Journal of Vector Borne Diseases最新文献

Serotypic and genotypic profile of dengue virus outbreaks in India between 2011 and 2017. 2011 年至 2017 年印度爆发的登革热病毒血清型和基因型概况。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_101_24

Ashvini Kumar Yadav, Divya Namdeo, Prashant Khare, Shashwati Nema, Abhijit Pakhare, Rashmi Chowdhary, Debasis Biswas

{"title":"Serotypic and genotypic profile of dengue virus outbreaks in India between 2011 and 2017.","authors":"Ashvini Kumar Yadav, Divya Namdeo, Prashant Khare, Shashwati Nema, Abhijit Pakhare, Rashmi Chowdhary, Debasis Biswas","doi":"10.4103/JVBD.JVBD_101_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_101_24","url":null,"abstract":"The epidemiology of dengue has been demonstrating significant changes in recent years, with rising incidence of infection in countries with known endemicity and occurrence of fresh outbreaks in previously unaffected territories. India, which has been a traditional hotspot dengue virus (DENV) transmission in the endemic south-east Asian region, has also been affected by the sweeping changes in dengue epidemiology. Two remarkable developments characterize the alterations witnessed by India 2011-2017. Firstly, all parts of the country have witnessed abrupt replacement of existing DENV lineages with emerging novel strains. Secondly, co-circulation of multiple serotypes of DENV have been reported from all across the country 2011-2017; thereby hinting at the transition of the country towards hyper-endemicity. Considering the potential clinical implications of such epidemiological transformation in terms increasing involvement of pediatric patients and growing predisposition to serious complications, the present review provides an update on the serotypic and genotypic profile of dengue outbreaks that have been witnessed by different zones of India between 2011 and 2017. Dividing the country into northern, southern, eastern, western, central and north-eastern zones, we describe discrete zone-specific distribution patterns of DENV serotypes and genotypes and observe simultaneous circulation of different DENV strains in different parts of the country. Random shifts in the genetic characteristics of the circulating strains and the widespread co- circulation of all four serotypes underscore the need for undertaking continuous and representative molecular surveillance of the circulating DENV strains across the country for prompt identification of emerging strains and novel mutants; gain insights into the formulation of Dengue vaccines and develop a clearer understanding of the molecular basis of immune evasion, disease epidemiology and pathogenesis.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of larvicidal, growth-suppressing, and developmentaltering bioefficacy of Ageratum houstonianum against Aedes aegypti (L.). 评估Ageratum houstonianum对埃及伊蚊的杀幼虫、抑制生长和发育的生物功效。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_100_24

Vijay Kumar Shah, Kamal Kumar Gupta

{"title":"Assessment of larvicidal, growth-suppressing, and developmentaltering bioefficacy of Ageratum houstonianum against Aedes aegypti (L.).","authors":"Vijay Kumar Shah, Kamal Kumar Gupta","doi":"10.4103/JVBD.JVBD_100_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_100_24","url":null,"abstract":"Background objectives: Aedes aegypti is a major vector responsible for spreading dengue, chikungunya, yellow fever, and Zika viruses worldwide. These illnesses have increased globally due to climate and environmental changes. Vector control and management are the principal tactics for combating mosquitoes-borne diseases in the absence of an effective vaccine. The study aimed to ascertain bioactivities of Ageratum houstonianum leaf acetone extract (AhLAE) against Aedes aegypti.Methods: Bioefficacy of AhLAE was tested against fourth instar larvae (L4) of Ae. aegypti using standard WHO protocol. The mortality, growth, and development of larvae, pupae and adults were recorded after exposure to the extract.Results: The AhLAE showed larvicidal activity against L4 with LC50 and LC90 values of 401.88 and 691.24 mg/L, respectively. The mortality of the larvae further increased on subsequent days. The AhLAE caused a significant reduction in pupae formation and adult emergence. It also increased the larval duration of L4 and development duration of the pupa formed from the treated L4, indicating its growth-suppressing effects. The impact of the AhLAE was dose-dependent; high concentrations caused reduction in survival and growth of L4. Consequently, the L4-pupal and L4-adult growth indexes decreased. Additionally, the AhLAE induced developmental anomalies in the form of larva-pupa (L-P) intermediates.Interpretation conclusion: The study found that the AhLAE exhibited larvicidal, growth-suppressing, and development-altering activities against Ae. aegypti. The findings suggest the potential of AhALE as a natural insecticidal agent for controlling mosquitoes.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of the Pharmacokinetic Properties Prediction of ADME. 将化合物与 DNA 螺旋酶 Q1 恶性疟原虫 3D7 相互螯合：药代动力学特性评估 ADME 预测。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_65_24

