Klinische Padiatrie最新文献

{"title":"Do Systemic Inflammatory Indices, Urinalysis, and Radiological Findings Vary by Causative Pathogen in Neonatal Urinary Tract Infections?","authors":"Sarkhan Elbayiyev, Gülsüm Kadıoğlu Şimşek, Tevfik Çevirici, Nazmiye Bengü Karaçağlar, Hayriye Gözde Kanmaz Kutman, Fuat Emre Canpolat","doi":"10.1055/a-2467-0057","DOIUrl":"10.1055/a-2467-0057","url":null,"abstract":"<p><strong>Abstract: </strong>OBJECTIVES: Urinary tract infections (UTI) are the most common occult infections in infants under three months of age with high fever, caused by various pathogens, and can progress with different symptoms from mild to severe. We planned to explore and compare pathogen-specific systemic inflammatory indices, urinalysis, and radiological findings in newborns.</p><p><strong>Abstract: </strong>METHODS: The retrospective study included preterm and term neonates with single pathogen growth of≥50.000 colony-forming units (CFU) /mL from urine cultures obtained by first-time catheterization between September 2019 and November 2021. Baseline hemogram parameters, acute phase reactants, systemic inflammatory indexes, urinalysis, and radiological findings were analyzed in pathogen-specific groups.</p><p><strong>Abstract: </strong>RESULTS: Of the 132 patients included in the study, gastrointestinal symptoms were the most common. C-reactive protein values were higher in the non- E. Coli group (p<0.05). Procalcitonin values were higher in patients with Klebsiella spp. isolates (p<0.05). Systemic inflammatory indexes were higher in patients with Coagulase-Negative Staphylococci isolates (p<0.05). Urinary acidity was higher in the non-E. Coli group (p<0.05). Escherichia Coli and Klebsiella Spp. were isolated in two-thirds of patients with leukocyte esterase positivity. The most common cause of UTI in patients with abnormal renal ultrasound findings was E. Coli (33.3%).</p><p><strong>Abstract: </strong>CONCLUSION: Our findings imply that unconventional tests could assist in pathogen differentiation, determining clinical presentation, and prognosis.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"220-226"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 Inhibition: A New Glimmer of Hope to Slow Chronic Kidney Disease Progression in Children?","authors":"Emre Leventoğlu, Sevcan A Bakkaloğlu","doi":"10.1055/a-2431-6764","DOIUrl":"10.1055/a-2431-6764","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"230-231"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of abdominal symptoms in people with Cystic Fibrosis during therapy with Elexacaftor/Tezacaftor/Ivacaftor brings gastrointestinal involvement into the paediatric pulmonologist's focus.","authors":"Pauline Sadrieh, Lutz Nährlich, Carsten Schwarz, Olaf Eickmeier, Patience Eschenhagen, Louise Polte, Samira Dabelow, Franziska Duckstein, Carlos Zagoya, Jochen G Mainz","doi":"10.1055/a-2551-2560","DOIUrl":"10.1055/a-2551-2560","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"227-229"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Postnatal Echocardiographic Screening for Congenital Heart Defects - a Prospective Cohort Study at a German University Hospital.","authors":"Victoria Delphine Haberkern, Laura Luisa Kilarski, Thomas Schaible","doi":"10.1055/a-2451-6770","DOIUrl":"10.1055/a-2451-6770","url":null,"abstract":"<p><strong>Abstract: </strong>BACKGROUND: Congenital heart defects (CHD) being the most common congenital malformation, significantly impact mortality and morbidity in children and adults. Early detection greatly improves treatment and prognosis. Routine pulse oximetry screening and fetal echocardiography in Germany have advanced early CHD diagnosis. However, a diagnostic gap persists, leaving some CHD cases undetected, worsening prognosis. This study aimed to evaluate echocardiographic screening in newborns at a German university hospital as well as to record numerous potential risk factors in a database.</p><p><strong>Abstract: </strong>PATIENTS AND METHODS: This monocentric, prospective cohort study included ostensibly healthy newborns delivered between 03/2015 and 04/2016. Echocardiography was performed at an average age of 3.15 days, with follow-up by a specialist within six weeks and by telephone interview in 2019.</p><p><strong>Abstract: </strong>RESULTS: Of 1006 newborns, 518 (51.49%) underwent echocardiography. CHD were diagnosed in 7.14% (37/518) with the following frequencies: atrial septal defect (ASD) (45.95%), ventricular septal defect (VSD) (35.14%), persistent ductus arteriosus (PDA) (8.11%), coarctation of aorta (CoA) with ASD (2.70%), quadricuspid aortic valve with VSD (2.70%), VSD with PDA (2.70%), and significant tricuspid regurgitation (2.70%). Follow-up in 2019 showed resolution of 31 CHD, while four patients continued regular cardiologist visits, with one requiring urgent surgery for severe CoA.