Klinische Padiatrie最新文献

Nasal CPAP and BiPAP as the Initial Respiratory Support in Preterm Infants: A Randomized Controlled Trial. 鼻CPAP和BiPAP作为早产儿初始呼吸支持：一项随机对照试验。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2025-05-06 DOI: 10.1055/a-2546-1381

Sema Arayici, Gulsum Kadioglu Simsek, Birgul Say, Mehmet Yekta Oncel, Fatma Nur Sari, Nurdan Uras, Evrim Dizdar

{"title":"Nasal CPAP and BiPAP as the Initial Respiratory Support in Preterm Infants: A Randomized Controlled Trial.","authors":"Sema Arayici, Gulsum Kadioglu Simsek, Birgul Say, Mehmet Yekta Oncel, Fatma Nur Sari, Nurdan Uras, Evrim Dizdar","doi":"10.1055/a-2546-1381","DOIUrl":"https://doi.org/10.1055/a-2546-1381","url":null,"abstract":"This study aimed to compare the nasal continuous positive airway pressure (nCPAP) and bi-level positive airway pressure (BiPAP) in preterm infants with respiratory distress syndrome (RDS).Preterm infants (≤32 weeks of gestation) were randomly assigned, at birth, into two study groups: nCPAP or BiPAP. Primary outcomes (surfactant administration and failure of non-invasive respiratory support within the first 72 hours), and secondary outcomes (duration of ventilation support, pneumothorax, bronchopulmonary dysplasia, patent ductus arteriosus, necrotizing enterocolitis, intraventricular haemorrhage, retinopathy of prematurity, time to total enteral feeding, length of hospital stay, and mortality) were assessed.A total of 188 preterm infants with RDS were analysed. Mean gestational age was 28.8±1.8 weeks (nCPAP) versus 29±1.9 weeks (BiPAP). There were no statistically significant differences between groups in the failure of non-invasive respiratory support (25% vs. 33%, RR: 0.74, 95% CI: 0.47-1.17) or surfactant administration (35% vs. 38%, RR: 0.92, 95% CI: 0.49-1.71). No significant differences were observed in secondary outcomes between the two groups. Subgroup analysis of infants<30 weeks yielded similar results.Although two-level CPAP theoretically offers benefits, BiPAP was not superior to nCPAP as initial support in preterm infants with RDS. This underscores the continued value of the simpler, well-established nCPAP and the need for multicentre trials involving preterm infants of varying gestational ages.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine Disorders Can Be Reversible After Renal Transplantation in Patients with Chronic Kidney Disease: A Case Report. 慢性肾病患者肾移植后内分泌紊乱可逆转1例报告

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2025-05-06 DOI: 10.1055/a-2563-4573

Nilüfer Uyar, İbrahim Mert Erbaş, Derya Özmen, Behzat Özkan

引用次数: 0

[Qualifications of examiners for first neonatal exam in Germany: status quo]. 【德国新生儿首次体检医师资格：现状】。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2025-05-06 DOI: 10.1055/a-2547-2793

Linda Plail, Sven Wellmann, Christian Apfelbacher, Michael Kabesch

{"title":"[Qualifications of examiners for first neonatal exam in Germany: status quo].","authors":"Linda Plail, Sven Wellmann, Christian Apfelbacher, Michael Kabesch","doi":"10.1055/a-2547-2793","DOIUrl":"https://doi.org/10.1055/a-2547-2793","url":null,"abstract":"Midwives as well as medical doctors may carry out the initial examination of a newborn after birth in accordance with German health care regulation and guidelines. However, it is unclear which profession based on which qualification is performing these examinations in current clinical practice.The aim of the study was to assess which professions are carrying out the initial examinations of a newborn in the largest German maternity hospitals as of today.University maternity hospitals and maternity hospitals with more than 2000 births in 2021 were asked to anwer a webbased questionnaire. A chi-square test was used for group comparisons.77 out of 111 contacted maternity hospitals participated. In total, five different professions carry out Apgar scores and the initial neonatal examinations in a healthy newborn in the largest German maternity hospitals. In 92% of maternity hospitals, midwives regularly collect Apgar scores. In most hospitals, initial examinations of the newborn are also regularly carried out by midwives (74%), but significantly less often than Apgar scores (p≤0,001). University and non-university maternity hospitals do not differ significantly in the rate at which midwives performed Apgar scores (93.9% vs. 90.9%, p=0.623) and initial examinations of the newborn (72.7% vs. 75%, p=0.822).Midwives are the predominant medical profession carrying out initial examinations of the newborn in German maternity hospitals as of today. Thus, they should also be the primary target group for quality assurance and quality improvement measures for these examinations in in the future.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2025-05-06 DOI: 10.1055/a-2544-3857

