早产儿血清表皮生长因子水平与坏死性小肠结肠炎的关系。

Korean Journal of Pediatrics Pub Date : 2019-08-01 Epub Date: 2019-03-15 DOI:10.3345/kjp.2018.07108
Heba Mostafa Ahmed, Nsreen Mostafa Kamel
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引用次数: 4

摘要

目的:坏死性小肠结肠炎(NEC)是早产最严重的并发症之一。许多危险因素可导致NEC的发展。表皮生长因子(epidermal growth factor, EGF)在肠道屏障功能、提高肠道酶活性、改善营养物质运输等方面发挥重要作用。本研究的目的是评估表皮生长因子在早产儿NEC发展中的作用。方法:本研究将130例新生儿分为3组,分别为:1组40例NEC早产儿;2、脓毒症早产儿50例;第三组40名健康早产儿作为对照。NEC组再细分为内科和外科NEC亚组。采用酶联免疫吸附法测定血清EGF水平。结果:NEC组血清EGF水平(pg/dL)(中位数[四分位数间距,IQR], 9.6[2-14])明显低于脓毒症组(10.1[8-14])和对照组(11.2 [8-14])
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates.

The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates.

The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates.

Purpose: Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport. The aim of this study was to assess the role of epidermal growth factor in the development of NEC in preterm neonates.

Methods: In this study, 130 preterm neonates were included and divided into 3 groups, as follows: group 1, 40 preterm neonates with NEC; group 2, 50 preterm neonates with sepsis; and group 3, 40 healthy preterm neonates as controls. The NEC group was then subdivided into medical and surgical NEC subgroups. The serum EGF level was measured using enzyme-linked immunosorbent assay.

Results: Serum EGF levels (pg/dL) were significantly lower in the NEC group (median [interquartile range, IQR], 9.6 [2-14]) than in the sepsis (10.1 [8-14]) and control groups (11.2 [8-14], P<0.001), with no significant difference between the sepsis and control groups, and were positively correlated with gestational age (r=0.7, P<0.001). A binary logistic regression test revealed that low EGF levels and gestational ages could significantly predict the development of NEC. The receiver-operating characteristic curve for EGF showed an optimal cutoff value of 8 pg/mL, with 73.3% sensitivity, 98% specificity, and an area under the curve of 0.92.

Conclusion: The patients with NEC in this study had significantly lower serum EGF levels (P<0.001), which indicated that EGF could be a reliable marker of NEC in preterm neonates.

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来源期刊
自引率
0.00%
发文量
0
审稿时长
12 weeks
期刊介绍: Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.
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