Klinische Padiatrie最新文献_第2页

Management of RSV Bronchiolitis in Outpatient Setting. 在门诊治疗 RSV 支气管炎。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2024-09-20 DOI: 10.1055/a-2380-2878

Johannes Borgmann, Lea Sandmann, Simon Ritter, Axel Heep, Holger Köster, Martin Wetzke, Matthias Lange

{"title":"Management of RSV Bronchiolitis in Outpatient Setting.","authors":"Johannes Borgmann, Lea Sandmann, Simon Ritter, Axel Heep, Holger Köster, Martin Wetzke, Matthias Lange","doi":"10.1055/a-2380-2878","DOIUrl":"https://doi.org/10.1055/a-2380-2878","url":null,"abstract":"Seasonal respiratory syncytial virus (RSV) lower respiratory infections (RSV-LRI) and bronchiolitis in children remain a high burden to medical facilities. Studies evaluating the practical approach in outpatient settings are scarce. We conducted a survey to provide an insight into management in pediatric offices in Germany. Invitations for participation in an online survey were sent to 623 providers of pediatric primary care via email. Recipients were randomly chosen from national databanks based on zip codes. The response rate was 16,2%, n=92 (14,7%) questionnaires were fully answered and analyzed. 93,5% (n=86) are board certified pediatricians. In outpatient setting, every second patient with suspected or confirmed RSV-LRI is presented three times or more. 40,7% of our participants refer less than 10% of all patients to hospital, 83,7% refer less than one third (<30%). 33,7% of all participants never perform virological testing in suspected cases of RSV-LRI. More than 50% of all participants prescribe bronchodilators, hypertonic saline inhalation is prescribed by 17,4%. Antibiotics are prescribed in less than 10% of all cases of RSV-LRI. About 3/4 ask for a clearer, more conclusive guideline regarding prophylaxis. The diagnostic approach varies significantly. Although not recommended in international guidelines, bronchodilators are still frequently used. Considering emerging options for passive immunization, broader inclusion criteria into immunization regimes are requested by the participants. More conclusive guidelines and recommendations could further improve the management of outpatient RSV-LRI in children.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Prospective Study on Different Doses of Gammaglobulin Plus Aspirin in the Pediatric Kawasaki Disease and the Impacts on CRP and WBC Levels. 关于不同剂量丙种球蛋白加阿司匹林治疗小儿川崎病及其对 CRP 和白细胞水平影响的前瞻性研究

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2024-09-20 DOI: 10.1055/a-2373-0867

Xiufang Su, Pingping Wang, Biao Li

{"title":"A Prospective Study on Different Doses of Gammaglobulin Plus Aspirin in the Pediatric Kawasaki Disease and the Impacts on CRP and WBC Levels.","authors":"Xiufang Su, Pingping Wang, Biao Li","doi":"10.1055/a-2373-0867","DOIUrl":"https://doi.org/10.1055/a-2373-0867","url":null,"abstract":"Objective: To evaluate the efficacy of different doses of gammaglobulin combined with aspirin in treating pediatric Kawasaki disease and its impact on C-reactive protein (CRP) and white blood cell (WBC) levels.Methods: A prospective study was conducted with 150 children (3groups) diagnosed with Kawasaki disease. Group A received a higher dose of intravenous gammaglobulin (2.5 g/kg) combined with aspirin, Group B received a standard dose of intravenous gammaglobulin (2 g/kg) combined with aspirin, and Group C received a lower dose of intravenous gammaglobulin (1 g/kg) combined with aspirin. All groups received oral aspirin therapy (30 mg/kg/day) for a standard duration. The time to symptom improvement, treatment efficacy, laboratory parameters, and adverse reactions were monitored and analyzed.Results: Group B showed a shorter time to symptom relief compared to Groups A and C, particularly in fever reduction, mucosal congestion, cervical lymph node enlargement, and limb symptoms. The total effective rate was higher in Group B compared to Groups A and C. Group B showed improvements in WBC, CRP, ESR, and PLT levels.Conclusion: Standard-dose intravenous gammaglobulin combined with aspirin was more effective in treating pediatric Kawasaki disease compared to higher and lower doses. The treatment regimen in Group B resulted in shorter time to symptom relief, higher total effective rate, improved biochemical markers. Incidence of adverse reactions was similar among the three groups, demonstrating the safety of standard dosage.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Nursing and medical delegable measures for children and adolescents with cancer as outpatient outreach care - The pilot project XXX]. [癌症儿童和青少年门诊外展护理的护理和医疗可委托措施--XXX 试点项目]。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2024-09-16 DOI: 10.1055/a-2415-7856