Sibel Tabea Savas, Stefan A Tschanz, Philipp Latzin, Carmen Casaulta, Loretta Müller

{"title":"Similar effect of lidocaine and saline on ciliary beating of nasal epithelial cells in vitro.","authors":"Sibel Tabea Savas, Stefan A Tschanz, Philipp Latzin, Carmen Casaulta, Loretta Müller","doi":"10.1055/a-2544-3857","DOIUrl":"10.1055/a-2544-3857","url":null,"abstract":"Primary ciliary dyskinesia is a rare genetic disease affecting ciliary motility and causing respiratory symptoms. Diagnosis can be done by high-speed-videomicroscopy using nasal epithelial cells (NECs) obtained via brushings. This procedure can be painful, especially for children. The use of lidocaine is proposed to reduce this pain; however, it is not clear whether lidocaine changes ciliary beating frequency (CBF) or pattern (CBP) in the subsequent high-speed-videomicroscopy. The aim of this study was to analyse the effect of lidocaine on the CBF and the CBP of differentiated, air-liquid-interface cultured NECs.NECs from healthy volunteers were obtained via brushings and cultured at the air-liquid-interface. After differentiation, lidocaine or isotonic saline (IS, control) were added apically for 1 or 5 min each and CBF (in top view of whole inserts and side views of scratched cells) and CBP (only side view) were assessed and recorded up to 150 min. CBF was computed and CBP was analysed semiquantitatively.Lidocaine as well as IS increased the CBF in the top view approach significantly compared to baseline. However, we found no significant differences between lidocaine and IS (control) treatment. Additionally, no effect of lidocaine on CBF, CBP, amplitude, inter- and intracellular coordination or transport was seen in the side view approach.We conclude that the observed CBF increase is related to the addition of liquid on the mucus layer and not by the lidocaine itself. Therefore, it seems possible to use lidocaine for nasal analgesia without impact on subsequent analysis of the ciliary motility.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of abdominal symptoms in people with Cystic Fibrosis during therapy with Elexacaftor/Tezacaftor/Ivacaftor brings gastrointestinal involvement into the paediatric pulmonologist's focus. 在使用Elexacaftor/Tezacaftor/Ivacaftor治疗期间，囊性纤维化患者腹部症状的改善使胃肠道受累成为儿科肺病学家关注的焦点。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2025-05-06 DOI: 10.1055/a-2551-2560

Pauline Sadrieh, Lutz Nährlich, Carsten Schwarz, Olaf Eickmeier, Patience Eschenhagen, Louise Polte, Samira Dabelow, Franziska Duckstein, Carlos Zagoya, Jochen G Mainz

引用次数: 0

A case of non-accidental injury with ileal perforation. 非意外伤害致回肠穿孔1例。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2025-05-06 DOI: 10.1055/a-2565-7306

Johannes Meyer, Frank-Mattias Schäfer, Maximilian Stehr, Christine Burgmeier

引用次数: 0

Investigation of the Oxidative Process by Measuring Total Antioxidant Capacity and Total Oxidant Capacity in Patients with Gaucher Disease. 通过测定戈谢病患者的总抗氧化能力和总氧化能力来研究氧化过程。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2025-05-05 DOI: 10.1055/a-2515-2164

Aynur Küçükçongar Yavaş, Eylem Şerife Kalkan, Özlem Ünal Uzun, Mehmet Gunduz, Özcan Erel

