Journal of Vector Borne Diseases最新文献

{"title":"Coverage and Determinants of Mass Drug Administration against Lymphatic Filariasis in Southeast Asian Regional Countries during the End-game Strategy: A Systematic Review & Meta-analysis of published articles from January 2019 to March 2025.","authors":"Indranil Saha, Joydeep Majumder, Bhavani Shankara Bagepally, Deepanjan Ray, Saibal Das, Manoj Kalita, M Devaraja, Anoop Velayudhan, Devi Das, Bobby Paul, Sanjit Dey","doi":"10.4103/jvbd.jvbd_58_25","DOIUrl":"https://doi.org/10.4103/jvbd.jvbd_58_25","url":null,"abstract":"<p><strong>Background objectives: </strong>Mass Drug Administration (MDA) is one of the important pillars of eliminating lymphatic filariasis. The present study aimed to determine the pooled coverage and compliance of the MDA and its determinants in the Southeast Asian Regional countries.</p><p><strong>Methods: </strong>This proposal was registered in PROSPERO. The study focused on four databases (PubMed, Scopus, Embase, and Cochrane Central) and articles published between January 2019 and March 2025. The setting was taken from studies performed across the Southeast Asian Region. Stata Version 17 was used for meta-analysis of the selected studies. The overall and subgroup-wise analysis was computed using the DerSimonian-Laird method for the random-effects model in Forest plots. A funnel plot was done to find out the publication bias.</p><p><strong>Results: </strong>Altogether, 34 articles were analysed. Of the 34 articles, 28 (82.3%) and 4 (11.8%) articles were published in India and Indonesia, respectively. The pooled coverage and compliance of MDA were found to be 80.16% (95% CI: 74.68-85.64%) and 67.25% (95% CI: 60.17-74.33%), respectively. Subgroup-wise, both coverage and compliance decreased in studies conducted in 2020 or afterwards. Side effects of the drugs, non-diseased status, suffering from some other diseases, too many drugs, bad taste of the drugs were some of the common barriers to successful MDA implementation.</p><p><strong>Interpretation conclusion: </strong>Thus, the time has come to develop strategies to improve MDA coverage and compliance at the community level. The strategy would be bilateral, involving both providers and beneficiaries, who need to be engaged in the proper implementation of MDA administration at the grassroots level.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Human Brucellosis in India: A Systematic Review.","authors":"Dhanashree V Manjrekar, Tushar N Nale, Yogesh A Bahurupi, Ajit D Shewale, Jitesh S Kuwatada, Simmi Tiwari","doi":"10.4103/jvbd.jvbd_235_24","DOIUrl":"https://doi.org/10.4103/jvbd.jvbd_235_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Brucellosis, a bacterial zoonotic disease, is caused by various species of Brucella, predominantly affecting livestock. In India, human brucellosis is a significant public health concern due to the proximity between humans and animals. Moreover, the under-reporting of cases and misdiagnosis of human brucellosis make it difficult to assess the problem and develop effective public health interventions. Therefore, the study's objectives were to estimate the prevalence, geographic spread, and seasonal patterns of human brucellosis in India; identify affected age groups and occupations, and examine risk factors contributing to its spread.</p><p><strong>Methods: </strong>'PubMed, Embase, and Scopus' databases were explored for literature until September 3, 2024. Terms included in the search strategy were 'Human Brucellosis' AND 'Prevalence,' 'Risk factors,' 'India.' Manual searches were also conducted on 'Google Scholar,' and relevant articles were selected.</p><p><strong>Results: </strong>Final review included twenty-nine articles. According to the 'JOANNA BRIGGS INSTITUTE (JBI) CHECKLIST,' 4 studies have a low 'risk of bias' and 15 studies have moderate 'risk of bias.' Brucellosis affects individuals across all age groups, from children to older adults, with the highest number of cases occurring in the 20-40-year age group. Men are most affected, and IgG ELISA has the highest seropositive cases in all the studies.</p><p><strong>Interpretation conclusion: </strong>This review highlights that human brucellosis constitutes a major public health issue in India, with higher prevalence in rural areas and among individuals with occupational exposure to livestock or animal products. Males are most affected; however, findings on gender susceptibility remain inconsistent, warranting further investigation.