</p><p><strong>Abstract: </strong>CONCLUSION: This study demonstrates that echocardiographic screening in newborns can detect previously undiagnosed CHD, including critical cases.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"213-219"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Study on Different Doses of Gammaglobulin Plus Aspirin in the Pediatric Kawasaki Disease and the Impacts on CRP and WBC Levels.","authors":"Xiufang Su, Pingping Wang, Biao Li","doi":"10.1055/a-2373-0867","DOIUrl":"10.1055/a-2373-0867","url":null,"abstract":"<p><strong>Abstract: </strong>OBJECTIVE: To evaluate the efficacy of different doses of gammaglobulin combined with aspirin in treating pediatric Kawasaki disease and its impact on C-reactive protein (CRP) and white blood cell (WBC) levels.</p><p><strong>Abstract: </strong>METHODS: A prospective study was conducted with 150 children (3groups) diagnosed with Kawasaki disease. Group A received a higher dose of intravenous gammaglobulin (2.5 g/kg) combined with aspirin, Group B received a standard dose of intravenous gammaglobulin (2 g/kg) combined with aspirin, and Group C received a lower dose of intravenous gammaglobulin (1 g/kg) combined with aspirin. All groups received oral aspirin therapy (30 mg/kg/day) for a standard duration. The time to symptom improvement, treatment efficacy, laboratory parameters, and adverse reactions were monitored and analyzed.</p><p><strong>Abstract: </strong>RESULTS: Group B showed a shorter time to symptom relief compared to Groups A and C, particularly in fever reduction, mucosal congestion, cervical lymph node enlargement, and limb symptoms. The total effective rate was higher in Group B compared to Groups A and C. Group B showed improvements in WBC, CRP, ESR, and PLT levels.</p><p><strong>Abstract: </strong>CONCLUSION: Standard-dose intravenous gammaglobulin combined with aspirin was more effective in treating pediatric Kawasaki disease compared to higher and lower doses. The treatment regimen in Group B resulted in shorter time to symptom relief, higher total effective rate, improved biochemical markers. Incidence of adverse reactions was similar among the three groups, demonstrating the safety of standard dosage.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":"196-203"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidance for the Diagnosis and Treatment of Rare Embryonal and Sarcomatous Brain Tumors-a Report from the Central Nervous System-International Registry for Rare Embryonal and Sarcomatous Tumors German Society of Pediatric Oncology and Hematology Study Group.","authors":"Pascal Johann, Dominik Sturm, Rolf Kortmann, Brigitte Bison, David Capper, Ahmed El Damaty, Lars Behrens, Selma Manea, Johannes Gojo, Michael Frühwald, Ulrich-Wilhelm Thomale, Martin U Schuhmann, Rudolf Schwarz, Anna Tietze, Matthias Wagner, Beate Timmermann, Barbara von Zezschwitz","doi":"10.1055/a-2889-3506","DOIUrl":"https://doi.org/10.1055/a-2889-3506","url":null,"abstract":"<p><strong>Abstract: </strong>With the advent of multi-omic molecular profiling techniques, central nervous system tumor types previously not recognized by conventional neuropathological assessment have emerged, particularly among tumors formerly termed as \"CNS- primitive neuroectodermal tumors.\" Given the diverse histopathological, molecular, radiological, and clinical characteristics of these tumors, diagnostic approaches and treatment strategies need to be adapted to our increasing knowledge. The small number of patients per year for individual tumor types precludes large cohort studies and mandates international cooperation and harmonization. To this end, the SIOPE Brain Tumor Group together with the European Reference Network for Pediatric Cancers has published the European Standards of Clinical Practice guidelines for rare embryonal and sarcomatous tumors.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Evaluation of Catheterization Outcomes and Complication Profiles in Critically Ill Children: Associations between Clinical Indications, Procedural Variables, and Mortality.","authors":"Abdullah Sert, Ayhan Yaman","doi":"10.1055/a-2880-2772","DOIUrl":"10.1055/a-2880-2772","url":null,"abstract":"<p><strong>Background: </strong>Central venous catheter placement is essential for managing critically ill children. This study aimed to evaluate the factors associated with procedural success and complication rates of central venous catheterization in a pediatric intensive care unit setting.