Korean Journal of Pediatrics最新文献_第5页

Efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy. 辅助perampanel治疗12岁以下顽固性癫痫的疗效和耐受性。

Korean Journal of Pediatrics Pub Date : 2019-07-01 Epub Date: 2018-12-26 DOI: 10.3345/kjp.2018.06863

Yuni Yun, Dongsub Kim, Yun-Jeong Lee, Soonhak Kwon, Su-Kyeong Hwang

{"title":"Efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy.","authors":"Yuni Yun, Dongsub Kim, Yun-Jeong Lee, Soonhak Kwon, Su-Kyeong Hwang","doi":"10.3345/kjp.2018.06863","DOIUrl":"https://doi.org/10.3345/kjp.2018.06863","url":null,"abstract":"Purpose: There is limited data on the use of perampanel in children under 12 years of age. We evaluated the efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy.Methods: This retrospective observational study was performed in Kyungpook National University Hospital from July 2016 to March 2018. A responder was defined as a patient with ≥50% reduction in monthly seizure frequency compared with the baseline. Adverse events and discontinuation data were obtained to evaluate tolerability.Results: Twenty-two patients (8 males, 14 females) aged 3.1-11.4 years (mean, 8.0±2.5 years) were included in this study. After an average of 9.2 months (range, 0.5-19 months) of follow-up, 15 patients (68%) showed a reduction in seizure frequency, including 5 patients (23%) with seizure freedom. The age at epilepsy onset was significantly lower (P=0.048), and the duration of epilepsy was significantly longer (P=0.019) in responders than in nonresponders. Nine patients (41%) experienced adverse events, including somnolence (23%), respiratory depression (9%), violence (4.5%), and seizure aggravation (4.5%). The most serious adverse event was respiratory depression, which required mechanical ventilation in 2 patients (9%). Eight patients (36%) discontinued perampanel due to lack of efficacy or adverse events. Three out of 4 patients (75%) who discontinued perampanel due to adverse events had an underlying medical condition.Conclusion: Perampanel offers a treatment option for refractory epilepsy in children. Adjunctive treatment with perampanel requires special consideration in those with underlying medical conditions to prevent serious adverse events.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 7","pages":"269-273"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/55/a7/kjp-2018-06863.PMC6642925.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36817291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016–2017 Korea National Health and Nutrition Examination Survey 韩国儿童和青少年高尿酸血症患病率及其与代谢综合征和心脏代谢危险因素的关联:基于2016-2017年韩国国家健康与营养检查调查的分析

Korean Journal of Pediatrics Pub Date : 2019-06-24 DOI: 10.3345/kjp.2019.00444

Jung Hyun Lee

{"title":"Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016–2017 Korea National Health and Nutrition Examination Survey","authors":"Jung Hyun Lee","doi":"10.3345/kjp.2019.00444","DOIUrl":"https://doi.org/10.3345/kjp.2019.00444","url":null,"abstract":"Purpose Investigating the prevalence of hyperuricemia and its association with metabolic syndrome (MetS) and cardiometabolic risk factors (CMRFs) in Korean children and adolescents. Methods This cross-sectional survey used data from the 7th Korea National Health and Nutrition Examination Survey (2016–2017); 1,256 males and females aged 10–18 years were included. Hyperuricemia was defined as serum uric acid levels were >6.6 mg/dL at 10–11 years of age (both sexes), >7.7 mg/dL for males at 12–18 years of age and >5.7 mg/dL for females at 12–18 years of age. MetS was defined by the International Diabetes Federation criteria. Logistic regression analysis was used to analyze hyperuricemia-associated risk factors. Results The prevalence of hyperuricemia was 9.4% (male, 8.4%; female, 10.5%) (P<0.281). After adjusting for sociodemographic factors and health behaviors in multivariate analysis (model 1), the odds ratio (OR) for hyperuricemia of MetS was 3.05 (95% confidence interval [CI], 1.17–7.92; P=0.022). After adjusting for the same variables in model 1 plus obesity and all MetS components (model 2), only abdominal obesity was significant, and the OR for hyperuricemia was 3.38 (95% CI, 1.72–6.63; P<0.001) After adjusting for the same variables in model 1 plus body mass index (BMI) z scores and all MetS components except abdominal obesity (model 3), only BMI z scores was significant, and the OR for hyperuricemia was 1.59 (95% CI, 1.34–1.89; P<0.001). Conclusion MetS, abdominal obesity, and BMI z scores were CMRFs significantly associated with hyperuricemia in Korean children and adolescents. Therefore, attention should be paid to hyperuricemia in patients with obesity or MetS.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 1","pages":"317 - 323"},"PeriodicalIF":0.0,"publicationDate":"2019-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44093624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Why should we monitor for hematologic adverse drug reactions to oxcarbazepine? 为什么我们要监测奥卡西平的血液不良反应?

