Journal of Vector Borne Diseases最新文献_第9页

Distribution changes of cutaneous leishmaniasis: A postulated risk of disease transmission in Hambantota, Sri Lanka. 皮肤利什曼病的分布变化：斯里兰卡汉班托塔的疾病传播风险推测。

IF 0.5 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-01-16 DOI: 10.4103/0972-9062.393969

K A Mangala Sudarshani

{"title":"Distribution changes of cutaneous leishmaniasis: A postulated risk of disease transmission in Hambantota, Sri Lanka.","authors":"K A Mangala Sudarshani","doi":"10.4103/0972-9062.393969","DOIUrl":"https://doi.org/10.4103/0972-9062.393969","url":null,"abstract":"Background objectives: Leishmaniasis is caused by various species of Leishmania. Approximately 20 of them are pathogenic to mammals. In Sri Lanka, cutaneous leishmaniasis (CL) is an established vector-borne disease. CL originates and spreads mainly through sand fly bite in many endemic countries. Objective of the present study was to compare the geographical distribution and demographic features of CL cases in 2014 and 2016 in Hambantota district, Sri Lanka.Methods: The patients who were presented to the Tangalle Base Hospital from June to December in 2014 and 2016 were examined and a descriptive study was carried out using a structured-questionnaire. Slit -skin smears were collected from each patient, Giemsa-stained and examined under the light microscope to identify Leishmania amastigotes.Results: Out of 256 and 314 suspected CL patients, 156 and 155 were identified positive for the year 2014 and 2016 respectively. Out of 12 District Secretary Divisions in the Hambantota district, highest number of CL cases, 85 and 86 was reported from Tangalle DSD in 2014 and 2016 respectively. Number of identified CL patients in Beliatta DSD had increased from 50 to 67 during the study period. In both years, majority of the CL patients were ≥ 50 years old with males more infected than females. Although CL association with occupations were insignificant, housewives were the highly (23%) infected occupants in this area.Interpretation conclusion: Based on present findings, geographical distribution within DSDs in Hambantota district had changed. It emphasizes the importance of CL as a health problem in Hambantota district.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary survey on the distribution of Ixodid ticks in domestic ruminants and vegetation of Pathanamthitta district, Kerala, South India. 印度南部喀拉拉邦帕坦阿姆蒂塔地区家养反刍动物和植被中 Ixodid 蜱分布情况的初步调查。

IF 0.5 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-01-16 DOI: 10.4103/0972-9062.393970

S Sahina, S Sithalakshmi, R Balasubramanian

{"title":"Preliminary survey on the distribution of Ixodid ticks in domestic ruminants and vegetation of Pathanamthitta district, Kerala, South India.","authors":"S Sahina, S Sithalakshmi, R Balasubramanian","doi":"10.4103/0972-9062.393970","DOIUrl":"https://doi.org/10.4103/0972-9062.393970","url":null,"abstract":"Background objectives: Tick borne diseases (TBD) are becoming a major public and animal health problem in the Kerala. Recently, during 2021 - 2022, a new focus of tick nuisance and associated fever has been reported in some villages of Pathanamthitta district.Methods: The study on the diversity of tick fauna in Southern Kerala is limited. Therefore, a preliminary survey was carried out for the first time in this focus for implementation of future tick borne pathogen detection and control measures. This research may provide a proper understanding of tick density and acarological risk by tick ecology through surveillance and identification. A cross sectional study was conducted during the summer season of 2021 and 2022 in the tick bite infected area - Naduvathumoozhy, Vayakkara, Malayalappuzha and Pallikuzhi.Results: Ticks were manually collected from ruminants and by dragging method from vegetation. A total of 727 ticks of 8 different species were collected from the genus Amblyomma, Haemaphysalis, Hyalomma, and Rhipicephalus. The most prevalent species were H. bispinosa and H.turturis, at 38.7% and 29.1%, respectively. Ticks were sampled from 197 animals with the proportion of infestation being 73.60%. It was highest in goats (85.9%), followed by buffalo (73.6%) and cow (65.4%).Interpretation conclusion: The study concludes that, despite the absence of any TBD outbreaks, the Pathanamthitta district has a high diversity of tick fauna and a high rate of tick infestation in domestic ruminants, especially in goats. Hence active tick surveillance is necessary in order to prevent TBD outbreaks in future; the study also emphasizes the importance of performing tick surveillance in both KFD endemic and non-endemic regions.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-based virtual screening study for identification of potent insecticides against the Anopheles gambiae to combat the malaria. 基于结构的虚拟筛选研究，以确定对抗冈比亚按蚊的强效杀虫剂，从而防治疟疾。