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stegomyia mosquitoes in the airport and seaports of Sri Vijaya Puram, Andaman and Nicobar Islands: A popular tourist destination.","authors":"M Kaliyamoorthy, Avijit Roy, Kannan Thiruvengadam, Sunish I Pulikkottil, Tapash Kumar Dakuya, Ajit Kumar, B Sumit Kumar Rao, Vivek K Sahu, Addepalli Premkumar","doi":"10.4103/jvbd.jvbd_44_25","DOIUrl":"https://doi.org/10.4103/jvbd.jvbd_44_25","url":null,"abstract":"<p><strong>Background objectives: </strong>The breeding potential of vector mosquitoes of dengue and chikungunya viruses in and around airport and seaport of Sri Vijaya Puram (Port Blair), Andaman & Nicobar Islands was explored.</p><p><strong>Methods: </strong>The survey was carried out for two years during the months of March and April. All the water holding containers in the residential and non-residential areas of airport and seaport were surveyed for Aedes immatures.</p><p><strong>Results: </strong>The Stegomyia indices were higher in 2023 compared to 2024. The indices in 2023; the HI, CI, BI and PI were 20.1, 5.6, 32.4 and 86.0, respectively, whereas in 2024, these values declined to 6.8, 1.9, 9.6 and 17.4. Two Aedes species; Ae. aegypti and Ae. albopictus were found in the surveyed containers, with the former in higher proportion. In 2023, larger drum/tanks had higher CI values, while in 2024 smaller containers had more positivity. Ovitrap index showed significant difference (P<0.05) between the two years in both airport and seaport. The percentage positivity for Aedes eggs was 41.2% (n=97) and 36.7% (n=79) in airport and seaport respectively.</p><p><strong>Interpretation conclusion: </strong>This study is the first comprehensive entomological survey conducted at the Sri Vijaya Puram International Airport and seaport. It offers the data on Aedes mosquitoes, especially Ae. aegypti, principal vector of arboviruses, at critical entry points, which are the key vulnerable zones of Andaman and Nicobar archipelago. Study highlights the urgent need for systematic vector surveillance and effective control measures.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of pharmacokinetic properties prediction of ADME.","authors":"Afnan Shakoori, Zain Alhindi, Mohammad Alobaidy, Amna Moulana, Ayman Qashgari, Rehab M Bagadood, Ghadir Sindi, Banan Atwah, Anmar Anwar Khan","doi":"10.4103/jvbd.jvbd_65_24","DOIUrl":"10.4103/jvbd.jvbd_65_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Quantum chemical and molecular docking practices deliver new perceptions into how etoposide, novobiocin, nogalamycin and netropsin interact with the biological targets PF3D7_0918600 ( Plasmodium falciparum 3D7). Further, pharmacokinetics of a drug candidate which is influenced by a variety of factors, including P-glycoprotein (Pgp) transport, PBB (Plasma protein binding), and BBB (Blood-brain barrier) permeation, help to forecast the pharmacological characteristics of acetyl-CoA reductase inhibitors (ADMEs) and their metabolites.</p><p><strong>Methods: </strong>We have elevated four compounds, etoposide, novobiocin, nogalamycin and netropsin. We have studied molecular docking against target protein of Plasmodium falciparum (PF3D7_0918600) through AutoDock Vina platform and AutoDock-Tools (ADT) and pharmacokinetic properties were carried out using ADMET 2.0.</p><p><strong>Results: </strong>The relative results of molecular docking recommended a greater binding affinity of novobiocin with the selected receptors among other compounds. In silico ADME screening is a computational approach utilised to forecast the pharmacological characteristics of acetyl-CoA reductase inhibitors (ADMEs) and their metabolites.</p><p><strong>Interpretation conclusion: </strong>The ADMEs are based on adsorption-desorption kinetics and pharmacopoeia. Adsorption and distribution analysis is used to assess the potential of a drug candidate. In vitro ADME is exploited to expect the effect of Pgp transport on the drug candidates. ADME has been used to predict CYP1A2 inhibitors and to predict PPB and BBB penetration. This work summarizes the current knowledge on molecular docking, ADME and identifies potential drug candidates for ADME in vitro and in vivo .