Journal of Vector Borne Diseases最新文献

{"title":"Imported viremic dengue case in a southeastern European country: Established Aedes mosquitoes warrant urgent surveillance.","authors":"Kostadin Poposki, Zaklina Shopova, Arlinda Osmani Loga, Dejan Jakimovski, Mile Bosilkovski","doi":"10.4103/JVBD.JVBD_9_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_9_24","url":null,"abstract":"","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive evaluation on progressive development strategies in DENV surveillance and monitoring infection rate among vector population","authors":"Bidisha Das, S. Datta, Vanlalhmuaka, Pichili Vijaya Bhaskar Reddy","doi":"10.4103/jvbd.jvbd_86_23","DOIUrl":"https://doi.org/10.4103/jvbd.jvbd_86_23","url":null,"abstract":"\u0000 The elevated rise in dengue infection rate has been a health burden worldwide and it will continue to impact on global health for years to come. Accumulated literature holds accountable to the geographical expansion of the mosquito species transmitting the DENV. The frequency of this viral disease outbreaks have increased rapidly in the recent years, owing to various geo-climatic and anthropological activities. In situation of scarcity of any effective control measures, there has been a continuous traceable rise in mortality and morbidity rates. However, it has been reported that the spate of incidences is directly related to density of the virus infected vector (mosquito) population in a given region. In such a scenario, systems capable of detecting virus infected vector population would aid in estimating prediction of outbreak, as well as shall provide time to deploy suitable management strategies for vector control, and to break the vector-human transmission chain. This would also help in identifying areas, where much improvement is needed for vector management.\u0000 To this context, we illustrate an exhaustive overview of both gold standards and as well as emerging advents for sensitive and specific mosquito population strategized viral detection technologies. We summarize the cutting-edge technologies and the challenges faced in pioneering to field application.\u0000 Regardless the proven popularity of the gold standards for detection purpose, they offer certain limitations. Thus with the surge in the infection rate globally, approaches for development of newer advancements and technique upgradation to arrest the infection escalation and for early detection as a part of vector management should be prioritized.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139775692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive evaluation on progressive development strategies in DENV surveillance and monitoring infection rate among vector population","authors":"Bidisha Das, S. Datta, Vanlalhmuaka, Pichili Vijaya Bhaskar Reddy","doi":"10.4103/jvbd.jvbd_86_23","DOIUrl":"https://doi.org/10.4103/jvbd.jvbd_86_23","url":null,"abstract":"\u0000 The elevated rise in dengue infection rate has been a health burden worldwide and it will continue to impact on global health for years to come. Accumulated literature holds accountable to the geographical expansion of the mosquito species transmitting the DENV. The frequency of this viral disease outbreaks have increased rapidly in the recent years, owing to various geo-climatic and anthropological activities. In situation of scarcity of any effective control measures, there has been a continuous traceable rise in mortality and morbidity rates. However, it has been reported that the spate of incidences is directly related to density of the virus infected vector (mosquito) population in a given region. In such a scenario, systems capable of detecting virus infected vector population would aid in estimating prediction of outbreak, as well as shall provide time to deploy suitable management strategies for vector control, and to break the vector-human transmission chain. This would also help in identifying areas, where much improvement is needed for vector management.\u0000 To this context, we illustrate an exhaustive overview of both gold standards and as well as emerging advents for sensitive and specific mosquito population strategized viral detection technologies. We summarize the cutting-edge technologies and the challenges faced in pioneering to field application.\u0000 Regardless the proven popularity of the gold standards for detection purpose, they offer certain limitations. Thus with the surge in the infection rate globally, approaches for development of newer advancements and technique upgradation to arrest the infection escalation and for early detection as a part of vector management should be prioritized.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139835441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice.","authors":"Leila Shirani-Bidabadi","doi":"10.4103/JVBD.JVBD_114_22","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_114_22","url":null,"abstract":"<p><strong>Background objectives: </strong>Amphotericin B, Allopurinol, Glucantime and Beta-Glucan are the main drugs currently used for the treatment of cutaneous leishmaniasis. In present study, we evaluated the effect of medical leeches on BALB/c mice models infected with Leishmania parasites.