Klinische Padiatrie最新文献_第7页

Quality of Life and Related Factors in Patients Diagnosed with Mucopolysaccharidosis and Their Caregivers. 粘多糖病患者及其照护者的生活质量及相关因素。

IF 0.9 4区医学

Klinische Padiatrie Pub Date : 2026-05-01 Epub Date: 2024-12-10 DOI: 10.1055/a-2451-6562

Merve Koç Yekedüz, Kubra Cilesiz, İlknur Sürücü Kara, Aslı İnci, Engin Kose, Leyla Tümer, Fatma Tuba Eminoğlu

{"title":"Quality of Life and Related Factors in Patients Diagnosed with Mucopolysaccharidosis and Their Caregivers.","authors":"Merve Koç Yekedüz, Kubra Cilesiz, İlknur Sürücü Kara, Aslı İnci, Engin Kose, Leyla Tümer, Fatma Tuba Eminoğlu","doi":"10.1055/a-2451-6562","DOIUrl":"10.1055/a-2451-6562","url":null,"abstract":"Abstract: OBJECTIVES: Quality of life (QoL) is directly associated with physical-psychological well-being, family and environmental factors in patients with Mucopolysaccharidosis (MPS). The present study aims to investigate the factors affecting QoL in both MPS patients and their caregivers.Abstract: METHODS: The sociodemographic characteristics, clinical findings, and special needs of 37 patients with MPS were questioned, among which 28 pediatric patients were evaluated for QoL using the KINDL-parents scale. The World Health Organization Quality of Life Assessment (WHO-QoL-BREF) was used to assess the QoL of 37 caregivers of patients.Abstract: RESULTS: The patients with MPS type III had the lowest median score in the self-esteem domain among the other types. The patients undergoing enzyme replacement therapy scored high in the friends domain, while the physical-psychological/emotional domain scores of the patients with sleep disturbance and their parents were lower than those without. Patients with appetite/eating problems scored low in the self-esteem domain and their caregivers scored low in the social relationship domain. The psychological/emotional domain scores of the patients who needed special education and their parents were lower than those who did not. Total scores and KINDL disease domain scores were decreased in those receiving psychiatric medical treatment.Abstract: CONCLUSIONS: In this study, the aim was to simultaneously assess the quality of life of MPS patients and their parents. Sleep disturbances, appetite problems, special education, and psychiatric treatment negatively impacted QoL.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"133-146"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and Surgical Management of Pulmonary Artery Sling: A Case Report. 肺动脉吊带的诊断和手术治疗：病例报告

IF 0.9 4区医学

Klinische Padiatrie Pub Date : 2026-05-01 Epub Date: 2024-07-01 DOI: 10.1055/a-2348-0443

Ismail Yurtsever, Hafize Otcu Temur, Can Yilmaz Yozgat, Ahmet Berk Erol, Hazar Dogus Kus, Faraz Talebazadeh, Yilmaz Yozgat

引用次数: 0

Evaluation of Clinical and Hematological Findings of Pediatric Patients with Crimean-Congo Hemorrhagic Fever. 克里米亚-刚果出血热患儿临床和血液学表现的评价。

IF 0.9 4区医学

Klinische Padiatrie Pub Date : 2026-05-01 Epub Date: 2025-09-15 DOI: 10.1055/a-2669-8035

Emine Hafize Erdeniz, Yeter Düzenli Kar

{"title":"Evaluation of Clinical and Hematological Findings of Pediatric Patients with Crimean-Congo Hemorrhagic Fever.","authors":"Emine Hafize Erdeniz, Yeter Düzenli Kar","doi":"10.1055/a-2669-8035","DOIUrl":"10.1055/a-2669-8035","url":null,"abstract":"Background: Crimean-Congo hemorrhagic fever (CCHF) is one of the most common viral hemorrhagic fevers. After entering the body, the virus replicates in regional lymph nodes and tissues, then spreads via lymph and monocytes, causing systemic inflammatory response syndrome, septic shock, and disseminated intravascular coagulation (DIC).Methods: Sociodemographic, clinical, and hematological data of children (0-18 years) diagnosed with CCHF at the Pediatric Infectious Diseases Clinic of Erzurum Training and Research Hospital between September 2018 and June 2020 were analyzed.Results: Of 19 patients, 14 were male and 5 female, with a mean age of 14.2±3.2 years. Common presenting symptoms included fever, fatigue, and myalgia. Initial lab results showed a white blood cell count of 3012±1559/mm³, platelet count of 102.105 ± 50.350/mm³, and PT of 17.3±3.5 seconds. Two patients with persistent fever (>5 days) developed CCHF-associated hemophagocytic syndrome and received intravenous immunoglobulin in addition to ribavirin. Eleven patients with severe thrombocytopenia and/or bleeding received apheresis platelet concentrates; six received fresh frozen plasma.Conclusion: CCHF should be considered in patients-regardless of tick exposure-presenting with sudden fever, fatigue, leukopenia, thrombocytopenia, abnormal coagulation, and elevated liver enzymes.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"164-168"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fecal Calprotectin as a Potential Biomarker of Gastrointestinal Inflammation in Children With Cerebral Palsy: A Prospective Pilot Study. 粪便钙保护蛋白作为脑瘫儿童胃肠道炎症的潜在生物标志物：一项前瞻性先导研究。

