Journal of VitreoRetinal Diseases最新文献

Possible Association Between Dopamine Antagonists and Increased Conversion to Exudative Age-Related Macular Degeneration.

IF 0.5

Journal of VitreoRetinal Diseases Pub Date : 2025-04-02 DOI: 10.1177/24741264251330338

Peter J Weng, Richard Morgan, Dilraj S Grewal, Sharon Fekrat

{"title":"Possible Association Between Dopamine Antagonists and Increased Conversion to Exudative Age-Related Macular Degeneration.","authors":"Peter J Weng, Richard Morgan, Dilraj S Grewal, Sharon Fekrat","doi":"10.1177/24741264251330338","DOIUrl":"10.1177/24741264251330338","url":null,"abstract":"Purpose: To investigate whether modulating dopamine signaling affects conversion to exudative age-related macular degeneration (AMD). Methods: A retrospective cohort study was performed using the Duke Epic database. Eyes from patients with a diagnosis of nonexudative AMD with at least 1 year of follow-up were evaluated for conversion to exudative AMD. Eyes with an AMD diagnosis were evaluated for age, sex, smoking history, hypertension, Age-Related Eye Disease Study (AREDS) or AREDS2 prescription, dopamine-modulating therapy prescription, and indication for dopamine-modulating therapy. Generalized estimating equations were used to calculate odds ratios for individual variables on conversion from nonexudative to exudative AMD. Results: Five hundred fifty-eight eyes of 354 patients with an initial diagnosis of nonexudative AMD were evaluated for conversion to exudative AMD. Conversion to exudative AMD was significantly higher in patients who had been on dopamine antagonist therapies for at least 3 years than in patients who were not on any dopamine-modulating therapies. After controlling for other variables, dopamine antagonists were associated with an increased risk for conversion to exudative AMD at 3 years of follow-up (P = .005). Conclusions: These findings suggest that antagonizing dopamine signaling may be associated with the development of macular neovascularization in eyes with nonexudative AMD. Although the data are observational, these findings warrant further investigation of dopamine signaling in conversion to exudative AMD.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251330338"},"PeriodicalIF":0.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative Methotrexate to Reduce Reoperation Rate and Improve Vision in Patients With Complex Retinal Detachments, Advanced Diabetic Retinopathy, and Trauma.

IF 0.5

Journal of VitreoRetinal Diseases Pub Date : 2025-03-18 DOI: 10.1177/24741264251323305

Lauren Gibson, Alyson Nguyen, Jared Ridgeway, Mariam Omar, Christopher Purvis, Yazen Shihab, Christopher D Riemann, Alan J Franklin

{"title":"Postoperative Methotrexate to Reduce Reoperation Rate and Improve Vision in Patients With Complex Retinal Detachments, Advanced Diabetic Retinopathy, and Trauma.","authors":"Lauren Gibson, Alyson Nguyen, Jared Ridgeway, Mariam Omar, Christopher Purvis, Yazen Shihab, Christopher D Riemann, Alan J Franklin","doi":"10.1177/24741264251323305","DOIUrl":"10.1177/24741264251323305","url":null,"abstract":"Purpose: To identify the potential benefits of postoperative intravitreal (IVT) methotrexate (MTX) for proliferative vitreoretinopathy (PVR), trauma, or advanced diabetic retinopathy (DR). Methods: A retrospective chart review was performed of previously unoperated eyes at high risk for failure as a result of preexisting PVR, trauma, or advanced DR. Patients were included who had retinal detachment (RD) surgery for the following reasons: failed previous retinal reattachment surgery, advanced proliferative DR (PDR), initial surgery for RD associated with trauma, or primary RD associated with grade C PVR. MTX 200 to 400 µg was administered intravitreally at postoperative weeks 1, 2, 4, 7, and 11. Data analyzed included the reoperation rate, visual acuity (VA), physical examination findings, and optical coherence tomography biomarkers. Results: Of the 255 eyes evaluated, 94 received IVT MTX (MTX group) and 161 eyes did not (control group). The mean number of reoperations was 0.39 in the MTX group and 0.94 in the control group (P < .01). The MTX group had a mean gain in VA of 1 line, while the control group had a mean loss of 2.9 lines (P < .01). Conclusions: Postoperative IVT MTX in eyes with advanced PDR or complicated RD yields comparable effective results, including reduced reoperation rates and improved VA.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251323305"},"PeriodicalIF":0.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issues in Medicine: Equity and Site Neutrality.

IF 0.5

Journal of VitreoRetinal Diseases Pub Date : 2025-03-16 eCollection Date: 2025-03-01 DOI: 10.1177/24741264251322832

引用次数: 0

Suprachoroidal Injection of Tattoo Ink.

IF 0.5

Journal of VitreoRetinal Diseases Pub Date : 2025-03-14 DOI: 10.1177/24741264251324972

Carson C Petrash, R Gary Lane

引用次数: 0

Vitreoretinal Involvement in Patients With Fungemia at a Tertiary Care Hospital.

