长双歧杆菌亚种的协同作用。婴儿B8762和乳源性骨桥蛋白对小鼠雄性生殖健康的影响。

IF 3.5 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-08-21 DOI:10.1002/jsfa.70121

Chunyan Zhao, Guangqi Gao, Tao Zhang, Na Li, Yue Zhao, Zerong Lu, Yong Zhang, Zhihong Sun

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引用次数: 0

摘要

背景：男性生殖健康与饮食成分和肠道菌群平衡有着复杂的联系。骨桥蛋白（OPN）缺乏和肠道生态失调与精子发生受损有关，但益生菌和OPN的协同作用仍未被探索。结果：在opn缺陷小鼠中，长双歧杆菌亚群联合干预；婴儿B8762和OPN增加了肠道微生物群α多样性，上调了关键生殖基因（Etv4, Adamts16, Prok2, Gpr55, Rad54b）。睾丸组织学显示生精细胞密度和精小管完整性恢复。结论：本研究表明，B8762和OPN可通过调节肠道菌群和睾丸基因调控来缓解生殖功能障碍，为提高男性生育能力提供了一种新的营养策略。©2025作者。约翰威利父子有限公司代表化学工业协会出版的《食品与农业科学杂志》。

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Synergistic effects of Bifidobacterium longum subsp. infantis B8762 and milk-derived osteopontin on male reproductive health in mice.

Background: Male reproductive health is intricately linked to dietary components and gut microbiota balance. Osteopontin (OPN) deficiency and gut dysbiosis are associated with impaired spermatogenesis, yet the synergistic effects of probiotics and OPN remain unexplored.

Results: In OPN-deficient mice, combined intervention with Bifidobacterium longum subsp. infantis B8762 and OPN increased gut microbiota alpha diversity and upregulated key reproductive genes (Etv4, Adamts16, Prok2, Gpr55, Rad54b). Testicular histology revealed restored spermatogenic cell density and seminiferous tubule integrity.

Conclusion: This study demonstrates that co-administration of B8762 and OPN alleviates reproductive dysfunction via gut microbiota modulation and testicular gene regulation, offering a novel nutritional strategy for male fertility enhancement. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.