Korean Journal of Pediatrics最新文献_第4页

Is determining nasal eosinophil count and nasal eosinophil peroxidase concentration clinically useful in children with rhinits? 测定鼻嗜酸性粒细胞计数和鼻嗜酸性粒细胞过氧化物酶浓度对鼻炎患儿临床有用吗?

Korean Journal of Pediatrics Pub Date : 2019-07-09 DOI: 10.3345/kjp.2019.00556

B. Choi

引用次数: 0

Eosinophil count and neutrophil-to-lymphocyte count ratio as biomarkers for predicting early-onset neonatal sepsis 嗜酸性粒细胞计数和中性粒细胞与淋巴细胞计数比作为预测早发新生儿败血症的生物标志物

Korean Journal of Pediatrics Pub Date : 2019-07-09 DOI: 10.3345/kjp.2019.00297

Jang Hoon Lee

引用次数: 2

Influence of proton pump inhibitor therapy on intestinal inflammation assessed by fecal calprotectin in pediatric patients 粪便钙卫蛋白评价质子泵抑制剂治疗对儿童肠道炎症的影响

Korean Journal of Pediatrics Pub Date : 2019-07-03 DOI: 10.3345/kjp.2019.00115

Su Yeong Kim, Na Mi Lee, S. Yun, S. Chae, I. Lim, E. Choi, D. Yi

{"title":"Influence of proton pump inhibitor therapy on intestinal inflammation assessed by fecal calprotectin in pediatric patients","authors":"Su Yeong Kim, Na Mi Lee, S. Yun, S. Chae, I. Lim, E. Choi, D. Yi","doi":"10.3345/kjp.2019.00115","DOIUrl":"https://doi.org/10.3345/kjp.2019.00115","url":null,"abstract":"Background An increase in the numbers of patients with gastrointestinal symptoms has recently been observed. Purpose To investigate the effects of proton pump inhibitor (PPI) therapy on intestinal inflammation in children and adolescents as confirmed by clinical manifestations and objectively assessed by fecal calprotectin (FC) level measurement. Methods Consecutive children (aged 3–18 years) who presented with gastrointestinal symptoms and were treated with or without PPI for at least 1 month were enrolled. Patients were divided into PPI and non-PPI groups. The PPI group was further subdivided by treatment duration and type of PPI used. Stool samples were collected for FC evaluation at baseline and after treatment and clinical data and FC levels were compared between the groups. Results Fifty-one patients (15 boys, 36 girls) were enrolled in the study. The PPI group included 37 patients, while the non-PPI group included 14 patients. Clinical symptoms were not significantly different. FC levels and laboratory results, including C-reactive protein levels, white blood cell count, and absolute neutrophil count, were not statistically different before versus after PPI treatment. After treatment, FC levels decreased to 8.1 mg/kg (-575.4 to 340.3 mg/kg) in the PPI group and increased to 5.6 mg/kg (-460.0 to 186.9 mg/kg) in the non-PPI group compared to those before treatment (P=0.841). The number of patients with increased FC levels was not significantly different between the 2 groups (48.6% vs. 64.3%, P=0.363), similar to that observed in patients with an FC level > 50 mg/kg (24.3% and 7.1%, P=0.250). PPI therapy type and duration did not affect the FC levels (P=0.811 and P=0.502, respectively). Conclusion Although we aimed to confirm the evidence of intestinal inflammation due to PPI use in children and adolescents through clinical symptoms and FC measurement, no significant changes were observed.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 1","pages":"400 - 404"},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44525587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Secular change in waist circumference and waist-height ratio and optimal cutoff of waist-height ratio for abdominal obesity among Korean children and adolescents over 10 years. 10年以上韩国儿童青少年腰围、腰高比的长期变化及腰高比的最佳截点

Korean Journal of Pediatrics Pub Date : 2019-07-01 Epub Date: 2018-12-03 DOI: 10.3345/kjp.2018.07038

