{"title":"Preliminary survey on the distribution of Ixodid ticks in domestic ruminants and vegetation of Pathanamthitta district, Kerala, South India.","authors":"S Sahina, S Sithalakshmi, R Balasubramanian","doi":"10.4103/0972-9062.393970","DOIUrl":"https://doi.org/10.4103/0972-9062.393970","url":null,"abstract":"<p><strong>Background objectives: </strong>Tick borne diseases (TBD) are becoming a major public and animal health problem in the Kerala. Recently, during 2021 - 2022, a new focus of tick nuisance and associated fever has been reported in some villages of Pathanamthitta district.</p><p><strong>Methods: </strong>The study on the diversity of tick fauna in Southern Kerala is limited. Therefore, a preliminary survey was carried out for the first time in this focus for implementation of future tick borne pathogen detection and control measures. This research may provide a proper understanding of tick density and acarological risk by tick ecology through surveillance and identification. A cross sectional study was conducted during the summer season of 2021 and 2022 in the tick bite infected area - Naduvathumoozhy, Vayakkara, Malayalappuzha and Pallikuzhi.</p><p><strong>Results: </strong>Ticks were manually collected from ruminants and by dragging method from vegetation. A total of 727 ticks of 8 different species were collected from the genus Amblyomma, Haemaphysalis, Hyalomma, and Rhipicephalus. The most prevalent species were H. bispinosa and H.turturis, at 38.7% and 29.1%, respectively. Ticks were sampled from 197 animals with the proportion of infestation being 73.60%. It was highest in goats (85.9%), followed by buffalo (73.6%) and cow (65.4%).</p><p><strong>Interpretation conclusion: </strong>The study concludes that, despite the absence of any TBD outbreaks, the Pathanamthitta district has a high diversity of tick fauna and a high rate of tick infestation in domestic ruminants, especially in goats. Hence active tick surveillance is necessary in order to prevent TBD outbreaks in future; the study also emphasizes the importance of performing tick surveillance in both KFD endemic and non-endemic regions.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structure-based virtual screening study for identification of potent insecticides against the Anopheles gambiae to combat the malaria.","authors":"Nawal Helmi","doi":"10.4103/0972-9062.393977","DOIUrl":"https://doi.org/10.4103/0972-9062.393977","url":null,"abstract":"<p><strong>Background objectives: </strong>Vector-borne infectious diseases contribute significantly to global mortality, with over 700,000 annual deaths, and malaria alone accounts for more than 400,000 of these fatalities. Anopheles gambiae, a prominent mosquito species, serves as a primary vector for transmitting malaria to humans. To address this issue, researchers have identified the D1-like dopamine receptor (DAR), specifically DOP2, as a promising target for developing new insecticides.</p><p><strong>Methods: </strong>The three-dimensional structure of DOP2 from A. gambiae was unavailable in the PDB database, an in-silico approach was used to model and validate the DOP2 protein's structure. The Discovery Studio 2021 program was then used to identify potential binding sites on the DOP2 protein. A virtual screening of 235 anti-parasitic compounds was performed against DOP2 using PyRx 0.8.</p><p><strong>Results: </strong>The screening demonstrated strong binding and interactions with active site residues of the DOP2 protein for five compounds: Diclazuril, Kaempferol, Deracoxib, Clindamycin, and Diaveridine. These compounds exhibited higher binding affinity values compared to the control (Asenapine). In addition, the predicted physiochemical properties for these compounds were within acceptable ranges, and there were no violations in druglikeness properties.</p><p><strong>Interpretation conclusion: </strong>These compounds show promise as potential new insecticides targeting the A. gambiae mosquito by inhibiting the DOP2 protein. However, additional experimental validation is required to optimize their efficacy as DOP2 protein inhibitors.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bamboo stumps that are artificially in use put pressure on Dengue and Chikungunya vector control in Dhaka City, Bangladesh.","authors":"Rajib Chowdhury, Shyla Faria, Vashkar Chowdhury, Md Sahidul Islam, Shireen Akther, Sakila Akter","doi":"10.4103/0972-9062.393974","DOIUrl":"https://doi.org/10.4103/0972-9062.393974","url":null,"abstract":"<p><strong>Background objectives: </strong>Aedes aegypti and Ae. albopictus mosquitoes breed in natural and artificial containers, and they transmit dengue and chikungunya. Therefore, a study was conducted to identify the contribution of bamboo stumps to these disease vectors that were used in the flower garden as pillars to hold the bamboo flex fence.