与脉络膜黑色素瘤相关的视网膜上膜。

IF 0.5 Q4 OPHTHALMOLOGY
Feng Li, David M Hinkle, Paul T Finger
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引用次数: 0

摘要

目的:探讨视网膜前膜(ERM)在脉络膜黑色素瘤患者中的患病率。方法:回顾性分析临床病例,评估erm的患病率。检查包括眼科检查、眼底摄影和光学相干断层扫描。多变量分析评估了治疗前伴有脉络膜黑色素瘤、视网膜脱离(RD)、斑块辐射剂量到中央窝、放射性视网膜病变和玻璃体内(IVT)抗血管内皮生长因子(anti-VEGF)治疗的erm。对侧眼作为对照。结果:纳入373例患者(746只眼)。在接受治疗的脉络膜黑色素瘤的眼睛中,有34%的眼睛和12.1%的对照组眼睛中发现了erm。较大的肿瘤大小(增加美国癌症联合委员会cT分类)与基线时ERM的存在显著相关。此外,较高的中央凹辐射剂量与ERM的发生有关。多因素分析确定的危险因素包括放射性视网膜病变(优势比[OR], 3.00)、抗vegf注射(OR, 2.87)和首发时RD (OR, 3.19)。结论:本研究发现视网膜脉络膜黑色素瘤的眼中erm的患病率明显较高。导致ERM发生的危险因素包括辐射剂量、放射性视网膜病变、IVT抗vegf注射和RD。在这些因素中,最初诊断时RD的存在是继发性ERM发生的最强预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epiretinal Membranes Associated With Choroidal Melanoma.

Purpose: To describe the prevalence of epiretinal membrane (ERM) in eyes with choroidal melanoma. Methods: A retrospective clinical case review was conducted to evaluate the prevalence of ERMs. Examinations included ophthalmoscopy, fundus photography, and optical coherence tomography. Multivariate analysis evaluated ERMs with choroidal melanoma, retinal detachment (RD) before treatment, plaque radiation dose to the fovea, radiation retinopathy, and intravitreal (IVT) antivascular endothelial growth factor (anti-VEGF) treatment. Contralateral eyes were used as controls. Results: The study included 373 patients (746 eyes). ERMs were found in 34% of eyes with choroidal melanoma that were treated and 12.1% of control eyes. A larger tumor size (increasing American Joint Committee on Cancer cT category) was significantly associated with the presence of an ERM at baseline. In addition, a higher radiation dose to the fovea was associated with ERM development. Risk factors determined by multivariate analysis included radiation retinopathy (odds ratio [OR], 3.00), anti-VEGF injections (OR, 2.87), and RD at presentation (OR, 3.19). Conclusions: This study found a significantly higher prevalence of ERMs in eyes with choroidal melanoma. Risk factors contributing to ERM development included the radiation dose, radiation retinopathy, IVT anti-VEGF injections, and RD. Of these factors, the presence of RD at the initial diagnosis was the strongest predictor of the occurrence of a secondary ERM.

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来源期刊
CiteScore
1.20
自引率
16.70%
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