Rebecca Toenne, Rebecca Kristiment, Katharina Waack, Dominik T Schneider, Thorsten Simon, Dirk Reinhardt

引用次数: 0

A Misdiagnosis of MIS-C: Acute Pneumococcal Meningitis Due to Serotype 19F in A Child with Acute SARS-CoV-2 Infection with a Severe Disease Course. 误诊为 MIS-C：一名急性 SARS-CoV-2 感染儿童因血清型 19F 而导致急性肺炎球菌脑膜炎，病程严重。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2024-09-01 Epub Date: 2024-05-31 DOI: 10.1055/a-2296-2298

Rumeysa Yalcinkaya, Fatma Nur Oz, Zeynep Savas Sen, Ayse Kaman, Suna Ozdem, Ruveyda Gumuser Cinni, Gonul Tanir

{"title":"A Misdiagnosis of MIS-C: Acute Pneumococcal Meningitis Due to Serotype 19F in A Child with Acute SARS-CoV-2 Infection with a Severe Disease Course.","authors":"Rumeysa Yalcinkaya, Fatma Nur Oz, Zeynep Savas Sen, Ayse Kaman, Suna Ozdem, Ruveyda Gumuser Cinni, Gonul Tanir","doi":"10.1055/a-2296-2298","DOIUrl":"10.1055/a-2296-2298","url":null,"abstract":"According to the 2020 CDC criteria, multisystem inflammatory syndrome in children (MIS-C) due to Coronavirus disease-19 (COVID-19) is diagnosed when all of the following criteria are met: fever for+≥+24 hours, laboratory evidence of inflammation, multisystem (+≥+2) organ involvement, evidence of SARS-CoV-2 infection or exposure, and no alternative plausible diagnoses (CDC, 2020). Alternative diagnosis need to be excluded before coming upon an MIS-C diagnosis since there are plenty of infectious diseases that may mimic MIS-C (Dworsky et al., Pediatr Infect Dis J 2021; 40; e159-e161; Yalçinkaya et al., Pediatr Infect Dis J 2021; 40; e524-e525; Kaneta et al., Pediatr Infect Dis J 2023; 42; 590-593; Stanzelova et al., Pediatr Infect Dis J 2023; 42; e201-e203; Kolsi et al., Arch Pediatr 2023; 30; 521-523). Herein, we present a 6-year-old girl who was preliminarily diagnosed with MIS-C and received intravenous immunoglobulin (IVIG) treatment before referral to our center. She was diagnosed with acute pneumococcal meningitis due to serotype 19 F and ultimately suffered from sensorineural hearing loss (SNHL) as a sequela. We present this case to remind physicians that MIS-C should not be diagnosed unless other infectious causes are excluded.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sildenafil as a Potential Therapeutic Option for Refractory Congenital Chylous Ascites in a Premature Neonate: A Case Report and Literature Review. 西地那非作为早产新生儿难治性先天性乳糜腹水的潜在治疗方案：病例报告与文献综述

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1055/a-2319-2490

Filiz Aktürk Acar, Mehmet Mutlu, Yakup Aslan

引用次数: 0

Effect of Colchicine Treatment on Clinical Course in Children with PFAPA Syndrome. 秋水仙碱治疗对 PFAPA 综合征患儿临床病程的影响。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2024-09-01 Epub Date: 2024-02-22 DOI: 10.1055/a-2274-9046

İlknur Bagrul, Elif Arslanoglu Aydin, Serife Tuncez, Esra Baglan, Semanur Özdel, Mehmet Bülbül

