关于不同剂量丙种球蛋白加阿司匹林治疗小儿川崎病及其对 CRP 和白细胞水平影响的前瞻性研究

IF 1.2 4区 医学 Q3 PEDIATRICS
Xiufang Su, Pingping Wang, Biao Li
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引用次数: 0

摘要

目的评估不同剂量丙种球蛋白联合阿司匹林治疗小儿川崎病的疗效及其对C反应蛋白(CRP)和白细胞(WBC)水平的影响:对 150 名确诊为川崎病的儿童(3 组)进行了前瞻性研究。A组接受高剂量静脉注射丙种球蛋白(2.5 克/千克)联合阿司匹林,B组接受标准剂量静脉注射丙种球蛋白(2 克/千克)联合阿司匹林,C组接受低剂量静脉注射丙种球蛋白(1 克/千克)联合阿司匹林。所有组别均在标准疗程内口服阿司匹林(30 毫克/千克/天)。对症状改善时间、疗效、实验室指标和不良反应进行了监测和分析:结果:与 A 组和 C 组相比,B 组症状缓解时间更短,尤其是在退热、粘膜充血、颈淋巴结肿大和肢体症状方面。与 A 组和 C 组相比,B 组的总有效率更高。B 组的白细胞、CRP、ESR 和 PLT 水平均有所改善:结论:与高剂量和低剂量相比,标准剂量静脉注射丙种球蛋白联合阿司匹林治疗小儿川崎病更有效。B组的治疗方案可缩短症状缓解时间,提高总有效率,改善生化指标。三组的不良反应发生率相似,表明标准剂量是安全的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Prospective Study on Different Doses of Gammaglobulin Plus Aspirin in the Pediatric Kawasaki Disease and the Impacts on CRP and WBC Levels.

Objective: To evaluate the efficacy of different doses of gammaglobulin combined with aspirin in treating pediatric Kawasaki disease and its impact on C-reactive protein (CRP) and white blood cell (WBC) levels.

Methods: A prospective study was conducted with 150 children (3groups) diagnosed with Kawasaki disease. Group A received a higher dose of intravenous gammaglobulin (2.5 g/kg) combined with aspirin, Group B received a standard dose of intravenous gammaglobulin (2 g/kg) combined with aspirin, and Group C received a lower dose of intravenous gammaglobulin (1 g/kg) combined with aspirin. All groups received oral aspirin therapy (30 mg/kg/day) for a standard duration. The time to symptom improvement, treatment efficacy, laboratory parameters, and adverse reactions were monitored and analyzed.

Results: Group B showed a shorter time to symptom relief compared to Groups A and C, particularly in fever reduction, mucosal congestion, cervical lymph node enlargement, and limb symptoms. The total effective rate was higher in Group B compared to Groups A and C. Group B showed improvements in WBC, CRP, ESR, and PLT levels.

Conclusion: Standard-dose intravenous gammaglobulin combined with aspirin was more effective in treating pediatric Kawasaki disease compared to higher and lower doses. The treatment regimen in Group B resulted in shorter time to symptom relief, higher total effective rate, improved biochemical markers. Incidence of adverse reactions was similar among the three groups, demonstrating the safety of standard dosage.

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来源期刊
Klinische Padiatrie
Klinische Padiatrie 医学-小儿科
CiteScore
1.10
自引率
0.00%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Das Forum für wissenschaftliche Information in der Kinderheilkunde ausgewählte Originalarbeiten aus allen Bereichen der Pädiatrie Visite: Ihr Forum für interessante Krankengeschichten und außergewöhnliche Kasuistiken aktuelle Fortschritte in Diagnostik und Therapie jährliche Schwerpunkthefte: Ergebnisse der pädiatrischen Onkologie plus Medizin und Markt topaktuelle Informationen aus der Industrie
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