Klinische Padiatrie最新文献_第3页

The effect of anti-nausea wristbands and STW-5 in children suffering from dyspepsia - a randomized double-blind placebo-controlled pilot-study. 抗恶心腕带和STW-5对患有消化不良的儿童的影响——一项随机双盲安慰剂对照试验研究。

IF 0.8 4区医学

Klinische Padiatrie Pub Date : 2026-09-01 Epub Date: 2025-08-21 DOI: 10.1055/a-2652-1298

Corinne Légeret, Sebastian Ludyga, Muriel D'Aujourdhui, Selina Schneider, Sarah Hagmann, Annemarie Acket, Henrik Köhler, Raoul Furlano

{"title":"The effect of anti-nausea wristbands and STW-5 in children suffering from dyspepsia - a randomized double-blind placebo-controlled pilot-study.","authors":"Corinne Légeret, Sebastian Ludyga, Muriel D'Aujourdhui, Selina Schneider, Sarah Hagmann, Annemarie Acket, Henrik Köhler, Raoul Furlano","doi":"10.1055/a-2652-1298","DOIUrl":"10.1055/a-2652-1298","url":null,"abstract":"Background: Functional dyspepsia (FD) is common in children and refers to discomfort in the epigastric/duodenal region, which cannot be explained by structural or biochemical abnormalities. Since the pathophysiology is still not fully understood, no guidelines in terms of treatment do exist.Aim: The aim of this study was to compare the therapeutical effect of plant extracts (STW-5) and acupressure in children with functional dyspepsia.Methods: This is a randomized, double-blind placebo-controlled trial. Before and after the allocated intervention of four weeks, participants had to fill in a cross-cultural validated questionnaire consisting of 52 questions to assess quality of life, as well as the extent of their discomfort (using a standardized visual analog scale (VAS)).Results: 33 patients were included in the study: 12 male and 21 female with an average age of 12.09 years (range: 7-17 years). Symptoms improved after four weeks of intervention in most treatment-groups: By 68% in children, who received STW-5, by 40% in the wristband (WB)- group and by 35% in the wrist-band-Placebo-group (WBPL). Patients receiving STW-5- Placebo showed even an increase of symptoms.Discussion: This double-blind, placebo-controlled pilot study showed, that STW-5 and/or anti-nausea wristbands are a cheap and effective option to treat children and teenagers suffering from functional dyspepsia.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"272-279"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Serum Uric Acid to Creatinine Ratio Associated with Hypertension and Metabolic Syndrome in Children with Obesity? 血清尿酸/肌酐比值与肥胖儿童高血压和代谢综合征相关吗？

IF 0.8 4区医学

Klinische Padiatrie Pub Date : 2026-09-01 Epub Date: 2025-02-04 DOI: 10.1055/a-2510-5233

Emine Gulsah Ozdemir, Ayse Derya Bulus

{"title":"Is Serum Uric Acid to Creatinine Ratio Associated with Hypertension and Metabolic Syndrome in Children with Obesity?","authors":"Emine Gulsah Ozdemir, Ayse Derya Bulus","doi":"10.1055/a-2510-5233","DOIUrl":"10.1055/a-2510-5233","url":null,"abstract":"Background: Childhood obesity is a global health problem with increasing prevalence, leading to long-term cardiovascular complications. Research conducted on adults has established a correlation between serum uric acid to creatinine ratio (SUA/Cr) and metabolic syndrome (MetS) components. The study investigates the relationship between SUA/Cr and hypertension (HT) and MetS components in children with obesity.Methods: A total of 103 children with obesity who underwent ambulatory blood pressure measurement (ABPM) were included the study and patients were divided into two groups \"HT\" (n=60) and \"Normal\" (n=43). Demographic, anthropometric, and laboratory characteristics were retrospectively analyzed.Results: The study included 103 children (42 female, 61 male) with a mean age of 13.7±2.9 years. HT prevalence was significantly higher in patients with severe obesity and dyslipidemia (p=0.045, p=0.01). Males exhibited significantly higher SUA/Cr than females (p<0.001). However, SUA/Cr showed no significant differences between patients with and without HT, MetS, dyslipidemia, or hyperglycemia (p=0.69, p=0.64, p=0.90, p=0.37). Furthermore, linear regression analysis did not establish a significant effect of SUA/Cr on ABPM parameters (p>0.05).Conclusion: In our cohort, no significant association was found between SUA/Cr and HT, as well as MetS components in children with obesity. These findings highlight the need for further investigation into the complex mechanisms regulating uric acid metabolism, obesity, and cardiovascular risk in children.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"254-260"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Fulminant Pertussis in Neonates and Young Infants: Two Case Reports and Current Implications for Prevention]. [新生儿和婴幼儿的暴发性百日咳：两例报告和当前预防的意义]。

