{"title":"Issues in Medicine: Equity and Site Neutrality.","authors":"","doi":"10.1177/24741264251322832","DOIUrl":"10.1177/24741264251322832","url":null,"abstract":"","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":"9 2","pages":"125-130"},"PeriodicalIF":0.5,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Suprachoroidal Injection of Tattoo Ink.","authors":"Carson C Petrash, R Gary Lane","doi":"10.1177/24741264251324972","DOIUrl":"https://doi.org/10.1177/24741264251324972","url":null,"abstract":"<p><p><b>Purpose:</b> To describe a case of injection of tattoo dye into the suprachoroidal space. <b>Methods:</b> A single case and its findings were analyzed. <b>Results:</b> A 40-year-old man with a recent history of scleral tattooing presented for evaluation of right-sided blurry vision. An examination of the right eye showed slightly decreased acuity and pupillary response in the right eye compared with the left eye as well as black ink not only in the bilateral subconjunctival spaces but also in the suprachoroidal space. Remarkably, there was no apparent inflammatory reaction. The patient was followed for 8 months after the scleral tattooing procedure and never developed inflammatory sequelae. <b>Conclusions:</b> Suprachoroidal injection of dye is a potential complication of eyeball tattooing. Infection and noninfectious inflammation are common concerns, but some patients may tolerate the dye surprisingly well.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251324972"},"PeriodicalIF":0.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carl S Wilkins, Karina Esquenazi, Kyle Hirabayashi, Jeffrey Brown, Rupak Bhuyan, Niathi Kona, Alexander Barash, Robin B Ginsburg, Avnish Deobhakta, Gareth M Lema
{"title":"Vitreoretinal Involvement in Patients With Fungemia at a Tertiary Care Hospital.","authors":"Carl S Wilkins, Karina Esquenazi, Kyle Hirabayashi, Jeffrey Brown, Rupak Bhuyan, Niathi Kona, Alexander Barash, Robin B Ginsburg, Avnish Deobhakta, Gareth M Lema","doi":"10.1177/24741264251321366","DOIUrl":"https://doi.org/10.1177/24741264251321366","url":null,"abstract":"<p><p><b>Purpose:</b> To identify the prevalence of fungal ophthalmic involvement and evaluate risk factors for positive screening for inpatients at an academic tertiary care hospital by assessing a priori screening criteria that may determine which patients need ophthalmic evaluation. <b>Methods:</b> This retrospective cohort study comprised patients with a documented positive blood culture for fungemia and an ophthalmic screening examination from January 1, 2015, to September 30, 2019. Ophthalmology notes and laboratory results taken during admission were evaluated. The primary outcomes were ocular involvement, presence of visual complaints, and duration of blood culture positivity. Variables assessed included recent gastrointestinal surgery, organ transplantation, HIV infection, diabetes mellitus, intravenous drug use, and central venous access. Analyses, including the Student <i>t</i> test, χ<sup>2</sup> test, and logistic regression, were performed. <b>Results:</b> Of 291 patients with fungemia, 7 had ocular involvement (3 with chorioretinitis; 4 with endophthalmitis). One patient with endophthalmitis required an intravitreal antifungal injection. No patient with chorioretinitis required injections or surgery. The mean culture positivity length was 5 days for those with vitreoretinal involvement and 4 days for those without vitreoretinal involvement (<i>P</i> > .05). Of patients with ocular involvement, 40.0% had a visual complaint compared with 4.2% without ocular involvement (<i>P</i> < .05). The negative predictive value was 99.3% for patients without complaints or persistent fungemia. <b>Conclusions:</b> Patients with visual complaints at the time of a positive blood culture for fungemia are at risk for ocular disease and require screening.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251321366"},"PeriodicalIF":0.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashish Sharma, Frank G Holz, Nilesh Kumar, David Sarraf, Seemantini Ayachit, Chitaranjan Mishra, Adnan Tufail, Debdulal Chakraborty, Aleksandra Rachitskaya, David Eichenbaum, Alay Banker, Nikulaa Parachuri, Ashish Kumar, Anat Loewenstein, Francesco Bandello, Taku Wakabayashi, Se Joon Woo, Baruch D Kuppermann
