Journal of veterinary emergency and critical care最新文献

{"title":"Clinical Features, Medical Management, and Patient Outcomes Following Sand Ingestion in 55 Dogs (2018–2024)","authors":"Ashley Gao,&nbsp;Rebecca Walton,&nbsp;Jennifer Hall,&nbsp;Sarah Nugen,&nbsp;Jiazhang Cai,&nbsp;Andreas Handel,&nbsp;Jonathan P. Mochel","doi":"10.1111/vec.70150","DOIUrl":"10.1111/vec.70150","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the management and outcome in dogs after sand ingestion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective study performed between January 2018 and December 2024, including 55 dogs with radiographically confirmed sand ingestion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nineteen dogs (35%) had radiographs consistent with a gastrointestinal obstruction. All dogs were medically managed, and no dog underwent surgical intervention. Twenty-six dogs (47%) were hospitalized, while 29 (53%) received outpatient therapy. Hospitalization was recommended but was declined by the owner in 19 dogs (66%) managed as outpatients. Hospitalization was not recommended in 10 dogs due to the identification of sand only in the distal small intestines or colon. Dogs that were managed as outpatients were significantly younger and had lower total plasma protein concentration than dogs that were managed as inpatients. In addition, dogs managed as outpatients had lower blood lactate concentrations than inpatients. All hospitalized dogs (100%) had resolution of clinical signs, and 29 of the 30 dogs that received outpatient care (97%) had complete resolution of clinical signs. One dog (3%) was lost to follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The prognosis associated with medical management for sand ingestion in dogs is excellent, and dogs managed as inpatients or outpatients had resolution of clinical signs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 5","pages":"668-672"},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference in Collection Times, Blood Gas Variables, and Atelectasis Between Two Arterial Sampling Methods in Dogs","authors":"Kento Sakai,&nbsp;Seijirow Goya,&nbsp;Chieko Ishikawa,&nbsp;Naoko Shiozawa,&nbsp;Tomohiro Nakayama","doi":"10.1111/vec.70171","DOIUrl":"10.1111/vec.70171","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess how two different arterial blood sampling methods, from the femoral artery (FA) or the dorsal pedal artery (DPA), influence the collection time, gas variables, and pulmonary atelectasis on computed tomography (CT) under sedation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Experimental, single-blind, crossover study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Veterinary university research facility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Eight healthy Beagle dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interventions</h3>\u0000 \u0000 <p>Butorphanol was administered subcutaneously before sampling. Arterial blood samples were collected using the FA or DPA in lateral or sternal recumbency, respectively, followed by hemostasis. Medetomidine was then administered intravenously, and thoracic CT was performed under sedation. Dogs remained in the same position throughout the procedure, from blood collection to completion of the thoracic CT scan. All variables were tested for normality using the Kolmogorov–Smirnov test. CT values were analyzed using the Student's <i>t</i>-test. PaO₂ and sampling time were analyzed using the Wilcoxon signed-rank test. Statistical significance was set at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements and Main Results</h3>\u0000 \u0000 <p>Collection time using the DPA method (47.5 s [31–69 s]) was significantly shorter than the FA method (94.5 s [65–126 s]) (<i>p</i> = 0.0156). No significant differences in gas variables were observed between the two methods. The mean CT values that indicated atelectasis in the cranial (<i>p</i> &lt; 0.01), middle (<i>p</i> = 0.0107), and caudal (<i>p</i> = 0.0146) lung lobes using the FA method were significantly higher than those using the DPA method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Blood collection was faster using the DPA method than the FA method, and even brief lateral recumbency during the FA method is associated with atelectasis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 5","pages":"640-648"},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome","authors":"Andreza Conti-Patara,&nbsp;Linda G. Martin","doi":"10.1111/vec.70167","DOIUrl":"10.1111/vec.70167","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To determine the use of resting serum cortisol concentration as a marker of outcome and illness severity as assessed by the Acute Patient Physiologic and Laboratory Evaluation (APPLE) full and fast scores in critically ill dogs with and without systemic inflammatory response syndrome (SIRS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Prospective, observational study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>University teaching hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Client-owned dogs were enrolled into three different groups: SIRS (30 dogs), non-SIRS (25), and healthy controls (19). Dogs with acute critical illness (&lt;48 h) admitted to the ICU were enrolled and classified into SIRS and non-SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interventions</h3>\u0000 \u0000 <p>None.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements and Results</h3>\u0000 \u0000 <p>Resting serum cortisol concentrations were higher in the SIRS and non-SIRS groups compared with the control group (<i>p</i> &lt; 0.001); however, there was no significant difference (<i>p</i> = 0.59) between the SIRS and non-SIRS groups. APPLE_full scores were higher in the SIRS group compared with the non-SIRS (<i>p</i> &lt; 0.0001) and control (<i>p</i> &lt; 0.0001) groups. The APPLE_full scores increased by 1 (95% CI: 0.6–1.4) for every increase of 62.5 nmol/L (2.2 µg/dL) in resting serum cortisol concentration. Resting serum cortisol concentrations were not associated with mortality (<i>p</i> = 0.33). There was moderate evidence that APPLE_full scores can predict mortality (<i>p</i> = 0.03).