Korean Journal of Pediatrics最新文献_第3页

Practical considerations when administering surfactants to preterm infants with respiratory distress syndrome 给患有呼吸窘迫综合征的早产儿服用表面活性剂时的实际注意事项

Korean Journal of Pediatrics Pub Date : 2019-08-16 DOI: 10.3345/kjp.2019.00374

H. Jo

引用次数: 1

Association between Body Mass Index and Hepatitis B antibody seropositivity in children 儿童体重指数与乙型肝炎抗体血清阳性的关系

Korean Journal of Pediatrics Pub Date : 2019-08-12 DOI: 10.3345/kjp.2019.00563

Yoowon Kwon, S. Jeong

{"title":"Association between Body Mass Index and Hepatitis B antibody seropositivity in children","authors":"Yoowon Kwon, S. Jeong","doi":"10.3345/kjp.2019.00563","DOIUrl":"https://doi.org/10.3345/kjp.2019.00563","url":null,"abstract":"Background The seropositivity rate of hepatitis B surface antigen (anti-HBs) antibodies is known to be ≥95% after hepatitis B virus vaccination during infancy. However, a low level or absence of anti-HBs in healthy children is discovered in many cases. Recent studies in adults reported that a reduced anti-HBs production rate is related to obesity. Purpose To investigate whether body mass index (BMI) affects anti-HBs levels in healthy children following 3 serial dose vaccinations in infancy. Methods We recruited 1,200 healthy volunteers aged 3, 5, 7, or 10 years from 4-day care centers and 4 elementary schools. All subjects completed a questionnaire including body weight, height, and vaccine type received. Levels of serum hepatitis B surface antigen (HBsAg) and anti-HBs in all subjects were analyzed using electrochemiluminescence immunoassay. The standardized scores (z score) for each sex and age were obtained using the lambda-mu-sigma method in the 2017 Korean National Growth Charts for children and adolescents. Results Our subjects (n=1,200) comprised 750 males (62.5%) and 450 females (37.5%). The overall anti-HBs seropositivity rate was 57.9% (695 of 1,200). We identified significant differences in mean BMI values between seronegative and seropositive groups (17.45 vs. 16.62, respectively; P<0.001). The anti-HBs titer was significantly decreased as the BMI z score increased adjusting for age and sex (B=-15.725; standard error=5.494; P=0.004). The probability of anti-HBs seropositivity based on BMI z score was decreased to an OR of 0.820 after the control for confounding variables (95% confidence interval, 0.728–0.923; P=0.001). Conclusion There was a significant association between anti-HBs titer and BMI z score after adjustment for age and sex. Our results indicate that BMI is a potential factor affecting anti-HBs titer in healthy children.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 1","pages":"416 - 421"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48388872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The role of fecal calprotectin in pediatric disease. 粪便钙保护蛋白在儿科疾病中的作用。

Korean Journal of Pediatrics Pub Date : 2019-08-01 Epub Date: 2019-03-28 DOI: 10.3345/kjp.2019.00059

Su Jin Jeong

引用次数: 15

Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease. 缺铁性贫血作为川崎病冠状动脉异常的预测因子。

Korean Journal of Pediatrics Pub Date : 2019-08-01 Epub Date: 2019-02-08 DOI: 10.3345/kjp.2018.06905

Sohyun Kim, Lucy Youngmin Eun

{"title":"Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease.","authors":"Sohyun Kim, Lucy Youngmin Eun","doi":"10.3345/kjp.2018.06905","DOIUrl":"https://doi.org/10.3345/kjp.2018.06905","url":null,"abstract":"Purpose: Coronary artery abnormalities (CAA) are the most important complications of Kawasaki disease (KD). Iron deficiency anemia (IDA) is a prevalent micronutrient deficiency and its association with KD remains unknown. We hypothesized that presence of IDA could be a predictor of CAA.Methods: This retrospective study included 173 KD patients, divided into 2 groups according to absence (group 1) and presence (group 2) of CAA. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a logistic regression model to estimate the association between CAA and other indicators. Due to collinearity between indicators of IDA, each indicator was paired with anemia in 3 models.Results: Serum iron, iron saturation, and ferritin concentration, the 3 indicators of IDA, were significantly higher in group 1 than in group 2. Three sets of models including anemia with iron indicators produced the OR of CAA of 3.513, 3.171, and 2.256, respectively. The 3 indicators of IDA were negatively associated with CAA, by OR of 0.965, 0.914, and 0.944, respectively. The areas under the curve (AUCs) of ferritin concentration, iron saturation, serum iron, anemia, and Kobayashi score were 0.907 (95% CI, 0.851-0.963), 0.729 (95% CI, 0.648-0.810), 0.711 (95% CI, 0.629-0.793), 0.638 (95% CI, 0.545-0.731), and 0.563 (95% CI, 0.489-0.636), respectively.Conclusion: Indicators of IDA, especially ferritin, were highly associated with CAA; therefore, they were stronger predictors of CAA than Kobayashi scores. IDA indicators can be used to predict CAA development and to suggest requirements for early interventions.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 8","pages":"301-306"},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/78/kjp-2018-06905.PMC6702116.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36545735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Can iron be a risk factor for coronary lesions in Kawasaki disease? 铁会成为川崎病冠状动脉病变的危险因素吗？