IF 0.8 4区医学

Klinische Padiatrie Pub Date : 2026-08-25 DOI: 10.1055/a-2919-4632

Stephan Seeliger, Elena Neumann

引用次数: 0

[The Gap between Need and Reality in Neuropsychological Care in Pediatric Oncology - Position Paper]. [儿童肿瘤神经心理护理需求与现实之间的差距-立场文件]。

IF 0.8 4区医学

Klinische Padiatrie Pub Date : 2026-08-18 DOI: 10.1055/a-2880-2057

Peggy Lüttich, Ulrike Leiss, Henning Ross, Lisa Bußenius, Anne Rossius, Marike Johanna Johnsdorf, Antonia Goller, Ulrike Bachmann, Carolin Galisch, Thomas Traunwieser, Andreas Wiener

{"title":"[The Gap between Need and Reality in Neuropsychological Care in Pediatric Oncology - Position Paper].","authors":"Peggy Lüttich, Ulrike Leiss, Henning Ross, Lisa Bußenius, Anne Rossius, Marike Johanna Johnsdorf, Antonia Goller, Ulrike Bachmann, Carolin Galisch, Thomas Traunwieser, Andreas Wiener","doi":"10.1055/a-2880-2057","DOIUrl":"https://doi.org/10.1055/a-2880-2057","url":null,"abstract":"Abstract: Improved survival in pediatric oncology has resulted in a growing number of children, adolescents, and young adults affected by neuropsychological late effects of disease and/or treatment. Patientswith brain tumors and malignancies involving the central nervous system are particularly at risk. Neuropsychological impairments affect cognitive, emotional, and behavioral functioning and have sustained consequences for education, daily life, and social participation. In accordance with the concept of \"growing into deficit,\" clinically relevant impairments may only emerge years after completion of therapy. Neuropsychological care is considered an integral component of comprehensive medical and psychosocial care. It comprises hypothesis-driven assessment beyond global IQ measures, counseling, everyday-oriented interventions and therapy, and continuous evaluation of treatment goals. Prerequisites include specialized developmental and clinical neuropsychological expertise, methodological quality assurance, multiprofessional collaboration, and adequate resources. In addition to neuropsychological care during oncological treatment, long-term neuropsychological monitoring from diagnosis through adult long-term follow-up is required. Outpatient and inpatient rehabilitation are essential to promote autonomy, quality of life, and participation. The Neuropsychology Working Group of PSAPOH identifies a significant gap in care and calls for the establishment and sustainable implementation of routine neuropsychological services, standardized transition processes, reimbursement of services, and nationwide access.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silent but Dangerous: The Hidden Threat of Unwitnessed Button Battery Ingestion in a Toddler. 无声但危险：幼儿无意识吞下纽扣电池的潜在威胁。

IF 0.8 4区医学

Klinische Padiatrie Pub Date : 2026-08-18 DOI: 10.1055/a-2933-2425

Johanne Hammelbeck, Matthias Volkmar Kopp, Gabriela Marta Dekany, Enno Stranzinger, Susanne Schibli, Daniela Denier

