{"title":"Epiretinal Membranes Associated With Choroidal Melanoma.","authors":"Feng Li, David M Hinkle, Paul T Finger","doi":"10.1177/24741264251336334","DOIUrl":"10.1177/24741264251336334","url":null,"abstract":"<p><p><b>Purpose:</b> To describe the prevalence of epiretinal membrane (ERM) in eyes with choroidal melanoma. <b>Methods:</b> A retrospective clinical case review was conducted to evaluate the prevalence of ERMs. Examinations included ophthalmoscopy, fundus photography, and optical coherence tomography. Multivariate analysis evaluated ERMs with choroidal melanoma, retinal detachment (RD) before treatment, plaque radiation dose to the fovea, radiation retinopathy, and intravitreal (IVT) antivascular endothelial growth factor (anti-VEGF) treatment. Contralateral eyes were used as controls. <b>Results:</b> The study included 373 patients (746 eyes). ERMs were found in 34% of eyes with choroidal melanoma that were treated and 12.1% of control eyes. A larger tumor size (increasing American Joint Committee on Cancer cT category) was significantly associated with the presence of an ERM at baseline. In addition, a higher radiation dose to the fovea was associated with ERM development. Risk factors determined by multivariate analysis included radiation retinopathy (odds ratio [OR], 3.00), anti-VEGF injections (OR, 2.87), and RD at presentation (OR, 3.19). <b>Conclusions:</b> This study found a significantly higher prevalence of ERMs in eyes with choroidal melanoma. Risk factors contributing to ERM development included the radiation dose, radiation retinopathy, IVT anti-VEGF injections, and RD. Of these factors, the presence of RD at the initial diagnosis was the strongest predictor of the occurrence of a secondary ERM.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251336334"},"PeriodicalIF":0.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prithvi R Bomdica, E Anne Shepherd, Rishabh Gupta, Vivek Chaturvedi
{"title":"Timing of Epiretinal Membrane Surgery After Uncomplicated Retinal Detachment Repair.","authors":"Prithvi R Bomdica, E Anne Shepherd, Rishabh Gupta, Vivek Chaturvedi","doi":"10.1177/24741264251337107","DOIUrl":"10.1177/24741264251337107","url":null,"abstract":"<p><p><b>Purpose:</b> To evaluate the features and outcomes of postoperative epiretinal membranes (ERMs) after retinal detachment (RD) repair based on the timing of macular peeling (MP). <b>Methods:</b> This retrospective consecutive case series comprised patients who had rhegmatogenous RD repair, developed an ERM, and had MP within 1 year. <b>Results:</b> Of the ERMs, 91% (50/55) were diagnosed between 1 month and 3 months after RD repair. When MP was performed less than 6 months after RD repair (n = 37), the final logMAR visual acuity (VA) was 0.31; this was statistically better than when MP was performed 6 months after RD repair or later (0.63, n = 18) (<i>P</i> = .005). In the 6-months or later MP cohort, 61% (11/18) had cataract surgery between the RD repair and MP while 7 patients were pseudophakic at RD presentation. Of the ERMs, 65%, 24%, and 11% were stage 4, stage 3, and stage 2, respectively; the final logMAR VA was 0.43, 0.38, and 0.30, respectively. There was no significant difference in the final VA or macular status between the stages. Overall, the mean logMAR VA before MP was 0.87, which improved to a final VA of 0.41 after MP (<i>P</i> < .001). <b>Conclusions:</b> ERMs formed after RD repair were most likely to be stage 4; however, this did not affect the final VA. The final VA was significantly better when MP was performed less than 6 months after RD repair. This is relevant because retina surgeons may be delaying MP until after cataract surgery.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251337107"},"PeriodicalIF":0.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gregg T Kokame, Shay Nakahira, Kael Yamane, Jasmine Chen, Emi Luo, Elysse S Tom
{"title":"Resolution of Myopic Macular Retinoschisis and Macular Hole With Topical Medical Therapy.","authors":"Gregg T Kokame, Shay Nakahira, Kael Yamane, Jasmine Chen, Emi Luo, Elysse S Tom","doi":"10.1177/24741264251340107","DOIUrl":"10.1177/24741264251340107","url":null,"abstract":"<p><p><b>Purpose:</b> To report a case of myopic macular retinoschisis and full-thickness macular hole (FTMH) that both resolved with topical medical therapy alone. <b>Methods:</b> A retrospective chart review was performed. <b>Results:</b> A patient with myopic retinoschisis with an FTMH and increased symptoms of metamorphopsia was treated with topical medical therapy consisting of 1% prednisolone, 4 times daily, and 0.07% bromfenac, daily. Anatomic changes at 6 weeks included drawing together of the inner retinal edges around the MH and its subsequent closure with marked resolution of the myopic retinoschisis. <b>Conclusions:</b> Severe myopic macular retinoschisis and an FTMH both resolved with topical therapy consisting of steroidal and nonsteroidal anti-inflammatory medications. This rapid resolution contradicts current theories of the pathogenesis of myopic macular retinoschisis.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251340107"},"PeriodicalIF":0.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Embodying Resilience in Retina Specialty Care.","authors":"Timothy G Murray","doi":"10.1177/24741264251337795","DOIUrl":"10.1177/24741264251337795","url":null,"abstract":"","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":"9 3","pages":"287-290"},"PeriodicalIF":0.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josephine R Seela, Jade Y Moon, Sandra R Montezuma
