Journal of Vector Borne Diseases最新文献

{"title":"Molecular docking of daunorubicin and etoposide drugs against Leishmania donovani : A theoretical study.","authors":"Afnan Mohammed Shakoori, Fatemah Alhakami, Ghadir Sindi, Areej Yahya Alyahyawi, Rasha Abdullah Alhazzaa","doi":"10.4103/JVBD.JVBD_174_23","DOIUrl":"10.4103/JVBD.JVBD_174_23","url":null,"abstract":"<p><strong>Background objectives: </strong>The human blood parasite Leishmania donovani causes visceral leishmaniasis or grayish discoloration of the skin (black fever/kala-azar). Antitumor drugs such as daunorubicin and etoposide can help to treat such diseases. The computational approach is used to find a better interaction of drugs with the active site of the protein and help to design new drugs.</p><p><strong>Methods: </strong>In this study, we have optimized two antitumor drugs, daunorubicin and etoposide. We studied frontier molecular orbitals, electrostatic potential (MEP) maps, and the natural bond order analysis of these anticancer drugs, followed by molecular docking with Leishmania donovani protein.</p><p><strong>Results: </strong>The three-dimensional structure of MapK from Leishmania donovani is LDBPK-331470. Our computational calculations reveal that daunorubicin and etoposide drugs can have an affinity with MapK from Leishmania donovani .</p><p><strong>Interpretation conclusion: </strong>Our study predicted that both daunorubicin and etoposide could have a similar affinity with the protein (UvrD) Leishmania donovani .</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"369-375"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correspondence between the physiological cold tolerance and the distribution border of Mediterranean sandflies in Southeast Europe.","authors":"A J Trájer","doi":"10.4103/JVBD.JVBD_63_22","DOIUrl":"10.4103/JVBD.JVBD_63_22","url":null,"abstract":"<p><strong>Background objectives: </strong>The distribution of sandflies is influenced by several climatic factors, like winter temperature limits, summer humidity, and drought. Only a few studies were performed to search for the connection between the physiological tolerance of sandflies and the result of the Climate Envelope Models projected distribution borders.</p><p><strong>Methods: </strong>It was studied how the depth of rodent burrows could determine the occurrence of five European Phlebotomus species based on their known physiological cold tolerances.</p><p><strong>Results: </strong>The modelled distributions based on the monthly minimum temperatures showed notable differences by soil depth and species. The observed and modelled European distribution areas of sandflies according to - 20 cm soil depth showed good coincidence with the observed occurrences of Phlebotomus neglectus , Ph. papatasi , and Ph. perfiliewi in East-Central, Southeast, and East Europe. Also, a good coincidence was found in the case of the modelled and observed occurrences of Phlebotomus perniciosus in Western Europe.</p><p><strong>Interpretation conclusion: </strong>It can be concluded that in their north-eastern distribution borders, sandflies can overwinter in rabbit and rodent burrows at depths of - 20 cm below the surface. The physical cold tolerance of Ph. ariasi could be underestimated. In more than - 50 cm of depth, the stable and continuously cold environment of the shelters (mean temperature less than 10°C) could inhibit the post-winter diapause activation of sandflies in the northern regions.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"376-388"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between malaria parasite density and hematological profile in malaria infected children at a Nigerian Private hospital.","authors":"Oyedeji Olusola Adetunji","doi":"10.4103/0972-9062.393971","DOIUrl":"10.4103/0972-9062.393971","url":null,"abstract":"<p><strong>Background objectives: </strong>The correct association between Plasmodium falciparum parasite density and the cellular constituents of blood is not known in entirety in Nigerian children. Thus, we decided to study the association between cellular blood constituents and malaria parasite density in malaria infected children attending a Nigerian hospital.</p><p><strong>Methods: </strong>A study of all children diagnosed with malaria fever at the Pediatric out-patient clinic, Cedar Crest Hospital, Abuja, Nigeria, was conducted. Packed cell volume, white blood cells with differentials and platelet counts and malaria parasite densities obtained from blood samples were studied. Malaria parasite densities more than 2 pluses were classified as significant parasitemia and 1 plus as non-significant. Information obtained was recorded and analysed with SPSS 22 software.</p><p><strong>Results: </strong>A total 143 children (74 boys and 69 girls) diagnosed with malaria of ages between 5 months to 17 years (mean 5.24 ±4.60) were studied. The majority of 141 (98.6%) had non-significant P. falciparum parasitemia, while 2 (2.4%) had significant parasitemia. Of the 143 children with malaria, 116 (81.1%) had a normal leucocyte count. All children with significant parasitemia had a normal leucocyte count. Of the 143 children, 11 (7.7%) had anemia and 10 (7.0%) thrombocytopenia. Anemia, monocytosis and thrombocytopenia were significantly associated with significant malaria parasitemia (p<0.05). Mean platelet counts was significantly less amongst those with significant parasitemia (p<0.01).