Klinische Padiatrie最新文献

{"title":"Intrauterine Ulceration of the Lower Limbs: A Not-so-rare Complication Following Vesicoamniotic Shunting with Somatex.","authors":"Jules Kohaut, Alessia Pantani, Ingo Gottschalk, Janina Fischer-Mertens, Martin Dübbers","doi":"10.1055/a-2873-3543","DOIUrl":"https://doi.org/10.1055/a-2873-3543","url":null,"abstract":"<p><strong>Introduction: </strong>The recent use of Somatex shunts in the prenatal drainage of megacystis remains poorly documented. Here, we describe a number of complications affecting the cutaneous and muscular tissues that have not been reported to date.</p><p><strong>Methods: </strong>The records of all male patients born alive after receiving a vesicoamniotic shunt were studied retrospectively. The primary end point was the presence of a cutaneous partially muscular lesion at birth. In addition, we analyzed the impact of shunt placement timing on the occurrence of these injuries.</p><p><strong>Results: </strong>Thirty patients were included. Seven patients received a Harrison fetal bladder stent, and none of them had skin ulceration visible at birth. Among the 23 patients who received a Somatex shunt, we observed ulcerative lesions of the lower limbs in 12 patients, representing 52% of children. In these patients, a single lesion was found, except for one case showing affected tissues on both lower limbs. Seventeen of these Somatex shunts were placed in the first 17 weeks of gestation. Among them, 10 showed ulcerative lesions whereas among the 6 Somatex shunts inserted later in pregnancy, two patients had an ulcerative skin lesion. There was no statistically significant difference in the occurrence of skin lesions between these two groups (10/17 vs. 2/6, <i>p </i>= 0.37).</p><p><strong>Conclusions: </strong>The implantation of Somatex shunts in the prenatal treatment of megacystis is associated with cutaneous and muscular lesions in more than half of the newborns. Our results underline the importance of antenatal advice prior to the implantation of these shunts, regarding also the esthetic consequences of these lesions.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Fat-free Mass Index and Body Mass Index on Pulmonary Function Tests in Children with Rheumatological Disease-associated Interstitial Lung Disease.","authors":"Aslı İmran Yılmaz, Sevgi Pekcan, Tuğba Şişmanlar Eyüboğlu, Müşerref Kasap Cüceoğlu, Ayca Burcu Kahraman, Zafer Bağcı, Malik Süleyman Güzel, Fatih Ercan, Hanife Tuğçe Çağlar, Fatma Nur Ayman, Suat Savaş","doi":"10.1055/a-2875-4698","DOIUrl":"https://doi.org/10.1055/a-2875-4698","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatological diseases may cause interstitial lung damage. This study aimed to investigate the association between pediatric body composition parameters and interstitial lung disease in patients with rheumatological conditions.</p><p><strong>Methods: </strong>In this cross-sectional study, all patients aged 8-18 years with rheumatological diseases and chronic respiratory symptoms were evaluated for interstitial lung disease using spirometry, thorax computed tomography, and carbon monoxide diffusion tests. Nutritional status and body composition were assessed using bioelectrical impedance analysis, body mass index, and fat-free mass index. Patients were categorized into three groups, group I (normal fat-free mass index and body mass index), group II (sarcopenia-low fat-free mass index but normal body mass index), and group III (malnutrition with both low fat-free mass index and body mass index).</p><p><strong>Results: </strong>A total of 26 patients were included, and the median age was 169.03 (94-216) months. The median body mass index was 21.9 (14.4-33.8) kg/m². Sixteen (62%) patients had normal body mass index and normal fat-free mass index (group I), four (15%) patients had normal body mass index and low fat-free mass index (group II), and six (23%) patients had low body mass index and low fat-free mass index (group III). Among the pulmonary function tests, the median (interquartile range) carbon monoxide diffusion tests​​​​​​ <i>z</i>-score was -2.3 (-4.9 to 0.06). A positive correlation was found between carbon monoxide diffusion tests <i>z</i>-scores and fat-free mass index (<i>r</i>=0.589, <i>p</i>=0.002). Fat-free mass index was significantly lower in the group with carbon monoxide diffusion tests <i>z</i>-scores of <-1.64.</p><p><strong>Conclusions: </strong>Nutritional status may be associated with pulmonary function test results in children with interstitial lung disease-related rheumatological diseases.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Costs of Diets for Metabolic Diseases in Children and Adolescents: Exemplary Scenario Calculations in Germany.","authors":"Aziza Janice Belgardt, Mathilde Kersting, Anjona Schmidt-Choudhury, Kathrin Sinningen, Frank Jochum, Martin Claßen, Thomas Lücke","doi":"10.1055/a-2867-9742","DOIUrl":"https://doi.org/10.1055/a-2867-9742","url":null,"abstract":"<p><strong>Objectives: </strong>Several metabolic diseases require indicated diets, often including special foods and supplements. The assessed scenario calculations aim to quantify the additional expenses caused by necessary dietary treatment in children and adolescents in alignment with a healthy diet based on the 'optimized mixed diet'. The optimized mixed diet fulfils the nutrient requirements for all ages (1-18 y) by adjusting the food amounts to their age-dependent energy requirements.