引用次数: 0

BK Virus Associated Hemorrhagic Cystitis in Pediatric Hematopoietic Stem Cell Transplantation Recipients: A Retrospective Analysis. 小儿造血干细胞移植受者的BK病毒相关性出血性膀胱炎：回顾性分析

IF 0.8 4区医学

Klinische Padiatrie Pub Date : 2026-08-13 DOI: 10.1055/a-2763-6066

Hatice Burcu Çağlar Kızıl, Tuğçe Tural Kara, Ayşe Kübra Açık, Onur Tekeli, Hafize Selma Çetin, Funda Tayfun Küpesiz, Osman Alphan Küpesiz, Elif Güler

{"title":"BK Virus Associated Hemorrhagic Cystitis in Pediatric Hematopoietic Stem Cell Transplantation Recipients: A Retrospective Analysis.","authors":"Hatice Burcu Çağlar Kızıl, Tuğçe Tural Kara, Ayşe Kübra Açık, Onur Tekeli, Hafize Selma Çetin, Funda Tayfun Küpesiz, Osman Alphan Küpesiz, Elif Güler","doi":"10.1055/a-2763-6066","DOIUrl":"https://doi.org/10.1055/a-2763-6066","url":null,"abstract":"Background: BK polyomavirus is one of the most common viral causes of late-stage hemorrhagic cystitis in pediatric allogeneic hematopoietic stem cell transplantation. However, there are no established diagnostic and therapeutic standards. This study examined the clinical features, risk factors, and treatment approaches of BK polyomavirus-associated hemorrhagic cystitis in pediatric hematopoietic stem cell transplantation patients.Methods: Pediatric patients who underwent hematopoietic stem cell transplantation at our center between January 2018 and October 2023 and developed BK polyomavirus-associated hemorrhagic cystitis were retrospectively included.Results: A total of 34 pediatric hematopoietic stem cell transplantation recipients with BK polyomavirus associated hemorrhagic cystitis were analyzed. Viruria was seen in all patients and viremia in 55.8% of patients. Hematuria was graded 1-4 in all patients; among which, 52.9% (18) had mild hemorrhagic cystitis (grades 1 and 2) and 47.1% (16) had severe hemorrhagic cystitis (grades 3 and 4). Bladder hematomas occurred far more frequently in severe hemorrhagic cystitis (p<0.01). Spontaneous recovery was more common in the mild hemorrhagic cystitis group (68.8%) than in the severe group (31.3%), whereas mortality occurred more frequently in severe hemorrhagic cystitis, although not BK polyomavirus-mediated (p=0.01). Treatment included immunosuppression reduction, intravesical and intravenous cidofovir, hyperbaric oxygen, and supportive care.Conclusions: BK polyomavirus associated hemorrhagic cystitis is a common and challenging complication in pediatric hematopoietic stem cell transplantation recipients. Clarification of risk factors and optimization of supportive and antiviral treatments can potentially reduce the morbidity of this process.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring Participation in Children and Adolescents: A Systematic Review. [儿童和青少年参与的测量-系统综述]。

IF 0.8 4区医学

Klinische Padiatrie Pub Date : 2026-08-11 DOI: 10.1055/a-2918-3079

Karoline Spiess, Dustin Fornefeld, Ibrahim Duran, Eckhard Schönau, Stephanie Gross, Stefanie Steven, Oliver Fricke