Korean Journal of Pediatrics Pub Date : 2019-06-24 DOI: 10.3345/kjp.2019.00472

G. Jang

引用次数: 0

Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures 内镜下扩张后丝裂霉素C在顽固性食管狭窄儿童中的应用

Korean Journal of Pediatrics Pub Date : 2019-06-24 DOI: 10.3345/kjp.2018.07157

Yasser K. Rashed, M. El-Guindi

{"title":"Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures","authors":"Yasser K. Rashed, M. El-Guindi","doi":"10.3345/kjp.2018.07157","DOIUrl":"https://doi.org/10.3345/kjp.2018.07157","url":null,"abstract":"Background The esophagus is the most common part of gastrointestinal (GI) tract at the risk of stricture. Benign disorders are the leading causes of narrowing. Caustic ingestion is the most common cause of esophageal stricture in children, especially in developing countries. Clinical responses to the topical application of Mitomycin C in various medical procedures have been reported. Purpose The study aimed to evaluate the methodology, efficacy, and side effects of Mitomycin C in the treatment of esophageal strictures. Methods This study included 30 children with resistant esophageal strictures. Upper GI endoscopy was performed up to the area of stricture, esophageal dilatation was done, endoscopy was repeated, and Mitomycin C was applied topically under direct endoscopic vision. The effect of the procedure was followed over a period of 3–5 years. Results The response to Mitomycin C was excellent (clinically and endoscopically) in 28 patients (93.3%) and good (endoscopically only) in 2 patients (6.7%). No side effects of topical Mitomycin C in children with esophageal strictures were reported in this study. Conclusion Esophageal dilatation followed by local Mitomycin C application may be a useful strategy for treating resistant esophageal strictures.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 1","pages":"395 - 399"},"PeriodicalIF":0.0,"publicationDate":"2019-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43892718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Controversy in the diagnosis and treatment of hemodynamically significant patent ductus arteriosus in preterm infants 早产儿血液动力学显著动脉导管未闭的诊断和治疗存在争议

Korean Journal of Pediatrics Pub Date : 2019-06-21 DOI: 10.3345/kjp.2019.00570

S. Sung

引用次数: 2

Benefits and risks of therapeutic alternatives for macrolide resistant Mycoplasma pneumoniae pneumonia in children. 治疗对大环内酯类药物耐药的儿童肺炎支原体肺炎的其他疗法的益处和风险。

Korean Journal of Pediatrics Pub Date : 2019-06-01 Epub Date: 2019-03-15 DOI: 10.3345/kjp.2018.07367

Hyeon-Jong Yang

{"title":"Benefits and risks of therapeutic alternatives for macrolide resistant Mycoplasma pneumoniae pneumonia in children.","authors":"Hyeon-Jong Yang","doi":"10.3345/kjp.2018.07367","DOIUrl":"10.3345/kjp.2018.07367","url":null,"abstract":"Although Mycoplasma pneumoniae pneumonia (MPP) has been generally susceptible to macrolides, the emergence of macrolide-resistant MPP (MRMP) has made its treatment challenging. MRMP rapidly spread after the 2000s, especially in East Asia. MRMP is more common in children and adolescents than in adults, which is likely related to the frequent use of macrolides for treating M. pneumoniae infections in children. MRMP is unlikely to be related to clinical, laboratory, or radiological severity, although it likely prolongs the persistence of symptoms and the length of hospital stay. Thereby, it causes an increased burden of the disease and poor quality of life for the patient as well as a societal socioeconomic burden. To date, the only alternative treatments for MRMP are secondary antimicrobials such as tetracyclines (TCs) or fluoroquinolones (FQs) or systemic corticosteroids; however, the former are contraindicated in children because of concerns about potential adverse events (i.e., tooth discoloration or tendinopathy). A few guidelines recommended TCs or FQs as the second-line drug of choice for treating MRMP. However, there have been no evidence-based guidelines. Furthermore, safety issues have not yet been resolved. Therefore, this article aimed to review the benefits and risks of therapeutic alternatives for treating MRMP in children and review the recommendations of international or regional guidelines and specific considerations for their practical application.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 6","pages":"199-205"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/41/kjp-2018-07367.PMC6584239.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37164811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does any specific infection cause Kawasaki disease? 是否有特定的感染会导致川崎病？

Korean Journal of Pediatrics Pub Date : 2019-06-01 Epub Date: 2019-05-03 DOI: 10.3345/kjp.2019.00129