IF 0.9 4区医学

Klinische Padiatrie Pub Date : 2026-04-15 DOI: 10.1055/a-2842-7680

Ece Gültekin, Abdullah Sert, Meryem K Başaran

{"title":"Fecal Calprotectin as a Potential Biomarker of Gastrointestinal Inflammation in Children With Cerebral Palsy: A Prospective Pilot Study.","authors":"Ece Gültekin, Abdullah Sert, Meryem K Başaran","doi":"10.1055/a-2842-7680","DOIUrl":"https://doi.org/10.1055/a-2842-7680","url":null,"abstract":"The presence of calprotectin in feces may be a consequence of neutrophil migration into the gastrointestinal tissue thanks to an inflammatory process. Fecal calprotectin is a non-invasive, cost-effective, specific, and sensitive test used to compare fecal calprotectin concentrations between cerebral palsy children and healthy children and to investigate the relationship between fecal calprotectin levels and cerebral palsy.A total of 25 patients with cerebral palsy and 27 healthy children were included in the study. We conducted a 3-month cohort study following two groups of children. One stool sample was collected from each participant. Subjects provided a single fecal sample for calprotectin measurements. Fecal samples were frozen on receipt at -80°C for further analysis.Median fecal calprotectin levels were found to be statistically significantly higher in the cerebral palsy group than in the control group (p=0.01). Albumin levels in the cerebral palsy group were found to be statistically significantly higher than in the control group (p=0.04). Total protein levels were statistically significantly higher in the cerebral palsy group than in the control group (p=0.01). This study confirms the possible association between increased calprotectin and cerebral palsy disease. The cut-off point, determined as 23.5 μg/g based on fecal calprotectin levels, yielded a sensitivity value of 0.92 and a specificity value of 0.96.Children with cerebral palsy exhibit elevated fecal calprotectin levels compared to healthy peers, suggesting altered intestinal inflammatory activity. Although fecal calprotectin is not proposed as a diagnostic marker for cerebral palsy, it may serve as an adjunctive indicator of subclinical intestinal inflammation in this population.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do Paediatric Patients with a Trichobezoar Benefit from a Modified Laparoscopic Approach? A Systematic Review. 有毛癣的儿科患者从改良的腹腔镜入路中获益吗？系统评价。

IF 0.9 4区医学

Klinische Padiatrie Pub Date : 2026-04-15 DOI: 10.1055/a-2833-9457

Frauke Alexandra Blaum, Ahmad Alsweed, Wolfgang Eberl, Esther Lau, Johannes Leonhardt

{"title":"Do Paediatric Patients with a Trichobezoar Benefit from a Modified Laparoscopic Approach? A Systematic Review.","authors":"Frauke Alexandra Blaum, Ahmad Alsweed, Wolfgang Eberl, Esther Lau, Johannes Leonhardt","doi":"10.1055/a-2833-9457","DOIUrl":"https://doi.org/10.1055/a-2833-9457","url":null,"abstract":"Trichobezoars represent a rare condition in paediatric patients, and evidence-based treatment recommendations are lacking. Most reported cases describe surgical removal, predominantly by laparotomy.We present a minimally invasive surgical strategy based on two paediatric cases of gastric trichobezoars and review the current literature. A PubMed search was performed including research articles and case reports published between 2016 and 2020. Inclusion criteria were isolated trichobezoars in patients aged ≤18 years, while reports describing combined bezoars were excluded. Extracted data included age, sex distribution, clinical presentation, medical history, imaging, treatment modality, and follow-up management.Thirty-four publications comprising 41 paediatric cases of trichobezoars were identified (age range: 2-17 y; female-to-male ratio: approximately 7:1). Endoscopic removal was attempted in 10 cases, requiring conversion to laparotomy in nine cases and to a modified laparoscopic technique in one case. Overall, 36 bezoars were removed by laparotomy, 5 by a modified laparoscopic technique, and only 1 by purely laparoscopic extraction without auxiliary incision.Our modified minimally invasive approach resulted in an uncomplicated postoperative course and a favourable cosmetic outcome. The technique enables safe removal of trichobezoars while minimising the risk of intra-abdominal contamination.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Presentation of Duchenne Muscular Dystrophy: Acute Rhabdomyolysis. 罕见的杜氏肌营养不良的表现：急性横纹肌溶解。