Afnan Shakoori, Zain Alhindi, Mohammad Alobaidy, Amna Moulana, Ayman Qashgari, Rehab M Bagadood, Ghadir Sindi, Banan Atwah, Anmar Anwar Khan

{"title":"Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of the Pharmacokinetic Properties Prediction of ADME.","authors":"Afnan Shakoori, Zain Alhindi, Mohammad Alobaidy, Amna Moulana, Ayman Qashgari, Rehab M Bagadood, Ghadir Sindi, Banan Atwah, Anmar Anwar Khan","doi":"10.4103/JVBD.JVBD_65_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_65_24","url":null,"abstract":"Background objectives: Quantum chemical & molecular docking practices to deliver new perceptions into how etoposide, novobiocin, nogalamycin and netropsin interact with the biological targets PF3D7_0918600 (Plasmodium falciparum 3D7). Further the pharmacokinetics of a drug candidate which influenced by a variety of factors, including P- glycoprotein (Pgp) transport, PBB (Plasma protein binding), & BBB (Blood-brain barrier) permeation help to forecast the pharmacological characteristics of acetyl-CoA reductase inhibitors (ADMEs) and their metabolites.Methods: At this point, we have elevated four compounds such as etoposide, novobiocin, nogalamycin & netropsin. We have also studied molecular docking against the target protein of the Plasmodium falciparum (PF3D7_0918600) through exhausting the AutoDock Vina platform and AutoDock-Tools (ADT) and pharmacokinetic properties were carried out using the ADMET 2.0.Results: The relative results of molecular docking recommended a greater binding affinity of novobiocin with the selected receptors among other compounds. In-silico ADME screening is a computational approach utilised to forecast the pharmacological characteristics of acetyl- CoA reductase inhibitors (ADMEs) and their metabolites.Interpretation conclusion: The ADMEs are based on the adsorption-desorption kinetics and pharmacopoeia. Adsorption and distribution analysis are used to assess the potential of the drug candidate. In vitro ADME is exploited to expect the effect of Pgp transport on the drug candidates. ADME has been used to predict CYP1A2 inhibitors and to predict PPB and BBB penetration. This paper summarizes the current knowledge on molecular docking, ADME and identifies potential drug candidates for ADME in vitro and in vivo.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the gaps: prioritizing research strategies for enhanced malaria control and elimination. 缩小差距：确定加强疟疾控制和消除的研究战略的优先次序。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_45_24

Rashed Alghamdi

{"title":"Bridging the gaps: prioritizing research strategies for enhanced malaria control and elimination.","authors":"Rashed Alghamdi","doi":"10.4103/JVBD.JVBD_45_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_45_24","url":null,"abstract":"Malaria continues to be a significant global health challenge, with millions of cases and hundreds of thousands of deaths reported annually. To combat this disease effectively, it is imperative to identify and address significant research gaps in malaria control and elimination efforts. This review synthesizes current knowledge and highlights critical gaps in several crucial areas of malaria research. Firstly, we discuss the complexities of vector biology and control, emphasizing the need for a deeper understanding of vector behavior, particularly in urban settings. Secondly, the study examines the challenges posed by drug resistance and the urgent need for alternative treatment strategies and novel drug targets. Thirdly, the review explores the ongoing quest for an effective malaria vaccine, underscoring the importance of understanding immunological correlates of protection. The study also explores medication resistance genes and genomic epidemiology, highlighting the need for more investigation into potential targets for drugs and vaccine candidates. Furthermore, it addresses the socioeconomic and environmental determinants of malaria transmission, highlighting the importance of integrating multidisciplinary approaches to address transmission dynamics. The study concludes with a discussion of how malaria transmission is impacted by climate change and the necessity of research to guide adaptation measures.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Japanese encephalitis virus: An overview. 日本脑炎病毒：概述。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_49_24

Qiuyang Li, Xiaoling Cheng, Min Luo, Jinrong Shi

引用次数: 0

Accelerating the fight towards malaria elimination: bridging gaps to achieve health equity in India. 加快消除疟疾的斗争：弥合差距，实现印度的卫生公平。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_92_24