</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"295-302"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embryonic dormancy in Aedes aegypti and Aedes albopictus (Diptera: Culicidae): A survival and dispersal mechanism.","authors":"Kelly de Oliveira Germano, Lucas Alexandre Farias de Souza, Ana Margarida Ribeiro do Amaral, Nildimar Alves Honório, Tamara Lima Camara, Magda Clara Vieira da Costa-Ribeiro","doi":"10.4103/jvbd.jvbd_115_24","DOIUrl":"10.4103/jvbd.jvbd_115_24","url":null,"abstract":"<p><p>Aedes aegypti and Aedes albopictus are the main vectors of arboviruses such as dengue, Zika virus, and chikungunya. Ae. aegypti is a widely spread mosquito in tropical and subtropical regions, whereas Ae. albopictus is a culicid of Asian origin that shows exophilic behavior and can be found in subtropical and temperate areas. Climatic factors could influence the distribution of both species, making them use genetic and environmental resources to adapt to the environment, activating survival mechanisms (embryonic dormancy) that increase the developmental period and keep their offspring in the environment. This review aimed to compare the different physiological mechanisms of embryonic dormancy between Ae. aegypti and Ae. albopictus and their impact on the development and environmental adaptability of these two species. A total of 62 articles were identified from PubMed, Scopus, and Web of Science databases corresponding to the period from 1981 to 2021. In diapause, the results mentioned above are indirectly linked to temperature and directly linked to photoperiod variations. With regard to quiescence, temperature and humidity are directly related to the activation of this mechanism. In conclusion, it is essential to highlight the expansion of arboviruses such as dengue, chikungunya, yellow fever, and Zika virus and their relationship with embryonic dormancy, diapause and quiescence which are extremely important strategies for Ae. aegypti and Ae. albopictus to keep their offspring in the environment under adverse conditions.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"253-260"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lyme disease: A comprehensive perspective on pathogen biology, clinical aspects and epidemiology in India.","authors":"Pulamoola Kelu Sarath, Embalil Mathachan Aneesh","doi":"10.4103/jvbd.jvbd_177_24","DOIUrl":"10.4103/jvbd.jvbd_177_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Lyme disease is a multisystem illness caused by the spirochaetes bacteria belonging to the genus Borrelia . It is a tick-borne disease that poses serious health concerns in major parts of the world including India. This review aims to comprehend the disease in depth encompassing its pathogen biology, clinical presentations, diagnosis, treatment strategies, epidemiology in India, and preventive measures against it.</p><p><strong>Methods: </strong>Peer-reviewed articles, reviews, meta-analyses and clinical studies relating to the topic were searched across reliable electronic databases like PubMed, and ScienceDirect, without imposing any time restriction for up-to-date information with a focus on sources indexed in the Science Citation Index (SCI).</p><p><strong>Results: </strong>The pathogen is a gram-negative bacterium namely Borrelia burgdorferi infesting ticks mainly belonging to the genus Ixodes . Clinical presentations vary from single Erethema Chronicum Migrans (ECM) to neurological complexities, cardiac disorders, and severe arthritic conditions. A two-tiered test recommended by Centre for Disease Control is currently employed to diagnose the disease. Fifteen out of 28 states in India have reports of Lyme disease; most of these states also have Ixodes ticks. However, the exact vector is not confirmed in India.</p><p><strong>Interpretation conclusion: </strong>Thirteen of the 15 states where Lyme disease cases have been reported have also had ticks belonging to the genus Ixodes . Thus, it can be assumed that vectors of Lyme disease in India are Ixodes sp. More studies are required to confirm and validate this assumption, and find the exact species of the vector tick. As an ignored vector-borne disease in India, Lyme disease warrants more research and surveillance.