</p><p><strong>Methods: </strong>For the food cost calculation, a sample patient (age group 4<7 y) was used. To determine additional costs, the 7-day model menu of the optimized mixed diet was modified based on specific requirements for each disease. Nutritional adequacy of all menus was assured using nutrition software 'Diät 2020'. Food amounts for all different age groups 1<18 years were determined by using calculation factors. Menu costs were calculated using current food prices collected in two supermarkets, pharmacies and online; lowest available prices were recorded.</p><p><strong>Results: </strong>Fourteen diseases were expected to cause additional costs and included in the calculations. The average additional costs of all diseases amounted for 48.88 €/mo for the reference group. The range for the expected additional costs for the reference group was between approx. 16 €-101 €/mo.</p><p><strong>Conclusions: </strong>The results of this first assessment of food costs required by certain metabolic diseases shall provide guidance for possible targeted financial support for caregivers of children with special dietary needs in Germany, from which other countries may benefit likewise.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Serum Vitamin D Levels, Clinical Disease Activity and Magnetic Resonance Imaging Lesion Burden in Pediatric Chronic Recurrent Multifocal Osteomyelitis.","authors":"Firat Gundogmus, Halil Kazanasmaz, Ender Can Eroglu, Mukaddes Kalyoncu","doi":"10.1055/a-2859-0223","DOIUrl":"https://doi.org/10.1055/a-2859-0223","url":null,"abstract":"<p><strong>Background: </strong>Chronic recurrent multifocal osteomyelitis is a rare autoinflammatory bone disorder in children. Vitamin D regulates immune and inflammatory pathways, but its impact on chronic recurrent multifocal osteomyelitis remains unclear. This study investigated the relationship between serum 25-hydroxyvitamin D levels and clinical, laboratory, and radiological characteristics of pediatric chronic recurrent multifocal osteomyelitis.</p><p><strong>Methods: </strong>Pediatric chronic recurrent multifocal osteomyelitis patients and age- and sex-matched healthy controls were retrospectively evaluated. Serum 25-hydroxyvitamin D, inflammatory markers, clinical disease activity score, and whole-body magnetic resonance imaging findings were analyzed.</p><p><strong>Results: </strong>Thirty-one chronic recurrent multifocal osteomyelitis patients and 31 controls were included. Chronic recurrent multifocal osteomyelitis patients had significantly lower 25-hydroxyvitamin D levels and a higher frequency of vitamin D deficiency (<i>p</i><0.001). Serum 25-hydroxyvitamin D levels showed no correlation with C-reactive protein, erythrocyte sedimentation rate, or the neutrophil-to-lymphocyte ratio, but were inversely correlated with the clinical disease activity score (<i>r</i>=- 0.429 and <i>p</i>=0.020) and the number of magnetic resonance imaging-detected skeletal lesions (<i>r</i>=- 0.376 and <i>p</i>=0.044). Logistic regression confirmed vitamin D deficiency as independently associated with chronic recurrent multifocal osteomyelitis (odds ratio=0.59, 95% confidence interva: 0.41-0.88, and <i>p</i>=0.007).</p><p><strong>Conclusions: </strong>Vitamin D deficiency is highly prevalent in pediatric chronic recurrent multifocal osteomyelitis and correlates with disease severity, reflected by clinical activity and lesion burden, independent of systemic inflammation. These findings suggest vitamin D as a potential biomarker in chronic recurrent multifocal osteomyelitis and highlight the need for prospective studies assessing its therapeutic role.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Influenza vaccination in healthy infants: Should healthy infants be included in the vaccination recommendations?]","authors":"Barbara Gärtner, Johannes Huebner, Jörg Schelling, Tilmann Schober","doi":"10.1055/a-2851-4526","DOIUrl":"10.1055/a-2851-4526","url":null,"abstract":"<p><strong>Abstract: </strong>Influenza is one of the most common vaccine-preventable infectious diseases in Germany, with sometimes severe, even fatal courses. Young children in particular, with or without a prevalent primary disease, have an increased risk of contracting influenza and play a crucial role in transmitting the virus to others. Vaccinations are the most effective medical measure to reduce the risk for influenza infections and complications. However, contrary to WHO recommendations, in Germany, healthy children are not included in the recommendations for influenza vaccinations. Data from various countries demonstrate that routine vaccination of children is well tolerated and reduces the number of influenza-related hospitalizations and deaths. Furthermore, a reduction in influenza infections in the general population and health economic benefits have been observed. The aim of this review is to advance the debate on the necessity of vaccinating healthy children in Germany, taking into account the current challenges.