{"title":"Investigation of the Oxidative Process by Measuring Total Antioxidant Capacity and Total Oxidant Capacity in Patients with Gaucher Disease.","authors":"Aynur Küçükçongar Yavaş, Eylem Şerife Kalkan, Özlem Ünal Uzun, Mehmet Gunduz, Özcan Erel","doi":"10.1055/a-2515-2164","DOIUrl":"https://doi.org/10.1055/a-2515-2164","url":null,"abstract":"Gaucher disease is caused by mutations in the GBA1 gene, which encodes the β-glucocerebrosidase enzyme. The deficiency of this enzyme result in glucosylceramide and glucosylsphingosine accumulation, within lysosomes and resulted triggering inflammation and accumulating substrates affect multiple organ systems, causing progressive cellular damage. Evidence has shown that the accumulation of glucosylceramide in macrophages is associated with inflammatory processes, reactive oxygen species production and an imbalance between the pro-oxidants and the antioxidant reserve, resulting in oxidative stress and inflammation. The aim of this study was to compare the oxidative stress status between patients with Gaucher disease and healthy controls.Case-control study This study included 10 patients with Gaucher disease aged between 2-40 years, and 30 healthy controls. Total antioxidant capacity and total oxidant capacity parameters between these groups were compared. Although the total antioxidant capacity value of the case group was higher, it was not significant. The total oxidant capacity and oxidative stress index values were significantly higher in the patient group (p<0.05). Our study showed that oxidative stress increased in patients with Gaucher disease. The results of our study may guide the application of antioxidant treatment in Gaucher disease patients as a supportive treatment.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term evaluation of neurological outcomes in chemotherapy-associated posterior reversible encephalopathy (PRES) syndrome in children. 儿童化疗相关后可逆性脑病（PRES）综合征神经系统预后的长期评估

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2025-05-01 Epub Date: 2024-12-20 DOI: 10.1055/a-2468-3799

Gökçe Pınar Reis İskenderoğlu, Beril Dilber, İlker Eyüboğlu, Ayşenur Bahadır, Erol Erduran

{"title":"Long-term evaluation of neurological outcomes in chemotherapy-associated posterior reversible encephalopathy (PRES) syndrome in children.","authors":"Gökçe Pınar Reis İskenderoğlu, Beril Dilber, İlker Eyüboğlu, Ayşenur Bahadır, Erol Erduran","doi":"10.1055/a-2468-3799","DOIUrl":"10.1055/a-2468-3799","url":null,"abstract":"Background: Posterior reversible encephalopathy syndrome (PRES) is a clinical syndrome with numerous etiologies, mostly characterized by magnetic resonance imaging (MRI) abnormalities in the posterior cerebral white and gray matter and acute neurological symptoms.Aim: To examine the predisposing factors, clinical results, and radiological features of PRES in children diagnosed with malignancy.Materials and methods: The study included 20 patients (7 F/13 M) aged 4-16 years at the time of diagnosis who were diagnosed with malignancy and developed PRES during chemotherapy.Results: All the patients were diagnosed as having PRES both clinically and radiographically during chemotherapy. The time from the initiation of the chemotherapy to the onset of PRES ranged from 7-675 days. Hypertension was detected in nine patients, seizure was the most common presenting symptom - had involvement in the occipital and parietal lobes on MRI (n=14)/followed by headache (n=8)/altered consciousness (n=5)/visual impairment (n=4). Hydrocephalus and tentorial herniation were observed in one patient. Most of the lesions on MRI resolved within 10-33 days and the EEG findings within 9 months. Clinical symptoms of PRES also disappeared completely the 5-year Press frequency was found to be 2.48%.Conclusion: PRES may complicate the oncological treatment in children. Hypertension is a leading risk factor for PRES, while it should be kept in mind that the blood pressure may be normal in chemotherapy-induced PRES cases. PRES should be included in the differential diagnosis of all patients receiving chemotherapy and presenting with acute neurological symptoms.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"141-152"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Chondroblastic Variant of Osteosarcoma After Root Channel Treatment in the Base of Maxillary Sinus. 上颌窦根部根通道治疗后成骨肉瘤成软骨变异体的发展。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2025-05-01 Epub Date: 2024-12-11 DOI: 10.1055/a-2467-8600

Serdar Balsak, Fatma Yabul Çelik, Bahar Atasoy, Ismail Yurtsever, Can Yilmaz Yozgat, Ahmet Akcay, Sabahattin Yuzkan, Alpay Alkan

引用次数: 0

Diagnosis and Management of Giant Ventricular Fibroma in a 14-Month-Old Toddler: Insights from Cardiac MRI. 14个月大的幼儿巨大心室纤维瘤的诊断和治疗：来自心脏MRI的见解。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2025-05-01 Epub Date: 2025-02-07 DOI: 10.1055/a-2523-4533

Hafize Otcu Temur, Özkan Bekler, Can Yilmaz Yozgat, Mehmet Nuri Belge, Yilmaz Yozgat

引用次数: 0