</p><p><strong>Methods: </strong>Two sizes of whole bamboo were used to hold fences around gardens at Dhaka University, Bangladesh, and they were painted red and green. Mosquito larvae and pupae were collected from bamboo stumps between July and August, and vectors were identified up to the species level. The data were analyzed using the STATA/MP 14.2 version.</p><p><strong>Results: </strong>We found 83.5% and 0.2% were Ae. albopictus and Ae. aegypti, respectively, and the rest were Culex and Armigeres species. Ae. albopictus, Ae. aegypti, and both species-positive bamboo stumps were 46.9, 0.7, and 47.1 percent, respectively. 54.5% of bamboo stumps had at least one mosquito species. The average stump depth for Aedes positive stumps (mean =11.7 cm, SE = 0.5) was significantly (p <0.001) higher than the Aedes negative stumps (mean = 9.5 cm, SE = 0.4). 53.8% and 38.0% stumps were found Aedes positive on the ground and upper sides of fences, respectively, and found significant (p<0.01) differences between both sides. A zero-inflated negative binomial count model is significant at a 5% level of significance, χ2(4) = 11.8, p = 0.019 (<0.05) for Ae. albopictus. Stump depth is found to have a significant positive effect on the number of Aedes-positive stumps.</p><p><strong>Interpretation conclusion: </strong>Artificially used natural containers are adding pressure to current mosquito control activities as mosquitoes are breeding on them, which needs additional attention.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling Malaria's Silent Threat: From Socioeconomic Divides to Religious Influences, A Path to Effective Prevention in India.","authors":"Ume Aiman, Zainab Azad, Abdul Raffay Awais","doi":"10.4103/0972-9062.393978","DOIUrl":"https://doi.org/10.4103/0972-9062.393978","url":null,"abstract":"<p><strong>Abstract: </strong>Malaria remains a formidable public health challenge in India, particularly in low-socioeconomic regions, where it exacts a heavy toll on lives every year. This pressing issue gains prominence in light of a recent study conducted by Ronald et al. in Uganda, which illuminates the factors contributing to the elevated prevalence of malaria in economically disadvantaged areas. The study underscores the efficacy of interventions such as insecticide-treated nets (ITNs) and indoor residual spraying (IRS) in curtailing malaria incidence. Additionally, the World Health Organization's endorsement of the RTS, S/AS01 (RTS, S) malaria vaccine presents a promising development in the battle against this devastating disease. This letter underscores the imperative nature of implementing comprehensive strategies in India, which encompass widespread ITN distribution, the expansion of IRS programs, and the integration of the RTS, S/AS01 vaccine into the national immunization regimen. These concerted efforts are pivotal in furnishing cost-effective preventive measures to counter the mounting wave of malaria cases in India. Confronting malaria through a multifaceted approach stands as an essential approach to mitigate the disease's burden and ultimately safeguard the lives of India's vulnerable populations.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dhyanjyoti Sarma, Bhupamani Das, Niral Patel, Arun Patel, Abhinav Suthar, Ankit Prajapati, R M Patel
{"title":"Microscopic and molecular investigation of vector borne haemoprotozoan diseases in dromedary camel of North Gujarat.","authors":"Dhyanjyoti Sarma, Bhupamani Das, Niral Patel, Arun Patel, Abhinav Suthar, Ankit Prajapati, R M Patel","doi":"10.4103/0972-9062.393968","DOIUrl":"https://doi.org/10.4103/0972-9062.393968","url":null,"abstract":"<p><strong>Background objectives: </strong>Vector borne haemoprotozoan diseases comprise diverse group of single celled organism transmitted by haematophagus invertebrates. The current study was aimed at identification of major haemoprotozoan (Babesia, Theileria and Trypanosoma) in dromedary camel of North Gujarat region using microscopy and Polymerase Chain Reaction (PCR).</p><p><strong>Methods: </strong>A total of 234 blood samples were screened by the microscopic and molecular detection assays. Molecular prevalence studies of Theileria, Trypanosoma spp and Babesia was undertaken using 18s ribosomal DNA, RoTat 1.2 and SS rRNA gene respectively. The data relating to microscopic and molecular prevalence along with associated risk factors were analysed by statistical methods.</p><p><strong>Results: </strong>The overall prevalence of hamoprotozoan disease based on microscopic and molecular investigation was 23.50%. The sensitivity and specificity (95% Confidence Interval) of PCR assay was 100% in comparison to microscopy (45.45% and 100%). The kappa coefficient between PCR and microscopy indicated good level of agreement with a value of 0.704 and SE of 0.159.</p><p><strong>Interpretation conclusion: </strong>Despite holding much significance to the animal sector, little work has been undertaken in regional part of India regarding camel parasites. The present paper offers the first preliminary research data investigating haemoprotozoan disease using parasitological and molecular methods in camels in the region.