{"title":"Biosimilar Ranibizumab (Ranieyes) Safety and Efficacy in the Real World: BRESER Study.","authors":"Ashish Sharma, Frank G Holz, Nilesh Kumar, David Sarraf, Seemantini Ayachit, Chitaranjan Mishra, Adnan Tufail, Debdulal Chakraborty, Aleksandra Rachitskaya, David Eichenbaum, Alay Banker, Nikulaa Parachuri, Ashish Kumar, Anat Loewenstein, Francesco Bandello, Taku Wakabayashi, Se Joon Woo, Baruch D Kuppermann","doi":"10.1177/24741264251322213","DOIUrl":"https://doi.org/10.1177/24741264251322213","url":null,"abstract":"<p><p><b>Purpose:</b> To evaluate the early real-world clinical outcomes regarding the safety and efficacy after administration of a ranibizumab biosimilar (Ranieyes). <b>Methods:</b> This multicenter retrospective uncontrolled observational study incorporated data from 7 centers in India. All patients were treated with at least 1 intravitreal injection of 0.5 mg of ranibizumab biosimilar between July 2022 and July 2023 for various indications. <b>Results:</b> A total of 474 ranibizumab biosimilar injections were given in 268 eyes of 254 patients. Indications were diabetic macular edema (DME) (n = 112), macular neovascularization (MNV) (n = 92), retinal vein occlusion (RVO) (n = 54), cystoid macular edema (n = 4), and proliferative diabetic retinopathy with vitreous hemorrhage (n = 6). The mean logMAR BCVA (±SD) improved significantly from baseline to the last follow-up as follows: DME cases, from 0.77 ± 0.37 (Snellen equivalent, 6/36) to 0.43 ± 0.25 (6/15) (<i>z</i> = -8.0; <i>r</i> = -0.8); MNV cases, from 0.95 ± 0.53 (6/60) to 0.59 ± 0.42 (6/24) (<i>z</i> = -7.1; <i>r</i> = -0.8); RVO cases, from 0.83 ± 0.40 (6/45) to 0.44 ± 0.32 (6/15) (<i>z</i> = -5.5; <i>r</i> = -0.8) (all <i>P</i> < .001). All groups also had significant improvement in the central subfield thickness (all <i>P</i> < .001). No site reported drug-related adverse events (eg, inflammation, vasculitis, systemic adverse effects). <b>Conclusions:</b> The preliminary real-world data from this limited early series suggest that Ranieyes has clinical efficacy and is safe as a ranibizumab biosimilar across the approved indications.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251322213"},"PeriodicalIF":0.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bilateral Sequential Ocular Vascular Occlusions With Subsequent Unilateral Acute Retinal Necrosis in a Patient With HIV Infection.","authors":"Diana Vemulapalli, Soumyava Basu, Sameera Nayak, Niroj Kumar Sahoo","doi":"10.1177/24741264251323310","DOIUrl":"10.1177/24741264251323310","url":null,"abstract":"<p><p><b>Purpose:</b> To report a case of bilateral ocular vascular occlusion with subsequent development of unilateral acute retinal necrosis in a patient with HIV infection. <b>Methods:</b> A single case was evaluated. <b>Results:</b> A 40-year-old woman presented with a sudden decrease in vision in the right eye for a 1-month duration. Disc pallor, arteriolar attenuation, and blot hemorrhages were seen in the midperiphery of the fundus of the right eye. On follow-up, the patient presented with reduced vision in the left eye for a 10-day duration. A fundus examination of the right eye showed extensive retinitis patches, and a cherry-red spot, boxcarring, and multiple sclerosed arterioles were seen in the left eye. The patient was later found to be positive for HIV infection but had never started therapy. <b>Conclusions:</b> A sequential progression from the occlusive event to retinitis should be kept in mind to customize follow-up for patients with HIV infection.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251323310"},"PeriodicalIF":0.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Araliya N Gunawardene, Sanjana Suraneni, Landon J Rohowetz, Jayanth Sridhar
