaptad pegol 2 mg (0.1 mL of 20 mg/mL) injections. The mean follow-up time was 120 days. The mean injection interval was 52 days. Fourteen eyes (3%) developed an acute rise in intraocular pressure, and there were no reports of endophthalmitis, intraocular inflammation, or nonarteritic anterior ischemic optic neuropathy. Eight eyes (2.03%) converted to neovascular age-related macular degeneration, with an average of 2 injections before conversion and a predicted annualized rate of conversion of approximately 6.17%. One eye (0.2%) developed a vitreous hemorrhage. <b>Conclusions:</b> This study describes the real-world safety profile of avacincaptad pegol that may aid clinicians in understanding the risk of adverse events associated with this relatively new treatment for GA.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251367100"},"PeriodicalIF":0.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal Layer Thickness and Volume Measurements in Traumatic Brain Injury. 外伤性脑损伤视网膜层厚度和体积测量。
IF 0.8
Journal of VitreoRetinal Diseases Pub Date : 2025-09-03 DOI: 10.1177/24741264251367104
Naveen Karthik, Sejal D Patel, Grant A Justin, Sandra S Stinnett, Stephanie J Chiu, Nathan T Tagg, Rupesh Agrawal, Dilraj S Grewal, Sharon Fekrat
{"title":"Retinal Layer Thickness and Volume Measurements in Traumatic Brain Injury.","authors":"Naveen Karthik, Sejal D Patel, Grant A Justin, Sandra S Stinnett, Stephanie J Chiu, Nathan T Tagg, Rupesh Agrawal, Dilraj S Grewal, Sharon Fekrat","doi":"10.1177/24741264251367104","DOIUrl":"10.1177/24741264251367104","url":null,"abstract":"<p><p><b>Purpose:</b> To assess retinal layer thickness and volume by optical coherence tomography (OCT) in patients with prior traumatic brain injury (TBI). <b>Methods:</b> Adults (≥18 years) with prior TBI were prospectively recruited. 512 × 128-mm macular cube scans were obtained using Zeiss Cirrus HD-5000 OCT. The previously validated Duke Reading Center's DRCVisualizer semiautomatically segmented (manually corrected) the ganglion cell-inner plexiform (GC-IPL), inner nuclear (INL), outer plexiform (OPL), outer nuclear (ONL), photoreceptors (PR), and retinal pigment epithelium (RPE) layers. Mean thickness and volume were obtained within 3- and 6-mm ETDRS perifoveal rings. Individuals were age- and sex-matched (±5 years) with controls. <b>Results:</b> Thirty-eight patients with TBI (66 eyes; mean ± SD age 45 ± 19 years) and 37 controls (66 eyes; age 44 ± 18 years) were enrolled. Time from TBI to imaging was a mean ± SD 136 ± 89 weeks. TBI was categorized by severity (mild without loss of consciousness [LOC] [n = 25], mild with LOC [n = 35], moderate [n = 6]) and injury mechanism (nonpenetrating contact [n = 54], acceleration-deceleration [n = 12]). Mean GC-IPL was significantly decreased and mean OPL thickness and volume were significantly increased in male TBI patients versus controls. Eyes with moderate TBI had significantly increased mean neurosensory retina, INL, OPL, and RPE thickness and volume versus other TBI severity groups. Eyes with nonpenetrating contact TBI had significantly increased mean neurosensory retina and ONL thickness and volume versus eyes with acceleration-deceleration TBI. All eyes showed a significant correlation for decreasing mean GC-IPL thickness and volume with time from TBI to imaging. <b>Conclusions:</b> TBI may impact thickness and volume of the retinal layers, and changes may be progressive over time.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251367104"},"PeriodicalIF":0.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal B-Scan Ultrasonography Findings and their Relation to Visual Outcomes in Endophthalmitis. 眼内炎的颞叶b超表现及其与视力的关系。
IF 0.8
Journal of VitreoRetinal Diseases Pub Date : 2025-09-02 DOI: 10.1177/24741264251364818
Caroline Cotton, Sandra Hoyek, Sloane McTavish, Marisa Tieger, Celine Chaaya, Elizabeth Rossin, David Wu, James Harris, Nimesh A Patel