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In silico screening of potential plant peptides against the Non-structural proteins of Dengue virus.","authors":"G Reena, R Ranjani, D Gowtham, K Sangeetha","doi":"10.4103/0972-9062.393979","DOIUrl":"https://doi.org/10.4103/0972-9062.393979","url":null,"abstract":"<p><strong>Background objectives: </strong>Peptides isolated from different sources of plants have the advantages of specificity, lower toxicity, and increased therapeutic effects; hence, it is necessary to search for newer antivirals from plant sources for the treatment of dengue viral infections.</p><p><strong>Methods: </strong>In silico screening of selected plant peptides against the non-structural protein 1, NS3 protease domain (NS2B-NS3Pro) with the cofactor and ATPase/Helicase domain (NS3 helicase domain/NS3hel) of Dengue virus was performed. The physicochemical characteristics of the peptides were calculated using Protparam tools, and the allergenicity and toxicity profiles were assessed using allergenFP and ToxinPred, respectively.</p><p><strong>Results: </strong>Among the tested compounds, Ginkbilobin demonstrated higher binding energy against three tested non-structural protein targets. Kalata β-8 demonstrated maximum binding energy against NSP-1 and NSP-2, whereas Circulin A acted against the NSP3 protein of the dengue virus.</p><p><strong>Interpretation conclusion: </strong>Hence, the three compounds identified by in silico screening can be tested further for in vitro studies, which could act as potential leads as they are involved in hampering the replication of the dengue virus by interacting with the three prime non-structural proteins.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AI in the repurposing of potential herbs for filariasis therapy.","authors":"Somsri Wiwanitmkit, Viroj Wiwanitkit","doi":"10.4103/0972-9062.393975","DOIUrl":"https://doi.org/10.4103/0972-9062.393975","url":null,"abstract":"<p><strong>Background objectives: </strong>The goal of this study was to see how well an AI language model called Chat Generative Pre-trained Transformer (ChatGPT) assisted healthcare personnel in selecting relevant medications for filariasis therapy. A team of medical specialists and tropical medicine experts reviewed ChatGPT's recommendations for ten hypothetical filariasis clinical situations.</p><p><strong>Methods: </strong>The purpose of this study was to look at the effectiveness of an AI language model called Chat Generative Pre-trained Transformer (ChatGPT) in supporting healthcare providers in picking appropriate drugs for filariasis treatment. Ten hypothetical filariasis clinical cases were submitted to ChatGPT, and its recommendations were evaluated by a panel of medical professionals and tropical medicine experts.</p><p><strong>Results: </strong>ChatGPT gave appropriate suggestions for potential medication repurposing in filariasis treatment in all ten clinical scenarios. Its drug recommendations were in line with current medical research and literature. Despite the lack of particular treatment regimens, ChatGPT's general ideas proved useful for healthcare practitioners, providing insights and updates on prospective drug repurposing tactics.</p><p><strong>Interpretation conclusion: </strong>ChatGPT shows promise as a useful method for repurposing drugs in the treatment of filariasis. Its thorough and brief responses make it useful for finding possible pharmacological candidates. However, it is critical to recognize ChatGPT's limitations, such as the requirement for additional clinical information and the inability to change therapy. Further research and development are required to optimize its use in filariasis therapy settings.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sandra Enríquez, Jazzmín Arrivillaga-Henríquez, Paul Duque, Vanessa Herrera, Franklin Vaca, Marco Sánchez, Mateo Roldán, Lenin Ron-Garrido, C Alfonso Molina
{"title":"Indicators sand flies and environment associated to spatial landscaping change in Choco Biosphere Reserve UNESCO.","authors":"Sandra Enríquez, Jazzmín Arrivillaga-Henríquez, Paul Duque, Vanessa Herrera, Franklin Vaca, Marco Sánchez, Mateo Roldán, Lenin Ron-Garrido, C Alfonso Molina","doi":"10.4103/0972-9062.393980","DOIUrl":"https://doi.org/10.4103/0972-9062.393980","url":null,"abstract":"<p><strong>Background objectives: </strong>Sand flies are insects vector associated with terrestrial forest ecosystems; in the Ecuadorian Andes, they participate in the transmission of human cutaneous leishmaniasis. This geographical area is an opportunity to evaluate the role of sand flies as bioindicators od the degree of intervention of a tropical humid forest ecosystems (THF) associated with changes in the ecology of the local landscape.</p><p><strong>Methods: </strong>CDC-light traps were used for collecting adults' sand flies in February 2020 in a humid tropical forest within Choco Biosphere Reserve. All species were identified using morphological keys. Analysis data about abundance, richness, species accumulation, diversity index, species composition communities, species sex proportion, spatial sand flies environmental, Renyi's Diversity Profile were performed to compare six spatial habitats in Mashpi locality, Ecuador.