Min Sub Kim, Se Young Kim, Jae Hyun Kim

{"title":"Secular change in waist circumference and waist-height ratio and optimal cutoff of waist-height ratio for abdominal obesity among Korean children and adolescents over 10 years.","authors":"Min Sub Kim, Se Young Kim, Jae Hyun Kim","doi":"10.3345/kjp.2018.07038","DOIUrl":"https://doi.org/10.3345/kjp.2018.07038","url":null,"abstract":"Purpose: This study aimed to evaluate the time trends of waist circumference (WC) and waist-height ratio (WHR), and to present WC and WHR distributions with optimal WHR cutoff for abdominal obesity in Korean children and adolescents.Methods: We performed a retrospective cross-sectional analysis of data from 13,257 children and adolescents (6,987 boys and 6,270 girls) aged 6-18 years who were included in the third to sixth Korea National Health and Nutrition Examination Survey (KNHANES, 2005-2015). Linear regression analyses were used to identify secular changes in WC and WHR by age, sex, and KNHANES waves. A receiver operating characteristic curve analysis was used to determine the optimal WHR cutoff values for abdominal obesity and cardiometabolic risk factors.Results: The mean WC and WHR distributions from 2005 to 2015 showed no significant secular changes between the KNHANES 4 waves (P for trend ≥0.05 in all ages and both sexes). The mean WCs in the present study were lower than those in the 2007 Korean National Growth Charts. The mean WHR at ages <13 years was statistically higher in the boys than in the girls, but did not significantly differ between the sexes among those aged 13 to 18 years. The optimal WHR cutoff for abdominal obesity was 0.48 (area under the curve, 0.985; 95% confidence interval, 0.985-0.985) in the 13- to 18-yearold adolescents.Conclusion: WC and WHR showed no secular changes over 10 years. The optimal WHR cutoff for abdominal obesity of 0.48 is useful for diagnosing and managing obesity and thus preventing obesityrelated cardiometabolic complications in 13- to 18-year-old Korean adolescents.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 7","pages":"261-268"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/e5/kjp-2018-07038.PMC6642921.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36749774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Correlation of serum S100B levels with brain magnetic resonance imaging abnormalities in children with status epilepticus. 癫痫持续状态儿童血清S100B水平与脑磁共振成像异常的相关性。

Korean Journal of Pediatrics Pub Date : 2019-07-01 Epub Date: 2019-05-08 DOI: 10.3345/kjp.2018.07017

Prastiya Indra Gunawan, Darto Saharso, Dian Purnama Sari

{"title":"Correlation of serum S100B levels with brain magnetic resonance imaging abnormalities in children with status epilepticus.","authors":"Prastiya Indra Gunawan, Darto Saharso, Dian Purnama Sari","doi":"10.3345/kjp.2018.07017","DOIUrl":"10.3345/kjp.2018.07017","url":null,"abstract":"Purpose: To evaluate the association between elevated S100B levels with brain tissue damage seen in abnormalities of head magnetic resonance imaging (MRI; diffusion tensor imaging [DTI] sequence) in patients with status epilepticus (SE).Methods: An analytical observational study was conducted in children hospitalized at Dr Soetomo Hospital, Surabaya, from July to December 2016. The patients were divided into 2 groups: SE included all children with a history of SE; control included all children with febrile seizure. Blood samples of patients were drawn within 24 hours after admission. SE patients also underwent cranial MRI with additional DTI sequencing. The Mann-Whitney test and Spearman test were used for statistical analysis.Results: Fifty-three patients were enrolled the study. In the 24 children with SE who met the inclusion criteria, serum S100B and cranial MRI findings were assessed. Twenty-two children admitted with febrile seizures became the control group. Most patients were male (66.7%); the mean age was 35.8 months (standard deviation, 31.09). Mean S100B values of the SE group (3.430±0.141 μg/L) and the control group (2.998±0.572 μg/L) were significantly different (P<0.05). A significant difference was noted among each level of encephalopathy based on the cranial MRI results with serum S100B levels and the correlation was strongly positive with a coefficient value of 0.758 (P<0.001).Conclusion: In SE patients, there is an increase of serum S100B levels within 24 hours after seizure, which has a strong positive correlation with brain damage seen in head MRI and DTI.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 7","pages":"281-285"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1b/93/kjp-2018-07017.PMC6642919.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37410498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Practice for preterm patent ductus arteriosus; focusing on the hemodynamic significance and the impact on the neonatal outcomes. 早产儿动脉导管未闭的治疗方法重点关注血流动力学意义和对新生儿结局的影响。

