Journal of Vector Borne Diseases最新文献_第4页

Effect of dexamethasone therapy in Crimean-Congo hemorrhagic fever in Giresun during 2021-2023: an analytical study. 2021-2023 年地塞米松疗法对吉雷松克里米亚-刚果出血热的影响：一项分析研究。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-29 DOI: 10.4103/JVBD_JVBD_95_24

Sinan Çetin, Ahmet Melih Şahin, Emrullah Ataş, Emsal Aydın, İlknur Şenel, Meltem Arzu Yetkin

{"title":"Effect of dexamethasone therapy in Crimean-Congo hemorrhagic fever in Giresun during 2021-2023: an analytical study.","authors":"Sinan Çetin, Ahmet Melih Şahin, Emrullah Ataş, Emsal Aydın, İlknur Şenel, Meltem Arzu Yetkin","doi":"10.4103/JVBD_JVBD_95_24","DOIUrl":"https://doi.org/10.4103/JVBD_JVBD_95_24","url":null,"abstract":"Background objectives: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic disease and significant health concern particularly in endemic regions. We aimed to evaluate the efficacy in dexamethasone treatment on clinical outcomes in CCHF patients.Methods: We included adult patients diagnosed with CCHF and those whose platelet count dropped to 70,000/mm3 or lower. The efficacy of dexamethasone on clinical outcomes was evaluated. It was a retrospective analytical study.Results: The study included 55 patients. All patients received standard supportive treatment, and none of them received ribavirin therapy. It was observed that 23 (41.8%) of the patients were treated with dexamethasone. No significant differences were observed between patients treated with dexamethasone and those without dexamethasone treatment, regarding factors such as bleeding incidents during hospitalization, the need for blood product transfusions, thrombocyte recovery status, intensive care unit admission, and in-hospital mortality. In-hospital mortality was observed in two patients among all patients (3.6%).Interpretation conclusion: Our study found that dexamethasone treatment did not lead to a significant improvement in clinical outcomes for CCHF patients.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serotypic and genotypic profile of dengue virus outbreaks in India between 2011 and 2017. 2011 年至 2017 年印度爆发的登革热病毒血清型和基因型概况。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_101_24

Ashvini Kumar Yadav, Divya Namdeo, Prashant Khare, Shashwati Nema, Abhijit Pakhare, Rashmi Chowdhary, Debasis Biswas

{"title":"Serotypic and genotypic profile of dengue virus outbreaks in India between 2011 and 2017.","authors":"Ashvini Kumar Yadav, Divya Namdeo, Prashant Khare, Shashwati Nema, Abhijit Pakhare, Rashmi Chowdhary, Debasis Biswas","doi":"10.4103/JVBD.JVBD_101_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_101_24","url":null,"abstract":"The epidemiology of dengue has been demonstrating significant changes in recent years, with rising incidence of infection in countries with known endemicity and occurrence of fresh outbreaks in previously unaffected territories. India, which has been a traditional hotspot dengue virus (DENV) transmission in the endemic south-east Asian region, has also been affected by the sweeping changes in dengue epidemiology. Two remarkable developments characterize the alterations witnessed by India 2011-2017. Firstly, all parts of the country have witnessed abrupt replacement of existing DENV lineages with emerging novel strains. Secondly, co-circulation of multiple serotypes of DENV have been reported from all across the country 2011-2017; thereby hinting at the transition of the country towards hyper-endemicity. Considering the potential clinical implications of such epidemiological transformation in terms increasing involvement of pediatric patients and growing predisposition to serious complications, the present review provides an update on the serotypic and genotypic profile of dengue outbreaks that have been witnessed by different zones of India between 2011 and 2017. Dividing the country into northern, southern, eastern, western, central and north-eastern zones, we describe discrete zone-specific distribution patterns of DENV serotypes and genotypes and observe simultaneous circulation of different DENV strains in different parts of the country. Random shifts in the genetic characteristics of the circulating strains and the widespread co- circulation of all four serotypes underscore the need for undertaking continuous and representative molecular surveillance of the circulating DENV strains across the country for prompt identification of emerging strains and novel mutants; gain insights into the formulation of Dengue vaccines and develop a clearer understanding of the molecular basis of immune evasion, disease epidemiology and pathogenesis.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of larvicidal, growth-suppressing, and developmentaltering bioefficacy of Ageratum houstonianum against Aedes aegypti (L.). 评估Ageratum houstonianum对埃及伊蚊的杀幼虫、抑制生长和发育的生物功效。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_100_24

