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Long-term evaluation of neurological outcomes in chemotherapy-associated posterior reversible encephalopathy (PRES) syndrome in children. 儿童化疗相关后可逆性脑病（PRES）综合征神经系统预后的长期评估
IF 1.2 4区 医学
Klinische Padiatrie Pub Date : 2025-05-01 Epub Date: 2024-12-20 DOI: 10.1055/a-2468-3799
Gökçe Pınar Reis İskenderoğlu, Beril Dilber, İlker Eyüboğlu, Ayşenur Bahadır, Erol Erduran
{"title":"Long-term evaluation of neurological outcomes in chemotherapy-associated posterior reversible encephalopathy (PRES) syndrome in children.","authors":"Gökçe Pınar Reis İskenderoğlu, Beril Dilber, İlker Eyüboğlu, Ayşenur Bahadır, Erol Erduran","doi":"10.1055/a-2468-3799","DOIUrl":"10.1055/a-2468-3799","url":null,"abstract":"<p><strong>Background: </strong>Posterior reversible encephalopathy syndrome (PRES) is a clinical syndrome with numerous etiologies, mostly characterized by magnetic resonance imaging (MRI) abnormalities in the posterior cerebral white and gray matter and acute neurological symptoms.</p><p><strong>Aim: </strong>To examine the predisposing factors, clinical results, and radiological features of PRES in children diagnosed with malignancy.</p><p><strong>Materials and methods: </strong>The study included 20 patients (7 F/13 M) aged 4-16 years at the time of diagnosis who were diagnosed with malignancy and developed PRES during chemotherapy.</p><p><strong>Results: </strong>All the patients were diagnosed as having PRES both clinically and radiographically during chemotherapy. The time from the initiation of the chemotherapy to the onset of PRES ranged from 7-675 days. Hypertension was detected in nine patients, seizure was the most common presenting symptom - had involvement in the occipital and parietal lobes on MRI (n=14)/followed by headache (n=8)/altered consciousness (n=5)/visual impairment (n=4). Hydrocephalus and tentorial herniation were observed in one patient. Most of the lesions on MRI resolved within 10-33 days and the EEG findings within 9 months. Clinical symptoms of PRES also disappeared completely the 5-year Press frequency was found to be 2.48%.</p><p><strong>Conclusion: </strong>PRES may complicate the oncological treatment in children. Hypertension is a leading risk factor for PRES, while it should be kept in mind that the blood pressure may be normal in chemotherapy-induced PRES cases. PRES should be included in the differential diagnosis of all patients receiving chemotherapy and presenting with acute neurological symptoms.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"141-152"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Chondroblastic Variant of Osteosarcoma After Root Channel Treatment in the Base of Maxillary Sinus. 上颌窦根部根通道治疗后成骨肉瘤成软骨变异体的发展。
IF 1.2 4区 医学
Klinische Padiatrie Pub Date : 2025-05-01 Epub Date: 2024-12-11 DOI: 10.1055/a-2467-8600
Serdar Balsak, Fatma Yabul Çelik, Bahar Atasoy, Ismail Yurtsever, Can Yilmaz Yozgat, Ahmet Akcay, Sabahattin Yuzkan, Alpay Alkan
{"title":"Development of Chondroblastic Variant of Osteosarcoma After Root Channel Treatment in the Base of Maxillary Sinus.","authors":"Serdar Balsak, Fatma Yabul Çelik, Bahar Atasoy, Ismail Yurtsever, Can Yilmaz Yozgat, Ahmet Akcay, Sabahattin Yuzkan, Alpay Alkan","doi":"10.1055/a-2467-8600","DOIUrl":"10.1055/a-2467-8600","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"163-165"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and Management of Giant Ventricular Fibroma in a 14-Month-Old Toddler: Insights from Cardiac MRI. 14个月大的幼儿巨大心室纤维瘤的诊断和治疗：来自心脏MRI的见解。
IF 1.2 4区 医学
Klinische Padiatrie Pub Date : 2025-05-01 Epub Date: 2025-02-07 DOI: 10.1055/a-2523-4533
Hafize Otcu Temur, Özkan Bekler, Can Yilmaz Yozgat, Mehmet Nuri Belge, Yilmaz Yozgat