Vani H Chalageri, B M Shrinivasa, N Sujith Nath, Prerana Nandish, Anup Anvikar

引用次数: 0

Characterization of Anopheles mosquito breeding habitats for malaria vector control in Mazowe and Shamva districts, Zimbabwe. 津巴布韦 Mazowe 和 Shamva 地区疟蚊孳生地的特征，以控制疟疾病媒。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_85_24

S Nyasvisvo David, Nhiwatiwa Tamuka, Sithole Rudo, Sande Shadreck

{"title":"Characterization of Anopheles mosquito breeding habitats for malaria vector control in Mazowe and Shamva districts, Zimbabwe.","authors":"S Nyasvisvo David, Nhiwatiwa Tamuka, Sithole Rudo, Sande Shadreck","doi":"10.4103/JVBD.JVBD_85_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_85_24","url":null,"abstract":"Background objectives: Area-specific identification and studies of Anopheles breeding habitat diversity, distribution, and productivity in different seasons are important in designing and advancing effective malaria vector control according to the local context and needs. This study identified and characterized Anopheles breeding habitats for targeted control of malaria vectors in Mazowe and Shamva districts.Methods: Repeated cross-sectional surveys were conducted in Mazowe and Shamva districts between April and December 2023. Habitat productivity and physicochemical parameters were measured. Anopheles larvae were collected, reared to adults, and identified using morphological keys. SPSS software was used for data analysis. One-way ANOVA, Fisher's exact, Pearson's correlation, and simple linear regression tests were conducted.Results: Seven different types of Anopheles breeding habitats were identified from 56 sites. The highest mean density of larvae was recorded in stream edge pools during the post-rainfall period. Anophelespretoriensis (67.4%), An. gambiae s.l. (23.1%), An. rufipes (9.2%) and An. coustani (0.38%) were breeding in the study area. Anopheles pretoriensis bred in all habitat types, An. coustani in swamps only while An. gambiae s.l. and An. rufipes preferred stream edge pools, roadside pools, and hoof prints. There was a significant positive correlation between larval density and dissolved oxygen (r = 0.535; p < 0.001) and conductivity (r = 0.288; p = 0.032).Interpretation conclusion: Size, origin, and type of breeding habitat were positive indicators for different Anopheles species in the study area. Potential malaria vector breeding habitats should be targeted for larval control under the current malaria control and elimination phases in the two districts.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coverage and evaluation survey of post-mass drug administration for lymphatic filariasis in four endemic districts of Uttar Pradesh: are we on the track? 北方邦四个淋巴丝虫病流行区大规模用药后的覆盖面和评估调查：我们是否已步入正轨？

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_102_24

Sourabh Paul, Aswani Kumar Seth, Neeraj Pawar, Abhay Singh, Mukesh Shukla, Bhola Nath

{"title":"Coverage and evaluation survey of post-mass drug administration for lymphatic filariasis in four endemic districts of Uttar Pradesh: are we on the track?","authors":"Sourabh Paul, Aswani Kumar Seth, Neeraj Pawar, Abhay Singh, Mukesh Shukla, Bhola Nath","doi":"10.4103/JVBD.JVBD_102_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_102_24","url":null,"abstract":"Background objectives: There is a persistent high microfilaria rate and variable reporting of coverage of Mass Drug Administration (MDA). The study aims to estimate the coverage, effective coverage, and compliance of drugs administered under MDA and to determine the predictors affecting the effective coverage.Methods: A community-based cross-sectional study was conducted in Amethi, Lucknow, Raebareli and Sultanpur districts of Uttar Pradesh, India. The study participants were selected using multi-stage random sampling using Probability Proportional to Estimated Size (PPES). The coverage, effective coverage and compliance of drugs were presented as proportion. The multivariable logistic regression model was applied to identify the significant predictors for effective coverage.Results: Of 4151 participants, 997 (24.0%), 340 (8.2%), 1158 (27.9%) and 1656 (39.9%) belonged to Amethi, Lucknow, Raebareli and Sultanpur districts respectively. The coverage ranged from 49.8% to 87.9% and effective coverage ranged from 51.8% to 73.2% across districts. The compliance was the poorest (70.7%) in Sultanpur. The source of information about MDA, the sex of the study participants and the area of residence emerged as predictors for effective coverage in the districts.Interpretation conclusion: The effective coverage was poor with good drug complianceacross the districts. There is a need for a well-designed pre-MDA campaign addressing the fear of side effects of drugs and emphasising the presence of the community during the MDA round along with monitoring and evaluation of the round.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistence of West Nile Virus circulation in North-East region of India: A prospective facility-based study spanning over a decade. 印度东北部地区西尼罗河病毒传播的持续性：一项基于设施的前瞻性研究，历时十年。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_168_23

