缺铁性贫血作为川崎病冠状动脉异常的预测因子。

Korean Journal of Pediatrics Pub Date : 2019-08-01 Epub Date: 2019-02-08 DOI:10.3345/kjp.2018.06905
Sohyun Kim, Lucy Youngmin Eun
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引用次数: 6

摘要

目的:冠状动脉异常(CAA)是川崎病(KD)最重要的并发症。缺铁性贫血(IDA)是一种普遍的微量营养素缺乏症,其与KD的关系尚不清楚。我们假设IDA的存在可能是CAA的预测因子。方法:回顾性研究173例KD患者,根据有无CAA分为2组(1组)。使用logistic回归模型计算95%置信区间(ci)的比值比(ORs),以估计CAA与其他指标之间的相关性。由于IDA指标之间共线性,在3个模型中,每个指标都与贫血配对。结果:血清铁、铁饱和度、铁蛋白浓度3项IDA指标1组显著高于2组。含铁贫血三组模型的CAA OR分别为3.513、3.171、2.256。IDA 3项指标与CAA呈负相关,OR分别为0.965、0.914、0.944。铁蛋白浓度、铁饱和度、血清铁、贫血、Kobayashi评分的曲线下面积(auc)分别为0.907 (95% CI, 0.851 ~ 0.963)、0.729 (95% CI, 0.648 ~ 0.810)、0.711 (95% CI, 0.629 ~ 0.793)、0.638 (95% CI, 0.545 ~ 0.731)、0.563 (95% CI, 0.489 ~ 0.636)。结论:IDA的各项指标,尤其是铁蛋白与CAA高度相关;因此,它们比Kobayashi分数更能预测CAA。IDA指标可用于预测CAA的发展,并建议早期干预的需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease.

Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease.

Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease.

Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease.

Purpose: Coronary artery abnormalities (CAA) are the most important complications of Kawasaki disease (KD). Iron deficiency anemia (IDA) is a prevalent micronutrient deficiency and its association with KD remains unknown. We hypothesized that presence of IDA could be a predictor of CAA.

Methods: This retrospective study included 173 KD patients, divided into 2 groups according to absence (group 1) and presence (group 2) of CAA. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a logistic regression model to estimate the association between CAA and other indicators. Due to collinearity between indicators of IDA, each indicator was paired with anemia in 3 models.

Results: Serum iron, iron saturation, and ferritin concentration, the 3 indicators of IDA, were significantly higher in group 1 than in group 2. Three sets of models including anemia with iron indicators produced the OR of CAA of 3.513, 3.171, and 2.256, respectively. The 3 indicators of IDA were negatively associated with CAA, by OR of 0.965, 0.914, and 0.944, respectively. The areas under the curve (AUCs) of ferritin concentration, iron saturation, serum iron, anemia, and Kobayashi score were 0.907 (95% CI, 0.851-0.963), 0.729 (95% CI, 0.648-0.810), 0.711 (95% CI, 0.629-0.793), 0.638 (95% CI, 0.545-0.731), and 0.563 (95% CI, 0.489-0.636), respectively.

Conclusion: Indicators of IDA, especially ferritin, were highly associated with CAA; therefore, they were stronger predictors of CAA than Kobayashi scores. IDA indicators can be used to predict CAA development and to suggest requirements for early interventions.

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来源期刊
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审稿时长
12 weeks
期刊介绍: Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.
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