Journal of Vector Borne Diseases最新文献

{"title":"Effects of different diets and blood sources on selected biological parameters of Phlebotomus Sergenti and Leishmania Tropica development in its digestive tract.","authors":"Mahboubeh Fatemi, Arshad Veysi, Mojgan Mohammadnejad, Arman Izadian, Yahya Maroufi, Amir Ahmad Akhavan","doi":"10.4103/JVBD.JVBD_30_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_30_24","url":null,"abstract":"<p><strong>Background objectives: </strong>The present study aimed to assess the impact of various blood or food sources on specific biological parameters of Phlebotomus sergenti, Parrot, 1917, adult and immature stages, as well as the development of Leishmania tropica Wright 1903.</p><p><strong>Methods: </strong>Sand flies were collected from a rural district and subsequently reared in an insectary using standard methods. Three larval diets were formulated and administered to the larvae. Adult sand flies were provided with three blood sources: BALB/c mice, humans, and poultry. The infection of sand flies with the parasite was examined to determine the development of Leishmania.</p><p><strong>Results: </strong>The duration of larval and pupal stage development exhibited significant differences among the three food sources. However, these variations did not significantly affect the overall length of the immature period of Ph. sergenti (P= 0.098) or the mortality rate (P= 0.338) across the groups. The time required for oviposition differed significantly depending on the blood source (P= 0.007). Nevertheless, the fecundity and longevity of sand flies that fed on the three different blood sources did not show statistically significant differences (fecundity (P= 0.106)/longevity (P= 0.209)). Furthermore, no significant disparity was observed among the three types of blood sources concerning their ability to support L. tropica infection within Ph. sergenti's gut.</p><p><strong>Interpretation conclusion: </strong>Redirecting the vector, Ph. sergenti, towards these specific food or blood sources as a means to reduce vector population or their vectorial capacity would not be a successful approach for interrupting the transmission cycle.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions and practices of community and ward health, sanitation and nutrition committee (WHSNC) members on dengue fever and Aedes vector management in Kollam district, Kerala, India, 2023.","authors":"Anjali Krishna, Abey Sushan, Aby Robinson, Boopathy Kangusamy, Sendhilkumar Muthappan, Rizwan Suliankatchi Abdulkader","doi":"10.4103/JVBD.JVBD_207_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_207_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Dengue fever incidence has tripled from 1990 to 2017, with a 107.6% increase in disability-adjusted life years (DALYs). An evaluation study in Kollam district, Kerala, India found limited community involvement in vector management. This study explores the perceptions and practices of community members and ward health, sanitation and nutrition committee (WHSNC) members regarding vector management in high-incidence areas of dengue in Kollam district, Kerala, India.</p><p><strong>Methods: </strong>We conducted a mixed-method study from December 2022 to May 2023, featuring a community survey for residents and qualitative interviews with key stakeholders. We assessed community knowledge, attitudes, and practices with a structured questionnaire, and summarized the results as proportions. We also interviewed 18 members of the WHSNC about dengue control and vector management.</p><p><strong>Results: </strong>Among 450 participants, 262 (58%) had moderate knowledge of dengue and its vector management, 122 (27.1%) had poor knowledge, and 66 (14.7%) had good knowledge. The majority, 440 participants (97.8%), showed a positive attitude toward dengue control, while only 10 (2.2%) had a negative attitude. Only 187 of 427 participants (25.5%) reported eliminating mosquito breeding sites at home. The qualitative study highlighted perceived barriers and strengths in the community mobilization efforts of the WHSNC for dengue control.</p><p><strong>Interpretation conclusion: </strong>Awareness about dengue and its prevention methods is relatively high, but this has not led to commensurate preventive actions, despite positive attitudes among community members. The research highlights the need for improved community capacity through focused social and behavioural change communication.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of dengue, chikungunya, malaria, typhoid fever, scrub typhus, and leptospirosis in patients presenting with acute febrile illness at a tertiary care hospital, Amritsar.","authors":"Anu Bala, Kanwardeep Singh, Ajay Chhabra, Shailpreet Kaur Sidhu, Loveena Oberoi","doi":"10.4103/JVBD.JVBD_165_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_165_24","url":null,"abstract":"<p><strong>Background objectives: </strong>India is both a tropical and subtropical region, where common causes of acute undifferentiated febrile illness (AUFI) include malaria, dengue fever, chikungunya fever, enteric fever, leptospirosis, scrub typhus, and Japanese encephalitis. These illnesses contribute significantly to patient morbidity and mortality, although the exact burden of each infection varies regionally. Given the high prevalence of these tropical diseases, prioritizing