{"title":"Effect of Colchicine Treatment on Clinical Course in Children with PFAPA Syndrome.","authors":"İlknur Bagrul, Elif Arslanoglu Aydin, Serife Tuncez, Esra Baglan, Semanur Özdel, Mehmet Bülbül","doi":"10.1055/a-2274-9046","DOIUrl":"10.1055/a-2274-9046","url":null,"abstract":"Introduction: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome (PFAPA) is the most common periodic fever condition in children. There is no consensus on treatment to prevent attacks and reduce their frequency. In this study, we aimed to evaluate the effectiveness of colchicine treatment in PFAPA syndrome. In addition, we described the demographic and clinical features of PFAPA patients.Materials and methods: We retrospectively analyzed 58 PFAPA patients who were started on colchicine treatment between January 2017 and January 2022. Demographic data, clinical features, laboratory tests, genetic analysis of MEditerranean FeVer (MEFV) mutations, and autoinflammatory disease activity index (AIDAI) scores of all patients were evaluated. In addition, patients were divided into two groups according to MEFV variants and compared.Results: Attack frequency, duration, and AIDAI scores decreased in all patients after colchicine treatment. Duration of follow-up was 13.53±6.65 months. The median±IQR age at diagnosis was 3.2 (2-5) years. Thirty three (56.9%) patients had heterozygous mutations of MEFV. The most common MEFV variants were M694V (63.6%). There was no significant difference between the two groups in terms of colchicine responses.Conclusion: Colchicine treatment is effective and safe in patients with PFAPA who have frequent attacks. No association was established between the presence of heterozygous mutations of MEFV and colchicine response.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139931747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Bilateral Optic Neuritis (Mogad) in a Five Year Old Girl. [一名 5 岁女孩的髓鞘少突胶质细胞糖蛋白抗体相关性双侧视神经神经炎]。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2024-09-01 Epub Date: 2024-05-07 DOI: 10.1055/a-2322-1681

Magdalena Hittmann, Ivan Rodriguez, Uwe Wintergerst

引用次数: 0

Allelic Variants of the Complement Genes in Acute Postinfectious Glomerulonephritis. 急性感染后肾小球肾炎中补体基因的等位基因变异。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2024-09-01 Epub Date: 2024-02-08 DOI: 10.1055/a-2244-7935

Emre Leventoğlu, Betül Öğüt, İpek Işık Gönül, Kibriya Fidan, Oğuz Söylemezoğlu

引用次数: 0

Correction: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Bilateral Optic Neuritis (Mogad) in a Five Year Old Girl. 更正：一名五岁女孩的髓鞘寡突胶质细胞蛋白抗体相关性双侧视神经炎（Mogad）。

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2024-09-01 Epub Date: 2024-06-11 DOI: 10.1055/a-2339-0393

Magdalena Hittmann, Ivan Rodriguez, Uwe Wintergerst

引用次数: 0

Low Birth Weight is Associated with More Severe Course of Steroid-Sensitive Nephrotic Syndrome in Children, Multicentric Study. 多中心研究：低出生体重与儿童类固醇敏感性肾病综合征更严重的病程有关

IF 1.2 4区医学

Klinische Padiatrie Pub Date : 2024-09-01 Epub Date: 2024-02-06 DOI: 10.1055/a-2227-4892

Patrik Konopásek, Sylva Skálová, Eva Sládková, Monika Pecková, Eva Flachsová, Ivana Urbanová, Jana Laubová, Martina Samešová, Pavel Dvořák, Jakub Zieg

{"title":"Low Birth Weight is Associated with More Severe Course of Steroid-Sensitive Nephrotic Syndrome in Children, Multicentric Study.","authors":"Patrik Konopásek, Sylva Skálová, Eva Sládková, Monika Pecková, Eva Flachsová, Ivana Urbanová, Jana Laubová, Martina Samešová, Pavel Dvořák, Jakub Zieg","doi":"10.1055/a-2227-4892","DOIUrl":"10.1055/a-2227-4892","url":null,"abstract":"Background: Several previous studies have reported a more severe course of nephrotic syndrome in children with low birth weight.Patients: Cohort of 223 children with idiopathic nephrotic syndrome.Methods: We aimed to investigate the association between course of nephrotic syndrome and low birth weight. Data from seven paediatric nephrology centres were used.Results: Children with low birth weight had 3.84 times higher odds for a more severe course of steroid-sensitive nephrotic syndrome (95% CI 1.20-17.22, P=0.041), and those with low birth weight and remission after 7 days had much higher odds for a more severe course of disease (OR 8.7). Low birth weight children had a longer time to remission (median 12 vs. 10 days, P=0.03). They had a higher need for steroid-sparing agents (OR for the same sex=3.26 [95% CI 1.17-11.62, P=0.039]), and the odds were even higher in females with low birth weight (OR 6.81). There was no evidence of an association either between low birth weight and focal segmental glomerulosclerosis or between low birth weight and steroid-resistant nephrotic syndrome.Discussion: We conducted the first multicentric study confirming the worse outcomes of children with NS and LBW and we found additional risk factors.Conclusions: Low birth weight is associated with a more severe course of steroid-sensitive nephrotic syndrome, while being female and achieving remission after 7 days are additional risk factors.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0