Journal of the Science of Food and Agriculture最新文献

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Comparative assessment on osteoprotective effects of bone collagen peptides from diverse animal sources: Insights from the characteristics of gastrointestinal digestion and absorption. 不同动物来源的骨胶原肽的护骨作用的比较评价:从胃肠道消化和吸收特征的见解。
IF 4 2区 农林科学
Journal of the Science of Food and Agriculture Pub Date : 2026-09-01 Epub Date: 2026-06-03 DOI: 10.1002/jsfa.70759
Hong Liu, Ishmael Festus Jaja, Chunhui Zhang, Zhiqin Wang, Yujie Guo
{"title":"Comparative assessment on osteoprotective effects of bone collagen peptides from diverse animal sources: Insights from the characteristics of gastrointestinal digestion and absorption.","authors":"Hong Liu, Ishmael Festus Jaja, Chunhui Zhang, Zhiqin Wang, Yujie Guo","doi":"10.1002/jsfa.70759","DOIUrl":"10.1002/jsfa.70759","url":null,"abstract":"<p><strong>Background: </strong>Although livestock and poultry bone collagen peptides (LBPs) have been reported to exhibit protective effects against osteoporosis, the in vitro osteogenic and in vivo anti-osteoporotic bioactivity of LBPs may vary depending on the animal sources, and the underlying mechanisms remain unclear. The present study aimed to investigate the divergence in the osteoprotective effects of yak (YBPs)/bovine (BBPs)/porcine (PBPs)/chicken (CBPs) bone collagen peptides, and to elucidate how gastrointestinal digestion and absorption characteristics contribute to their distinct osteoprotective mechanisms.</p><p><strong>Results: </strong>YBPs/BBPs exhibited the highest osteoprotective effects, whereas PBPs exhibited weaker in vitro osteogenic but stronger in vivo anti-osteoporotic bioactivity than CBPs. Four osteogenic peptides were obtained by virtual screening, their retention rates after simulated gastrointestinal digestion and apparent permeability coefficients in a Caco-2 monolayer model ranged from 12.95% to 30.13% and 0.15 to 0.55 × 10<sup>-7</sup> cm s<sup>-1</sup>, respectively. Integrated in silico analyses, gastrointestinal digestion stability and intestinal absorption/transportation data suggest that the divergent osteoprotective effects of LBPs likely stem from distinct absorptive/digestive properties mediated by their structural differences.</p><p><strong>Conclusion: </strong>The divergent osteoprotective effects of YBP/BBPs/PBPs/CBPs are likely attributable to their structural determinants including gastrointestinal digestion/absorption/transportation, and affinity/binding modes to epidermal growth factor receptor, as well as possible RGD (arginine, glycine and aspartic acid) sequence similarity. These findings provide mechanistic insights and identify potential molecular targets for optimizing peptide-based functional food ingredients for bone health. © 2026 Society of Chemical Industry.</p>","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":"7171-7183"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Turmeric essential oil-loaded wheat starch cryogels as superabsorbent pads for active packaging of fish fillets. 含姜黄精油的小麦淀粉冷冻剂作为鱼片活性包装的高吸水性衬垫。
IF 4 2区 农林科学
Journal of the Science of Food and Agriculture Pub Date : 2026-09-01 Epub Date: 2026-06-17 DOI: 10.1002/jsfa.70764
Elder Pacheco da Cruz, Laura Martins Fonseca, Cristina Jansen, Rosane Lopes Crizel, Gabriel Lucas Pail, Camila de Oliveira Pacheco, Alvaro Renato Guerra Dias, Elessandra da Rosa Zavareze