</p><p><strong>Interpretation conclusion: </strong>All patients with significant malaria parasitemia had normal leucocyte count. Significant malaria parasitemia is significantly associated with anemia, thrombocytopenia and monocytosis. Blood film appearances showing these changes are suggestive of significant malaria parasitemia.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"364-368"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria and dengue outbreaks: A double health threat in southeastern Iran.","authors":"Jalil Nejati, Rubén Bueno-Marí","doi":"10.4103/JVBD.JVBD_186_23","DOIUrl":"10.4103/JVBD.JVBD_186_23","url":null,"abstract":"","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"501-502"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vector-control potential of Unani medicines: A review of classical Unani texts and contemporary scientific literature.","authors":"Fauzia Shahabuddin, Malik Itrat, Sampath Kumar","doi":"10.4103/JVBD.JVBD_173_23","DOIUrl":"10.4103/JVBD.JVBD_173_23","url":null,"abstract":"<p><strong>Background objectives: </strong>Vector-borne diseases pose substantial global health challenges, with a notable impact on India. Effective vector control strategies are crucial to mitigating these diseases as there are no effective vaccines available. Synthetic chemicals are widely used but concerns about safety and environmental impact have prompted exploration of alternative natural solutions. Unani medicine offers a potential source of natural products. This study aims to systematically review classical Unani texts and contemporary scientific literature to evaluate the vector control potential of Unani medicines.</p><p><strong>Methods: </strong>A comprehensive review of classical Unani texts was carried out to compile data on herbal and mineral substances suggested in Unani medicine for control of insects. Furthermore, electronic databases like PubMed, Google Scholar, and Science Direct were explored for research studies evaluating the insect repellent, larvicidal, and insecticidal activities of the Unani medicines. Time restriction was not imposed to ensure comprehensive retrieval of pertinent and up-to-date information.</p><p><strong>Results: </strong>From classical Unani texts, 29 drugs were identified for control of insects, primarily of plant origin from diverse botanical families. Recent scientific investigations have confirmed the insect-repellent, insecticidal, and larvicidal activities of 19 of these Unani medicines against various insect species, including mosquitoes.</p><p><strong>Interpretation conclusion: </strong>These findings underscore the potential of Unani medicines as a natural source for vector control. However, further research is essential to explore mechanism, delivery methods, and optimal concentrations for developing effective vector-control formulations.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"315-326"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing healthcare access and malaria management via mobile clinics and phone call services in Nuh district of Haryana, India.","authors":"Manju Rahi, Aarifa Nazmeen, Sanjeev Kumar, Chander Prakash Yadav, Gaurav Kumar, Peeyush Mittal, Sam Joy, Sachin Sharma, Rajendra Kumar Baharia, Gaurav Bhati, Pawan Goel, Amit Sharma","doi":"10.4103/JVBD.JVBD_163_23","DOIUrl":"10.4103/JVBD.JVBD_163_23","url":null,"abstract":"<p><strong>Background objectives: </strong>Malaria remains a complex challenge in India due to its diverse epidemiology, multi-ethnic population, and multiplicity of malaria vectors. While progress has been made in reducing malaria nationally, persistent pockets hinder elimination efforts. These challenges include hidden reservoirs, inadequate healthcare, suboptimal surveillance, non-compliance, and subclinical infections. Shortage of grassroot level and primary care health staff, transportation issues and general inaccessibility and unavailability of healthcare services are additional challenges.</p><p><strong>Methods: </strong>Mobile healthcare vans have been tried and found useful in enhancing healthcare availability in several health conditions in different settings. Nuh district in Haryana, India is a malaria endemic region; it is indeed one of the districts included by India's NITI Aayog in the Aspirational Districts Programme, a government initiative that focuses on rapidly transforming and developing the most underdeveloped districts in country. With an aim to improve the healthcare seeking behavior of malaria-endemic community of selected villages of Nuh district, we carried out a study using interventions in two villages of the district, that had mobile malaria clinics and toll-free telephone services in enhancing healthcare access.