{"title":"Characteristics and Medical Accuracy of Online Discussions of Retinal Conditions on a Social Media Platform.","authors":"Araliya N Gunawardene, Sanjana Suraneni, Landon J Rohowetz, Jayanth Sridhar","doi":"10.1177/24741264251315139","DOIUrl":"10.1177/24741264251315139","url":null,"abstract":"<p><p><b>Purpose:</b> To assess the content and medical accuracy of retina-related patient discussions on Reddit, an anonymous social media platform, to better understand the main concerns and reliability of a highly accessible resource. <b>Methods:</b> A cross-sectional analysis was performed of the top 20 posts and top 3 comments from 2011 to 2022 on the Reddit subforums r/Optometry and r/EyeTriage containing the following keywords: \"retinal detachment\", \"macular edema\", \"macular degeneration\", and \"diabetic retinopathy\". <b>Results:</b> This study assessed 407 posts and comments. Most users who posted were current patients (n = 71 [60.2%]). Most commenters did not specify their identity (n = 172 [59.5%]). A portion of respondents identified as optometrists (n = 51 [17.6%]), and few identified as ophthalmologists (n = 11 [3.8%]). Many statements were medically inaccurate (n = 31 [40.8%]), with pathophysiology comprising the most commonly misunderstood topic (n = 15 [48.4%]). <b>Conclusions:</b> Given the prevalence of inaccurate information and the lack of credibility among Reddit posters, patients should take caution in using these sites for medical guidance regarding retinal conditions.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251315139"},"PeriodicalIF":0.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Axial Length and Refractive Outcomes in Patients With Dense Vitreous Hemorrhage Who Have Phacovitrectomy.","authors":"Yucel Ozturk, Abdullah Ağın, Aysun Yucel Gencoglu","doi":"10.1177/24741264251322211","DOIUrl":"10.1177/24741264251322211","url":null,"abstract":"<p><p><b>Purpose:</b> To evaluate the axial length (AL) measurement and refractive results in patients with dense vitreous hemorrhage who had phacovitrectomy and investigate the effectiveness of ultrasound biometry in this population. <b>Methods:</b> This study included patients with cataracts and a dense vitreous hemorrhage who had phacovitrectomy (Group 1) and a control group of patients with cataracts who had phacoemulsification only (Group 2). The AL was measured preoperatively using A-scan contact ultrasound in Group 1 and partial coherence interferometry (PCI)-based biometry (IOLMaster 500) in Group 2. Postoperatively, the AL was measured using A-scan contact ultrasound and PCI-based biometry in Group 1. The refractive error was measured preoperatively and postoperatively in both groups with an autorefractometer (KR-1, Topcon). The primary outcome measures were the preoperative and postoperative AL and refractive outcomes. <b>Results:</b> In Group 1, the median AL was as follows: preoperative, 23.33 mm with ultrasound (I); postoperative, 23.18 mm with PCI biometry (II); postoperative, 23.44 mm with ultrasound (III) (I-II, <i>P =</i> .04; I-III, <i>P =</i> .01; II-III, <i>P <</i> .01). The AL measured preoperatively with ultrasound and postoperatively with PCI biometry had a statistically significant strong positive correlation with a high-reliability coefficient compared with the AL measured preoperatively and postoperatively with ultrasound. The median prediction error and absolute prediction error were similar in both groups. <b>Conclusions:</b> Ultrasound biometry is effective for intraocular lens calculation and AL measurement in eyes with a dense vitreous hemorrhage. This imaging modality may result in near-optimum refractive outcomes.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251322211"},"PeriodicalIF":0.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angela J Kim, Omar Sabbagh, Osama Sabbagh, Michelle Abou-Jaoude, John W Kitchens
{"title":"Tractional Retinal Detachment in a Patient With a History of Methamphetamine Use.","authors":"Angela J Kim, Omar Sabbagh, Osama Sabbagh, Michelle Abou-Jaoude, John W Kitchens","doi":"10.1177/24741264241302870","DOIUrl":"10.1177/24741264241302870","url":null,"abstract":"<p><p><b>Purpose:</b> To describe the development of tractional retinal detachments (TRD) in a patient with diabetic retinopathy (DR) and a history of methamphetamine use. <b>Methods:</b> A single case was evaluated. <b>Results:</b> A 38-year-old man with type 2 diabetes mellitus presented to the clinic with worsening blurry vision in both eyes. A fundus examination, fundus photography, and optical coherence tomography were performed. The patient's bilateral TRDs were attributed to poorly controlled DR; thus, he was administered 1 intravitreal aflibercept injection in each eye and scheduled for surgery. His glycosylated hemoglobin A<sub>1c</sub> was only 6.3% and was controlled with metformin. In the interim, the patient was admitted for a stroke workup and diagnosed with Moyamoya disease and methamphetamine abuse. <b>Conclusions:</b> In patients with underlying DR and presumed Moyamoya disease, TRDs can be exacerbated by methamphetamine use.