Chanrim Park, Seo Young Park, Hwa Jung Kim, Hee Jung Shin
{"title":"Statistical Methods for Comparing Predictive Values in Medical Diagnosis.","authors":"Chanrim Park, Seo Young Park, Hwa Jung Kim, Hee Jung Shin","doi":"10.3348/kjr.2024.0049","DOIUrl":"10.3348/kjr.2024.0049","url":null,"abstract":"<p><p>Evaluating the performance of a binary diagnostic test, including artificial intelligence classification algorithms, involves measuring sensitivity, specificity, positive predictive value, and negative predictive value. Particularly when comparing the performance of two diagnostic tests applied on the same set of patients, these metrics are crucial for identifying the more accurate test. However, comparing predictive values presents statistical challenges because their denominators depend on the test outcomes, unlike the comparison of sensitivities and specificities. This paper reviews existing methods for comparing predictive values and proposes using the permutation test. The permutation test is an intuitive, non-parametric method suitable for datasets with small sample sizes. We demonstrate each method using a dataset from MRI and combined modality of mammography and ultrasound in diagnosing breast cancer.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"25 7","pages":"656-661"},"PeriodicalIF":4.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiology Loading and Coverage Hours in Hong Kong.","authors":"Alta Yee Tak Lai","doi":"10.3348/kjr.2024.0440","DOIUrl":"10.3348/kjr.2024.0440","url":null,"abstract":"","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"25 7","pages":"595-596"},"PeriodicalIF":4.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Incidental Pancreatic Cyst: When to Worry About Cancer.","authors":"Danielle E Kruse, Erik K Paulson","doi":"10.3348/kjr.2024.0085","DOIUrl":"10.3348/kjr.2024.0085","url":null,"abstract":"<p><p>Incidental pancreatic cystic lesions are a common challenge encountered by diagnostic radiologists. Specifically, given the prevalence of benign pancreatic cystic lesions, determining when to recommend aggressive actions such as surgical resection or endoscopic ultrasound with sampling is difficult. In this article, we review the common types of cystic pancreatic lesions including serous cystadenoma, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm with imaging examples of each. We also discuss high-risk or worrisome imaging features that warrant a referral to a surgeon or endoscopist and provid several examples of these features. These imaging features adhere to the latest guidelines from the International Consensus Guidelines, American Gastroenterological Association (2015), American College of Gastroenterology (2018), American College of Radiology (2010, 2017), and European Guidelines (2013, 2018). Our focused article addresses the imaging dilemma of managing incidental cystic pancreatic lesions, weighing the options between imaging follow-up and aggressive interventions.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"25 6","pages":"559-564"},"PeriodicalIF":4.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to \"Before Diagnosing CHANTER Syndrome, All Possible Differential Diagnoses Must Be Carefully Excluded\".","authors":"Renu Pandit, Siddhartha Gaddamanugu","doi":"10.3348/kjr.2024.0314","DOIUrl":"10.3348/kjr.2024.0314","url":null,"abstract":"","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"25 6","pages":"591-594"},"PeriodicalIF":4.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pae Sun Suh, Seung Chai Jung, Hye Hyeon Moon, Yun Hwa Roh, Yunsun Song, Minjae Kim, Jungbok Lee, Keum Mi Choi