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"279-286"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with dengue outbreaks in Pulau Pinang, Malaysia from the eDengue Database: A cross-sectional study.","authors":"Mohamad Zuhair Mohamed Yusoff, Aimi Nadira Mat Ruzlin, Mariam Mohamad, Mohamad Azfar Zainuddin","doi":"10.4103/jvbd.jvbd_127_24","DOIUrl":"10.4103/jvbd.jvbd_127_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Dengue is now endemic in over 100 countries, with Asia bearing over 70% of the global burden. In Malaysia, dengue cases have increased dramatically, particularly in Pulau Pinang, where cases rose from 1621 in 2022 to 7343 in 2023. This study aimed to examine factors associated with dengue outbreaks in Pulau Pinang in 2023 by comparing outbreak cases with single cases.</p><p><strong>Methods: </strong>This is a cross-sectional study using eDengue database, the Malaysian National Dengue Registry.</p><p><strong>Results: </strong>The study included 1106 confirmed dengue cases, with 553 categorised as outbreak cases and 553 as single cases. Significant associations were found between dengue outbreaks and Priority Locality 1 (areas with Uncontrolled Outbreaks/ Hotspots/ Recurrent Outbreaks/ Dengue Deaths in the previous year) (aOR: 0.15, 95% CI: 0.06,0.37, p<0.001), Aedes Index ≥1% (aOR: 1.35, 95% CI: 1.02,1.77, p=0.031), patients initially visiting government clinics (aOR: 1.63, 95% CI: 1.10,2.43, p=0.015), hospitalized dengue patients (aOR: 0.70. 95%CI: 0.52,0.96, p=0.029), the time taken from notification to source reduction (aOR: 0.57, 95% CI: 0.50,0.66, p<0.001) and time taken from notification to investigation (aOR: 2.40 95%CI: 1.77,3.24, p<0.001).</p><p><strong>Interpretation conclusion: </strong>This study identifies key factors associated with dengue outbreaks in Pulau Pinang such as Aedes Index, Priority Locality 1 areas and initial visits to government clinics. These findings underscore the need for targeted vector control and early intervention in high-risk areas to reduce outbreak risk. Early healthcare seeking behavior and timely intervention are critical in managing the spread of dengue. Further research is needed to explore additional factors and improve public health strategies.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"310-319"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lectin microarray analysis of salivary gland glycoproteins from arboviral vector Aedes aegypti and malaria vector Anopheles stephensi.","authors":"Ranjan Ramasamy, Xi Chen, Jian Zhang, Kokila Sivabalakrishnan, Sivasingham Arthiyan, Sinnathamby N Surendran","doi":"10.4103/jvbd.jvbd_147_24","DOIUrl":"10.4103/jvbd.jvbd_147_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Salivary gland proteins but not glycoconjugates have been previously studied in mosquito vectors of human diseases. Glycoconjugates from salivary gland-derived proteins from human-feeding tick vectors can elicit hypersensitivity reactions which may also occur with mosquito bites. Protein glycoconjugate in salivary glands of the principal arboviral vector Aedes aegypti and the rapidly spreading malaria vector Anopheles stephensi were investigated.</p><p><strong>Methods: </strong>Forty different lectins in a microarray were used to analyse glycoconjugates in salivary gland proteins from both mosquito species.</p><p><strong>Results: </strong>Salivary gland glycoproteins of both mosquitoes possessed similar lectin-binding specificities. Lectin-binding profiles in both mosquitoes showed the significant presence of oligomannose N-linked glycans, O-linked glycans, a limited presence of glycan structures capped with terminal GalNAc, GlcNAc, β-linked Gal, αl-6 linked fucose, and no detectable sialic acids or terminal α-linked Gal in salivary gland glycoproteins.</p><p><strong>Interpretation conclusion: </strong>Aedes aegypti and An. stephensi possess similar salivary gland protein glycoconjugates to mosquito larval tissues. They differ from arachnid ticks in lacking detectable α-gal epitopes that are responsible for red meat allergy caused by tick bites.