{"title":"Diagnosis and Management of Giant Ventricular Fibroma in a 14-Month-Old Toddler: Insights from Cardiac MRI.","authors":"Hafize Otcu Temur, Özkan Bekler, Can Yilmaz Yozgat, Mehmet Nuri Belge, Yilmaz Yozgat","doi":"10.1055/a-2523-4533","DOIUrl":"10.1055/a-2523-4533","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"161-162"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: GPOH Guidelines for Diagnosis and First-line Treatment of Patients with Neuroblastic Tumors, update 2025. 更正：GPOH神经母细胞肿瘤患者诊断和一线治疗指南，更新于2025年。
IF 1.2 4区 医学
Klinische Padiatrie Pub Date : 2025-05-01 Epub Date: 2025-06-05 DOI: 10.1055/a-2623-7760
Thorsten Simon, Theresa Thole, Sveva Castelli, Beate Timmermann, Danny Jazmati, Rudolf Schwarz, Jörg Fuchs, Steven Warmann, Jochen Hubertus, Matthias Schmidt, Julian Rogasch, Friederike Körber, Christian Vokuhl, Jürgen Schäfer, Johannes Hubertus Schulte, Hedwig Deubzer, Carolina Rosswog, Matthias Fischer, Peter Lang, Thorsten Langer, Kathy Astrahantseff, Holger Lode, Barbara Hero, Angelika Eggert
{"title":"Correction: GPOH Guidelines for Diagnosis and First-line Treatment of Patients with Neuroblastic Tumors, update 2025.","authors":"Thorsten Simon, Theresa Thole, Sveva Castelli, Beate Timmermann, Danny Jazmati, Rudolf Schwarz, Jörg Fuchs, Steven Warmann, Jochen Hubertus, Matthias Schmidt, Julian Rogasch, Friederike Körber, Christian Vokuhl, Jürgen Schäfer, Johannes Hubertus Schulte, Hedwig Deubzer, Carolina Rosswog, Matthias Fischer, Peter Lang, Thorsten Langer, Kathy Astrahantseff, Holger Lode, Barbara Hero, Angelika Eggert","doi":"10.1055/a-2623-7760","DOIUrl":"https://doi.org/10.1055/a-2623-7760","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":"237 3","pages":"e3"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GPOH Guidelines for Diagnosis and First-line Treatment of Patients with Neuroblastic Tumors, update 2025. GPOH神经母细胞肿瘤患者诊断和一线治疗指南，更新至2025年。
IF 1.2 4区 医学
Klinische Padiatrie Pub Date : 2025-05-01 Epub Date: 2025-05-09 DOI: 10.1055/a-2556-4302
Thorsten Simon, Theresa Thole, Sveva Castelli, Beate Timmermann, Danny Jazmati, Rudolf Schwarz, Jörg Fuchs, Steven Warmann, Jochen Hubertus, Matthias Schmidt, Julian Rogasch, Friederike Körber, Christian Vokuhl, Jürgen Schäfer, Johannes Hubertus Schulte, Hedwig Deubzer, Carolina Rosswog, Matthias Fischer, Peter Lang, Thorsten Langer, Kathy Astrahantseff, Holger Lode, Barbara Hero, Angelika Eggert
{"title":"GPOH Guidelines for Diagnosis and First-line Treatment of Patients with Neuroblastic Tumors, update 2025.","authors":"Thorsten Simon, Theresa Thole, Sveva Castelli, Beate Timmermann, Danny Jazmati, Rudolf Schwarz, Jörg Fuchs, Steven Warmann, Jochen Hubertus, Matthias Schmidt, Julian Rogasch, Friederike Körber, Christian Vokuhl, Jürgen Schäfer, Johannes Hubertus Schulte, Hedwig Deubzer, Carolina Rosswog, Matthias Fischer, Peter Lang, Thorsten Langer, Kathy Astrahantseff, Holger Lode, Barbara Hero, Angelika Eggert","doi":"10.1055/a-2556-4302","DOIUrl":"10.1055/a-2556-4302","url":null,"abstract":"<p><p>The clinical course of neuroblastoma is more heterogeneous than any other malignant disease. Many low-risk patients experience regression after limited or even no chemotherapy. However, more than half of high-risk patients die from disease despite intensive multimodal treatment. Precise disease characterization for each patient at diagnosis is key for risk-adapted treatment. The guidelines presented here incorporate results from national and international clinical trials to produce recommendations for diagnosing and treating neuroblastoma patients in German hospitals outside of clinical trials.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":"237 3","pages":"117-140"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of Cerebral-Placental Ratio in the Prenatal Diagnosis, Management, and Postnatal Outcome of a Fetus with Giant Cardiac Rhabdomyoma. 巨大心脏横纹肌瘤胎儿的产前诊断、处理和产后结局中脑胎盘比值的重要性。