{"title":"Diagnosis of Unruptured Intracranial Aneurysms Using Proton-Density Magnetic Resonance Angiography: A Comparison With High-Resolution Time-of-Flight Magnetic Resonance Angiography.","authors":"Pae Sun Suh, Seung Chai Jung, Hye Hyeon Moon, Yun Hwa Roh, Yunsun Song, Minjae Kim, Jungbok Lee, Keum Mi Choi","doi":"10.3348/kjr.2023.1241","DOIUrl":"10.3348/kjr.2023.1241","url":null,"abstract":"<p><strong>Objective: </strong>Differentiating intracranial aneurysms from normal variants using CT angiography (CTA) or MR angiography (MRA) poses significant challenges. This study aimed to evaluate the efficacy of proton-density MRA (PD-MRA) compared to high-resolution time-of-flight MRA (HR-MRA) in diagnosing aneurysms among patients with indeterminate findings on conventional CTA or MRA.</p><p><strong>Materials and methods: </strong>In this retrospective analysis, we included patients who underwent both PD-MRA and HR-MRA from August 2020 to July 2022 to assess lesions deemed indeterminate on prior conventional CTA or MRA examinations. Three experienced neuroradiologists independently reviewed the lesions using HR-MRA and PD-MRA with reconstructed voxel sizes of 0.25<sup>3</sup> mm<sup>3</sup> or 0.2<sup>3</sup> mm<sup>3</sup>, respectively. A neurointerventionist established the gold standard with digital subtraction angiography. We compared the performance of HR-MRA, PD-MRA (0.25<sup>3</sup>-mm<sup>3</sup> voxel), and PD-MRA (0.2<sup>3</sup>-mm<sup>3</sup> voxel) in diagnosing aneurysms, both per lesion and per patient. The Fleiss kappa statistic was used to calculate inter-reader agreement.</p><p><strong>Results: </strong>The study involved 109 patients (average age 57.4 ± 11.0 years; male:female ratio, 11:98) with 141 indeterminate lesions. Of these, 78 lesions (55.3%) in 69 patients were confirmed as aneurysms by the reference standard. PD-MRA (0.25<sup>3</sup>-mm<sup>3</sup> voxel) exhibited significantly higher per-lesion diagnostic performance compared to HR-MRA across all three readers: sensitivity ranged from 87.2%-91.0% versus 66.7%-70.5%; specificity from 93.7%-96.8% versus 58.7%-68.3%; and accuracy from 90.8%-92.9% versus 63.8%-69.5% (<i>P</i> ≤ 0.003). Furthermore, PD-MRA (0.25<sup>3</sup>-mm<sup>3</sup> voxel) demonstrated significantly superior per-patient specificity and accuracy compared to HR-MRA across all evaluators (<i>P</i> ≤ 0.013). The diagnostic accuracy of PD-MRA (0.2<sup>3</sup>-mm<sup>3</sup> voxel) surpassed that of HR-MRA and was comparable to PD-MRA (0.25<sup>3</sup>-mm<sup>3</sup> voxel). The kappa values for inter-reader agreements were significantly higher in PD-MRA (0.820-0.938) than in HR-MRA (0.447-0.510).</p><p><strong>Conclusion: </strong>PD-MRA outperformed HR-MRA in diagnostic accuracy and demonstrated almost perfect inter-reader consistency in identifying intracranial aneurysms among patients with lesions initially indeterminate on CTA or MRA.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"25 6","pages":"575-588"},"PeriodicalIF":4.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Su Nam Lee, Andrew Lin, Damini Dey, Daniel S Berman, Donghee Han
{"title":"Application of Quantitative Assessment of Coronary Atherosclerosis by Coronary Computed Tomographic Angiography.","authors":"Su Nam Lee, Andrew Lin, Damini Dey, Daniel S Berman, Donghee Han","doi":"10.3348/kjr.2023.1311","DOIUrl":"10.3348/kjr.2023.1311","url":null,"abstract":"<p><p>Coronary computed tomography angiography (CCTA) has emerged as a pivotal tool for diagnosing and risk-stratifying patients with suspected coronary artery disease (CAD). Recent advancements in image analysis and artificial intelligence (AI) techniques have enabled the comprehensive quantitative analysis of coronary atherosclerosis. Fully quantitative assessments of coronary stenosis and lumen attenuation have improved the accuracy of assessing stenosis severity and predicting hemodynamically significant lesions. In addition to stenosis evaluation, quantitative plaque analysis plays a crucial role in predicting and monitoring CAD progression. Studies have demonstrated that the quantitative assessment of plaque subtypes based on CT attenuation provides a nuanced understanding of plaque characteristics and their association with cardiovascular events. Quantitative