Korean Journal of Pediatrics Pub Date : 2019-08-01 Epub Date: 2019-06-07 DOI: 10.3345/kjp.2019.00311

Kyung Lim Yoon

引用次数: 1

Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine. 使用奥卡西平治疗的患者可能需要评估血液学特征。

Korean Journal of Pediatrics Pub Date : 2019-08-01 Epub Date: 2019-04-11 DOI: 10.3345/kjp.2019.00017

Gu Hyun Jung, Su Jeong You

{"title":"Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine.","authors":"Gu Hyun Jung, Su Jeong You","doi":"10.3345/kjp.2019.00017","DOIUrl":"https://doi.org/10.3345/kjp.2019.00017","url":null,"abstract":"Purpose: The major side effects of treatment with oxcarbazepine (OXC) are skin rash and hyponatremia. Hematologic side effects are reported rarely. The aim of this study was to investigate the rate and types of the hematologic side effects of OXC.Methods: The medical records of 184 patients diagnosed with epilepsy or movement disorder and on OXC monotherapy, at the Department of Pediatrics of Inje University Sanggye Paik Hospital from July 2001 to July 2018, were retrospectively reviewed.Results: Of the 184 patients, 10 (5.4%) developed leukopenia in addition to pancytopenia and 2 (1.0%) developed pancytopenia. Leukopenia developed in 11 days to 14 years after OXC administration and was more frequent in males than in females (male vs. female, 9 vs. 1; Fisher exact test, P<0.05). Of the eight patients with leukopenia alone, 7 continued OXC treatment; 6 improved without intervention; 1 was lost to follow-up; and 1 received a reduced OXC dose, who improved after intervention. Pancytopenia developed within 2 months of initiation of OXC treatment. Both patients initially continued OXC. One improved within 1 month and continued treatment with OXC, but the other showed progression of the side effect, leading to the discontinuation of OXC and subsequent improvement within 1 month. There were no significant differences in the ages of the patients, OXC dose, and duration of OXC treatment between patients with and without these side effects of OXC (P >0.05, t -test).Conclusion: OXC-induced leukopenia is not rare and may result in pancytopenia. Patients being treated with OXC should be regularly monitored for abnormal complete blood count profiles.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 8","pages":"312-316"},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/89/kjp-2019-00017.PMC6702114.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37164803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates. 早产儿血清表皮生长因子水平与坏死性小肠结肠炎的关系。

Korean Journal of Pediatrics Pub Date : 2019-08-01 Epub Date: 2019-03-15 DOI: 10.3345/kjp.2018.07108

Heba Mostafa Ahmed, Nsreen Mostafa Kamel

{"title":"The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates.","authors":"Heba Mostafa Ahmed, Nsreen Mostafa Kamel","doi":"10.3345/kjp.2018.07108","DOIUrl":"https://doi.org/10.3345/kjp.2018.07108","url":null,"abstract":"Purpose: Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport. The aim of this study was to assess the role of epidermal growth factor in the development of NEC in preterm neonates.Methods: In this study, 130 preterm neonates were included and divided into 3 groups, as follows: group 1, 40 preterm neonates with NEC; group 2, 50 preterm neonates with sepsis; and group 3, 40 healthy preterm neonates as controls. The NEC group was then subdivided into medical and surgical NEC subgroups. The serum EGF level was measured using enzyme-linked immunosorbent assay.Results: Serum EGF levels (pg/dL) were significantly lower in the NEC group (median [interquartile range, IQR], 9.6 [2-14]) than in the sepsis (10.1 [8-14]) and control groups (11.2 [8-14], P<0.001), with no significant difference between the sepsis and control groups, and were positively correlated with gestational age (r=0.7, P<0.001). A binary logistic regression test revealed that low EGF levels and gestational ages could significantly predict the development of NEC. The receiver-operating characteristic curve for EGF showed an optimal cutoff value of 8 pg/mL, with 73.3% sensitivity, 98% specificity, and an area under the curve of 0.92.Conclusion: The patients with NEC in this study had significantly lower serum EGF levels (P<0.001), which indicated that EGF could be a reliable marker of NEC in preterm neonates.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 8","pages":"307-311"},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/d4/kjp-2018-07108.PMC6702115.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37164810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Central line-associated bloodstream infections in the neonatal intensive care unit 新生儿重症监护病房中心静脉相关血流感染

Korean Journal of Pediatrics Pub Date : 2019-07-17 DOI: 10.3345/kjp.2019.00269

Woo Ryoung Lee

引用次数: 0

Reality of Kawasaki disease epidemiology 川崎病流行病学现状

Korean Journal of Pediatrics Pub Date : 2019-07-09 DOI: 10.3345/kjp.2019.00157

G. Kim

引用次数: 54

Correlation between genetic heterogeneity and variability for response to growth hormone in Noonan syndrome 努南综合征生长激素反应的遗传异质性与变异性的相关性

Korean Journal of Pediatrics Pub Date : 2019-07-09 DOI: 10.3345/kjp.2019.00220

Young-Lim Shin

引用次数: 1