IF 0.5 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-01-16 DOI: 10.4103/0972-9062.393977

Nawal Helmi

{"title":"Structure-based virtual screening study for identification of potent insecticides against the Anopheles gambiae to combat the malaria.","authors":"Nawal Helmi","doi":"10.4103/0972-9062.393977","DOIUrl":"https://doi.org/10.4103/0972-9062.393977","url":null,"abstract":"Background objectives: Vector-borne infectious diseases contribute significantly to global mortality, with over 700,000 annual deaths, and malaria alone accounts for more than 400,000 of these fatalities. Anopheles gambiae, a prominent mosquito species, serves as a primary vector for transmitting malaria to humans. To address this issue, researchers have identified the D1-like dopamine receptor (DAR), specifically DOP2, as a promising target for developing new insecticides.Methods: The three-dimensional structure of DOP2 from A. gambiae was unavailable in the PDB database, an in-silico approach was used to model and validate the DOP2 protein's structure. The Discovery Studio 2021 program was then used to identify potential binding sites on the DOP2 protein. A virtual screening of 235 anti-parasitic compounds was performed against DOP2 using PyRx 0.8.Results: The screening demonstrated strong binding and interactions with active site residues of the DOP2 protein for five compounds: Diclazuril, Kaempferol, Deracoxib, Clindamycin, and Diaveridine. These compounds exhibited higher binding affinity values compared to the control (Asenapine). In addition, the predicted physiochemical properties for these compounds were within acceptable ranges, and there were no violations in druglikeness properties.Interpretation conclusion: These compounds show promise as potential new insecticides targeting the A. gambiae mosquito by inhibiting the DOP2 protein. However, additional experimental validation is required to optimize their efficacy as DOP2 protein inhibitors.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bamboo stumps that are artificially in use put pressure on Dengue and Chikungunya vector control in Dhaka City, Bangladesh. 人工使用的竹桩给孟加拉国达卡市的登革热和基孔肯雅病病媒控制工作带来了压力。

IF 0.5 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-01-16 DOI: 10.4103/0972-9062.393974

Rajib Chowdhury, Shyla Faria, Vashkar Chowdhury, Md Sahidul Islam, Shireen Akther, Sakila Akter

{"title":"Bamboo stumps that are artificially in use put pressure on Dengue and Chikungunya vector control in Dhaka City, Bangladesh.","authors":"Rajib Chowdhury, Shyla Faria, Vashkar Chowdhury, Md Sahidul Islam, Shireen Akther, Sakila Akter","doi":"10.4103/0972-9062.393974","DOIUrl":"https://doi.org/10.4103/0972-9062.393974","url":null,"abstract":"Background objectives: Aedes aegypti and Ae. albopictus mosquitoes breed in natural and artificial containers, and they transmit dengue and chikungunya. Therefore, a study was conducted to identify the contribution of bamboo stumps to these disease vectors that were used in the flower garden as pillars to hold the bamboo flex fence.Methods: Two sizes of whole bamboo were used to hold fences around gardens at Dhaka University, Bangladesh, and they were painted red and green. Mosquito larvae and pupae were collected from bamboo stumps between July and August, and vectors were identified up to the species level. The data were analyzed using the STATA/MP 14.2 version.Results: We found 83.5% and 0.2% were Ae. albopictus and Ae. aegypti, respectively, and the rest were Culex and Armigeres species. Ae. albopictus, Ae. aegypti, and both species-positive bamboo stumps were 46.9, 0.7, and 47.1 percent, respectively. 54.5% of bamboo stumps had at least one mosquito species. The average stump depth for Aedes positive stumps (mean =11.7 cm, SE = 0.5) was significantly (p <0.001) higher than the Aedes negative stumps (mean = 9.5 cm, SE = 0.4). 53.8% and 38.0% stumps were found Aedes positive on the ground and upper sides of fences, respectively, and found significant (p<0.01) differences between both sides. A zero-inflated negative binomial count model is significant at a 5% level of significance, χ2(4) = 11.8, p = 0.019 (<0.05) for Ae. albopictus. Stump depth is found to have a significant positive effect on the number of Aedes-positive stumps.Interpretation conclusion: Artificially used natural containers are adding pressure to current mosquito control activities as mosquitoes are breeding on them, which needs additional attention.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Malaria's Silent Threat: From Socioeconomic Divides to Religious Influences, A Path to Effective Prevention in India. 揭示疟疾的无声威胁：从社会经济鸿沟到宗教影响》，《印度的有效预防之路》。