</p><p><strong>Methods: </strong>To create animal models of leishmaniasis, BALB/c mice were inoculated with the standard Leishmania major strain MRHO / IR / 75 / ER. Treatment was performed through blood sampling with leeches. We used medical leech (Hirudo medicinalis) species. This leech is a European medicinal leech, one of several species known used as medicinal leech. 22 mice infected with Leishmania major were used for the tests .The studied mice were divided into two groups which were named with the letters L and D. The duration of blood sampling was 25 min for initial treatment, 20 min for the 2nd blood sampling and 15 min for the third times and onwards. Meglumine antimoniate (Glucantime) is a pentavalent antimony (SbV) that recommended by the World Health Organization as a golden standard treatment for all kind of leishmaniasis, but many side effects are still reported. Criteria for anti-leshmania assessment of Leech were including: Leech saliva has an anti-leishmania effect by acting on the purin pathway. Leech saliva prevents the growth and multiplication of Leishmania by a mechanism of action similar to Glucantim (breaking ATP).</p><p><strong>Results: </strong>The duration of leech treatment in BALB/c mice infected with L.major parasites was about 6-8 weeks. Out of the 22 leishmaniasis mice models that underwent treatment, 13 survived until the end of the treatment duration. The recovery rate was about 56%; lesions improved in five out of the 13 surviving mice models. Paired t-test showed a significant difference between the mean wound size at the beginning of treatment and the 8th week of treatment (PV <0.0001).</p><p><strong>Interpretation conclusion: </strong>Considering the fact that the standard drugs for the treatment of leishmaniasis have many side effects, alternative therapies such as leech therapy can be effectively used to treat these chronic wounds. There are about 20 active substances in leech saliva. These substances include antistasin, eglins, guamerin, hirudin, saratin, bdellins, complement, and carboxypeptidase inhibitors. Leech saliva is an anticoagulant, anti-inflammation and prevents the platelet. Leech therapy was effective in treating leishmaniasis wounds in BALB/c mice. In this study, there was complete wound healing in 56% of the mice models.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Exploration of the PfBLM Helicase-ATP Binding Domain and Its Implications in the Quest for Antimalarial Therapies.","authors":"Hattan S Gattan, Bassam M Al-Ahmadi, Abdullah F Shater, Nizar H Saeedi, Mohammed H Alruhaili","doi":"10.4103/JVBD.JVBD_176_23","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_176_23","url":null,"abstract":"<p><strong>Background objectives: </strong>The battle against malaria has witnessed remarkable progress in recent years, characterized by increased funding, the development of life-saving tools, and a significant reduction in disease prevalence. Yet, the formidable challenge of drug resistance persists, threatening to undo these gains.</p><p><strong>Methods: </strong>To tackle this issue, it is imperative to identify new effective drug candidates against the malaria parasite and exhibit minimal toxicity. This study focuses on discovering such candidates by targeting PfRecQ1, also known as PfBLM, a vital protein within the malaria parasite. PfRecQ1 plays a crucial role in the parasite's life cycle and DNA repair processes, making it an attractive drug development target. The research employs advanced computational techniques, including molecular modeling, structure-based virtual screening (SBVS), ADMET profiling, molecular docking, and dynamic simulations.</p><p><strong>Results: </strong>The study sources ligand molecules from the extensive MCULE database and utilizes strict filters to ensure the compounds meet essential criteria. Through these techniques, the research identifies MCULE-3763806507-0-9 as a promising anti-malarial drug candidate, surpassing the binding affinity of potential antimalarial drugs. However, it is essential to underscore that the drug-like properties are primarily based on in silico experiments, and wet lab experiments are necessary to validate these candidates' therapeutic potential.</p><p><strong>Interpretation conclusion: </strong>This study represents a critical step in addressing the challenge of drug resistance in the fight against malaria.