{"title":"Turmeric essential oil-loaded wheat starch cryogels as superabsorbent pads for active packaging of fish fillets.","authors":"Elder Pacheco da Cruz, Laura Martins Fonseca, Cristina Jansen, Rosane Lopes Crizel, Gabriel Lucas Pail, Camila de Oliveira Pacheco, Alvaro Renato Guerra Dias, Elessandra da Rosa Zavareze","doi":"10.1002/jsfa.70764","DOIUrl":"10.1002/jsfa.70764","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to create a cryogel with water-absorbing and antioxidant properties. Wheat starch (10%, w/v) was used to produce cryogels, which were then incorporated with turmeric essential oil (TEO) at two concentrations: 20% and 30% (w/w of starch). The production method consisted of gelatinization, freeze/thaw cycles, and subsequent freeze-drying. The materials were applied as an absorbent pad for fish fillet exudate. The major compounds of TEO were ar-turmerone (43.60%) and α-turmerone (23.49%), characterized by gas chromatography.</p><p><strong>Results: </strong>The cryogels showed a porous structure, and the thermal stability of TEO was improved when entrapped in the materials. The mechanical properties reached 260.79 g for hardness, 0.90 for cohesiveness and 0.97 for springiness for the dried form. The cryogels displayed low density (approximately 0.110 g cm<sup>-3</sup>) and high porosity (85.97%), not differing among the formulations. The water absorption capacity was high, with the control (0% TEO) reaching 1026% and reducing for those with TEO to approximately 883%. Cryogels demonstrated a high TEO loading capacity, exceeding 90%. In vitro release showed that, after 2880 min, the 30% TEO cryogels released 22% of their content in a hydrophilic medium and a substantially higher 69% in a lipophilic medium. The cryogels with 30% TEO achieved an antioxidant activity of 48% for ABTS [i.e. 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] radical inhibition and 23% for DPPH (i.e. 2,2-diphenyl-1-picrylhydrazyl) radical. When applied to fish fillets, after 7 days of storage, the cryogels maintained stable pH (6.06) and mass loss (5.6%) across treatments, at the same time as showing a comparable exudate absorption of approximately 35%.</p><p><strong>Conclusion: </strong>Exhibiting water-absorbing capacity, high loading capacity, controlled in vitro release, and antioxidant activity. The developed materials are promising three-dimensional materials for active food packaging applications in fish fillet preservation. © 2026 Society of Chemical Industry.</p>","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":"7300-7314"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-target effects of Limosilactobacillus reuteri RE225 on hyperuricemia through xanthine oxidase inhibition, nucleoside degradation, gut microbiota modulation, and renal TLR4-NF-κB suppression. 罗伊氏乳酸杆菌RE225通过抑制黄嘌呤氧化酶、核苷降解、调节肠道菌群和抑制肾脏TLR4-NF-κB对高尿酸血症的多靶点影响
IF 4 2区 农林科学
Journal of the Science of Food and Agriculture Pub Date : 2026-09-01 Epub Date: 2026-05-28 DOI: 10.1002/jsfa.70749
Xin Zhou, Ming Zhang, Jun Zhou, Jiaojiao Han
{"title":"Multi-target effects of Limosilactobacillus reuteri RE225 on hyperuricemia through xanthine oxidase inhibition, nucleoside degradation, gut microbiota modulation, and renal TLR4-NF-κB suppression.","authors":"Xin Zhou, Ming Zhang, Jun Zhou, Jiaojiao Han","doi":"10.1002/jsfa.70749","DOIUrl":"10.1002/jsfa.70749","url":null,"abstract":"<p><strong>Background: </strong>Hyperuricemia, a major risk factor for gout and kidney disease, requires safe and effective dietary strategies beyond conventional pharmacotherapy. This study investigated the multi-target effects of the food-grade probiotic Limosilactobacillus reuteri RE225 on hyperuricemia. It was evaluated in vitro for xanthine oxidase (XOD) inhibition and nucleoside degradation, and in vivo in hyperuricemic mice gavaged daily with low or high doses of RE225 (1 × 10<sup>6</sup> or 1 × 10<sup>9</sup> CFU). Serum uric acid (UA), XOD activity, inflammatory cytokines, intestinal permeability markers - fluorescein isothiocyanate-dextran (FITC-dextran), lipopolysaccharide (LPS), and d-lactate - and renal TLR4/NF-κB signaling were quantified. Fecal metagenomics and Kyoto Encyclopedia of Genes and Genomes ortholog (KO) profiling were used to assess microbiota structure and function.