differential diagnoses in cases of AUFI is crucial. In recent years, dengue, chikungunya, malaria, typhoid fever, scrub typhus, and leptospirosis along with coinfections between these diseases have reemerged as major causes of AUFI in many parts of India. These diseases are the most frequent contributors to AUFI and significantly increase patient morbidity and mortality compared to other causes. Although leptospirosis is not endemic in Punjab, cases are still screened as part of the National Centre for Disease Control (NCDC) National One Health Programme for Prevention and Control of Zoonoses (NOHPPCZ). Additionally, as a tertiary care hospital, the facility receives patients from migratory populations and other states beyond Punjab, thereby addressing a broader range of cases. To determine the incidence and clinical profile of dengue, chikungunya, malaria, typhoid fever, scrub typhus, and leptospirosis among patients presenting with acute undifferentiated fever admitted to the Department of Medicine at GNDH Tertiary Complex, Amritsar.</p><p><strong>Methods: </strong>The present study was conducted in the Viral Research and Diagnostic Laboratory, Department of Microbiology, Government Medical College, Amritsar, over a 12-month period from January 1, 2023, to December 31, 2023. A total of 276 patients aged over 18 years with acute undifferentiated febrile illness (AUFI) presenting to the inpatient services of the Medicine Department at Government Medical College, Amritsar, during the study period constituted the study population. The demographic and clinical profiles of the cases were recorded using a predesigned pro forma. Rapid immunochromatographic tests and enzyme-linked immunosorbent assays (ELISA) were performed on blood samples to identify active infections of dengue, chikungunya, scrub typhus, leptospirosis, typhoid fever, and malaria.</p><p><strong>Results: </strong>The overall incidences of dengue, chikungunya, malaria, typhoid fever, scrub typhus, and leptospirosis among AUFI cases were 11.6% (32/276), 24.6% (68/276), 0.7% (2/276), 5.4% (15/276), 1.4% (4/276), and 8.7% (24/276), respectively. The incidence of coinfected cases among AUFI cases was 15.6% (43/276). The most common coinfection was dengue + chikungunya, observed in 26 cases, followed by dengue + leptospirosis in 6 cases, leptospirosis + scrub typhus in 4 cases, chikungunya + typhoid fever in 3 cases, chikungunya + malaria in 2 cases, and leptospirosis + typhoid fever in 2 cases. The incidence of","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Docking and Pharmacokinetic Properties of Chrysin, Indole-3-carbinol, and Curcumin in the Biological Context of Plasmodium falciparum 3D7.","authors":"Hani Alothaid","doi":"10.4103/JVBD.JVBD_182_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_182_24","url":null,"abstract":"<p><strong>Background & objectives: </strong>Plasmodium falciparum is a protozoan parasite that causes malaria in humans. It is considered the most deadly species of Plasmodium that infects humans. Research continues to focus on understanding the biology and genetics of Plasmodium falciparum to develop new tools, vaccines, and treatments aimed at reducing the global burden of malaria caused by this deadly parasite.</p><p><strong>Methods: </strong>In this study, three active compounds-chrysin, indole-3-carbinol, and curcumin-were optimized using Gaussian16, and a molecular docking study was conducted against Plasmodium falciparum 3D7, along with an evaluation of pharmacokinetic properties.</p><p><strong>Results: </strong>Molecular docking studies indicated that the chrysin compound exhibits a stronger binding affinity to selected receptors of Plasmodium falciparum compared to the other compounds. Additionally, in-silico ADME screening was used to predict the pharmacological characteristics of acetyl-CoA reductase inhibitors and their metabolites.</p><p><strong>Interpretation & conclusion: </strong>The findings predict that the chrysin compound exhibits better affinity with Plasmodium falciparum proteins, suggesting that this compound can effectively interact with specific targets within the parasite. It also highlights the favorable electrostatic interactions that contribute to its pharmacological effectiveness as an acetyl-CoA reductase inhibitor.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Macrophage Polarization in Cutaneous Leishmaniasis.","authors":"May AlMoshary","doi":"10.4103/JVBD.JVBD_174_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_174_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Cutaneous Leishmaniasis (CL) is reported as the most neglected tropical disease. The polarization of macrophages such as M1 or M2 phenotypes significantly affects the development of leishmaniasis disease. However, the accurate immune responses behind the macrophage polarization process in cutaneous Leishmaniasis are poorly understood. This study was designed to determine the status of macrophage polarization in cutaneous Leishmaniasis.</p><p><strong>Methods: </strong>This case-control study was conducted at Princess Nourah bint Abdulrahman University, Saudi Arabia, from January to December 2023. Patients aged 18 to 65 yrs diagnosed with cutaneous Leishmaniasis were included. Patients with other immunocompromising conditions (e.g., HIV infection), those receiving immunosuppressive therapy, or those with systemic Leishmaniasis were excluded.