Dong Seok Lee

引用次数: 1

Importance of coronary artery dominance in children to determine coronary artery dilatation. 儿童冠状动脉优势对确定冠状动脉扩张的重要性。

Korean Journal of Pediatrics Pub Date : 2019-06-01 Epub Date: 2019-05-03 DOI: 10.3345/kjp.2019.00066

Hee Joung Choi

引用次数: 0

Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis. 红细胞减少和中性粒细胞/淋巴细胞比值对早期新生儿脓毒症的诊断价值。

Korean Journal of Pediatrics Pub Date : 2019-06-01 Epub Date: 2018-10-08 DOI: 10.3345/kjp.2018.06723

Rocky Wilar

{"title":"Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis.","authors":"Rocky Wilar","doi":"10.3345/kjp.2018.06723","DOIUrl":"https://doi.org/10.3345/kjp.2018.06723","url":null,"abstract":"Purpose To determine the diagnostic value of eosinopenia and the neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of early onset neonatal sepsis (EONS). Methods This cross-sectional study was conducted in the Neonatology Ward of R.D. Kandou General Hospital Manado between July and October 2017. Samples were obtained from all neonates meeting the inclusion criteria for EONS. Data were encoded using logistic regression analysis, the point-biserial correlation coefficient, chi-square test, and receiver operating characteristic curve analysis, with a P value <0.05 considered significant. Results Of 120 neonates who met the inclusion criteria, 73 (60.8%) were males and 47 (39.2%) were females. Ninety (75%) were included in the sepsis group and 30 (25%) in the nonsepsis group. The mean eosinophil count in EONS and non-EONS groups was 169.8±197.1 cells/mm3 and 405.7±288.9 cells/mm3 , respectively, with statistically significant difference (P<0.001). The diagnostic value of eosinopenia in the EONS group (cutoff point: 140 cells/mm3 ) showed 60.0% sensitivity and 90.0% specificity. The mean NLR in EONS and non-EONS groups was 2.82±2.29 and 0.82±0.32, respectively, with statistically significant difference (P<0.001). The diagnostic value of NLR in the EONS group (cutoff point, 1.24) showed 83.3% sensitivity and 93.3% specificity. Conclusion Eosinopenia has high specificity as a diagnostic marker for EONS and an increased NLR has high sensitivity and specificity as a diagnostic marker for EONS.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 6","pages":"217-223"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/aa/kjp-2018-06723.PMC6584235.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36573305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

High antistreptolysin O titer is associated with coronary artery lesions in patients with Kawasaki disease. 高抗链球菌溶血素 O 滴度与川崎病患者的冠状动脉病变有关。

Korean Journal of Pediatrics Pub Date : 2019-06-01 Epub Date: 2018-11-07 DOI: 10.3345/kjp.2018.06989

Dong Eun Min, Do Hee Kim, Mi Young Han, Sung Ho Cha, Kyung Lim Yoon

{"title":"High antistreptolysin O titer is associated with coronary artery lesions in patients with Kawasaki disease.","authors":"Dong Eun Min, Do Hee Kim, Mi Young Han, Sung Ho Cha, Kyung Lim Yoon","doi":"10.3345/kjp.2018.06989","DOIUrl":"10.3345/kjp.2018.06989","url":null,"abstract":"Purpose: In Kawasaki disease (KD) patients, coronary artery complications, incomplete and refractory types occur more frequently in patients with streptococcal or other bacterial/viral infections. Recently, we observed a higher incidence of coronary lesions in KD patients with high anti-streptolysin O (ASO) titer. Therefore, we hypothesized that KD patients diagnosed with concurrent streptococcal infection have poor prognosis, with respect to treatment response and development of coronary artery lesions.Methods: A retrospective review was performed in 723 patients with KD who were admitted to 2 major hospitals between June 2010 and September 2017.Results: Among 723 patients with KD, 11 initially showed an elevated ASO titer (>320 IU/mL) or elevated follow-up ASO titer after treatment. Of these patients, 5 showed no response to the first intravenous immunoglobulin treatment, 3 had abnormalities of the coronary arteries. This is a significantly higher proportion of patients with a high ASO titer (n=3, 27.3%) than those with a normal ASO titer (n=53, 7.4%; P=0.047). A severe clinical course was seen in 81.8% of patients in the high ASO group versus 14.5% of patients in the normal ASO group.Conclusion: It is not certain whether acute streptococcal infection may cause KD, but this study revealed that KD with high ASO titers showed higher rates of severe clinical course. It may be helpful to analyze concurrent streptococcal infection in patients with a severe clinical course.","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 6","pages":"235-239"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/e6/kjp-2018-06989.PMC6584233.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36656430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0