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria infection and associated household level risks in an urban and rural areas of West Bengal.","authors":"Noor Islam Bag, Bobby Paul, Madhumita Bhattacharyya, Subhrajit Sarkar","doi":"10.4103/JVBD.JVBD_162_23","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_162_23","url":null,"abstract":"<p><strong>Background objectives: </strong>Malaria is one of the most critical public health problem globally as well as nationally. Recent times have seen an increase in the importance of the possible effects of environmental and demographic factors on the local transmission of malaria. We conducted a community-level study between urban and rural areas to find out the factors associated with malaria infection.</p><p><strong>Methods: </strong>A community based observational cross-sectional study was conducted between October 2020 to September 2022 among 330 households from urban area of Chetla, Kolkata and rural areas of Singur district of West Bengal. Households were selected by two stage random sampling method. Study done by face-to-face interview, review of medical records and observation of the households. SPSS software was used for data analysis. Multivariable logistic regression (hierarchical model) done. (p-value equal to or less than 0.05 was taken as significant).</p><p><strong>Results: </strong>The prevalence of malaria infection among participants and household level risks of malaria infection were found 6.1%, 1.8% and 18.8%, 6.7% respectively in the urban and rural areas. Significant predictors of malaria infection were household with ≥5 family members [AOR=2.91{CI (1.19-7.15)}], households not used any mosquito protective measure [AOR=3.71{CI (1.04-13.13)}], presence of mosquito breeding place [AOR=4.93{CI (1.53-15.93)}], absence of effective window screen [AOR=3.19{CI (1.16-8.71)}], absence of separate kitchen [AOR=2.38{CI (1.06-5.34)}], and inadequate lighting condition of house [AOR=4.35{CI (1.78-10.64)}].</p><p><strong>Interpretation conclusion: </strong>This study provides important insights into the epidemiology of malaria in a high and also low-transmission setting in West Bengal. Intensified efforts to be strengthen towards community mobilization for preventing breeding places for mosquito. Policy should strengthen investment in housing programme that may complement reduction of malaria transmission. Disease reduction effects of Government and local NGOs should be directed towards those areas in order to decrease disease load.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Docking of Daunorubicin and Etoposide Drugs against Leishmania donovani: A Theoretical Study.","authors":"Afnan Mohammed Shakoori, Fatemah Alhakami, Ghadir Sindi, Areej Yahya Alyahyawi, Rasha Abdullah Alhazzaa","doi":"10.4103/JVBD.JVBD_174_23","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_174_23","url":null,"abstract":"<p><strong>Background objectives: </strong>The human blood parasite Leishmania donovani causes visceral leishmaniasis or grayish discoloration of the skin (black fever/kala-azar). Antitumor drugs such as daunorubicin and etoposide can help to treat such diseases. The computational approach is used to find the better interaction of drugs with the active site of the protein and help to design new drugs.</p><p><strong>Methods: </strong>In this study, we have optimized two antitumor drugs daunorubicin and etoposide. We have also studied frontier molecular orbitals, electrostatic potential (MEP) maps and the natural bond order analysis of these anticancer drugs followed by molecular docking with the protein Leishmania donovani.</p><p><strong>Results: </strong>The crystal structure of MapK from Leishmania donovani is LDBPK-331470. Our computational calculations reveal that daunorubicin and etoposide drugs can have an affinity with the protein Leishmania donovani.</p><p><strong>Interpretation conclusion: </strong>Our study predicted that both daunorubicin and etoposide can have a similar affinity with the protein (UvrD) Leishmania donovani.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correspondence between the physiological cold tolerance and the distribution border of Mediterranean sandflies in Southeast Europe.","authors":"A J Trájer","doi":"10.4103/JVBD.JVBD_63_22","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_63_22","url":null,"abstract":"<p><strong>Background objectives: </strong>The distribution of sandflies is influenced by several climatic factors, like winter temperature limits, summer humidity, and drought. Only a few studies were performed to search for the connection between the physiological tolerance of sandflies and the result of the Climate Envelope Models projected distribution borders.</p><p><strong>Methods: </strong>It was studied how the depth of rodent burrows could determine the occurrence of five European Phlebotomus species based on their known physiological cold tolerances.</p><p><strong>Results: </strong>The modelled distributions based on the monthly minimum temperatures showed notable differences by soil depth and species. The observed and modelled European distribution areas of sandflies according to -20 cm soil depth showed good coincidence with the observed occurrences of Phlebotomus neglectus, Ph. papatasi, and Ph. perfiliewi in East-Central, Southeast, and East Europe. Also, a good coincidence was found in the case of the modelled and observed occurrences of Phlebotomus perniciosus in Western Europe.