{"title":"Rare Presentation of Attenuated Mucopolysaccharidosis Type IIIA as Isolated Retinitis Pigmentosa.","authors":"Josephine R Seela, Jade Y Moon, Sandra R Montezuma","doi":"10.1177/24741264251340108","DOIUrl":"https://doi.org/10.1177/24741264251340108","url":null,"abstract":"<p><p><b>Purpose:</b> To describe a patient presenting in adulthood with isolated retinopathy found to have mucopolysaccharidosis type IIIA. <b>Methods:</b> A single case was evaluated. <b>Results:</b> A 36-year-old man presented with 5 years of worsening peripheral vision and night vision. The initial examination and testing raised concern for rod-cone dystrophy. Genetic testing with an Invitae Inherited Retinal Disorders Panel showed 2 variants of <i>SGSH</i>, which is associated with mucopolysaccharidosis type IIIA. Laboratory testing showed low heparan-N-sulfatase levels and elevated heparan sulfate levels. These results and a thorough review of the literature support a diagnosis of mild attenuated non-neuronopathic mucopolysaccharidosis type IIIA. <b>Conclusions:</b> This case highlights the necessity for collaboration with genetic counselors and the value of a provider's clinical acumen in interpreting genetic testing results. Furthermore, the importance of considering mucopolysaccharidosis type IIIA when adult patients present with new-onset isolated retinitis pigmentosa is emphasized.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251340108"},"PeriodicalIF":0.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bandage Contact Lens as an Alternative to a Temporary Keratoprosthesis for Vitrectomy With Concurrent Corneal Opacity.","authors":"Marta Latasiewicz, Mike Adams, Youssef Helmy","doi":"10.1177/24741264251340110","DOIUrl":"https://doi.org/10.1177/24741264251340110","url":null,"abstract":"<p><p><b>Purpose:</b> To present a case of a bandage contact lens being used as an alternative to a temporary keratoprosthesis for urgent vitreoretinal surgery. <b>Methods:</b> A single case was evaluated. <b>Results:</b> A 72-year-old man with monocular vision presented with a retinal detachment (RD) after repair of a traumatic globe rupture. His ocular history included previous penetrating keratoplasty (PKP) and RD surgery in the eye that had visual ability. The previous corneal graft was opacified and a conventional temporary keratoprosthesis was unavailable. After removal of the corneal graft, a bandage contact lens was used as an alternative to a temporary keratoprosthesis. Subsequently, pars plana vitrectomy and a PKP were performed. The bandage contact lens provided excellent visualization for the vitrectomy and resulted in a successful final outcome. <b>Conclusions:</b> When corneal opacity precludes vitrectomy and a temporary keratoprosthesis is unavailable, a bandage contact lens is a viable option.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251340110"},"PeriodicalIF":0.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Purtscher-Like Retinopathy After Acute Ischemic Colitis.","authors":"Smaran Teru, Cory A Christensen, Jamin Brown","doi":"10.1177/24741264251338038","DOIUrl":"https://doi.org/10.1177/24741264251338038","url":null,"abstract":"<p><p><b>Purpose:</b> To describe a case of Purtscher retinopathy, a rare microvascular process hypothesized to have an occlusive etiology. <b>Methods:</b> A single case was evaluated. <b>Results:</b> A 72-year-old White woman presented with acute, painless bilateral vision loss and severe abdominal pain. She was hospitalized for ischemic colitis of unknown origin. Although her symptoms were improving, funduscopic examination findings of retinal hemorrhages, cotton-wool spots, and Purtscher flecken prompted a referral to ophthalmology. The diagnosis of Purtscher-like retinopathy was made, and treatment of her precipitating ischemic colitis resolved her visual symptoms. <b>Conclusions:</b> Purtscher-like retinopathy is a rare clinical diagnosis of exclusion. By describing a previously unreported etiology, this case may improve our understanding of the pathogenesis, management, and treatment of this rare retinopathy.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251338038"},"PeriodicalIF":0.