Vijay Kumar Shah, Kamal Kumar Gupta

{"title":"Assessment of larvicidal, growth-suppressing, and developmentaltering bioefficacy of Ageratum houstonianum against Aedes aegypti (L.).","authors":"Vijay Kumar Shah, Kamal Kumar Gupta","doi":"10.4103/JVBD.JVBD_100_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_100_24","url":null,"abstract":"Background objectives: Aedes aegypti is a major vector responsible for spreading dengue, chikungunya, yellow fever, and Zika viruses worldwide. These illnesses have increased globally due to climate and environmental changes. Vector control and management are the principal tactics for combating mosquitoes-borne diseases in the absence of an effective vaccine. The study aimed to ascertain bioactivities of Ageratum houstonianum leaf acetone extract (AhLAE) against Aedes aegypti.Methods: Bioefficacy of AhLAE was tested against fourth instar larvae (L4) of Ae. aegypti using standard WHO protocol. The mortality, growth, and development of larvae, pupae and adults were recorded after exposure to the extract.Results: The AhLAE showed larvicidal activity against L4 with LC50 and LC90 values of 401.88 and 691.24 mg/L, respectively. The mortality of the larvae further increased on subsequent days. The AhLAE caused a significant reduction in pupae formation and adult emergence. It also increased the larval duration of L4 and development duration of the pupa formed from the treated L4, indicating its growth-suppressing effects. The impact of the AhLAE was dose-dependent; high concentrations caused reduction in survival and growth of L4. Consequently, the L4-pupal and L4-adult growth indexes decreased. Additionally, the AhLAE induced developmental anomalies in the form of larva-pupa (L-P) intermediates.Interpretation conclusion: The study found that the AhLAE exhibited larvicidal, growth-suppressing, and development-altering activities against Ae. aegypti. The findings suggest the potential of AhALE as a natural insecticidal agent for controlling mosquitoes.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of the Pharmacokinetic Properties Prediction of ADME. 将化合物与 DNA 螺旋酶 Q1 恶性疟原虫 3D7 相互螯合：药代动力学特性评估 ADME 预测。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_65_24

Afnan Shakoori, Zain Alhindi, Mohammad Alobaidy, Amna Moulana, Ayman Qashgari, Rehab M Bagadood, Ghadir Sindi, Banan Atwah, Anmar Anwar Khan

{"title":"Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of the Pharmacokinetic Properties Prediction of ADME.","authors":"Afnan Shakoori, Zain Alhindi, Mohammad Alobaidy, Amna Moulana, Ayman Qashgari, Rehab M Bagadood, Ghadir Sindi, Banan Atwah, Anmar Anwar Khan","doi":"10.4103/JVBD.JVBD_65_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_65_24","url":null,"abstract":"Background objectives: Quantum chemical & molecular docking practices to deliver new perceptions into how etoposide, novobiocin, nogalamycin and netropsin interact with the biological targets PF3D7_0918600 (Plasmodium falciparum 3D7). Further the pharmacokinetics of a drug candidate which influenced by a variety of factors, including P- glycoprotein (Pgp) transport, PBB (Plasma protein binding), & BBB (Blood-brain barrier) permeation help to forecast the pharmacological characteristics of acetyl-CoA reductase inhibitors (ADMEs) and their metabolites.Methods: At this point, we have elevated four compounds such as etoposide, novobiocin, nogalamycin & netropsin. We have also studied molecular docking against the target protein of the Plasmodium falciparum (PF3D7_0918600) through exhausting the AutoDock Vina platform and AutoDock-Tools (ADT) and pharmacokinetic properties were carried out using the ADMET 2.0.Results: The relative results of molecular docking recommended a greater binding affinity of novobiocin with the selected receptors among other compounds. In-silico ADME screening is a computational approach utilised to forecast the pharmacological characteristics of acetyl- CoA reductase inhibitors (ADMEs) and their metabolites.Interpretation conclusion: The ADMEs are based on the adsorption-desorption kinetics and pharmacopoeia. Adsorption and distribution analysis are used to assess the potential of the drug candidate. In vitro ADME is exploited to expect the effect of Pgp transport on the drug candidates. ADME has been used to predict CYP1A2 inhibitors and to predict PPB and BBB penetration. This paper summarizes the current knowledge on molecular docking, ADME and identifies potential drug candidates for ADME in vitro and in vivo.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embryonic dormancy in Aedes aegypti and Aedes albopictus (Diptera: Culicidae): a survival and dispersal mechanism. 埃及伊蚊和白纹伊蚊（双翅目：库蚊科）胚胎休眠：生存和传播机制。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_115_24

K O Germano, Laf De Souza, Amr Amaral, N A Honório, T Camara-Lima, McV Costa-Ribeiro