IF 0.9 4区医学

Klinische Padiatrie Pub Date : 2026-04-15 DOI: 10.1055/a-2842-7622

Esra Sayar, Mustafa Kılıç, Suzan İcil, Abdülkerim Kolkıran, Abdullah Sezer

引用次数: 0

Co-occurrence of Gluten-free Diet Adherence on Bone Mineral Density and Growth in Children with Celiac Disease. [乳糜泻儿童无谷蛋白饮食和骨密度与生长同时发生]。

IF 0.9 4区医学

Klinische Padiatrie Pub Date : 2026-04-08 DOI: 10.1055/a-2833-0306

Serhat Duman, Sadık Sami Hatipoglu, Hasret Ayyildiz Civan

{"title":"Co-occurrence of Gluten-free Diet Adherence on Bone Mineral Density and Growth in Children with Celiac Disease.","authors":"Serhat Duman, Sadık Sami Hatipoglu, Hasret Ayyildiz Civan","doi":"10.1055/a-2833-0306","DOIUrl":"10.1055/a-2833-0306","url":null,"abstract":"To investigate the impact of gluten-free diet adherence on bone mineral density and growth in children with celiac disease.This retrospective cross-sectional study reviewed the medical records of 75 pediatric patients diagnosed with celiac disease. Data on adherence to a gluten-free diet, bone mineral density assessed by dual-energy X-ray absorptiometry, anthropometric measurements, and laboratory parameters were collected. Bone mineral density was evaluated using Z-scores, and low bone mass for age was defined as a bone mineral density Z-score of<-2 according to International Society for Clinical Densitometry pediatric guidelines.Of the 75 patients, 26 (34.7%) patients were men and 49 (65.3%) patients were women; 48 (64%) patients adhered to the diet and 27 (36%) patients did not. Most patients (96%) had normal bone mineral density Z-scores, while 3 (4%) patients had low bone mass for age. The mean height was 141.09±19.34 cm and the mean weight was 37.50±14.95 kg. Growth failure was observed in 10.6% for height, 21.3% for weight, and 5.3% for both. No significant association was observed between diet adherence and sex, bone mineral density findings, growth failure, or most laboratory parameters. Ferritin levels were significantly higher in adherent patients, and positive correlations were observed between diet adherence and hemoglobin and ferritin levels.Adherence to a gluten-free diet showed a trend toward higher bone mineral density Z-scores but without statistically significant differences. The low prevalence of low bone mass for age may limit the detection of differences between groups. Prospective longitudinal studies are needed to clarify the long-term impact of dietary adherence on bone health in pediatric celiac disease.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Treatment of RSV in pediatric inpatients (Leave 5) and early effects of nirsevimab passive immunization in a regional German pediatric network]. [在德国地区儿科网络中，儿科住院患者RSV的治疗（Leave 5）和尼塞维单抗被动免疫的早期效果]。

IF 0.9 4区医学

Klinische Padiatrie Pub Date : 2026-04-07 DOI: 10.1055/a-2826-9348

Katharina Remke, Anna Hoffmann, Michael Zemlin, Marie-Claire Detemple, M Ghiath Shamdeen, Fabian Drautz, Wolfgang Thomas, Nicole Schröder, Sven Thorsten Nipken, Tania de la Rosa-Ramos, Fabian Berger, Daniel Picard, Arne Simon