Siraj Ahmed Khan, Pritom Chowdhury, Anisha Shah, Himanshu Medhi, Parveena Choudhury, Purvita Chowdhury, Pramit Ghosh

{"title":"Persistence of West Nile Virus circulation in North-East region of India: A prospective facility-based study spanning over a decade.","authors":"Siraj Ahmed Khan, Pritom Chowdhury, Anisha Shah, Himanshu Medhi, Parveena Choudhury, Purvita Chowdhury, Pramit Ghosh","doi":"10.4103/JVBD.JVBD_168_23","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_168_23","url":null,"abstract":"Background objectives: To understand the distribution and presence of West Nile (WN) among the acute encephalitis syndrome (AES) patients, a prospective facility-based study was conducted over 13 years (2007-2019).Methods: During the period, 8957 patients hospitalized with AES in northeastern India were tested for the evidence of WN virus infection by IgM ELISA followed by Plaque reduction neutralization test (PRNT).Results: Of the samples tested 324 (3.62%) were found positive for WN IgM antibodies and 73 paired sera showed a fourfold rise in neutralizing antibody titre by PRNT. The study establishes WN as a noteworthy cause of encephalitis in an erstwhile endemic area for Japanese encephalitis (JE).Interpretation conclusion: Therefore, it is important that WN is recognized as an important acute encephalitis syndrome (AES) causing aetiology in this region and the National centre for vector borne disease control (NCVBDC) guidelines for detection of AES may be modified accordingly. Thus, inclusion of WN in routine diagnosis, along with establishment of an integrative surveillance network with one-health approach will be important.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial analysis and mapping of malaria endemic-prone areas using environmental risk factors and spatial multi criteria decision analysis in the Northern Zone of Plateau State, Nigeria. 利用尼日利亚高原北部地区的环境风险因素和空间多标准决策分析，对疟疾流行区进行空间分析和绘图。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_63_24

Nanlok H Nimlang, Gilles Dusserre, Sandrine Bayle, Kivanc Ertugay, Sebnem Duzgun, Janaqi Stefan

{"title":"Spatial analysis and mapping of malaria endemic-prone areas using environmental risk factors and spatial multi criteria decision analysis in the Northern Zone of Plateau State, Nigeria.","authors":"Nanlok H Nimlang, Gilles Dusserre, Sandrine Bayle, Kivanc Ertugay, Sebnem Duzgun, Janaqi Stefan","doi":"10.4103/JVBD.JVBD_63_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_63_24","url":null,"abstract":"Background objectives: Compressive mapping and in-depth analysis of malaria vulnerability risk foci are important tools for strategic planning, vector surveillance, implementing necessary interventions, and managing scarce resources to combat the daunting challenges of malaria infections in Nigeria.Methods: The study utilized environmental risk factors and spatial multi-criteria decision analysis techniques to analyze and map the spatial variations in malaria-endemic prone areas within the Northern Zone of Plateau State.Results: Analysis of the criteria's weights of environmental risk factors and the stratification of the malaria risk vulnerability revealed that high-risk areas covered a total of 4017.25 Km2, while low-risk areas covered 1294.83Km2, having a close resemblance to the corresponding ground conditions. The results showed that a significant 60% of the study areas were characterized by high risk of malaria transmission, particularly in most settlements around the Jos North, Jos South and Barkin Ladi Local Government Areas. The malaria risk map's predictive abilities demonstrated a high level of accuracy, as indicated by the area under the curve score of 0.989. Furthermore, the risk map demonstrates a high-performance rate in identifying malaria hotspots, with a sensitivity of 98%, a proficiency rate of 54%, and a statistical significance confidence level ranging from 90% to 99% for identifying malaria hotspots and coldspots.Interpretation conclusion: The malaria risk analysis and mapping within the endemic prone areas of the Northern Zone of Plateau State not only equips policymakers with effective tools for identifying malaria foci but also offers a deeper comprehension of the appropriate intervention measures to be implemented.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0