{"title":"Embryonic dormancy in Aedes aegypti and Aedes albopictus (Diptera: Culicidae): a survival and dispersal mechanism.","authors":"K O Germano, Laf De Souza, Amr Amaral, N A Honório, T Camara-Lima, McV Costa-Ribeiro","doi":"10.4103/JVBD.JVBD_115_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_115_24","url":null,"abstract":"Aedes aegypti and Aedes albopictus are the main vectors of arboviruses such as dengue, Zika virus, and chikungunya. Ae. aegypti is a widely spread mosquito in tropical and subtropical regions, whereas Ae. albopictus is a culicid of Asian origin that shows exophilic behavior and can be found in subtropical and temperate areas. Climatic factors could influence the distribution of both species, making them use genetic and environmental resources to adapt to the environment, activating survival mechanisms (embryonic dormancy) that increase the developmental period and keep their offspring in the environment. From this perspective, this review aimed to compare the different physiological mechanisms of embryonic dormancy between Ae. aegypti and Ae. albopictus and their impact on the development and environmental adaptability of these two species. A total of 62 articles were identified in the PubMed, Scopus, and Web of Science databases corresponding to the period from 1981 to 2021. In diapause, the results mentioned above are indirectly linked to temperature and directly linked to photoperiod variations. With regard to quiescence, temperature and humidity are directly related to the activation of this mechanism. In conclusion, it is essential to highlight the expansion of arboviruses such as dengue, chikungunya, yellow fever, and Zika virus and their relationship with embryonic dormancy, diapause and quiescence, extremely important strategies for Ae. aegypti and Ae. albopictus to keep their offspring in the environment under adverse conditions.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the gaps: prioritizing research strategies for enhanced malaria control and elimination. 缩小差距：确定加强疟疾控制和消除的研究战略的优先次序。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_45_24

Rashed Alghamdi

{"title":"Bridging the gaps: prioritizing research strategies for enhanced malaria control and elimination.","authors":"Rashed Alghamdi","doi":"10.4103/JVBD.JVBD_45_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_45_24","url":null,"abstract":"Malaria continues to be a significant global health challenge, with millions of cases and hundreds of thousands of deaths reported annually. To combat this disease effectively, it is imperative to identify and address significant research gaps in malaria control and elimination efforts. This review synthesizes current knowledge and highlights critical gaps in several crucial areas of malaria research. Firstly, we discuss the complexities of vector biology and control, emphasizing the need for a deeper understanding of vector behavior, particularly in urban settings. Secondly, the study examines the challenges posed by drug resistance and the urgent need for alternative treatment strategies and novel drug targets. Thirdly, the review explores the ongoing quest for an effective malaria vaccine, underscoring the importance of understanding immunological correlates of protection. The study also explores medication resistance genes and genomic epidemiology, highlighting the need for more investigation into potential targets for drugs and vaccine candidates. Furthermore, it addresses the socioeconomic and environmental determinants of malaria transmission, highlighting the importance of integrating multidisciplinary approaches to address transmission dynamics. The study concludes with a discussion of how malaria transmission is impacted by climate change and the necessity of research to guide adaptation measures.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Susceptibility of temephos against Aedes aegypti and Anopheles stephensi mosquito larvae in Dehradun of Uttarakhand, India. 印度北阿坎德邦德拉敦地区双硫磷对埃及伊蚊和斯氏按蚊幼虫的敏感性分析。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_98_24

R K Singh, Gaurav Kumar, Subhash Joshi, Anup R Anvikar

{"title":"Susceptibility of temephos against Aedes aegypti and Anopheles stephensi mosquito larvae in Dehradun of Uttarakhand, India.","authors":"R K Singh, Gaurav Kumar, Subhash Joshi, Anup R Anvikar","doi":"10.4103/JVBD.JVBD_98_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_98_24","url":null,"abstract":"Background objectives: Temephos is being used regularly to control immature of vector borne diseases in various states in India.Methods: World Health Organization method was used to evaluate larval susceptibility status of Aedes aegypti and Anopheles stephensi against temephos in Dehradun of Uttarakhand.Results: The results of the study revealed that the larval mortality in different localities ranged from 67.11% to 98.22%, the-lowest mortality was recorded from Kedarpuram (67.11%) and highest larval was recorded from Vikash Nagar (98.88%). The study revealed that most of larval populations of Ae. aegypti were resistant or under verification required category against temephos at diagnostic concentrations collected from six different localities of study area of Dehradun while only one larval population of Ae. aegypti was found susceptible. However, Anopheles stephensi larvae collected from all sites were susceptible at diagnostic concentration of temephos.Interpretation conclusion: The study highlights the potential development of resistance to temephos in Ae. aegypti across most of the study areas in Dehradun.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Japanese encephalitis virus: An overview. 日本脑炎病毒：概述。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_49_24

Qiuyang Li, Xiaoling Cheng, Min Luo, Jinrong Shi

引用次数: 0

Application of Artificial Intelligence for quantifying Plasmodium berghei in blood samples from infected mice. 应用人工智能定量检测感染小鼠血液中的伯氏疟原虫。

IF 0.8 4区医学

Journal of Vector Borne Diseases Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_86_24

Noha Talal Zelai

引用次数: 0

Accelerating the fight towards malaria elimination: bridging gaps to achieve health equity in India. 加快消除疟疾的斗争：弥合差距，实现印度的卫生公平。