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"326-331"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of climatic factors on the perennial malaria cases in Kalahandi district of Odisha, eastern India.","authors":"Subrat Kumar Panigrahi, Smruti Ranjan Parida, Dibyanee Mohanty, Punyatoya Panda, Manoj Kumar Meher, Priyanka Mohanty, Pruthiraj Mohapatra, Aishwarya B Acharya, Bijayalaxmi Sahu, Tapan Kumar Barik","doi":"10.4103/jvbd.jvbd_190_24","DOIUrl":"10.4103/jvbd.jvbd_190_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Vector-borne diseases, particularly mosquito-bome illnesses, cause significant global health challenges, leading to approximately 700,000 deaths annually. In India, malaria remains a critical issue, especially in regions like Odisha state, where climatic factors heavily influence transmission dynamics. The study aimed to investigate the correlation between climatic factors (rainfall, temperature, and humidity) and malaria transmission in Kalahandi district of Odisha, India. This work focuses on understanding how local weather conditions affect mosquito breeding, population dynamics, and malaria incidence.</p><p><strong>Methods: </strong>Epidemiological data from 2019 to 2021 on malaria cases was collected from the Chief District Medical Officer's office in Kalahandi. Entomological data were gathered bimonthly by capturing mosquitoes from various locations in Kalahandi using standard methods. Meteorological data, including monthly rainfall, temperature, and humidity, were obtained from the Odisha government database. The data were analyzed using correlation analysis, linear regression, and Pearson correlation to explore the relationship between weather parameters and malaria cases.</p><p><strong>Results: </strong>The study found that rainfall positively correlates with malaria incidence, particularly during peak rainy seasons (July to September). Plasmodium falciparum cases showed a strong association with precipitation, while temperature and humidity showed mixed results. Excessive rainfall, however, may disrupt mosquito breeding sites.</p><p><strong>Interpretation conclusion: </strong>It was noticed that Anopheles culicifacies was prevalent year-round but was particularly dense during the winter and summer (pre-monsoon) seasons, often in conjunction with Anopheles fluviatilis . The findings highlight the complex interplay of climatic factors influencing malaria transmission in the region, with rainfall being the most significant driver.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"351-361"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of dengue infection and risk factors for severe dengue in Indian children.","authors":"Neeraj T Panchanadikar, Sonali H Palkar, Sanjay K Lalwani","doi":"10.4103/jvbd.jvbd_43_24","DOIUrl":"10.4103/jvbd.jvbd_43_24","url":null,"abstract":"<p><strong>Background objectives: </strong>Dengue, a fast-growing vector-borne disease, has an estimated case-fatality rate of 5% and India is largely affected by dengue. Due to its unpredictable course and non-availability of specific treatment, timely identification of risk factors of severe dengue and its management is crucial. This study aimed to evaluate the clinical profile of children admitted to a tertiary care hospital with dengue, including their outcome, and identify the risk factors for severe dengue.</p><p><strong>Methods: </strong>This prospective observational study included children admitted with serologically confirmed dengue. World Health Organization classification was used to classify the illness. The details of demographic characteristics, history, clinical examination, laboratory parameters, and outcome were noted. Various risk factors associated with severe dengue, including clinical and laboratory parameters, were determined using crude and adjusted odds ratios at 95% CI.</p><p><strong>Results: </strong>Out of 157 enrolled children, 51 (32.5%) had severe dengue, and 5 (3.2%) died. Severe dengue showed no predilection for age, gender, or baseline IgG positivity. Multivariate-logistic regression analysis identified only fever ≥39°C [aOR 4.06 (1.60-10.27)] and petechiae [aOR 9.91(3.07-32.03)] as the clinical risk factors for severe dengue. Prolonged prothrombin time (>14s) [aOR 37.21(1.46-946.23)] and platelet count less than 50,000/cu mm [aOR 12.83(1.12-147.17] were observed as independent laboratory risk factors for severe dengue.</p><p><strong>Interpretation conclusion: </strong>Simple clinical measures like a detailed history of fever >39°C and examination, especially for petechiae, should caution clinicians against progressing to severe dengue. Along with platelet count, prothrombin time should also be monitored during laboratory investigations.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":"344-350"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}