{"title":"Temporal B-Scan Ultrasonography Findings and their Relation to Visual Outcomes in Endophthalmitis.","authors":"Caroline Cotton, Sandra Hoyek, Sloane McTavish, Marisa Tieger, Celine Chaaya, Elizabeth Rossin, David Wu, James Harris, Nimesh A Patel","doi":"10.1177/24741264251364818","DOIUrl":"10.1177/24741264251364818","url":null,"abstract":"<p><p><b>Purpose:</b> To evaluate B-scan echographic features of endophthalmitis for their correlation with disease characteristics and long-term vision outcomes. <b>Methods:</b> Patients diagnosed with endophthalmitis at Massachusetts Eye and Ear between 2011 and 2021 were recruited (N = 209). Data included demographics, infection source, initial therapy, and findings from culture isolates, best corrected visual acuity (BCVA), slit lamp, and B-scan ultrasonography. <b>Results:</b> More patients with positive microbial cultures, versus those with negative cultures, had dense vitreous debris on initial B-scan (<i>P</i> = .008). Patients whose initial slit lamp examination provided difficult/no view into the anterior chamber had more frequent findings of retinal detachment (RD) and T-sign (<i>P</i> < .001 and <i>P</i> = .016, respectively) and worse final mean BCVA (<i>P</i> < .001) versus patients with adequate views. Patients with dense vitreous opacities (VO) on initial B-scan had significantly worse initial mean BCVA versus patients with mild or moderate VO (<i>P <</i> .001 and <i>P</i> = .013, respectively) and had significantly worse final mean BCVA versus patients with mild VO (<i>P <</i> .001). Final mean BCVA was significantly worse in patients with choroidal detachment (CD), RD, or T-sign than in patients without these features (each <i>P</i> < .001). Reductions in VO and vitreous membranes were observed at 1 month postpresentation, whereas CD was significantly more common at 1 week and RD more common at 1 month postpresentation. <b>Conclusions:</b> Positive cultures, specific microbial species, and B-scan findings (dense VO, CD, RD, and T-sign) are independent predictors of worse vision outcomes in patients with endophthalmitis.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251364818"},"PeriodicalIF":0.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IgA Nephropathy Associated Hypertensive Retinopathy and Purtscher-Like Retinopathy. IgA肾病相关高血压视网膜病变和purtscher样视网膜病变。
IF 0.8
Journal of VitreoRetinal Diseases Pub Date : 2025-08-31 DOI: 10.1177/24741264251366409
Taha Salim Çevik, Sena Kocaman Ata, Yasemin Özdamar Erol, Eylem Pınar Eser
{"title":"IgA Nephropathy Associated Hypertensive Retinopathy and Purtscher-Like Retinopathy.","authors":"Taha Salim Çevik, Sena Kocaman Ata, Yasemin Özdamar Erol, Eylem Pınar Eser","doi":"10.1177/24741264251366409","DOIUrl":"10.1177/24741264251366409","url":null,"abstract":"<p><p><b>Purpose:</b> Purtscher-like retinopathy is a condition similar to Purtscher's retinopathy but results from non-traumatic causes. Although its pathophysiology is not fully understood, it is thought to be related to the complement system. Renal diseases, which play a significant role in secondary hypertension, are known to be important in its etiology. <b>Methods:</b> Observational case report. <b>Results:</b> A 22-year-old male patient initially presented with vision-related findings, including both hypertensive retinopathy and Purtscher-like retinopathy, and on further investigation was diagnosed with IgA nephropathy with C3 immunocomplexes, a combination of poor prognostic factors, and rapidly progressive glomerulonephritis. <b>Conclusions:</b> The presence of both hypertensive retinopathy and Purtscher-like retinopathy in our patient indicates an advanced stage of ocular involvement. This emphasizes the critical role of ocular findings in the differential diagnosis and severity of systemic diseases.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251366409"},"PeriodicalIF":0.8,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Faricimab on Visual Acuity and Retinal Structure in Neovascular Age-Related Macular Degeneration Previously Treated With Anti-VEGF Therapy. 法利西单抗对抗vegf治疗的新生血管性年龄相关性黄斑变性患者的视力和视网膜结构的影响。
IF 0.8
Journal of VitreoRetinal Diseases Pub Date : 2025-08-30 DOI: 10.1177/24741264251366393