IF 0.5 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-01-16 DOI: 10.4103/0972-9062.393978

Ume Aiman, Zainab Azad, Abdul Raffay Awais

{"title":"Unveiling Malaria's Silent Threat: From Socioeconomic Divides to Religious Influences, A Path to Effective Prevention in India.","authors":"Ume Aiman, Zainab Azad, Abdul Raffay Awais","doi":"10.4103/0972-9062.393978","DOIUrl":"https://doi.org/10.4103/0972-9062.393978","url":null,"abstract":"Abstract: Malaria remains a formidable public health challenge in India, particularly in low-socioeconomic regions, where it exacts a heavy toll on lives every year. This pressing issue gains prominence in light of a recent study conducted by Ronald et al. in Uganda, which illuminates the factors contributing to the elevated prevalence of malaria in economically disadvantaged areas. The study underscores the efficacy of interventions such as insecticide-treated nets (ITNs) and indoor residual spraying (IRS) in curtailing malaria incidence. Additionally, the World Health Organization's endorsement of the RTS, S/AS01 (RTS, S) malaria vaccine presents a promising development in the battle against this devastating disease. This letter underscores the imperative nature of implementing comprehensive strategies in India, which encompass widespread ITN distribution, the expansion of IRS programs, and the integration of the RTS, S/AS01 vaccine into the national immunization regimen. These concerted efforts are pivotal in furnishing cost-effective preventive measures to counter the mounting wave of malaria cases in India. Confronting malaria through a multifaceted approach stands as an essential approach to mitigate the disease's burden and ultimately safeguard the lives of India's vulnerable populations.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microscopic and molecular investigation of vector borne haemoprotozoan diseases in dromedary camel of North Gujarat. 北古吉拉特单峰骆驼病媒血吸虫疾病的显微镜和分子研究。

IF 0.5 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-01-16 DOI: 10.4103/0972-9062.393968

Dhyanjyoti Sarma, Bhupamani Das, Niral Patel, Arun Patel, Abhinav Suthar, Ankit Prajapati, R M Patel

{"title":"Microscopic and molecular investigation of vector borne haemoprotozoan diseases in dromedary camel of North Gujarat.","authors":"Dhyanjyoti Sarma, Bhupamani Das, Niral Patel, Arun Patel, Abhinav Suthar, Ankit Prajapati, R M Patel","doi":"10.4103/0972-9062.393968","DOIUrl":"https://doi.org/10.4103/0972-9062.393968","url":null,"abstract":"Background objectives: Vector borne haemoprotozoan diseases comprise diverse group of single celled organism transmitted by haematophagus invertebrates. The current study was aimed at identification of major haemoprotozoan (Babesia, Theileria and Trypanosoma) in dromedary camel of North Gujarat region using microscopy and Polymerase Chain Reaction (PCR).Methods: A total of 234 blood samples were screened by the microscopic and molecular detection assays. Molecular prevalence studies of Theileria, Trypanosoma spp and Babesia was undertaken using 18s ribosomal DNA, RoTat 1.2 and SS rRNA gene respectively. The data relating to microscopic and molecular prevalence along with associated risk factors were analysed by statistical methods.Results: The overall prevalence of hamoprotozoan disease based on microscopic and molecular investigation was 23.50%. The sensitivity and specificity (95% Confidence Interval) of PCR assay was 100% in comparison to microscopy (45.45% and 100%). The kappa coefficient between PCR and microscopy indicated good level of agreement with a value of 0.704 and SE of 0.159.Interpretation conclusion: Despite holding much significance to the animal sector, little work has been undertaken in regional part of India regarding camel parasites. The present paper offers the first preliminary research data investigating haemoprotozoan disease using parasitological and molecular methods in camels in the region.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico screening of potential plant peptides against the Non-structural proteins of Dengue virus. 针对登革热病毒非结构蛋白的潜在植物肽的硅学筛选。