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264241302870"},"PeriodicalIF":0.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Visual Outcomes and Complications: Staged vs Simultaneous Pars Plana Vitrectomy and Scleral-Sutured Intraocular Lens Placement.","authors":"H Russell Day, Archana A Nair, Avni P Finn","doi":"10.1177/24741264251315156","DOIUrl":"10.1177/24741264251315156","url":null,"abstract":"<p><p><b>Purpose:</b> To compare the visual outcomes and postoperative complications after simultaneous scleral-sutured intraocular lens (IOL) placement and pars plana vitrectomy (PPV) (simultaneous group) with those of IOL implantation staged after PPV (staged group). <b>Methods:</b> In this retrospective cohort study, cases of scleral-sutured IOL placement were reviewed between July 1, 2016, and December 31, 2022. All patients had scleral-sutured Akreos AO60 IOL placement using 4-point fixation. <b>Results:</b> Of the 98 eyes, 83.7% had simultaneous surgery and 16.3% had staged surgery. The mean preoperative visual acuity (VA) was similar between the staged group and simultaneous group (1.8 logMAR [Snellen equivalent, 20/1262] vs 1.3 logMAR [Snellen equivalent, 20/400]; <i>P</i> = .104]. The mean logMAR VA improved to 0.98 (Snellen equivalent, 20/191) and to 0.50 (Snellen equivalent, 20/63), respectively. The median logMAR improvement was 0.93 (Snellen equivalent, 20/170) in the staged group and 0.80 (Snellen equivalent, 20/126) in the simultaneous group (<i>P</i> = .49). The overall transient postoperative hypotony rate was 8.2%, with all cases occurring in the simultaneous group (<i>P</i> = .194). <b>Conclusions:</b> Both staged surgery and simultaneous PPV with scleral-sutured Akreos AO60 IOL placement are safe and efficacious procedures for visual rehabilitation in patients with dislocated IOLs, retained lens material, and aphakia resulting from other causes. Staged scleral-sutured Akreos AO60 IOL placement after PPV may offer a safe approach for eyes with significant ocular comorbidities and decrease the risk for transient postoperative hypotony.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251315156"},"PeriodicalIF":0.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacob Light, Kristen E Schratz, Onnisa Nanegrungsunk, Noam Rudnick, Mary Armanios, Neil M Bressler
{"title":"Adult-Onset Presentations of Retinopathy Associated With Short Telomere Syndromes.","authors":"Jacob Light, Kristen E Schratz, Onnisa Nanegrungsunk, Noam Rudnick, Mary Armanios, Neil M Bressler","doi":"10.1177/24741264251316324","DOIUrl":"10.1177/24741264251316324","url":null,"abstract":"<p><p><b>Purpose:</b> To describe the association between short telomere syndrome and exudative retinopathies in adults. <b>Methods:</b> This case series compared the presentation, course of treatment, and visual outcomes of 2 patients with adult-onset retinopathy associated with short telomere syndrome. <b>Results:</b> In Case 1, a 53-year-old man initially presented with bilateral retinal telangiectasias and preretinal hemorrhage in the left eye, which was followed by multiple vitreous hemorrhages. In the subsequent 15 years, the patient was diagnosed with pulmonary fibrosis, liver cirrhosis, and a <i>RTEL1</i> gene mutation, consistent with short telomere syndrome. In Case 2, a previously asymptomatic 26-year-old man with paternally inherited short telomere syndrome (<i>TERC</i> gene mutation) presented with floaters, bilateral peripheral retinal capillary nonperfusion, and an aneurysmal lesion with surrounding exudation. <b>Conclusions:</b> Short telomere syndromes, with systemic features that can be life-threatening, can manifest initially in adulthood with retinal telangiectasia, aneurysmal lesions, exudation, or peripheral retinal capillary nonperfusion, preceding systemic manifestations. Because the systemic manifestations of retinal telangiectasia and peripheral retinal capillary nonperfusion are progressive and can be life-threatening, recognizing these findings in adults with retinal telangiectasia is crucial.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251316324"},"PeriodicalIF":0.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}