</p><p><strong>Materials and methods: </strong>A retrospective, single-center observational study was conducted in the pediatric intensive care unit of the University Faculty of Medicine between 2024 and 2025. A total of 153 central venous catheters were placed in critically ill children using the Seldinger technique. Patient characteristics, procedural variables, and complication data were analyzed using non-parametric tests and multivariable methods, where appropriate.</p><p><strong>Results: </strong>The total complication rate was 27.6%, and the first-attempt success rate was 98.7%. The most common complication was arterial puncture (20.4% of patients). Procedural variables, including the number of attempts (<i>p</i>=0.004), catheterization time (<i>p</i>=0.001), sedation use (<i>p</i>=0.046), and catheter duration (<i>p</i><0.001), were associated with survival status in the unadjusted analyses. However, these findings should be interpreted as associations rather than as causal relationships. Patients who survived tended to have fewer insertion attempts and shorter procedure durations; however, mortality outcomes are likely influenced by underlying clinical severity and confounding factors.</p><p><strong>Conclusions: </strong>Central venous catheterization is a fundamental procedure in the management of critically ill children, with a high success rate and measurable complication profile. Procedural factors were associated with complication rates; however, no causal relationship with mortality was established. The femoral and internal jugular access sites were more frequently used in this cohort; however, no adjusted comparison supports their superiority over subclavian access. The relatively low number of subclavian catheterizations limits meaningful comparisons between insertion sites; therefore, further prospective multicenter studies are required to define optimal procedural strategies.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-organ failure secondary to eltrombopag overexposure: a novel utilization of hemodiafiltration in pediatric critical care management.","authors":"Ayhan Yaman, Abdullah Sert, Adnan Yuksel","doi":"10.1055/a-2880-2828","DOIUrl":"https://doi.org/10.1055/a-2880-2828","url":null,"abstract":"","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous Differentiated Thyroid Carcinoma and Nonthyroid Malignancies in Pediatric Patients: A Registry-based Case Series.","authors":"Marina Kunstreich, Ralf Knöfler, Georg Christof Schwabe, Angela Wawer, Jan-Henning Klusmann, Dominik Schöndorf, Antje Redlich, Michaela Kuhlen","doi":"10.1055/a-2863-4534","DOIUrl":"https://doi.org/10.1055/a-2863-4534","url":null,"abstract":"<p><strong>Introduction: </strong>Differentiated thyroid carcinoma is the most common endocrine malignancy in children and typically presents as an isolated tumor. The synchronous occurrence of differentiated thyroid carcinoma with a second, non-thyroid primary malignancy is exceptionally rare and poorly characterized in pediatric patients.</p><p><strong>Patients and methods: </strong>We reviewed 571 pediatric patients with histologically confirmed differentiated thyroid carcinoma and enrolled in the national German Society for Pediatric Oncology and Hematology-malignant endocrine tumor registry between January 1997 and February 2025. Synchronous tumors were defined as two distinct malignancies diagnosed within 3 months prior to disease-specific therapy. Clinical, pathological, and genetic findings were analyzed descriptively.</p><p><strong>Results: </strong>Five patients (0.9%) were diagnosed with synchronous differentiated thyroid carcinoma and a second primary malignancy. All thyroid tumors were papillary thyroid carcinomas, identified in the context of Hodgkin lymphoma (<i>n</i>=2), pheochromocytoma, synovial sarcoma, and Ewing sarcoma. In four cases, the thyroid tumor was detected during staging or evaluation for the primary malignancy. In one patient, the papillary thyroid carcinoma was diagnosed and treated prior to the identification of Hodgkin lymphoma. One patient harbored a pathogenic succinate dehydrogenase [ubiquinone] iron-sulfur subunit variant, and two patients had coexisting Hashimoto thyroiditis. All patients achieved complete remission.</p><p><strong>Conclusions: </strong>Synchronous presentation of differentiated thyroid carcinoma and other malignancies in pediatric patients, while rare, poses significant diagnostic and therapeutic challenges. These cases warrant multidisciplinary evaluation and may reflect underlying cancer predisposition, immune dysregulation, or previously unrecognized risk factors.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding the Article \"Near-Fatal Asthma Due to Severe Airway Mucus Plugging in a 12-Year-Old Boy\".","authors":"Kıvanç Terzi","doi":"10.1055/a-2872-4636","DOIUrl":"10.1055/a-2872-4636","url":null,"abstract":"<p><p>N/A.</p>","PeriodicalId":17846,"journal":{"name":"Klinische Padiatrie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}