IF 1.2 4区 医学
Klinische Padiatrie Pub Date : 2025-05-01 Epub Date: 2025-01-23 DOI: 10.1055/a-2507-0743
Özkan Bekler, Can Yilmaz Yozgat, Yilmaz Yozgat
{"title":"Importance of Cerebral-Placental Ratio in the Prenatal Diagnosis, Management, and Postnatal Outcome of a Fetus with Giant Cardiac Rhabdomyoma.","authors":"Özkan Bekler, Can Yilmaz Yozgat, Yilmaz Yozgat","doi":"10.1055/a-2507-0743","DOIUrl":"10.1055/a-2507-0743","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"166-168"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Nursing and medical delegable measures for children and adolescents with cancer as outpatient outreach care - The pilot project KIK HomeCare]. [癌症儿童和青少年门诊外展护理的护理和医疗可委托措施--XXX 试点项目]。
IF 1.2 4区 医学
Klinische Padiatrie Pub Date : 2025-05-01 Epub Date: 2024-09-16 DOI: 10.1055/a-2415-7856
Rebecca Toenne, Rebecca Kristiment, Katharina Waack, Dominik T Schneider, Thorsten Simon, Dirk Reinhardt
{"title":"[Nursing and medical delegable measures for children and adolescents with cancer as outpatient outreach care - The pilot project KIK HomeCare].","authors":"Rebecca Toenne, Rebecca Kristiment, Katharina Waack, Dominik T Schneider, Thorsten Simon, Dirk Reinhardt","doi":"10.1055/a-2415-7856","DOIUrl":"10.1055/a-2415-7856","url":null,"abstract":"<p><strong>Background: </strong>In the period from 2019 to 2022, pediatric hemato-oncological patients were cared for in a pilot project in North Rhine-Westphalia (NRW). The project delivered care at the homes of the patients as opposed to care at the clinics and included both general nursing as well as specific treatments that were delegated from physicians. Patients were admitted to this form of care upon referral by a physician.</p><p><strong>Objectives: </strong>The project objective was to test the feasibility of such a method of care in the context of pediatric hemato-oncologic disease.</p><p><strong>Method: </strong>For the evaluation, a documentation system was designed and applied, which made it possible to evaluate relevant health care data. The evaluation was carried out by means of descriptive statistics and content-analytical categorization.</p><p><strong>Results: </strong>From 11/2019 to 12/2022, a total of N=475 hemato-oncological patients were enrolled in the care project and n=4005 home visits were performed in 242 different zip code areas in NRW. The majority of activities that could be delegated to physicians consisted of blood sampling (79.2%). Assessment of general condition (96.5%) represented the largest proportion of care services. Complications related to the method of care did not occur.</p><p><strong>Conclusion: </strong>The nurse-led outpatient care of pediatric, hemato-oncological patients was shown to be a patient- and team-oriented form of care and seems to be an alternative to purely clinic based care. Presumably, transfer to other pediatric specialties is possible. In the next step, a prospective multicenter randomized study is needed to draw relevant conclusions about the actual possibilities and limitations.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"153-160"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Manifestation of Granulomatosis with Polyangiitis in an Adolescent with Respiratory, Hemorrhagic and Vascular Occlusive Complications. 青少年肉芽肿病合并多血管炎的严重表现，并发呼吸道、出血性和血管闭塞并发症。
IF 1.2 4区 医学
Klinische Padiatrie Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI: 10.1055/a-2501-5886
Antje Bjelde, Dominik Leitz, Carl Christoph Goetzke, Anne Lim von Stuckrad, Julia Thumfart, Tilmann Kallinich