</p><p><strong>Results: </strong>Limosilactobacillus reuteri RE225 dose-dependently inhibited XOD and degraded more than 50% of nucleosides in vitro. In vivo, RE225 reduced serum urate, restored intestinal barrier function, suppressed inflammation, and downregulated renal TLR4/NF-κB signaling. Metagenomic analysis showed that L. reuteri RE225 reversed UA-induced loss of microbial richness and evenness, enriched Faecalibaculum and Erysipelotrichaceae, and shifted functional profiles from proliferation- and inflammation-related modules (K02315, K02970, and K03496) toward carbohydrate utilization and genetic stability pathways (K01784 and K07491).</p><p><strong>Conclusion: </strong>Limosilactobacillus reuteri RE225 shows promise as a dietary intervention for the management of hyperuricemia. © 2026 Society of Chemical Industry.</p>","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":"7197-7208"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calcium, methyl jasmonate and their combined foliar applications: Influence on Tempranillo grape amino acids composition over two seasons. 钙、茉莉酸甲酯及其复合叶面施用:两季对丹魄葡萄氨基酸组成的影响。
IF 4 2区 农林科学
Journal of the Science of Food and Agriculture Pub Date : 2026-09-01 Epub Date: 2026-06-02 DOI: 10.1002/jsfa.70771
Teresa Garde-Cerdán, Eva P Pérez-Álvarez, Itziar Sáenz de Urturi, Rebeca Murillo-Peña, Lesly L Torres-Díaz, Miriam González-Lázaro
{"title":"Calcium, methyl jasmonate and their combined foliar applications: Influence on Tempranillo grape amino acids composition over two seasons.","authors":"Teresa Garde-Cerdán, Eva P Pérez-Álvarez, Itziar Sáenz de Urturi, Rebeca Murillo-Peña, Lesly L Torres-Díaz, Miriam González-Lázaro","doi":"10.1002/jsfa.70771","DOIUrl":"10.1002/jsfa.70771","url":null,"abstract":"<p><strong>Background: </strong>Climate change is currently affecting chemical grape composition and, consequently, grape quality. The foliar application of biostimulants has emerged as a promising approach to mitigate these effects. This study investigated the effects of foliar applications of calcium (Ca), methyl jasmonate (MeJ), and their combination (Ca + MeJ) on the enological parameters and amino acid composition of Tempranillo grapes over two successive growing seasons (2022 and 2023). The effect of applying the treatments once or twice at post-veraison and 1 week later was also evaluated.</p><p><strong>Results: </strong>Foliar applications showed season-dependent effects on Tempranillo musts, generally increasing pH, malic acid, and total phenol content. Differences between seasons were attributed to climatic variability. In all samples, arginine was the predominant amino acid in grapes, followed by proline and glutamine. All foliar treatments modified the amino acid profile, although the effects varied between seasons. The observed increases in asparagine, glutamine, valine, methionine, isoleucine, ornithine, and leucine following foliar calcium application suggest stimulation of nitrogen assimilation and amino acid biosynthesis pathways. In 2022, Ca + MeJ1 and MeJ2 were the most effective treatments, whereas in 2023, MeJ1 and Ca2 produced the highest amino acid content in musts.</p><p><strong>Conclusion: </strong>Foliar application of these biostimulants may represent a useful strategy to improve grape nitrogen composition and mitigate the effects of climate change. The observed increase in amino acid content may also contribute to improved yeast assimilable nitrogen (YAN), supporting yeast metabolism and potentially improving fermentation performance. © 2026 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.</p>","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":"7380-7396"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noni fruit phenolic-rich extract ameliorated non-alcoholic fatty liver disease through regulating gut microbiota and bile acids profiling by targeting FXR-FGF15 signaling. 诺丽果酚类提取物通过靶向FXR-FGF15信号调节肠道微生物群和胆汁酸谱,改善非酒精性脂肪肝疾病。
IF 4 2区 农林科学