IF 0.5

Journal of VitreoRetinal Diseases Pub Date : 2025-03-14 DOI: 10.1177/24741264251321366

Carl S Wilkins, Karina Esquenazi, Kyle Hirabayashi, Jeffrey Brown, Rupak Bhuyan, Niathi Kona, Alexander Barash, Robin B Ginsburg, Avnish Deobhakta, Gareth M Lema

{"title":"Vitreoretinal Involvement in Patients With Fungemia at a Tertiary Care Hospital.","authors":"Carl S Wilkins, Karina Esquenazi, Kyle Hirabayashi, Jeffrey Brown, Rupak Bhuyan, Niathi Kona, Alexander Barash, Robin B Ginsburg, Avnish Deobhakta, Gareth M Lema","doi":"10.1177/24741264251321366","DOIUrl":"https://doi.org/10.1177/24741264251321366","url":null,"abstract":"Purpose: To identify the prevalence of fungal ophthalmic involvement and evaluate risk factors for positive screening for inpatients at an academic tertiary care hospital by assessing a priori screening criteria that may determine which patients need ophthalmic evaluation. Methods: This retrospective cohort study comprised patients with a documented positive blood culture for fungemia and an ophthalmic screening examination from January 1, 2015, to September 30, 2019. Ophthalmology notes and laboratory results taken during admission were evaluated. The primary outcomes were ocular involvement, presence of visual complaints, and duration of blood culture positivity. Variables assessed included recent gastrointestinal surgery, organ transplantation, HIV infection, diabetes mellitus, intravenous drug use, and central venous access. Analyses, including the Student t test, χ2 test, and logistic regression, were performed. Results: Of 291 patients with fungemia, 7 had ocular involvement (3 with chorioretinitis; 4 with endophthalmitis). One patient with endophthalmitis required an intravitreal antifungal injection. No patient with chorioretinitis required injections or surgery. The mean culture positivity length was 5 days for those with vitreoretinal involvement and 4 days for those without vitreoretinal involvement (P > .05). Of patients with ocular involvement, 40.0% had a visual complaint compared with 4.2% without ocular involvement (P < .05). The negative predictive value was 99.3% for patients without complaints or persistent fungemia. Conclusions: Patients with visual complaints at the time of a positive blood culture for fungemia are at risk for ocular disease and require screening.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251321366"},"PeriodicalIF":0.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosimilar Ranibizumab (Ranieyes) Safety and Efficacy in the Real World: BRESER Study.

IF 0.5

Journal of VitreoRetinal Diseases Pub Date : 2025-02-27 DOI: 10.1177/24741264251322213

Ashish Sharma, Frank G Holz, Nilesh Kumar, David Sarraf, Seemantini Ayachit, Chitaranjan Mishra, Adnan Tufail, Debdulal Chakraborty, Aleksandra Rachitskaya, David Eichenbaum, Alay Banker, Nikulaa Parachuri, Ashish Kumar, Anat Loewenstein, Francesco Bandello, Taku Wakabayashi, Se Joon Woo, Baruch D Kuppermann

{"title":"Biosimilar Ranibizumab (Ranieyes) Safety and Efficacy in the Real World: BRESER Study.","authors":"Ashish Sharma, Frank G Holz, Nilesh Kumar, David Sarraf, Seemantini Ayachit, Chitaranjan Mishra, Adnan Tufail, Debdulal Chakraborty, Aleksandra Rachitskaya, David Eichenbaum, Alay Banker, Nikulaa Parachuri, Ashish Kumar, Anat Loewenstein, Francesco Bandello, Taku Wakabayashi, Se Joon Woo, Baruch D Kuppermann","doi":"10.1177/24741264251322213","DOIUrl":"https://doi.org/10.1177/24741264251322213","url":null,"abstract":"Purpose: To evaluate the early real-world clinical outcomes regarding the safety and efficacy after administration of a ranibizumab biosimilar (Ranieyes). Methods: This multicenter retrospective uncontrolled observational study incorporated data from 7 centers in India. All patients were treated with at least 1 intravitreal injection of 0.5 mg of ranibizumab biosimilar between July 2022 and July 2023 for various indications. Results: A total of 474 ranibizumab biosimilar injections were given in 268 eyes of 254 patients. Indications were diabetic macular edema (DME) (n = 112), macular neovascularization (MNV) (n = 92), retinal vein occlusion (RVO) (n = 54), cystoid macular edema (n = 4), and proliferative diabetic retinopathy with vitreous hemorrhage (n = 6). The mean logMAR BCVA (±SD) improved significantly from baseline to the last follow-up as follows: DME cases, from 0.77 ± 0.37 (Snellen equivalent, 6/36) to 0.43 ± 0.25 (6/15) (z = -8.0; r = -0.8); MNV cases, from 0.95 ± 0.53 (6/60) to 0.59 ± 0.42 (6/24) (z = -7.1; r = -0.8); RVO cases, from 0.83 ± 0.40 (6/45) to 0.44 ± 0.32 (6/15) (z = -5.5; r = -0.8) (all P < .001). All groups also had significant improvement in the central subfield thickness (all P < .001). No site reported drug-related adverse events (eg, inflammation, vasculitis, systemic adverse effects). Conclusions: The preliminary real-world data from this limited early series suggest that Ranieyes has clinical efficacy and is safe as a ranibizumab biosimilar across the approved indications.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251322213"},"PeriodicalIF":0.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Sequential Ocular Vascular Occlusions With Subsequent Unilateral Acute Retinal Necrosis in a Patient With HIV Infection. 一名艾滋病病毒感染者双侧相继出现眼底血管闭塞，随后单侧急性视网膜坏死。

IF 0.5

Journal of VitreoRetinal Diseases Pub Date : 2025-02-25 DOI: 10.1177/24741264251323310

Diana Vemulapalli, Soumyava Basu, Sameera Nayak, Niroj Kumar Sahoo

引用次数: 0

Characteristics and Medical Accuracy of Online Discussions of Retinal Conditions on a Social Media Platform.