{"title":"Measuring Participation in Children and Adolescents: A Systematic Review.","authors":"Karoline Spiess, Dustin Fornefeld, Ibrahim Duran, Eckhard Schönau, Stephanie Gross, Stefanie Steven, Oliver Fricke","doi":"10.1055/a-2918-3079","DOIUrl":"10.1055/a-2918-3079","url":null,"abstract":"Background: The International Classification of Functioning, Disability and Health and its child and youth version provide a holistic view of health problems and describe health status at five different levels. Some levels have measurement methods that can be used to visualise the success of therapy. However, this is questionable for the level of participation. The aim of this review is to determine whether there are any valid measurement methods for assessing participation in health care intervention for children and adolescents according to the International Classification of Functioning, Disability and Health.Methods: A systematic literature review was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. The search query was created according to the Patient/Population, Intervention, Comparison, Outcome, and Study Design scheme and used in two search runs across five databases (PubMED, Cochrane Database, NeuroBITE, APA PsychNET and PEDro). Publications were included or excluded by three reviewers based on defined criteria. The included publications were evaluated using the AMSTAR-2 tool and the study and measurement characteristics and measurement properties in terms of validity and reliability were presented. This systematic review is listed in PROSPERO.Results: A total of four publications were included, describing 23 measurement methods. With regard to validity, there are indications of adequate content and construct validity, as well as adequate to the questionable criterion and structural validity.Conclusions: Measurement methods for assessing participation in health care interventions according to the International Classification of Functioning, Disability and Health for children and adolescents exist. There is evidence of validity, but the quality of the studies is low.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical phenotypes and household structure in pediatric invasive meningococcal disease: A retrospective cohort study. 儿童侵袭性脑膜炎球菌病的临床表型和家庭结构：一项回顾性队列研究

IF 0.8 4区医学

Klinische Padiatrie Pub Date : 2026-08-05 DOI: 10.1055/a-2918-3192

Kubra Boydag Guvenc, Cansu Durak, Nihal Akcay, Ulkem Kocoglu Barlas, Guner Ozcelik, Hasan Serdar Kıhtır, Bahar Salihoğlu, Nevin Hatipoglu, Esra Sevketoğlu

{"title":"Clinical phenotypes and household structure in pediatric invasive meningococcal disease: A retrospective cohort study.","authors":"Kubra Boydag Guvenc, Cansu Durak, Nihal Akcay, Ulkem Kocoglu Barlas, Guner Ozcelik, Hasan Serdar Kıhtır, Bahar Salihoğlu, Nevin Hatipoglu, Esra Sevketoğlu","doi":"10.1055/a-2918-3192","DOIUrl":"https://doi.org/10.1055/a-2918-3192","url":null,"abstract":"Background: Invasive meningococcal disease is a rapidly progressive infection with heterogeneous clinical presentations. Phenotype-related severity differences in critically ill children remain incompletely defined. We evaluated the association between clinical phenotypes, early disease severity, and outcomes in a pediatric intensive care unit cohort.Methods: This retrospective study included 42 children admitted to a tertiary pediatric intensive care unit with invasive meningococcal disease between 2006 and 2020. Patients were classified as meningococcal sepsis without meningitis or meningococcal meningitis. Disease severity was assessed using the Pediatric Risk of Mortality III score. Demographic, clinical, microbiological, and selected household characteristics were analyzed.Results: Twenty-three patients (54.8%) had meningococcal sepsis without meningitis and 19 patients (45.2%) had meningococcal meningitis. The overall mortality was 21.4%. The sepsis phenotype was associated with higher Pediatric Risk of Mortality III scores (median 20 vs. 11, p=0.007), higher lactate, lower platelet counts, more organ support, and higher mortality (34.8% vs. 5.3%, p=0.023). Extended family living was more frequent in the meningitis group (26.3% vs. 4.3%, p=0.043). Serogroup data were available in 40.5% of cases, with serogroup B predominating.Conclusions: In this pediatric intensive care unit cohort, meningococcal sepsis without meningitis was associated with greater early severity and higher mortality than meningococcal meningitis. Household-structure findings should be considered exploratory. Early phenotype-based risk assessment may support the management of critically ill children with invasive meningococcal disease.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgery in the Neonatal Intensive Care Unit: Current Practices and Perspectives of Pediatric Surgeons in Germany. 新生儿重症监护室的外科手术：德国儿科外科医生的当前实践和观点。