IF 0.5 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-01-16 DOI: 10.4103/0972-9062.393979

G Reena, R Ranjani, D Gowtham, K Sangeetha

{"title":"In silico screening of potential plant peptides against the Non-structural proteins of Dengue virus.","authors":"G Reena, R Ranjani, D Gowtham, K Sangeetha","doi":"10.4103/0972-9062.393979","DOIUrl":"https://doi.org/10.4103/0972-9062.393979","url":null,"abstract":"Background objectives: Peptides isolated from different sources of plants have the advantages of specificity, lower toxicity, and increased therapeutic effects; hence, it is necessary to search for newer antivirals from plant sources for the treatment of dengue viral infections.Methods: In silico screening of selected plant peptides against the non-structural protein 1, NS3 protease domain (NS2B-NS3Pro) with the cofactor and ATPase/Helicase domain (NS3 helicase domain/NS3hel) of Dengue virus was performed. The physicochemical characteristics of the peptides were calculated using Protparam tools, and the allergenicity and toxicity profiles were assessed using allergenFP and ToxinPred, respectively.Results: Among the tested compounds, Ginkbilobin demonstrated higher binding energy against three tested non-structural protein targets. Kalata β-8 demonstrated maximum binding energy against NSP-1 and NSP-2, whereas Circulin A acted against the NSP3 protein of the dengue virus.Interpretation conclusion: Hence, the three compounds identified by in silico screening can be tested further for in vitro studies, which could act as potential leads as they are involved in hampering the replication of the dengue virus by interacting with the three prime non-structural proteins.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI in the repurposing of potential herbs for filariasis therapy. 人工智能在丝虫病治疗中对潜在草药的再利用。

IF 0.5 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-01-16 DOI: 10.4103/0972-9062.393975

Somsri Wiwanitmkit, Viroj Wiwanitkit

{"title":"AI in the repurposing of potential herbs for filariasis therapy.","authors":"Somsri Wiwanitmkit, Viroj Wiwanitkit","doi":"10.4103/0972-9062.393975","DOIUrl":"https://doi.org/10.4103/0972-9062.393975","url":null,"abstract":"Background objectives: The goal of this study was to see how well an AI language model called Chat Generative Pre-trained Transformer (ChatGPT) assisted healthcare personnel in selecting relevant medications for filariasis therapy. A team of medical specialists and tropical medicine experts reviewed ChatGPT's recommendations for ten hypothetical filariasis clinical situations.Methods: The purpose of this study was to look at the effectiveness of an AI language model called Chat Generative Pre-trained Transformer (ChatGPT) in supporting healthcare providers in picking appropriate drugs for filariasis treatment. Ten hypothetical filariasis clinical cases were submitted to ChatGPT, and its recommendations were evaluated by a panel of medical professionals and tropical medicine experts.Results: ChatGPT gave appropriate suggestions for potential medication repurposing in filariasis treatment in all ten clinical scenarios. Its drug recommendations were in line with current medical research and literature. Despite the lack of particular treatment regimens, ChatGPT's general ideas proved useful for healthcare practitioners, providing insights and updates on prospective drug repurposing tactics.Interpretation conclusion: ChatGPT shows promise as a useful method for repurposing drugs in the treatment of filariasis. Its thorough and brief responses make it useful for finding possible pharmacological candidates. However, it is critical to recognize ChatGPT's limitations, such as the requirement for additional clinical information and the inability to change therapy. Further research and development are required to optimize its use in filariasis therapy settings.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indicators sand flies and environment associated to spatial landscaping change in Choco Biosphere Reserve UNESCO. 与乔科生物圈保护区空间景观变化相关的沙蝇和环境指标，联合国教科文组织。

IF 0.5 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-01-16 DOI: 10.4103/0972-9062.393980

Sandra Enríquez, Jazzmín Arrivillaga-Henríquez, Paul Duque, Vanessa Herrera, Franklin Vaca, Marco Sánchez, Mateo Roldán, Lenin Ron-Garrido, C Alfonso Molina