IF 0.5

Journal of VitreoRetinal Diseases Pub Date : 2025-02-19 DOI: 10.1177/24741264251315139

Araliya N Gunawardene, Sanjana Suraneni, Landon J Rohowetz, Jayanth Sridhar

{"title":"Characteristics and Medical Accuracy of Online Discussions of Retinal Conditions on a Social Media Platform.","authors":"Araliya N Gunawardene, Sanjana Suraneni, Landon J Rohowetz, Jayanth Sridhar","doi":"10.1177/24741264251315139","DOIUrl":"10.1177/24741264251315139","url":null,"abstract":"Purpose: To assess the content and medical accuracy of retina-related patient discussions on Reddit, an anonymous social media platform, to better understand the main concerns and reliability of a highly accessible resource. Methods: A cross-sectional analysis was performed of the top 20 posts and top 3 comments from 2011 to 2022 on the Reddit subforums r/Optometry and r/EyeTriage containing the following keywords: \"retinal detachment\", \"macular edema\", \"macular degeneration\", and \"diabetic retinopathy\". Results: This study assessed 407 posts and comments. Most users who posted were current patients (n = 71 [60.2%]). Most commenters did not specify their identity (n = 172 [59.5%]). A portion of respondents identified as optometrists (n = 51 [17.6%]), and few identified as ophthalmologists (n = 11 [3.8%]). Many statements were medically inaccurate (n = 31 [40.8%]), with pathophysiology comprising the most commonly misunderstood topic (n = 15 [48.4%]). Conclusions: Given the prevalence of inaccurate information and the lack of credibility among Reddit posters, patients should take caution in using these sites for medical guidance regarding retinal conditions.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251315139"},"PeriodicalIF":0.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Axial Length and Refractive Outcomes in Patients With Dense Vitreous Hemorrhage Who Have Phacovitrectomy.

IF 0.5

Journal of VitreoRetinal Diseases Pub Date : 2025-02-19 DOI: 10.1177/24741264251322211

Yucel Ozturk, Abdullah Ağın, Aysun Yucel Gencoglu

{"title":"Evaluation of Axial Length and Refractive Outcomes in Patients With Dense Vitreous Hemorrhage Who Have Phacovitrectomy.","authors":"Yucel Ozturk, Abdullah Ağın, Aysun Yucel Gencoglu","doi":"10.1177/24741264251322211","DOIUrl":"10.1177/24741264251322211","url":null,"abstract":"Purpose: To evaluate the axial length (AL) measurement and refractive results in patients with dense vitreous hemorrhage who had phacovitrectomy and investigate the effectiveness of ultrasound biometry in this population. Methods: This study included patients with cataracts and a dense vitreous hemorrhage who had phacovitrectomy (Group 1) and a control group of patients with cataracts who had phacoemulsification only (Group 2). The AL was measured preoperatively using A-scan contact ultrasound in Group 1 and partial coherence interferometry (PCI)-based biometry (IOLMaster 500) in Group 2. Postoperatively, the AL was measured using A-scan contact ultrasound and PCI-based biometry in Group 1. The refractive error was measured preoperatively and postoperatively in both groups with an autorefractometer (KR-1, Topcon). The primary outcome measures were the preoperative and postoperative AL and refractive outcomes. Results: In Group 1, the median AL was as follows: preoperative, 23.33 mm with ultrasound (I); postoperative, 23.18 mm with PCI biometry (II); postoperative, 23.44 mm with ultrasound (III) (I-II, P = .04; I-III, P = .01; II-III, P < .01). The AL measured preoperatively with ultrasound and postoperatively with PCI biometry had a statistically significant strong positive correlation with a high-reliability coefficient compared with the AL measured preoperatively and postoperatively with ultrasound. The median prediction error and absolute prediction error were similar in both groups. Conclusions: Ultrasound biometry is effective for intraocular lens calculation and AL measurement in eyes with a dense vitreous hemorrhage. This imaging modality may result in near-optimum refractive outcomes.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251322211"},"PeriodicalIF":0.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tractional Retinal Detachment in a Patient With a History of Methamphetamine Use.

IF 0.5

Journal of VitreoRetinal Diseases Pub Date : 2025-02-15 DOI: 10.1177/24741264241302870

Angela J Kim, Omar Sabbagh, Osama Sabbagh, Michelle Abou-Jaoude, John W Kitchens

引用次数: 0