IF 0.8 4区医学

Klinische Padiatrie Pub Date : 2026-07-29 DOI: 10.1055/a-2907-7952

Rim Kiblawi, Jens Dingemann, Fritz Kahl, Ludger Tüshaus

{"title":"Surgery in the Neonatal Intensive Care Unit: Current Practices and Perspectives of Pediatric Surgeons in Germany.","authors":"Rim Kiblawi, Jens Dingemann, Fritz Kahl, Ludger Tüshaus","doi":"10.1055/a-2907-7952","DOIUrl":"https://doi.org/10.1055/a-2907-7952","url":null,"abstract":"Aim: Surgery in the neonatal intensive care unit has become a standard practice for critically ill premature and newborn infants, minimizing the risks associated with patient transport to the operating theater. This study aimed to assess the current practice, challenges, and working conditions of pediatric surgeons performing surgery in the neonatal intensive care unit, based on a nationwide survey in Germany.Methods: A nationwide survey was conducted among members of the German Society of Pediatric Surgery, exploring surgeons' opinions about operating in the neonatal intensive care unit, including patients' conditions, environmental factors, technical needs, and logistic challenges. Ethical approval was obtained.Results: Fifty pediatric surgeons completed the survey. The most decisive factors influencing the decision to operate in the neonatal intensive care unit were the patient's non-transportability (100%) and cardiorespiratory instability (98%). Exploratory laparotomy was the most frequent procedure. Surgeons valued the direct communication with neonatologists (86% satisfaction), but identified relevant environmental concerns as inadequate lighting (98%), poor temperature regulation (94%), and limited working space (70%). Nonetheless, 88% of respondents considered the neonatal intensive care unit surgery as both safe and clinically effective, while 60% reported the absence of standardized protocols.Conclusions: Surgery in the neonatal intensive care unit is feasible and often preferred for critically ill neonates in Germany, yet improvements in ergonomics, environment and standardized procedural protocols remain essential.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Impact of the COVID-19 Pandemic on Voiding Diary Quality and its Relevance for the Treatment of Functional Urinary Incontinence in Children]. 【新冠肺炎疫情对儿童排尿日记质量的影响及其与功能性尿失禁治疗的相关性】。

IF 0.8 4区医学

Klinische Padiatrie Pub Date : 2026-07-24 DOI: 10.1055/a-2907-9060

Jonas Erdmann, Christopher Darr, Christian Rehme

{"title":"[Impact of the COVID-19 Pandemic on Voiding Diary Quality and its Relevance for the Treatment of Functional Urinary Incontinence in Children].","authors":"Jonas Erdmann, Christopher Darr, Christian Rehme","doi":"10.1055/a-2907-9060","DOIUrl":"10.1055/a-2907-9060","url":null,"abstract":"Background: Voiding diaries are essential in pediatric urinary incontinence. COVID-19 restrictions altered family routines. This study assessed effects on diary quality and treatment response.Patients: In a single-center retrospective analysis, 214 diaries from 187 patients (4-17 yrs) with non-organic urinary incontinence were evaluated from the pandemic period (Feb-Aug 2020) and 2022.Methods: Diary quality was scored (0-16) across four parameters (voiding frequency, urine volume, drinking frequency, volume);≥11 points were considered usable. Treatment response was assessed 3-6 months after therapy start. Mann-Whitney U and Chi-square tests were used.Results: Pandemic diaries showed higher quality (mean 14.3; 95% CI 13.67-14.89) than 2022 diaries (11.1; 95% CI 10.44-11.66; p<0.001) and were more often usable (93% vs. 55%; p<0.001). Treatment response was higher with usable diaries (70% vs. 23%; p<0.001).Discussion: Pandemic home conditions were associated with higher diary quality and treatment response.Conclusion: Structured home conditions during the 2-3 day documentation period may support improved diary quality. These findings highlight the clinical relevance of high-quality voiding diary completion.","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0