{"title":"Indicators sand flies and environment associated to spatial landscaping change in Choco Biosphere Reserve UNESCO.","authors":"Sandra Enríquez, Jazzmín Arrivillaga-Henríquez, Paul Duque, Vanessa Herrera, Franklin Vaca, Marco Sánchez, Mateo Roldán, Lenin Ron-Garrido, C Alfonso Molina","doi":"10.4103/0972-9062.393980","DOIUrl":"https://doi.org/10.4103/0972-9062.393980","url":null,"abstract":"Background objectives: Sand flies are insects vector associated with terrestrial forest ecosystems; in the Ecuadorian Andes, they participate in the transmission of human cutaneous leishmaniasis. This geographical area is an opportunity to evaluate the role of sand flies as bioindicators od the degree of intervention of a tropical humid forest ecosystems (THF) associated with changes in the ecology of the local landscape.Methods: CDC-light traps were used for collecting adults' sand flies in February 2020 in a humid tropical forest within Choco Biosphere Reserve. All species were identified using morphological keys. Analysis data about abundance, richness, species accumulation, diversity index, species composition communities, species sex proportion, spatial sand flies environmental, Renyi's Diversity Profile were performed to compare six spatial habitats in Mashpi locality, Ecuador.Results: Sand flies were collected (n-1435); the main species are represented by Th. reburra Ny. trapidoi, Pa. aclydifera, Py. panamensis and Lu. hartmanni. Only Th. reburra is associated with not intervened forest, while the other 3 species are associated with intervened forest within Mashpi in the Choco Biosphere Reserve. The secondary forest has the major sandflies' richness, while the primary forest exhibits the major abundance.Interpretation conclusion: The results indicated that Th. reburra is a sandfly restricted to the Andean Forest and is a bioindicator of the high environmental health quality of the forest, while Ny. trapidoi and Pa. aclydifera are bioindicators of environmental disturbances in the forest. Additionally, Ps. panamensis, Lu. hartmanni and Ny. trapidoi are bioindicators of human impact and the risk of leishmaniasis.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between malaria parasite density and hematological profile in malaria infected children at a Nigerian Private hospital. 尼日利亚一家私立医院受疟疾感染儿童的疟原虫密度与血液学特征之间的关系。

IF 0.5 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-01-16 DOI: 10.4103/0972-9062.393971

Oyedeji Olusola Adetunji

{"title":"Association between malaria parasite density and hematological profile in malaria infected children at a Nigerian Private hospital.","authors":"Oyedeji Olusola Adetunji","doi":"10.4103/0972-9062.393971","DOIUrl":"https://doi.org/10.4103/0972-9062.393971","url":null,"abstract":"Background objectives: The correct association between Plasmodium falciparum parasite density and the cellular constituents of blood is not known in entirety in Nigerian children. Thus, we decided to study the association between cellular blood constituents and malaria parasite density in malaria infected children attending a Nigerian hospital.Methods: A study of all the children diagnosed with malaria fever at the Paediatric out-patient clinic, Cedar Crest Hospital, Abuja. Packed cell volume, white blood cells with differentials and platelet counts and malaria parasite densities obtained from blood samples were studied. Malaria parasites densities more than 2 pluses were classified as significant parasitemia and 1 plus non-significant. Information obtained were recorded and analysed with SPSS 22 software.Results: A total 143 children (74 boys and 69 girls) diagnosed with malaria with ages between 5 months to 17 years (mean 5.24 ±4.60) were studied. The majority 141 (98.6%) had non-significant P. falciparum parasitemia, while 2 (2.4%) had significant parasitemia. Of the 143 children with malaria 116 (81.1%) had a normal leucocyte count. All children with significant parasitemia had a normal leucocyte count. Of the 143 children 11 (7.7%) had anemia and 10 (7.0%) thrombocytopenia. Anemia, monocytosis and thrombocytopenia were significantly associated with significant malaria parasitemia (p<0.05). Mean platelet counts was significantly less amongst those with significant parasitemia (P <0.01).Interpretation conclusion: All patients with significant malaria parasitemia had normal leucocyte counts. Significant malaria parasitemia is significantly associated with anemia, thrombocytopenia and monocytosis. Blood film appearances showing this changes are suggestive of significant malaria parasitemia.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0