Korean Journal of Pediatrics Pub Date : 2019-07-01 Epub Date: 2019-04-08 DOI: 10.3345/kjp.2018.07213

Jin A Lee

{"title":"Practice for preterm patent ductus arteriosus; focusing on the hemodynamic significance and the impact on the neonatal outcomes.","authors":"Jin A Lee","doi":"10.3345/kjp.2018.07213","DOIUrl":"https://doi.org/10.3345/kjp.2018.07213","url":null,"abstract":"Hemodynamically significant preterm patent ductus arteriosus (PDA) affects mortality; comorbidities such as necrotizing enterocolitis, intraventricular hemorrhage, and bronchopulmonary dysplasia; and adverse long-term neurodevelopmental outcomes in preterm infants, particularly in very low birth weight infants. However, recent studies have indicated that there is no consensus on the causal relationship between PDA and neonatal outcomes, the benefit of PDA treatment, the factors guiding the need for treatment, and optimal treatment strategies. Such uncertainty has resulted in wide variations in practice for treating preterm PDA between units, regions, and nations. Nowadays, there has been a paradigm shift to more conservative treatment for preterm PDA, and suggestions regarding selective management of preterm PDA considering risk factors and hemodynamic significance are increasing. Neonatologist-performed echocardiography and advances in modalities to assess hemodynamic significance such as biologic markers and near-infrared spectroscopy also help improve the efficacy of selective treatment of preterm PDA.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 7","pages":"245-251"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/2a/kjp-2018-07213.PMC6642924.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37164805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Simple universal cutoff point of waist-height ratio for metabolic risk in Korean children and adolescents. 韩国儿童和青少年代谢风险腰高比的简单通用截断点。

Korean Journal of Pediatrics Pub Date : 2019-07-01 Epub Date: 2019-03-28 DOI: 10.3345/kjp.2019.00045

Hae Soon Kim

引用次数: 1

Korean Journal of Pediatrics Pub Date : 2019-07-01 Epub Date: 2019-07-15 DOI: 10.3345/kjp.2019.00227

Eun Hwa Choi, Su Eun Park, Yae-Jean Kim, Dae Sun Jo, Yun-Kyung Kim, Byung-Wook Eun, Taek-Jin Lee, Jina Lee, Hyunju Lee, Ki Hwan Kim, Hye-Kyung Cho, Eun Young Cho, Jong-Hyun Kim