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-Term Follow-up of Cytomegalovirus Retinitis in an Immunocompetent Patient.","authors":"Michael J Maywood, Lisa J Faia, Tedi Begaj","doi":"10.1177/24741264251338042","DOIUrl":"https://doi.org/10.1177/24741264251338042","url":null,"abstract":"<p><p><b>Purpose:</b> To describe the long-term follow-up of an immunocompetent patient with cytomegalovirus (CMV) retinitis. <b>Methods:</b> A single case was analyzed and a literature review performed. <b>Results:</b> A 47-year-old woman presented with a paracentral scotoma in the left eye. Examination showed parafoveal retinitis. An aqueous fluid tap was positive for CMV on polymerase chain reaction; however, there was no recent surgery or local or systemic immunosuppression. A thorough workup, including pan imaging, was unremarkable. The retinitis resolved with oral valganciclovir and adjuvant intravitreal ganciclovir and foscarnet injections. At the 3-year follow-up, the patient's disease was inactive without development of systemic illness. <b>Conclusions:</b> In patients presenting with retinitis, the diagnostic use of aqueous polymerase chain reaction is critical, especially in atypical cases in which the retinitis might be associated with CMV.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251338042"},"PeriodicalIF":0.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wavefront Aberrometry in Pseudophakic Patients Before and After Vitrectomy for Bothersome Floaters.","authors":"Daniel A Adelberg, Mark T Parsons","doi":"10.1177/24741264251333200","DOIUrl":"https://doi.org/10.1177/24741264251333200","url":null,"abstract":"<p><p><b>Introduction:</b> To investigate whether the outcome of patients with persistent bothersome floaters who are managed with vitrectomy can be correlated with improvements in higher-order aberrations with wavefront aberrometry. <b>Methods:</b> Pseudophakic patients who had 27-gauge vitrectomy for persistent floaters and whose clinical assessment included preoperative and postoperative wavefront aberrometry were included. The primary outcome was the change in the higher-order aberration percentage measured by wavefront aberrometry. <b>Results:</b> The study included 76 eyes of 66 patients with a mean age (±SD) of 67.8 ± 7.5 years. The Snellen visual acuity improved from 20/32 preoperatively to 20/25 postoperatively (<i>P</i> = .004). Wavefront aberrometry showed a highly significant reduction in the higher-order aberration percentage (<i>P</i> < .000001), with a mean preoperative percentage of 53.9 and a mean postoperative percentage of 38.3. Subgroup analysis found a significant reduction in patients with no previous posterior capsulotomy (<i>P</i> = .001), previous neodymium:YAG capsulotomy (<i>P</i> < .000001), a monofocal intraocular lens (IOL) (<i>P</i> < .000001), and a multifocal IOL (<i>P</i> = .006). There was no significant difference in the mean preoperative and postoperative pupil size, sphere, cylinder, or spherical equivalent. <b>Conclusions:</b> Wavefront aberrometry demonstrates an objective, significant reduction in higher-order aberrations immediately after vitrectomy in pseudophakic patients with bothersome floaters.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251333200"},"PeriodicalIF":0.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bullous Central Serous Chorioretinopathy Associated With JAK Inhibitor Use.","authors":"Warren Apel, Ye Li","doi":"10.1177/24741264251337104","DOIUrl":"https://doi.org/10.1177/24741264251337104","url":null,"abstract":"<p><p><b>Purpose:</b> To report a case of bullous central serous chorioretinopathy (CSCR) after starting a Janus kinase (JAK) inhibitor and describe the results of focal laser treatment. <b>Methods:</b> A single case was evaluated. <b>Results:</b> A 54-year-old man with rheumatoid arthritis presented with a 2-week history of left superior field loss. His medications included prednisone 10 mg and upadacitinib, which was added to his regimen 3 weeks previously. His visual acuity (VA) was 20/25 OD and 20/30 OS. An ophthalmic examination of the left eye found an ill-defined white lesion of 2 × 3 disc diameters at the macula with an inferior retinal detachment (RD). Optical coherence tomography showed subretinal fibrin with subretinal fluid (SRF) and a pigment epithelial detachment. After a diagnosis of bullous CSCR was made, focal laser application was performed. One year later, the patient's VA recovered to 20/20 with resolved SRF. <b>Conclusions:</b> Bullous CSCR with a serous RD is an uncommon subtype of pachychoroid disease. Upadacitinib may be associated with its occurrence through disequilibrium of the coagulation cascade. Focal laser treatment offers a favorable outcome for this disease.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251337104"},"PeriodicalIF":0.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}