</p><p><strong>Results: </strong>In a sample of 70 cutaneous leishmaniasis patients, macrophage polarization profiles were assessed in 43 (61.42%) patients in the case group and 27 (38.57%) in the control group. The experimental group had a higher prevalence of mild iNOS expression (24/43), while the control group had more iNOS-negative subjects (11/27). Arg-1 expression analysis showed a higher adverse and mild expression incidence in both groups, with 26/43 and 16/43 cases, respectively. Ml macrophage polarization was significantly higher in patients with lesions <4 (65.11%) compared to M2 polarization (11.62%). Lesions lasting <12 months also showed greater M1 polarization (51.61%) compared to M2 (30.23%), with statistical significance (p < 0.001). Additionally, ulcerated lesions were more common in the M1 group (37.20%) than in the M2 group (16.27%) (p < 0.001).</p><p><strong>Interpretation conclusion: </strong>The findings reported that M1 macrophages are more prevalent in CL's early and acute stages, while M2 macrophages may be more active in the long-term or healing phases. There were also notable changes in macrophage polarization among the experimental and control groups.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serodiagnosis of urogenital schistosomiasis and profiling of immunoreactive protein(s) in Schistosoma haematobium soluble egg and adult worm antigens.","authors":"Kabirat A Sulaiman, Tajudeen O Oriade, Timothy Auta, Funmilayo I D Afolayan, Alexander B Odaibo, Rafaella Fq Grenfell, Ramzy G Fatem, Oyetunde T Oyeyemi","doi":"10.4103/JVBD_JVBD_150_24","DOIUrl":"https://doi.org/10.4103/JVBD_JVBD_150_24","url":null,"abstract":"<p><strong>Background objectives: </strong>To achieve schistosomiasis eradication plan by 2030, the development of efficient diagnosis is crucial. This study focuses on assessing the immunodiagnostic potential of S. haematobium (Sh) soluble egg antigen (SEA) and worm antigen (SWA) for urogenital schistosomiasis.</p><p><strong>Methods: </strong>Urine microscopy identified 50 S. haematobium-positive and 50 negative samples from a total of 500 examined. An additional 50 samples from a non-endemic area were included, bringing the total number of samples used for the assay to 150. Indirect ELISA immunoassays using SEA and SWA as the probing antigens evaluated 50 sera samples each from Sh positive, negative endemic (NE), and non-endemic (NNE) individuals. SDS-PAGE analysis of crude protein extracts was conducted, followed by Western blot analysis using primary antibodies from pooled Sh-infected sera samples.</p><p><strong>Results: </strong>Diagnostic performance was evaluated using the area under the receiver operating characteristic (ROC) curve (AUC), sensitivity, and specificity. The AUC values for Sh SEA and SWA were 0.75 and 0.76 in NE samples, and 0.91 and 0.89 in NNE samples, respectively. Sensitivities 90 (95% CI: 78.64 - 95.65)/ 64.71 (95% CI: 52.17 - 75.92), and specificities 50 (95% CI: 36.64 - 63.36)/ 81.25 (95% CI: 63.56 - 92.79) were recorded for SEA and SWA, respectively in NE samples. In addition, sensitivities 90 (78.64 - 95.65)/ 92 (95% CI: 80.77 - 97.78), and specificities 72 (95% CI: 58.33 - 82.53)/ 72.00 (95% CI: 57.51 - 83.77) were recorded for SEA and SWA, respectively in NNE samples. The mean antibody titer against Sh SEA in infected samples was significantly higher than in non-infected samples (P <0.0001). Eight (8) immunoreactive protein bands; 4 each of SEA and SWA were identified, indicating potential for diagnostic tool development.</p><p><strong>Interpretation conclusion: </strong>Sh SEA and SWA demonstrate promise for diagnosing urogenital schistosomiasis in both endemic and non-endemic regions.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dexamethasone therapy in Crimean-Congo hemorrhagic fever in Giresun during 2021-2023: an analytical study.","authors":"Sinan Çetin, Ahmet Melih Şahin, Emrullah Ataş, Emsal Aydın, İlknur Şenel, Meltem Arzu Yetkin","doi":"10.4103/JVBD_JVBD_95_24","DOIUrl":"https://doi.org/10.4103/JVBD_JVBD_95_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic disease and significant health concern particularly in endemic regions. We aimed to evaluate the efficacy in dexamethasone treatment on clinical outcomes in CCHF patients.</p><p><strong>Methods: </strong>We included adult patients diagnosed with CCHF and those whose platelet count dropped to 70,000/mm3 or lower. The efficacy of dexamethasone on clinical outcomes was evaluated. It was a retrospective analytical study.</p><p><strong>Results: </strong>The study included 55 patients. All patients received standard supportive treatment, and none of them received ribavirin therapy. It was observed that 23 (41.8%) of the patients were treated with dexamethasone. No significant differences were observed between patients treated with dexamethasone and those without dexamethasone treatment, regarding factors such as bleeding incidents during hospitalization, the need for blood product transfusions, thrombocyte recovery status, intensive care unit admission, and in-hospital mortality. In-hospital mortality was observed in two patients among all patients (3.6%).</p><p><strong>Interpretation conclusion: </strong>Our study found that dexamethasone treatment did not lead to a significant improvement in clinical outcomes for CCHF patients.