Journal of the Science of Food and Agriculture Pub Date : 2026-09-01 DOI: 10.1002/jsfa.71032
Huixian Wang, Derui Yang, Yi Huang, Xinhui Liu, Yunlan Liu, Zewei Ma, Ruimin Wang
{"title":"Noni fruit phenolic-rich extract ameliorated non-alcoholic fatty liver disease through regulating gut microbiota and bile acids profiling by targeting FXR-FGF15 signaling.","authors":"Huixian Wang, Derui Yang, Yi Huang, Xinhui Liu, Yunlan Liu, Zewei Ma, Ruimin Wang","doi":"10.1002/jsfa.71032","DOIUrl":"https://doi.org/10.1002/jsfa.71032","url":null,"abstract":"<p><strong>Background: </strong>Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease globally, covering a spectrum from simple hepatic steatosis to steatohepatitis. With limited pharmacological interventions available, there is growing interest in natural products for NAFLD prevention and management. The farnesoid X receptor (FXR)-fibroblast growth factor 15 (FGF15) signaling pathway plays a pivotal role in regulating bile acid (BA) and lipid metabolism, and its dysregulation is closely linked to NAFLD progression.</p><p><strong>Results: </strong>Noni fruit phenolic-rich extract (NFE) treatment ameliorated high-fat diet (HFD)-induced increases in body weight and lipid accumulation in both serum and hepatic tissues, accompanied by reduced serum aspartate aminotransferase and alanine aminotransferase activities, indicating improved hepatic function and reduced liver injury. Moreover, NFE intervention modulated the expression of key components of the FXR-FGF15 signaling pathway, leading to downregulation of hepatic CYP7A1 and subsequent modulation of BA and lipid metabolism. Notably, NFE intervention can modulate the gut microbiota and its metabolic functions, thereby sustaining BA homeostasis through feedback regulation of the FXR-FGF15 pathway.</p><p><strong>Conclusion: </strong>In summary, NFE intervention alleviates high-fat diet (HFD)-induced NAFLD by modulating the FXR-FGF15 pathway, regulating bile acid metabolism, and reshaping gut microbiota. These results support the potential application of NFE as a nutritional intervention for NAFLD. © 2026 Society of Chemical Industry.</p>","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation, characterization and evaluation of polysaccharides from Rosa roxburghii Tratt. fruit on ameliorating senior osteoporosis in rats induced by d-galactose and low calcium diet. 刺梨多糖的制备、表征及评价。水果对d-半乳糖和低钙饮食诱导的老年骨质疏松症的改善作用。
IF 4 2区 农林科学
Journal of the Science of Food and Agriculture Pub Date : 2026-09-01 Epub Date: 2026-06-23 DOI: 10.1002/jsfa.70756
Yanfang Yan, Liangqun Li, Zhongsheng Luo, Tingfei Deng, Mei Zhou, Juan Yang, Qiji Li, Xiaosheng Yang, Lei Tang, Haitao Liu
{"title":"Preparation, characterization and evaluation of polysaccharides from Rosa roxburghii Tratt. fruit on ameliorating senior osteoporosis in rats induced by d-galactose and low calcium diet.","authors":"Yanfang Yan, Liangqun Li, Zhongsheng Luo, Tingfei Deng, Mei Zhou, Juan Yang, Qiji Li, Xiaosheng Yang, Lei Tang, Haitao Liu","doi":"10.1002/jsfa.70756","DOIUrl":"10.1002/jsfa.70756","url":null,"abstract":"<p><strong>Background: </strong>Senior osteoporosis (SOP) represents a significant health concern that impacts quality of life among the elderly population. Calcium supplementation is the most common treatment for those diagnosed with osteoporosis. However, the administration of inorganic calcium supplements is often associated with adverse effects, including constipation and nephrolithiasis. The fruit of Rosa roxburghii, commonly known as 'Ci Li' in Chinese, is both a medicine and a food. It aids in digestion, strengthens the spleen and stomach, and improves intestinal inflammation. The polysaccharides from R. roxburghii (RRFP) also exhibit activities such as enhancing immunity, managing diabetes, and regulating intestinal function. The current methods for RRFP extraction either have low extraction rates or are not conducive to scale-up applications; in addition, the effect of RRFP on improving SOP is unclear.