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Drug-induced liver injury induced by nicotinamide: a case report].","authors":"Johannes Nadler, Isabel Wettstein, Peter Krieg, Uwe Stedtler, Maren Hermanns-Clausen","doi":"10.1055/a-2498-9641","DOIUrl":"10.1055/a-2498-9641","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"174-175"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine Disorders Can Be Reversible After Renal Transplantation in Patients with Chronic Kidney Disease: A Case Report.","authors":"Nilüfer Uyar, İbrahim Mert Erbaş, Derya Özmen, Behzat Özkan","doi":"10.1055/a-2563-4573","DOIUrl":"10.1055/a-2563-4573","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"176-178"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguishing Features of Childhood Renal Dysplasia.","authors":"Ece Mekik, Zeynep Birsin Özçakar, Nilgun Cakar, Burcu Biral Coşkun, Beyza Doğanay, Fatos Yalcinkaya","doi":"10.1055/a-2373-0785","DOIUrl":"10.1055/a-2373-0785","url":null,"abstract":"<p><strong>Abstract: </strong>BACKGROUND: Renal dysplasia (RD) is a major cause of chronic kidney disease (CKD) in childhood. Herein, we present a single-center experience about distinctive features of different subtypes of dysplasia.</p><p><strong>Abstract: </strong>METHODS: All children with RD admitted between January 2018 and June 2019 were included in this cross-sectional study. Patients were classified as having unilateral RD, bilateral RD, posterior urethral valves (PUV), and multicystic-dysplastic kidneys (MCDK).</p><p><strong>Abstract: </strong>RESULTS: A total of 198 patients (108 unilateral RD, 31 bilateral RD, 16 PUV, and 43 MCDK) with a follow-up period of 80 (1.5-240) months were included. The overall consanguinity rate was 22%, whereas it was 56% in bilateral RD patients. Two-thirds had additional urogenital anomalies. Hypertension was detected in 16% of the patients, and 20% had median proteinuria of 16 (5.2-173) mg/m²/h, which was significantly higher in the PUV and bilateral RD groups. The overall rate of CKD was 23%, which was more frequent in bilateral RD and PUV groups. The median age at end-stage renal disease was 91.5 (0.5-208) months, including 12 renal transplant patients.</p><p><strong>Abstract: </strong>CONCLUSIONS: As different subtypes of RD have distinct clinical and prognostic features, the follow-up of RD patients should be individualized, and modifiable complications such as proteinuria and HT should be monitored closely.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"156-163"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wolcott-Rallison Syndrome: A Case Report with Novel Homozygous EIF2AK3 Gene Mutation.","authors":"Qiaomian Zhu, Xiaolin Wang, Huiping Zhang","doi":"10.1055/a-2800-2131","DOIUrl":"10.1055/a-2800-2131","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"169-171"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Training for Parents Prevents Clinically Relevant Handling Errors in the Use of Long-Term Antiseizure Medication.","authors":"Almuth Kaune, Pia Madeleine Schumacher, Martina Patrizia Neininger, Steffen Syrbe, Andreas Hiemisch, Matthias Karl Bernhard, Andreas Merkenschlager, Wieland Kiess, Astrid Bertsche, Thilo Bertsche","doi":"10.1055/a-2457-6610","DOIUrl":"10.1055/a-2457-6610","url":null,"abstract":"<p><strong>Abstract: </strong>BACKGROUND: Medication handling errors (ME) in long-term antiseizure medication (ASM) compromise patient safety. Training programs to prevent those errors by parents are scarce.</p><p><strong>Abstract: </strong>PATIENTS: The intervention concept is designed for parents of children and adolescents aged 0-18 years with at least one long-term ASM.</p><p><strong>Abstract: </strong>METHOD: In a controlled prospective study, we assessed ME of ASM during home visits 3-6 weeks after a patient's in- or outpatient hospital visit (outpatient neuropediatric clinic and Social-Pediatric Center (SPZ)). We investigated the effectiveness of a patient specific, risk-adapted training (intervention group, IG) compared to routine care (control group, CG). For 54 ME in ASM handling, an expert panel classified the clinical risk ranging from Score-0 (no risk) to Score-6 (maximum risk) with the lowest risk actually classified as Score-3.</p><p><strong>Abstract: </strong>RESULTS: We analyzed data from 83 parents in the CG and 85 in the IG who administered 140 ASM per group. The intervention reduced ME per patient from 5 (median; Q25/Q75 3/9) to 4 (2/8; p=0.018). A total number of 589 ME occurred in the CG, 432 in the IG. ME in ASM handling rated Score-6 occurred once in the CG and not in the IG. A relative-risk-reduction (RRR) of ME (with p<0.001) was observed, with a RRR of 55.0% for Score-5, 27.6% for Score-4, and 23.1% for Score-3. RRR was 56.6% for ASM preparation (p<0.001) and 22.4% for oral administration (p=0.045).</p><p><strong>Abstract: </strong>CONCLUSION: Compared to controls, ME with high clinical risk significantly decreased in the IG after the training. Drug safety in chronically ill children with ASM was thereby improved.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"147-155"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}