Epidemiology of Human Brucellosis in India: A Systematic Review.

IF 0.8 4区医学 Q4 INFECTIOUS DISEASES

Journal of Vector Borne Diseases Pub Date : 2025-07-02 DOI:10.4103/jvbd.jvbd_235_24

Dhanashree V Manjrekar, Tushar N Nale, Yogesh A Bahurupi, Ajit D Shewale, Jitesh S Kuwatada, Simmi Tiwari

{"title":"Epidemiology of Human Brucellosis in India: A Systematic Review.","authors":"Dhanashree V Manjrekar, Tushar N Nale, Yogesh A Bahurupi, Ajit D Shewale, Jitesh S Kuwatada, Simmi Tiwari","doi":"10.4103/jvbd.jvbd_235_24","DOIUrl":null,"url":null,"abstract":"Background objectives: Brucellosis, a bacterial zoonotic disease, is caused by various species of Brucella, predominantly affecting livestock. In India, human brucellosis is a significant public health concern due to the proximity between humans and animals. Moreover, the under-reporting of cases and misdiagnosis of human brucellosis make it difficult to assess the problem and develop effective public health interventions. Therefore, the study's objectives were to estimate the prevalence, geographic spread, and seasonal patterns of human brucellosis in India; identify affected age groups and occupations, and examine risk factors contributing to its spread.Methods: 'PubMed, Embase, and Scopus' databases were explored for literature until September 3, 2024. Terms included in the search strategy were 'Human Brucellosis' AND 'Prevalence,' 'Risk factors,' 'India.' Manual searches were also conducted on 'Google Scholar,' and relevant articles were selected.Results: Final review included twenty-nine articles. According to the 'JOANNA BRIGGS INSTITUTE (JBI) CHECKLIST,' 4 studies have a low 'risk of bias' and 15 studies have moderate 'risk of bias.' Brucellosis affects individuals across all age groups, from children to older adults, with the highest number of cases occurring in the 20-40-year age group. Men are most affected, and IgG ELISA has the highest seropositive cases in all the studies.Interpretation conclusion: This review highlights that human brucellosis constitutes a major public health issue in India, with higher prevalence in rural areas and among individuals with occupational exposure to livestock or animal products. Males are most affected; however, findings on gender susceptibility remain inconsistent, warranting further investigation.","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Vector Borne Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/jvbd.jvbd_235_24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background objectives: Brucellosis, a bacterial zoonotic disease, is caused by various species of Brucella, predominantly affecting livestock. In India, human brucellosis is a significant public health concern due to the proximity between humans and animals. Moreover, the under-reporting of cases and misdiagnosis of human brucellosis make it difficult to assess the problem and develop effective public health interventions. Therefore, the study's objectives were to estimate the prevalence, geographic spread, and seasonal patterns of human brucellosis in India; identify affected age groups and occupations, and examine risk factors contributing to its spread.

Methods: 'PubMed, Embase, and Scopus' databases were explored for literature until September 3, 2024. Terms included in the search strategy were 'Human Brucellosis' AND 'Prevalence,' 'Risk factors,' 'India.' Manual searches were also conducted on 'Google Scholar,' and relevant articles were selected.

Results: Final review included twenty-nine articles. According to the 'JOANNA BRIGGS INSTITUTE (JBI) CHECKLIST,' 4 studies have a low 'risk of bias' and 15 studies have moderate 'risk of bias.' Brucellosis affects individuals across all age groups, from children to older adults, with the highest number of cases occurring in the 20-40-year age group. Men are most affected, and IgG ELISA has the highest seropositive cases in all the studies.

Interpretation conclusion: This review highlights that human brucellosis constitutes a major public health issue in India, with higher prevalence in rural areas and among individuals with occupational exposure to livestock or animal products. Males are most affected; however, findings on gender susceptibility remain inconsistent, warranting further investigation.

查看原文本刊更多论文

印度人类布鲁氏菌病的流行病学：系统综述。

背景目的：布鲁氏菌病是一种细菌性人畜共患疾病，由多种布鲁氏菌引起，主要影响牲畜。在印度，人类布鲁氏菌病是一个重大的公共卫生问题，因为人与动物接近。此外，人布鲁氏菌病病例的少报和误诊使得难以评估这一问题并制定有效的公共卫生干预措施。因此，该研究的目的是估计印度人类布鲁氏菌病的流行、地理传播和季节性模式；确定受影响的年龄组和职业，并检查导致其传播的危险因素。方法：检索PubMed、Embase和Scopus数据库，检索文献至2024年9月3日。搜索策略包括“人类布鲁氏菌病”和“流行”、“风险因素”、“印度”。在“谷歌Scholar”上也进行了人工搜索，并选择了相关文章。结果：终检纳入29篇文章。根据乔安娜布里格斯研究所（JOANNA BRIGGS INSTITUTE， JBI）的检查清单，4项研究具有低“偏倚风险”，15项研究具有中等“偏倚风险”。布鲁氏菌病影响所有年龄组的个体，从儿童到老年人，20-40岁年龄组的病例数最多。男性受影响最大，在所有研究中IgG ELISA的血清阳性病例最高。解读结论：本综述强调，人类布鲁氏菌病是印度的一个主要公共卫生问题，在农村地区和职业接触牲畜或动物产品的个人中发病率较高。男性受影响最大；然而，关于性别易感性的调查结果仍然不一致，需要进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Vector Borne Diseases INFECTIOUS DISEASES-PARASITOLOGY

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： National Institute of Malaria Research on behalf of Indian Council of Medical Research (ICMR) publishes the Journal of Vector Borne Diseases. This Journal was earlier published as the Indian Journal of Malariology, a peer reviewed and open access biomedical journal in the field of vector borne diseases. The Journal publishes review articles, original research articles, short research communications, case reports of prime importance, letters to the editor in the field of vector borne diseases and their control.