Nathan Sattah, Wufan Zhao, Alex Choi, Meible Chi, Kubra Sarici, Peter Weng, Richard Morgan, Yuxi Zheng, Naveen Karthik, Lejla Vajzovic, Majda Hadziahmetovic
{"title":"Effect of Faricimab on Visual Acuity and Retinal Structure in Neovascular Age-Related Macular Degeneration Previously Treated With Anti-VEGF Therapy.","authors":"Nathan Sattah, Wufan Zhao, Alex Choi, Meible Chi, Kubra Sarici, Peter Weng, Richard Morgan, Yuxi Zheng, Naveen Karthik, Lejla Vajzovic, Majda Hadziahmetovic","doi":"10.1177/24741264251366393","DOIUrl":"10.1177/24741264251366393","url":null,"abstract":"<p><p><b>Purpose:</b> To evaluate the effects of switching from traditional antivascular endothelial growth factor (anti-VEGF) therapies to faricimab, a biclonal antibody that targets both VEGF and angiopoietin-2, on eyes with neovascular age-related macular degeneration (nAMD). <b>Methods:</b> This study retrospectively reviewed patients with nAMD who were previously treated with bevacizumab, ranibizumab, or aflibercept and then switched to faricimab. We compared injection frequency and visual acuity (VA) during the time period before faricimab initiation (1 year prior) and after initiation (6-12 months after). Optical coherence tomography images were analyzed from initiation to final follow-up (6-12 months after initiation). <b>Results:</b> We evaluated 84 eyes of 68 patients. Following faricimab initiation, eyes had a reduced mean ± SE central macular thickness (CMT) (282.3 ± 16.2 μm vs 244.8 ± 14.3 μm; <i>P</i> < .01). Annual injection frequency increased from 7.73 ± 0.33 to 8.66 ± 0.28 injections (<i>P</i> < .001). VA did not change significantly during the year before faricimab initiation (<i>P</i> = .539) but decreased after initiation (from 0.56 ± 0.05 logMAR to 0.66 ± 0.06 logMAR; <i>P</i> < .01). Four eyes developed macular atrophy following faricimab initiation (<i>P</i> < .01). <b>Conclusions:</b> Eyes with nAMD that were previously treated with anti-VEGF therapy and later switched to faricimab showed reduced CMT; however, some patients had increased injection frequency, decreased VA, and macular atrophy. These findings should be explored further using larger datasets.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251366393"},"PeriodicalIF":0.8,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation and Management of Uveitis in a Patient With AIDS With Low CD4 Count and Prior CMV Retinitis. CD4低计数伴既往巨细胞病毒性视网膜炎的艾滋病患者葡萄膜炎的评估和处理。
IF 0.8
Journal of VitreoRetinal Diseases Pub Date : 2025-08-30 DOI: 10.1177/24741264251366408
Weilin Song, Jack Benjamin Margines, Yaqoob Qaseem, Adrian Au, Jayanth Sridhar
{"title":"Evaluation and Management of Uveitis in a Patient With AIDS With Low CD4 Count and Prior CMV Retinitis.","authors":"Weilin Song, Jack Benjamin Margines, Yaqoob Qaseem, Adrian Au, Jayanth Sridhar","doi":"10.1177/24741264251366408","DOIUrl":"10.1177/24741264251366408","url":null,"abstract":"<p><p><b>Purpose:</b> To report an unusual case of uveitis in a patient with AIDS with low CD4 count. <b>Methods:</b> A single case was evaluated. <b>Results:</b> A 28-year-old man with AIDS, central nervous system lymphoma, and cytomegalovirus (CMV) viremia developed subacute vitritis in the left eye. He endorsed 1 month of blurry vision 2 years after initiating antiretroviral therapy. Current CD4 count was 40 cells/mm<sup>3</sup> and HIV viral load was undetectable. He received empiric intravenous antiviral therapy and declined intravitreal injections. Due to worsening clinical course, diagnostic and therapeutic vitrectomy was performed, and intraoperative examination was consistent with prior CMV infection. Aqueous polymerase chain reaction (PCR) was positive for CMV. Infectious workup was otherwise unremarkable. Vitreous cytology and flow cytometry were negative for vitreoretinal lymphoma. <b>Conclusions:</b> Immune recovery uveitis from CMV retinitis should be included in the differential for subacute vitritis in a patient with AIDS and low (<50) CD4 count on antiretroviral therapy.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251366408"},"PeriodicalIF":0.8,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound Biomicroscopy of Patients With Hemorrhagic Complications Following Intravitreal Anti-Vascular Endothelial Growth Factor Injection. 玻璃体内注射抗血管内皮生长因子后出血并发症的超声生物显微镜观察。