</p><p><strong>Results: </strong>RRFP with molecular weights ranging from 50 to 100 kDa was enriched by ultrafiltration, and was composed of fucose, rhamnose, arabinose, galactose, glucose, xylose, and galacturonic acid. The functional groups of polysaccharides were confirmed by Fourier transform infrared spectroscopy. Scanning electron microscopy revealed that RRFP exhibited a porous morphology. Notable increases in antioxidant capacity, dry femur weight, femur bone mineral density, and femur calcium levels were observed in RRFP group rats. Protein expression of keap1 decreased while HO-1 and Nrf2 increased after RRFP-Ca treatment. RRFP altered the composition of the intestinal microbiota in rats.</p><p><strong>Conclusion: </strong>RRFP could enhance calcium absorption to improve SOP by activating the Nrf2/HO-1 pathway and modulating the gut microbiota, especially by altering the abundance of Lachnospiraceae. © 2026 Society of Chemical Industry.</p>","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":"7151-7162"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From narratives to numbers: Quantifying Euro2040 farm profiles using FADN data. 从叙述到数字:使用FADN数据量化2040年欧洲农场概况。
IF 4 2区 农林科学
Journal of the Science of Food and Agriculture Pub Date : 2026-09-01 Epub Date: 2026-06-07 DOI: 10.1002/jsfa.70779
Artiom Volkov, Agnė Žičkienė, Mangirdas Morkūnas, Elzė Rudienė
{"title":"From narratives to numbers: Quantifying Euro2040 farm profiles using FADN data.","authors":"Artiom Volkov, Agnė Žičkienė, Mangirdas Morkūnas, Elzė Rudienė","doi":"10.1002/jsfa.70779","DOIUrl":"10.1002/jsfa.70779","url":null,"abstract":"<p><strong>Background: </strong>European agriculture is becoming more diverse. However, policy and statistical systems still rely on a legacy of simplified farm classifications. These do not reflect newly emerging farming models or their heterogeneity. The Euro2040 profiles address this gap by offering a richer, narrative-based segmentation. They capture differences in motivations, business models and future pathways. However, Euro2040 profiles remain difficult to apply empirically and are not directly observable in standard datasets.</p><p><strong>Results: </strong>This study translates Euro2040 profiles into measurable variables. A structured expert elicitation was applied to define relevant indicators. An indicator-profile matrix was developed using FADN (i.e. Farm Accountancy Data Network)-based data. Key dimensions include economic size, land use, labour structure, diversification and dependence on subsidies. These dimensions enable systematic differentiation between farm types. The framework also allows linking qualitative narratives with observable standard European farm-level data. However, several profiles remain poorly captured. Urban, controlled-environment, social-care and cellular farms are often partially or fully 'invisible' in current datasets. This reflects limitations in existing statistical systems rather than conceptual weaknesses of the profiles.</p><p><strong>Conclusion: </strong>The framework links qualitative profiles with quantitative data. It enables more detailed empirical analysis and supports more targeted policy design. The results highlight a mismatch between farm diversity and existing monitoring systems. This suggests a need to extend current indicators to better capture emerging farming models and improve policy targeting. © 2026 Society of Chemical Industry.</p>","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":"7487-7502"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ursolic acid inhibits the proliferation and migration of breast cancer cells by suppressing the hippo/YAP signaling pathway. 熊果酸通过抑制hippo/YAP信号通路抑制乳腺癌细胞的增殖和迁移。
IF 4 2区 农林科学
Journal of the Science of Food and Agriculture Pub Date : 2026-09-01 Epub Date: 2026-06-04 DOI: 10.1002/jsfa.70766