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of larvicidal, growth-suppressing, and developmentaltering bioefficacy of Ageratum houstonianum against Aedes aegypti (L.).","authors":"Vijay Kumar Shah, Kamal Kumar Gupta","doi":"10.4103/JVBD.JVBD_100_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_100_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Aedes aegypti is a major vector responsible for spreading dengue, chikungunya, yellow fever, and Zika viruses worldwide. These illnesses have increased globally due to climate and environmental changes. Vector control and management are the principal tactics for combating mosquitoes-borne diseases in the absence of an effective vaccine. The study aimed to ascertain bioactivities of Ageratum houstonianum leaf acetone extract (AhLAE) against Aedes aegypti.</p><p><strong>Methods: </strong>Bioefficacy of AhLAE was tested against fourth instar larvae (L4) of Ae. aegypti using standard WHO protocol. The mortality, growth, and development of larvae, pupae and adults were recorded after exposure to the extract.</p><p><strong>Results: </strong>The AhLAE showed larvicidal activity against L4 with LC50 and LC90 values of 401.88 and 691.24 mg/L, respectively. The mortality of the larvae further increased on subsequent days. The AhLAE caused a significant reduction in pupae formation and adult emergence. It also increased the larval duration of L4 and development duration of the pupa formed from the treated L4, indicating its growth-suppressing effects. The impact of the AhLAE was dose-dependent; high concentrations caused reduction in survival and growth of L4. Consequently, the L4-pupal and L4-adult growth indexes decreased. Additionally, the AhLAE induced developmental anomalies in the form of larva-pupa (L-P) intermediates.</p><p><strong>Interpretation conclusion: </strong>The study found that the AhLAE exhibited larvicidal, growth-suppressing, and development-altering activities against Ae. aegypti. The findings suggest the potential of AhALE as a natural insecticidal agent for controlling mosquitoes.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gaps: prioritizing research strategies for enhanced malaria control and elimination.","authors":"Rashed Alghamdi","doi":"10.4103/JVBD.JVBD_45_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_45_24","url":null,"abstract":"<p><p>Malaria continues to be a significant global health challenge, with millions of cases and hundreds of thousands of deaths reported annually. To combat this disease effectively, it is imperative to identify and address significant research gaps in malaria control and elimination efforts. This review synthesizes current knowledge and highlights critical gaps in several crucial areas of malaria research. Firstly, we discuss the complexities of vector biology and control, emphasizing the need for a deeper understanding of vector behavior, particularly in urban settings. Secondly, the study examines the challenges posed by drug resistance and the urgent need for alternative treatment strategies and novel drug targets. Thirdly, the review explores the ongoing quest for an effective malaria vaccine, underscoring the importance of understanding immunological correlates of protection. The study also explores medication resistance genes and genomic epidemiology, highlighting the need for more investigation into potential targets for drugs and vaccine candidates. Furthermore, it addresses the socioeconomic and environmental determinants of malaria transmission, highlighting the importance of integrating multidisciplinary approaches to address transmission dynamics. The study concludes with a discussion of how malaria transmission is impacted by climate change and the necessity of research to guide adaptation measures.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Susceptibility of temephos against Aedes aegypti and Anopheles stephensi mosquito larvae in Dehradun of Uttarakhand, India.","authors":"R K Singh, Gaurav Kumar, Subhash Joshi, Anup R Anvikar","doi":"10.4103/JVBD.JVBD_98_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_98_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Temephos is being used regularly to control immature of vector borne diseases in various states in India.</p><p><strong>Methods: </strong>World Health Organization method was used to evaluate larval susceptibility status of Aedes aegypti and Anopheles stephensi against temephos in Dehradun of Uttarakhand.</p><p><strong>Results: </strong>The results of the study revealed that the larval mortality in different localities ranged from 67.11% to 98.22%, the-lowest mortality was recorded from Kedarpuram (67.11%) and highest larval was recorded from Vikash Nagar (98.88%). The study revealed that most of larval populations of Ae. aegypti were resistant or under verification required category against temephos at diagnostic concentrations collected from six different localities of study area of Dehradun while only one larval population of Ae. aegypti was found susceptible. However, Anopheles stephensi larvae collected from all sites were susceptible at diagnostic concentration of temephos.</p><p><strong>Interpretation conclusion: </strong>The study highlights the potential development of resistance to temephos in Ae. aegypti across most of the study areas in Dehradun.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}