IF 0.8
Journal of VitreoRetinal Diseases Pub Date : 2025-08-28 DOI: 10.1177/24741264251364011
Michael Antonietti, Stephen G Schwartz, Lazaro Aguero, Harry W Flynn
{"title":"Ultrasound Biomicroscopy of Patients With Hemorrhagic Complications Following Intravitreal Anti-Vascular Endothelial Growth Factor Injection.","authors":"Michael Antonietti, Stephen G Schwartz, Lazaro Aguero, Harry W Flynn","doi":"10.1177/24741264251364011","DOIUrl":"10.1177/24741264251364011","url":null,"abstract":"<p><p><b>Purpose:</b> To describe a case series of patients who experienced hemorrhagic complications following intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections. <b>Methods:</b> In a small case series of 3 patients with retinal disorders, imaging with ultrasound biomicroscopy (UBM) was performed within 1 day following anti-VEGF injection. <b>Results:</b> The first patient had a mild vitreous hemorrhage, and UBM demonstrated a suspected needle track through the pars plana; the hemorrhage cleared spontaneously. The second patient had a dense vitreous hemorrhage as well as hyphema, and UBM demonstrated a suspected needle track through the pars plicata; the hemorrhage did not clear and the patient was subsequently treated elsewhere with pars plana vitrectomy. The third patient had a subconjunctival hemorrhage but no vitreous hemorrhage, and UBM demonstrated no definite evidence of a needle track. <b>Conclusion:</b> In some patients with vitreous hemorrhage following anti-VEGF injection, a suspected needle track may be imaged with UBM within 1 day following injection.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251364011"},"PeriodicalIF":0.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sterile Intraocular Inflammation in Patients Receiving Both Faricimab and High-Dose Aflibercept in Consecutive Order. 连续服用法利西单抗和大剂量阿非利西普患者的无菌眼内炎症。
IF 0.8
Journal of VitreoRetinal Diseases Pub Date : 2025-08-25 DOI: 10.1177/24741264251365391
Emmanuel A Dwomoh, Anisa Prasad, Tavish Nanda
{"title":"Sterile Intraocular Inflammation in Patients Receiving Both Faricimab and High-Dose Aflibercept in Consecutive Order.","authors":"Emmanuel A Dwomoh, Anisa Prasad, Tavish Nanda","doi":"10.1177/24741264251365391","DOIUrl":"https://doi.org/10.1177/24741264251365391","url":null,"abstract":"<p><p><b>Purpose:</b> To describe 3 cases of intraocular inflammation (IOI) in patients who received faricimab and high-dose aflibercept in consecutive order. <b>Methods:</b> Retrospective case review. <b>Results:</b> Three patients, 2 with neovascular age-related macular degeneration (nAMD) and 1 with central retinal vein occlusion (CRVO), transitioned from 2 mg aflibercept to either faricimab (in cases 1 and 2) or high-dose aflibercept (in case 3) due to persistent disease activity. In all cases, contemporary medication provided minimal effect. Subsequently, patients in cases 1 and 2 were switched to high-dose aflibercept at their next visit, and the patient in case 3 was switched to faricimab. On follow-up, the disease worsened in all 3 cases. Each patient returned to their previous drug. Shortly after, each patient developed an episode of IOI. <b>Conclusions:</b> Patients receiving different high-dose or longer-acting agents in short order may be at risk for developing antidrug antibodies and IOI.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251365391"},"PeriodicalIF":0.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Nd:YAG Laser Posterior Membranotomy in the Treatment of Macular Preretinal Hemorrhage: A Systematic Review and Meta-Analysis. Nd:YAG激光后膜切开术治疗黄斑视网膜前出血的疗效:系统回顾和荟萃分析。
IF 0.8
Journal of VitreoRetinal Diseases Pub Date : 2025-08-22 DOI: 10.1177/24741264251364824
Michael Bouaziz, Daniel Zhu, Edward Zhu, Ethan Abizadeh, George Jiao, Talia R Kaden
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