Ranran Tao, Qiuxuan Zou, Siying Huang, Jun Yang, Yan Meng, Zhenpeng Qiu, Qi Wang, Yong Wu, Guohua Zheng, Junjie Hu
{"title":"Ursolic acid inhibits the proliferation and migration of breast cancer cells by suppressing the hippo/YAP signaling pathway.","authors":"Ranran Tao, Qiuxuan Zou, Siying Huang, Jun Yang, Yan Meng, Zhenpeng Qiu, Qi Wang, Yong Wu, Guohua Zheng, Junjie Hu","doi":"10.1002/jsfa.70766","DOIUrl":"10.1002/jsfa.70766","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) is one of the most frequent malignant tumors, with high morbidity and fatality rates. Abnormalities in the Hippo pathway or YAP overexpression alter the cell proliferation-apoptosis equilibrium, which promotes cancer progression. Ursolic acid (UA), a naturally occurring triterpenoid carboxylic acid, exhibits preventive and anticancer properties. This study aimed to evaluate the effects of UA on breast cancer via the Hippo-YAP pathway.</p><p><strong>Results: </strong>The findings revealed that UA hindered YAP nuclear translocation and increased its phosphorylation, preventing YAP from entering the nucleus from the cytoplasm and thus failing to motivate transcriptional expression of the downstream proliferation-related target genes, including CYR61 (i.e. cysteine-rich 61) and CTGF (i.e. connective tissue growth factor). Moreover, YAP overexpression reversed the inhibitory impact of UA on breast cancer cell proliferation and migration, whereas siYAP increased the inhibitory effects of UA on breast cancer cell proliferation and migration. Additionally, UA inhibited tumor growth in mice xenografted with MCF-7 cells.</p><p><strong>Conclusion: </strong>UA reduces breast cancer growth via the Hippo-YAP pathway, providing a theoretical foundation for its anticancer activity and suggesting that UA may serve as a promising candidate for breast cancer therapy. © 2026 Society of Chemical Industry.</p>","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":"7184-7196"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ohmic heating dominates and ultrasound modulates aquafaba structure: A combined approach to design stable plant-based emulsions. 欧姆加热占主导地位,超声波调节水凝胶结构:一种设计稳定的植物乳液的组合方法。
IF 4 2区 农林科学
Journal of the Science of Food and Agriculture Pub Date : 2026-09-01 Epub Date: 2026-05-27 DOI: 10.1002/jsfa.70743
Débora Krichanã, Thaís Caroline Buttow Rigolon, Paula Zambe Azevedo, João Paulo de Melo Lins, Gabriel Oliveira Horta, Linamarys Aparecida de Oliveira Paulo, Márcia Cristina Teixeira Ribeiro Vidigal, Taline Amorim Santos, Isis Rodrigues Toledo Renhe, Jaqueline de Araújo Bezerra, Paulo César Stringheta, Evandro Martins, Pedro Henrique Campelo
{"title":"Ohmic heating dominates and ultrasound modulates aquafaba structure: A combined approach to design stable plant-based emulsions.","authors":"Débora Krichanã, Thaís Caroline Buttow Rigolon, Paula Zambe Azevedo, João Paulo de Melo Lins, Gabriel Oliveira Horta, Linamarys Aparecida de Oliveira Paulo, Márcia Cristina Teixeira Ribeiro Vidigal, Taline Amorim Santos, Isis Rodrigues Toledo Renhe, Jaqueline de Araújo Bezerra, Paulo César Stringheta, Evandro Martins, Pedro Henrique Campelo","doi":"10.1002/jsfa.70743","DOIUrl":"10.1002/jsfa.70743","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the individual and combined effects of ohmic heating (OH, 20 and 40 V cm<sup>-1</sup>) and ultrasound (US, 425 and 850 W) on the chemical, physicochemical, and technological properties of chickpea aquafaba (AF) and its emulsions.