{"title":"[Treatment of RSV in pediatric inpatients (Leave 5) and early effects of nirsevimab passive immunization in a regional German pediatric network].","authors":"Katharina Remke, Anna Hoffmann, Michael Zemlin, Marie-Claire Detemple, M Ghiath Shamdeen, Fabian Drautz, Wolfgang Thomas, Nicole Schröder, Sven Thorsten Nipken, Tania de la Rosa-Ramos, Fabian Berger, Daniel Picard, Arne Simon","doi":"10.1055/a-2826-9348","DOIUrl":"https://doi.org/10.1055/a-2826-9348","url":null,"abstract":"Inpatient treatment of RSV infection involves non-evidence based measures, including excessive antibiotic therapy. The introduction of nirsevimab as a passive immunization is intended to reduce the number of infants requiring inpatient treatment.Can inpatient treatment of RSV infection be improved in a regional pediatric infectious diseases network? Does the introduction of nirsevimab have an impact on inpatient epidemiology?Prospective study (2024/2025) in six pediatric hospitals in one region. Agreement on a treatment standard including five interventions that should be avoided (Leave 5). Analysis of epidemiology (≤24 months and 25-36 months) 2022-2025.121 Clinical Review Forms (CRF) were collected, 101 (83.5%) patients were≤24 months old. The length of stay was 4±3 days vs. 3.5±2 days (≤24 months vs. 25-36 months). At least one risk factor was documented in 24% (≤24 months) and 25% (25-36 months; p=0.8). In 56% of cases, all 5 Leave 5 measures were avoided (≤24 months 58%, 25-36 months 45%). In patients≤24 months, only 9% received antibiotics. After the introduction of nirsevimab, there was a decrease in the number of RSV treatment cases≤24 months (over 60%; p<0.0001).Evidence-based, predominantly supportive therapy for RSV infection in hospitalized children≤24 months can be promoted through a coordinated approach in a pediatric infectious disease network. Shortly after the introduction of nirsevimab, a clear effect on inpatient epidemiology is already evident.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Course of Hyperostosis Due to SP7 (Osterix) Gain-of Function Mutation. SP7 （Osterix）功能获得性突变导致骨质增生的临床过程。

IF 0.9 4区医学

Klinische Padiatrie Pub Date : 2026-03-19 DOI: 10.1055/a-2808-3688

Uwe Wintergerst, Rainer Biedermann, Bernd Wegener, Adalbert Raimann, Gabriele Hartmann

引用次数: 0

Acute Abdominal Pain in Children and Adolescents-Can Enemas Reduce Unnecessary Inpatient Admissions? 儿童和青少年急性腹痛：灌肠能减少不必要的住院吗？

IF 0.9 4区医学

Klinische Padiatrie Pub Date : 2026-03-13 DOI: 10.1055/a-2787-7685

Benedikt Groß, Christoph von Schrottenberg, Eric Waltersbacher, Klaudia Lipinska, Julia Felber, Arend Rahrisch, Guido Fitze, Jurek Schultz

{"title":"Acute Abdominal Pain in Children and Adolescents-Can Enemas Reduce Unnecessary Inpatient Admissions?","authors":"Benedikt Groß, Christoph von Schrottenberg, Eric Waltersbacher, Klaudia Lipinska, Julia Felber, Arend Rahrisch, Guido Fitze, Jurek Schultz","doi":"10.1055/a-2787-7685","DOIUrl":"https://doi.org/10.1055/a-2787-7685","url":null,"abstract":"Introduction: Constipation is a common cause of pediatric acute abdominal pain and, consequently, may be a frequent cause for presenting to emergency departments. Data on the effectiveness of administering enemas in the emergency department are scarce. This study aimed to evaluate the effect of enemas in the emergency department on symptom relief and inpatient admission rates in patients with pediatric acute abdominal pain, including adverse events.Materials and methods: We retrospectively analyzed 1,723 pediatric acute abdominal pain patients aged 3-17 years presenting to the emergency department of our tertiary pediatric surgery center from 2018 to 2019. The clinical course, the rate of inpatient admission, the rate of surgical intervention, and final diagnosis were assessed in patients who did or did not receive an enema.Results: Symptom relief and consecutive discharge from the emergency department were more frequent in the enema group (81% vs. 67% and p<0.0001). Fewer patients in the enema-group were operated on (8% vs. 13% and p=0.0003). The rate of revisits to the emergency department within 14 days, the rate of surgery after revisits, the rate of intraoperatively confirmed appendicitis, and the rate of patients admitted but managed conservatively did not differ between the two groups. No enema-related complication was recorded.Conclusions: Administering an enema to otherwise healthy children and adolescents with acute abdominal pain is safe. Administering enemas to pediatric acute abdominal pain patients may decrease the rate of inpatient admissions. Discharging patients in whom an enema-prompted bowel movement has led to the relief of symptoms does not lead to an increased rate of readmissions or surgery.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0