</p><p><strong>Results: </strong>We found that Sangel village had higher literacy rates (60.6%) as compared to 39.4% in Naushera. Similarly, the unemployment rate was higher for Naushera. It the mobile malaria clinic was deployed from December 2019 to July 2020 and a total of 269 phone calls were received from both the villages. A similar number of rapid tests and microscopy smears were examined and all were negative for malaria. The febrile patients were referred to the nearest healthcare facility.</p><p><strong>Interpretation conclusion: </strong>The study shows that the community is open to using these healthcare interventions. These initiatives of mobile malaria clinics and toll-free telephone services can bridge healthcare gaps, especially in malaria-endemic regions, aligning with India's malaria elimination and equitable healthcare access goals.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"406-412"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating public understanding and actions regarding Aedes mosquitoes and dengue prevention across altitudinal range in central Nepal.","authors":"Punya Ram Sukupayo, Ram Chandra Poudel, Tirth Raj Ghimire","doi":"10.4103/JVBD.JVBD_24_24","DOIUrl":"10.4103/JVBD.JVBD_24_24","url":null,"abstract":"<p><strong>Backgrounds objectives: </strong>Dengue fever, transmitted by Aedes mosquitoes, is a significant public health concern in Nepal. An extensive Knowledge, Attitude, and Practice (KAP) survey related to Aedes mosquitoes and prevention of dengue was conducted along the route from Matihani (62 m above sea level) to Kalinchok (3840 m asl) in central Nepal. This research examined residents' awareness of Aedes mosquitoes and the diseases they transmit, aiming to support the World Health Organization's national and global fight against mosquito-borne diseases.</p><p><strong>Methods: </strong>The survey included 550 participants aged 18-75 years (249 males and 201 females). Door-to-door campaigns were conducted to gather data on knowledge scores, practices, and attitudes about Aedes mosquitoes using a standard structured questionnaire.</p><p><strong>Results: </strong>Findings of this study revealed a moderate level of knowledge across the study area, with a mean knowledge score of 5.525±2.58 (correct answer rate of 46.05%). While 99.6% of respondents were aware of dengue transmission by mosquitoes, only 64.5% were able to report Aedes mosquitoes as the key transmitter. Less than one-third of the participants (27.8%) were familiar with black-and-white stripes in Aedes. Additionally, only 36.7% were knowledgeable about the day-biting behavior of Aedes mosquitoes.</p><p><strong>Interpretation conclusion: </strong>This KAP survey provides valuable insights into community understanding of Aedes mosquitoes and dengue prevention practices associated with various Nepalese communities residing in low to high altitudes of central Nepal. These findings can be adopted to address the increasing health burden faced by countries with low-to-high altitude regions within the Hindu Kush Himalayas.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"461-471"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity of mosquito natural enemies and their feeding efficacy on Aedes vectors.","authors":"Dinithi Shamalee Dissanayake, Chandana Dammika Wijekoon, Hemantha Wegiriya","doi":"10.4103/JVBD.JVBD_50_24","DOIUrl":"10.4103/JVBD.JVBD_50_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Mosquito-borne diseases are a major health issue among communities in Asia, and dengue has grown up as a serious public health concern in Sri Lanka with varying magnitude since 1960. With the realization of the failures and limitations of current vector control strategies, the authorities are moving towards simple, low-cost, and eco-friendly vector management methods. Thus, the present study was devised to evaluate the potential densities of mosquito natural enemies in natural water habitats in Galle district, Sri Lanka, and to investigate the feeding efficacy of prominent mosquito natural enemies on main dengue vectors ( Aedes sp.) in a laboratory setting.</p><p><strong>Methods: </strong>The survey was carried out using eight sentinel sites in Galle district, and samples of mosquito natural enemies and mosquito larvae were collected, and then they were identified using taxonomic keys.</p><p><strong>Results: </strong>Study records, the aquatic insects of Family Hydrometridae, Belostomatidae, Notonectidae, Nepidae, Ranatridae, and Corixidae as dominant mosquito natural enemies, and Libellulidae and Dytiscidae insects as sub-dominant families. The highest density of the family Hydrometridae was recorded in rural, natural inland, and rocky study sites. The order Hemiptera was recorded as the key order of the mosquitoes natural enemies in Galle district. The family Hydrometridae had the highest density of recorded mosquito natural enemies.</p><p><strong>Interpretation conclusion: </strong>Aedes aegypti and Ae. albopictus were recorded as abundant vector mosquitoes. Family Nepidae is the most effective natural mosquito predator on Ae. aegypti and Ae. albopictus, and this knowledge will be vital for implementing future biological control strategies for Aedes vectors in Sri Lanka.