</p><p><strong>Results: </strong>Structural analyses demonstrated that OH was the predominant factor modulating protein unfolding, whereas US acted as a secondary modulator, dispersing aggregates and altering the extent of exposure of hydrophobic and sulfhydryl groups. At moderate OH intensity (20 V cm<sup>-1</sup>), combined treatments (particularly 20/425) promoted higher surface hydrophobicity, increased solubility, greater availability of sulfhydryl groups and more negative zeta potential. These modifications translated into improved emulsion properties, with smaller and more homogeneous oil droplets, higher viscosity and consistency indices, stronger gel-like behavior (G' ≫ G″), and enhanced physical stability (TSI < 4). By contrast, high OH intensity (40 V.cm<sup>-1</sup>), especially when combined with high-power US (40/850), induced excessive aggregation, reduced protein solubility and impaired interfacial coverage, and also led to unstable emulsions. Confocal microscopy confirmed that moderate treatments produced dense interfacial protein films, whereas severe conditions resulted in flocculation and coalescence.</p><p><strong>Conclusion: </strong>Overall, results highlight that OH drives protein modifications, whereas US fine-tunes structural rearrangements, and that controlled intensities are essential to enhance AF functionality in plant-based emulsions. © 2026 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.</p>","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":"7109-7124"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148032176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inter-annual and regional variability of agronomic and grain quality traits of major Korean wheat cultivars under multi-environmental conditions. 多环境条件下韩国主要小麦品种农艺性状和籽粒品质性状的年际和区域变异
IF 4 2区 农林科学
Journal of the Science of Food and Agriculture Pub Date : 2026-09-01 Epub Date: 2026-07-05 DOI: 10.1002/jsfa.70862
Goeun Lee, Jinhee Park, Kyeong-Min Kim, Chon-Sik Kang, Sookjin Kim, Jeong-Heui Lee, Hyun-Jin Jung
{"title":"Inter-annual and regional variability of agronomic and grain quality traits of major Korean wheat cultivars under multi-environmental conditions.","authors":"Goeun Lee, Jinhee Park, Kyeong-Min Kim, Chon-Sik Kang, Sookjin Kim, Jeong-Heui Lee, Hyun-Jin Jung","doi":"10.1002/jsfa.70862","DOIUrl":"10.1002/jsfa.70862","url":null,"abstract":"<p><strong>Background: </strong>Wheat agronomic performance and grain quality vary substantially depending on environmental conditions. However, few studies have evaluated agronomic performance, grain quality stability, and growth stage-specific climatic regulation together across representative Korean wheat-production environments.</p><p><strong>Results: </strong>Phenological traits and amylose content showed relatively high stability across multiple environmental conditions, whereas yield components and protein-related quality traits exhibited pronounced environmental variability. Climatic gradients integrating radiation, temperature, and moisture structured environmental differences and were differentially associated with crop responses across growth stages. Early season climate primarily influenced phenological development, whereas climatic conditions during reproductive growth exerted the strongest control over yield formation and protein-related traits. An integrated grain quality index further showed that environmental effects were reflected through changes in overall quality performance and differences in interannual stability.</p><p><strong>Conclusion: </strong>Variations in wheat performance and grain quality across different environments were governed by structured climatic gradients and developmental timing rather than by isolated site effects. This study provides an analytical framework for distinguishing stable and environment-sensitive wheat traits by integrating multi-environment field trials, growth stage-specific climate gradients, and composite grain quality assessment under Korean agro-climatic conditions. © 2026 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.</p>","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":"7512-7527"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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