改进印度黑热病后皮肤利什曼病的治疗：两步疗法。

IF 0.8 4区医学 Q4 INFECTIOUS DISEASES

Journal of Vector Borne Diseases Pub Date : 2025-02-12 DOI:10.4103/JVBD.JVBD_205_24

Sushruta Kathuria, Yugansh Gautam, Niti Khunger, Shruti Sharma, Ruchi Singh

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引用次数: 0

摘要

在目前的情况下，治疗后卡拉阿扎尔皮肤利什曼病（PKDL）是静脉注射两性霉素B脂质体或口服米替福辛。多年来，米替福辛的疗效逐渐下降，永久性视力丧失的情况有所增加。此外，在非流行国家，米地氟辛不是免费获得的。鉴于此，我们尝试用两性霉素B脂质体联合伊曲康唑两步方案治疗2例经组织病理学和PCR诊断为PKDL的患者。我们发现这种治疗非常有效，完全康复。

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Reworking the treatment of Indian Post Kala azar Dermal Leishmaniasis: 2-step therapy.

In the current scenario, treatment of Post Kala Azar Dermal leishmaniasis (PKDL) is intravenous liposomal amphotericin B or oral miltefosine. Over the years, there has been a gradual decline in efficacy of miltefosine and a rise in permanent loss of vision. Moreover, In non-endemic states, miltefosine is not freely available. In view of this, we attempted a two step regimen of liposomal amphotericin B and itraconazole to treat two patients of PKDL diagnosed on histopathology as well as PCR. We found this treatment to be highly effective with complete recovery.

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来源期刊

Journal of Vector Borne Diseases INFECTIOUS DISEASES-PARASITOLOGY

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： National Institute of Malaria Research on behalf of Indian Council of Medical Research (ICMR) publishes the Journal of Vector Borne Diseases. This Journal was earlier published as the Indian Journal of Malariology, a peer reviewed and open access biomedical journal in the field of vector borne diseases. The Journal publishes review articles, original research articles, short research communications, case reports of prime importance, letters to the editor in the field of vector borne diseases and their control.