</p><p><strong>Results: </strong>Sand flies were collected (n-1435); the main species are represented by Th. reburra Ny. trapidoi, Pa. aclydifera, Py. panamensis and Lu. hartmanni. Only Th. reburra is associated with not intervened forest, while the other 3 species are associated with intervened forest within Mashpi in the Choco Biosphere Reserve. The secondary forest has the major sandflies' richness, while the primary forest exhibits the major abundance.</p><p><strong>Interpretation conclusion: </strong>The results indicated that Th. reburra is a sandfly restricted to the Andean Forest and is a bioindicator of the high environmental health quality of the forest, while Ny. trapidoi and Pa. aclydifera are bioindicators of environmental disturbances in the forest. Additionally, Ps. panamensis, Lu. hartmanni and Ny. trapidoi are bioindicators of human impact and the risk of leishmaniasis.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The potential habitat and environmental fitness change of Aedes albopictus in Western Eurasia for 2081-2100.","authors":"Attila J Trájer","doi":"10.4103/0972-9062.393972","DOIUrl":"https://doi.org/10.4103/0972-9062.393972","url":null,"abstract":"<p><strong>Background objectives: </strong>The range of Aedes albopictus, the most important vector mosquito in Western Eurasia is growing due to climate change. However, it is not known how it will influence the habitats occupied by the species and its environmental fitness within its future range.</p><p><strong>Methods: </strong>To study this question, the habitat characteristic of the mosquito was investigated for 2081-2100.</p><p><strong>Results: </strong>The models suggest a notable future spread of the mosquito in the direction of Northern Europe and the parallel northward and westward shift of the southern and eastern potential occurrences of the mosquito. The models suggest a notable increase in generation numbers in the warmest quarter, which can reach 4-5 generations in the peri-Mediterranean region. However, both the joint survival rate of larvae and pupae and the number of survival days of adults in the warmest quarter exhibit decreasing values, as does the potential disappearance of the mosquito in the southern regions of Europe and Asia Minor, along with the growing atmospheric CO2 concentration-based scenarios.</p><p><strong>Interpretation conclusion: </strong>While in 1970-2000 Aedes albopictus mainly occupied the hot and warm summer temperate regions of Europe, the species will inhabit dominantly the cool summer temperate (oceanic) and the humid continental climate territories of North and North-Eastern Europe in 2081-2100.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sasmita Rani Jena, M Kaliyamoorthy, T K Bhattacharyya, Kalpana Baruah
{"title":"An eco-epidemiological analysis of Dengue outbreak in Port Blair, South Andaman Island, India, during 2022.","authors":"Sasmita Rani Jena, M Kaliyamoorthy, T K Bhattacharyya, Kalpana Baruah","doi":"10.4103/0972-9062.393973","DOIUrl":"https://doi.org/10.4103/0972-9062.393973","url":null,"abstract":"<p><strong>Background objectives: </strong>In Port Blair, the capital of Andaman & Nicobar Islands, in the Bay of Bengal, there was a sudden increase in fever cases resembling the symptoms of dengue in the monsoon period of 2022. Hence, an investigation was carried out to find out both epidemiological and entomological reasons behind the outbreak.</p><p><strong>Methods: </strong>An Entomological survey was carried out in 24 wards of Port Blair Municipal Council (PBMC) area, epidemiological data of last six years (January to December of 2017-2021 & January to October of 2022) and patient details of the year 2022 were collected. Both the epidemiological and entomological data were analyzed concerning time and place.</p><p><strong>Results: </strong>During this outbreak period tyres (22.4%) came out as a major breeding habitat followed by small discarded materials (17.5%), metal drums (15.3%), and plastic drums (11.7%). In rainy season peri-domestic breeding (55%) was more than the domestic breeding (45%) habitat. Ae. aegypti had a high preference for indoor large containers (100-1000 L) like plastic tank, metal drum and cement tank whereas Ae. albopictus prefers to breed in medium sized plastic container (20-100 L) and outdoor water receptacles like tyres, flower pots, domestic discarded materials etc.</p><p><strong>Interpretation conclusion: </strong>By source reduction, indoor space spray and outdoor fogging vector density was controlled which curtailed the transmission and within 8 weeks decreasing trend of dengue cases were noticed. A regular entomological survey is very important to know the seasonality and key breeding habitats of the vector for proper planning of vector control.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}