{"title":"Recommended immunization schedule for children and adolescents: Committee on Infectious Diseases of the Korean Pediatric Society, 2018.","authors":"Eun Hwa Choi, Su Eun Park, Yae-Jean Kim, Dae Sun Jo, Yun-Kyung Kim, Byung-Wook Eun, Taek-Jin Lee, Jina Lee, Hyunju Lee, Ki Hwan Kim, Hye-Kyung Cho, Eun Young Cho, Jong-Hyun Kim","doi":"10.3345/kjp.2019.00227","DOIUrl":"https://doi.org/10.3345/kjp.2019.00227","url":null,"abstract":"The Committee on Infectious Diseases of the Korean Pediatric Society recommended immunization schedule for children and adolescents aged 18 years or younger in the 9th (2018) edition of Immunization guideline. This report provides the revised recommendations made by the committee and summarizes several changes from the 2015 guideline. National immunization program (NIP) launched a human papillomavirus (HPV) immunization for girls aged 12 years in 2016. NIP has also expanded age indication for inactivated influenza vaccine (IIV) to 12 years of age in the 2018-2019 season. Quadrivalent IIVs with a full dose (0.5 mL) are approved for all children of 6 months or older. Recommendations of live attenuated influenza vaccine were removed. For inactivated Japanese encephalitis vaccine, first 2 doses are considered as the primary series. Recommendations for use of newly introduced vaccines (diphtheria-tetanus-acellular pertussis/inactivated poliovirus/Haemophilus influenzae type b, 9-valent HPV, new varicella vaccine, new quadrivalent IIV, and attenuated oral typhoid vaccine) were added. Lastly, monitoring system for adverse events following immunization was updated. Other changes can be found in the 9th edition of Immunization guideline in detail.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 7","pages":"252-256"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/b0/kjp-2019-00227.PMC6642926.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37301549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Comparison of effectiveness of growth hormone therapy according to disease-causing genes in children with Noonan syndrome. Noonan综合征患儿不同致病基因生长激素治疗效果比较。

Korean Journal of Pediatrics Pub Date : 2019-07-01 Epub Date: 2018-12-03 DOI: 10.3345/kjp.2018.06842

Kyo Jin Jo, Yoo Mi Kim, Ju Young Yoon, Yeoun Joo Lee, Young Mi Han, Han-Wook Yoo, Hyang-Sook Kim, Chong Kun Cheon

{"title":"Comparison of effectiveness of growth hormone therapy according to disease-causing genes in children with Noonan syndrome.","authors":"Kyo Jin Jo, Yoo Mi Kim, Ju Young Yoon, Yeoun Joo Lee, Young Mi Han, Han-Wook Yoo, Hyang-Sook Kim, Chong Kun Cheon","doi":"10.3345/kjp.2018.06842","DOIUrl":"https://doi.org/10.3345/kjp.2018.06842","url":null,"abstract":"Purpose: To analyze the growth response to growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations.Methods: Twenty-three patients with prepubertal NS treated at Pusan National University Children's Hospital between March 2009 and July 2017 were enrolled. According to the disease-causing genes identified, the patients with NS were divided into 4 groups. Three groups were positive for mutations of the PTPN11, RAF1, and SOS1 genes. The five genes undetected (FGU) group was negative for PTPN11, RAF1, SOS1, KRAS, and BRAF gene mutations. The influence of genotype was retrospectively analyzed by comparing the growth parameters after GH therapy.Results: The mean chronological age at the start of GH treatment was 5.85±2.67 years. At the beginning of the GH treatment, the height standard deviation score (SDS), growth velocity (GV), and lower levels of insulin-like growth factor-1 (IGF)-1 levels were not statistically different among the groups. All the 23 NS patients had significantly increased height SDS and serum IGF-1 level during the 3 years of treatment. GV was highest during the first year of treatment. During the 3 years of GH therapy, the PTPN11, RAF1, and SOS1 groups showed less improvement in height SDS, IGF-1 SDS, and GV, and less increase in bone age-to-chronological age ratio than the FGU group.Conclusion: The 3-year GH therapy in the 23 prepubertal patients with NS was effective in improving height SDS, GV, and serum IGF-1 levels. The FGU group showed a better response to recombinant human GH therapy than the PTPN11, RAF1, and SOS1 groups.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 7","pages":"274-280"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/29/kjp-2018-06842.PMC6642922.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36749775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Perampanel is also a useful adjunctive treatment option in refractory epilepsy in children. Perampanel也是儿童难治性癫痫的一种有用的辅助治疗选择。

Korean Journal of Pediatrics Pub Date : 2019-07-01 Epub Date: 2019-03-05 DOI: 10.3345/kjp.2019.00108

Jon Soo Kim, Won Seop Kim

引用次数: 0