</p><p><strong>Interpretation conclusion: </strong>It can be concluded that in their north-eastern distribution borders, sandflies can overwinter in rabbit and rodent burrows at depths of -20 cm below the surface. The physical cold tolerance of Ph. ariasi could be underestimated. In more than -50 cm of depth, the stable and continuously cold environment of the shelters (mean temperature less than 10°C) could inhibit the post-winter diapause activation of sandflies in the northern regions.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to implement tailored interventions in Chhattisgarh, east-central India to reach the Malaria elimination","authors":"Ritesh Ranjha, Sontee, Chander Prakash Yadav, Mradul Mohan, Kuldeep Singh, Jitendra Kumar, P. Bharti, Anup R Anvikar","doi":"10.4103/jvbd.jvbd_167_23","DOIUrl":"https://doi.org/10.4103/jvbd.jvbd_167_23","url":null,"abstract":"\u0000 \u0000 \u0000 Despite significant progress in malaria control throughout India, Chhattisgarh continues to be a significant contributor to both malaria morbidity and mortality. This study aims to identify key factors associated with malaria endemicity, with the goal of focusing on these factors for malaria elimination by 2030.\u0000 \u0000 \u0000 \u0000 We employed an analysis and narrative review methodology to summarize the existing evidence on malaria epidemiology in Chhattisgarh. Data, encompassing environmental conditions, dominant malaria vectors and their distribution, and the impact of previous interventions on malaria control, were extracted from published literature using PubMed and Google Scholar. This information was subsequently correlated with malaria incidence data using appropriate statistical and geographical methods.\u0000 \u0000 \u0000 \u0000 Much of the malaria burden in the states is concentrated in a few specific districts. The primary malaria vectors in these regions are Anopheles culicifacies and Anopheles fluviatilis. High transmission areas are found in tribal belts that are challenging to access, characterized by densely forested areas that provide a conducive habitat for malaria vectors.\u0000 \u0000 \u0000 \u0000 Conducive environmental conditions, characterized by high forest cover, community behavior, and insurgency, contribute to the high malaria endemicity in the area. Challenges include insecticide resistance in malaria vectors and asymptomatic malaria. Allocating additional resources to high-endemic districts is crucial. Innovative and focused malaria control programs, such as DAMAN and Malaria Mukt Abhiyan, hold immense importance.\u0000","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vector-Control Potential of Unani Medicines: A Review of Classical Unani Texts and Contemporary Scientific Literature.","authors":"Fauzia Shahabuddin, Malik Itrat, Sampath Kumar","doi":"10.4103/JVBD.JVBD_173_23","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_173_23","url":null,"abstract":"<p><strong>Background objectives: </strong>Vector-borne diseases pose substantial global health challenges, with a notable impact in India as well. Effective vector control strategies are crucial to mitigating these diseases as there are no effective vaccines available. Synthetic chemicals are widely used but concerns about safety and environmental impact have prompted exploration of alternative, natural solutions. Unani medicine offers a potential source of natural products. This study aims to systematically review classical Unani texts and contemporary scientific literature to evaluate the vector control potential of Unani medicines.</p><p><strong>Methods: </strong>A comprehensive review of classical Unani texts was carried out to compile data on herbal and mineral substances suggested in Unani Medicine for control of insects. Furthermore, electronic databases like PubMed, Google Scholar, and Science Direct were explored for research studies evaluating the insect-repellent, larvicidal, and insecticidal activities of the Unani medicines recommended in these texts. Time restriction was not imposed to ensure the comprehensive retrieval of pertinent and up-to-date information.</p><p><strong>Results: </strong>From classical Unani texts, 29 drugs were identified for control of insects, primarily of plant origin from diverse botanical families. Recent scientific investigations have confirmed the insect-repellent, insecticidal, and larvicidal activities of 19 of these Unani medicines against various insect species, including mosquitoes.</p><p><strong>Interpretation conclusion: </strong>These findings underscore the potential of Unani medicines as natural source for vector control. However, further research is essential to explore mechanism, delivery methods, and optimal concentrations for developing effective vector-control formulations.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}