{"title":"Severe Manifestation of Granulomatosis with Polyangiitis in an Adolescent with Respiratory, Hemorrhagic and Vascular Occlusive Complications.","authors":"Antje Bjelde, Dominik Leitz, Carl Christoph Goetzke, Anne Lim von Stuckrad, Julia Thumfart, Tilmann Kallinich","doi":"10.1055/a-2501-5886","DOIUrl":"10.1055/a-2501-5886","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"102-105"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pediatric pneumological aspects in the care of children with neuromuscular diseases with focus on Duchenne muscular dystrophy]. 【以杜氏肌营养不良为重点的神经肌肉疾病患儿护理中的儿科肺病】。
IF 1.2 4区 医学
Klinische Padiatrie Pub Date : 2025-03-01 Epub Date: 2024-12-10 DOI: 10.1055/a-2464-6210
Hans Fuchs, Lennart Gunst, Anke Wendt, Sebastian Becker, Ruth Margarethe Grychtol, Dejan Vlajnic, Dorit Aschmann-Muehlhans, Christiane Wuerfel, Mathis Steindor, Florian Stehling
{"title":"[Pediatric pneumological aspects in the care of children with neuromuscular diseases with focus on Duchenne muscular dystrophy].","authors":"Hans Fuchs, Lennart Gunst, Anke Wendt, Sebastian Becker, Ruth Margarethe Grychtol, Dejan Vlajnic, Dorit Aschmann-Muehlhans, Christiane Wuerfel, Mathis Steindor, Florian Stehling","doi":"10.1055/a-2464-6210","DOIUrl":"10.1055/a-2464-6210","url":null,"abstract":"<p><p>Duchenne muscular dystrophy is the most common inherited neuromuscular disease in children. In addition to the progressive loss of motor skills and cardiac involvement, respiratory muscle weakness leads to a restrictive lung disease and cough insufficiency. Specific respiratory interventions have significantly improved survival and quality of life of the affected boys. The pediatric pulmonologist's tasks include monitoring of the lung function, polysomnography, starting and adjusting of non-invasive or invasive nocturnal ventilation and optimizing of secretion management. Providing of vaccinations, enhancing of nutrition, treatment of intercurrent infections, and provision of advice and training are important tasks for the pediatric pulmonologist. This article emphasizes on the tasks for the pediatric pulmonologist in the treatment of children with neuromuscular diseases i. e. Duchenne muscular dystrophy in interaction with the other specialist disciplines.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"59-65"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Artificial intelligence in paediatric pneumology - opportunities and unanswered questions]. [人工智能在儿科肺炎学中的应用——机遇和未解之谜]。
IF 1.2 4区 医学
Klinische Padiatrie Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI: 10.1055/a-2511-8548
Stephanie Dramburg
{"title":"[Artificial intelligence in paediatric pneumology - opportunities and unanswered questions].","authors":"Stephanie Dramburg","doi":"10.1055/a-2511-8548","DOIUrl":"10.1055/a-2511-8548","url":null,"abstract":"<p><p>Artificial intelligence (AI) is already being used in most medical disciplines, including paediatric pneumology. This review describes current developments in AI-supported technologies and discusses their potential for the diagnosis and treatment of lung diseases in children and adolescents. The spectrum ranges from models for analysing respiratory sounds and the automated evaluation of medical imaging to systems for supporting clinical decisions. In particular, challenges in the adaptation of AI for paediatric populations are also described. Finally, open questions, such as the implementation of AI-based software in everyday clinical practice, will be discussed.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"73-80"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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