analysis of serial CCTA scans offers a unique perspective on the impact of medical therapies on plaque modification. However, challenges such as time-intensive analyses and variability in software platforms still need to be addressed for broader clinical implementation. The paradigm of CCTA has shifted towards comprehensive quantitative plaque analysis facilitated by technological advancements. As these methods continue to evolve, their integration into routine clinical practice has the potential to enhance risk assessment and guide individualized patient management. This article reviews the evolving landscape of quantitative plaque analysis in CCTA and explores its applications and limitations.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"25 6","pages":"518-539"},"PeriodicalIF":4.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Before Diagnosing CHANTER Syndrome, All Possible Differential Diagnoses Must Be Carefully Excluded.","authors":"Josef Finsterer, Sounira Mehri","doi":"10.3348/kjr.2024.0244","DOIUrl":"10.3348/kjr.2024.0244","url":null,"abstract":"","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"25 6","pages":"589-590"},"PeriodicalIF":4.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Na Young Kim, Dong Jin Im, Yoo Jin Hong, Byoung Wook Choi, Seok-Min Kang, Jong-Chan Youn, Hye-Jeong Lee
{"title":"Feasibility of the Threshold-Based Quantification of Myocardial Fibrosis on Cardiac CT as a Prognostic Marker in Nonischemic Dilated Cardiomyopathy.","authors":"Na Young Kim, Dong Jin Im, Yoo Jin Hong, Byoung Wook Choi, Seok-Min Kang, Jong-Chan Youn, Hye-Jeong Lee","doi":"10.3348/kjr.2023.1271","DOIUrl":"10.3348/kjr.2023.1271","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the feasibility and prognostic relevance of threshold-based quantification of myocardial delayed enhancement (MDE) on CT in patients with nonischemic dilated cardiomyopathy (NIDCM).</p><p><strong>Materials and methods: </strong>Forty-three patients with NIDCM (59.3 ± 17.1 years; 21 male) were included in the study and underwent cardiac CT and MRI. MDE was quantified manually and with a threshold-based quantification method using cutoffs of 2, 3, and 4 standard deviations (SDs) on three sets of CT images (100 kVp, 120 kVp, and 70 keV). Interobserver agreement in MDE quantification was assessed using the intraclass correlation coefficient (ICC). Agreement between CT and MRI was evaluated using the Bland-Altman method and the concordance correlation coefficient (CCC). Patients were followed up for the subsequent occurrence of the primary composite outcome, including cardiac death, heart transplantation, heart failure hospitalization, or appropriate use of an implantable cardioverter-defibrillator. The Kaplan-Meier method was used to estimate event-free survival according to MDE levels.</p><p><strong>Results: </strong>Late gadolinium enhancement (LGE) was observed in 29 patients (67%, 29/43), and the mean LGE found with the 5-SD threshold was 4.1% ± 3.6%. The 4-SD threshold on 70-keV CT showed excellent interobserver agreement (ICC = 0.810) and the highest concordance with MRI (CCC = 0.803). This method also yielded the smallest bias with the narrowest range of 95% limits of agreement compared to MRI (bias, -0.119%; 95% limits of agreement, -4.216% to 3.978%). During a median follow-up of 1625 days (interquartile range, 712-1430 days), 10 patients (23%, 10/43) experienced the primary composite outcome. Event-free survival significantly differed between risk subgroups divided by the optimal MDE cutoff of 4.3% (log-rank <i>P</i> = 0.005).</p><p><strong>Conclusion: </strong>The 4-SD threshold on 70-keV monochromatic CT yielded results comparable to those of MRI for quantifying MDE as a marker of myocardial fibrosis, which showed prognostic value in patients with NIDCM.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"25 6","pages":"540-549"},"PeriodicalIF":4.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}