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141260810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of climatic factors on the life stages of Aedes mosquitoes and vectorial transmission: A review.","authors":"Pooja Prasad, Sanjeev Kumar Gupta, Kaushal Kumar Mahto, Gaurav Kumar, Alka Rani, Iyyappan Velan, Deepak Kumar Arya, Himmat Singh","doi":"10.4103/JVBD.JVBD_42_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_42_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Aedes aegypti and Aedes albopictus are two sympatric mosquito species that compete with each other for resources when their breeding habitats overlap. This study examines what happens when sympatric Aedes aegypti and Aedes albopictus mosquitoes' mate with each other and other species by looking at insemination rates, fecundity, and hatchability rate.</p><p><strong>Methods: </strong>We performed controlled mating experiments in laboratory setting, assessing both conspecific and interspecific crosses. We measured insemination rates, egg numbers, and hatching success to examine the reproductive interference dynamics between these two distinct mosquito species.</p><p><strong>Results: </strong>In the context of conspecific mating, it was observed that both female Ae. aegypti and Ae. albopictus exhibited high insemination rates, with percentages of 98% and 94%, respectively. However, interspecific mating exhibited interesting asymmetries: Ae. albopictus males achieved a notable insemination success rate of 28% when mating with Ae. aegypti females, while Ae. aegypti males achieved only 8% insemination success with Ae. albopictus females. Additionally, females that mated with interspecific males had reduced production of viable eggs compared to conspecific mating. Most notably, interspecific mating resulted in the production of infertile eggs, while conspecific mating led to successful hatching.</p><p><strong>Interpretation conclusion: </strong>The study reveals that, Ae. aegypti and Ae. albopictus can asymmetrically interfere with each other's reproduction, causing a 'satyr' effect. This understanding of interspecific competition and reproductive interference in these mosquito species could impact their coexistence in shared breeding habitats.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of radiation-induced sterility, longevity, and reproductive characteristics of the Aedes aegypti (Diptera: Culicidae) strain of Swat: A step towards the implementation of SIT in Pakistan.","authors":"Inamullah Khan, Gul Zamin Khan, Jehangir Khan, Muhammad Amin","doi":"10.4103/JVBD.JVBD_131_23","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_131_23","url":null,"abstract":"<p><strong>Background objectives: </strong>Biological approaches for vector mosquito control such as sterile insect technique (SIT) requires sterilization of male mosquitoes through specific radiation doses for sterility induction in males. Under the SIT program, the males used must be compatible with the wild males in vigor, flight and selection of mate. Much of this potential is determined by the diet provided in the larval stages and optimizing the irradiation doses that cause complete sterility but have very minimal effect on the lives of irradiated males. The current study is designed to evaluate gamma radiation doses for inducing sterility in male Aedes aegypti mosquitoes with a genomic background from Pakistan (Swat district) and to assess the effects of radiation exposure on the competency of irradiated males and other life traits of irradiated mosquitoes.</p><p><strong>Methods: </strong>Sterilization of 17-hour-old male pupae (groups of 50 pupa/cup in three replicates) of the Ae. aegypti Swat strain was conducted using radiation doses of 30, 60, 70, 90, and 105 gray (Gy) from (Co60) at the Nuclear Institute for Food and Agriculture (NIFA) in Peshawar, Pakistan. Post-irradiated pupae were released in adult cages. Virgin females of the same cohort were released (1:1) to mate with the irradiated males. Mortality, longevity, mating competitiveness of males, and female fecundity were recorded.</p><p><strong>Results: </strong>An average of 71 eggs per female was recorded in control with 86% hatch rate. Individual females mated with a 60 Gy treated males produced 60 ± 0.6 eggs per female with 17% hatch rate, and those mated with 70 Gy males produced 42 ± 0.01 eggs with a nil hatch rate, whereas females mated with males treated with ≥70 Gy doses did not reproduce to next generation. Females in groups of 50 mated with 60, 70 Gy treated males (equal pairs), produced 369±1.3 and 98±0.01 eggs with 15% and zero hatch rate. Significant dose dependent reduction in longevity was observed for >30 Gy doses. The matting competence of irradiated males was about half that of un-irradiated males.</p><p><strong>Interpretation conclusion: </strong>Aedes aegypti with a Pakistani genomic background treated with a ≥70 Gy dose of gamma radiation induced complete sterility in males and provided the first- step foundation for SIT application in Pakistan. Further extensive studies are required to optimize the SIT techniques so that fully sterile males with very minor quality changes can be produced on large scales for field trials.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}