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Resting serum cortisol concentrations can be used as a marker of illness severity in critically ill patients with SIRS. Further studies enrolling larger numbers of cases may clarify its potential as a marker of outcome.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 5","pages":"632-639"},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Severe Bromethalin Toxicosis in a Dog, Including the Use of Prolonged Hemodiafiltration Therapy","authors":"Destinee T. Gardiner,&nbsp;Brett Montague","doi":"10.1111/vec.70165","DOIUrl":"10.1111/vec.70165","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To describe the management of severe bromethalin intoxication in a dog, including the use of extracorporeal therapies and their effects on serum desmethylbromethalin levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Summary</h3>\u0000 \u0000 <p>A 13-year-old neutered male miniature Australian Shepherd presented after suspected ingestion of bromethalin rodenticide. Despite intravenous fluids and activated charcoal, the dog progressively declined neurologically in a 24-h period, ultimately developing a Cushing reflex. Medical management included hyperosmotic therapies, antiepileptics, intralipids, and warm water enemas. Hemodiafiltration (HDF) was attempted due to the dog's continued decline and a persistently lipemic serum, which precluded repeated doses of intralipids. Serum desmethylbromethalin concentrations were measured before, during, and after HDF, and no clearance was noted across the filter or in the effluent. Regardless, the dog improved with a total hospitalization duration of 5 days and a complete return of neurologic function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> New or Unique Information Provided</h3>\u0000 \u0000 <p>This case describes the rapid and successful clinical recovery of a dog with the highest reported levels of desmethylbromethalin, with serum desmethylbromethalin concentrations decreasing faster than the expected half-life. HDF was attempted but was found to be unsuccessful in the clearance of bromethalin.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 5","pages":"703-708"},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Evaluation of the Association Between Mechanical Power and Outcome in Mechanically Ventilated Dogs from a Multicenter Database (2019–2025): 76 Cases","authors":"Tereza Stastny,&nbsp;Robert H. Markowitz,&nbsp;Dana J. Caldwell,&nbsp;Jiwoong Her,&nbsp;Rachel C. Clarkin-Breslin,&nbsp;Carolina S. Graham,&nbsp;Jeong E. Park,&nbsp;Deborah C. Silverstein","doi":"10.1111/vec.70159","DOIUrl":"10.1111/vec.70159","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To assess the association between mechanical power (MP) and survival in mechanically ventilated dogs with primary pulmonary parenchymal disease and to compare its prognostic performance against individual ventilator parameters and oxygenation indices.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Design&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Retrospective, multicenter observational cohort study.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Setting&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Three veterinary medical teaching institutions and one private veterinary referral center.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Animals&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Seventy-six client-owned dogs mechanically ventilated for primary pulmonary parenchymal disease between March 2019 and March 2025.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Interventions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;None.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;MP (J/min/kg) was calculated using a simplified equation for pressure-controlled (PC) ventilation: 0.098 × respiratory rate × tidal volume × (dynamic driving pressure + positive end-expiratory pressure). Median values were calculated per patient for each of the first 3 ventilation days. Multivariate logistic regression was used to assess associations between MP, its components, and survival. Area under the receiver operating characteristic curve was calculated to evaluate predictive performance.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Survivors had significantly lower MP values than nonsurvivors across all 3 initial days of ventilation (Day 1: 0.30 vs. 0.57 J/min/kg; Day 2: 0.33 vs. 0.55 J/min/kg; Day 3: 0.31 vs. 0.47 J/min/kg; &lt;i&gt;p&lt;/i&gt; = 0.008 to &lt;0.001). A 0.05-J/min/kg increase in MP was associated with a 19%, 26%, and 34% greater likelihood of mortality on Days 1, 2, and 3, respectively, with good discriminative performance (area under the receiver operating characteristic curve = 0.80, 0.84, and 0.84). Dynamic variables (respiratory rate, dynamic driving pressure, peak inspiratory pressure) were more strongly associated with survival than static variables (tidal volume, positive end-expiratory pressure).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;MP is associated with outcome in dogs undergoing mechanical ventilation and demonstrates ","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 5","pages":"659-667"},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.70159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causes and Outcome of Systemic Inflammatory Response Syndrome in Dogs: An Observational Study of 172 Cases","authors":"Myriam A. Knopf,&nbsp;Christiane Weingart,&nbsp;Roswitha Merle,&nbsp;Teresa Sandbrink,&nbsp;Antina Lübke-Becker,&nbsp;Marcus Fulde,&nbsp;Caroline Robé,&nbsp;Marianne Skrodzki,&nbsp;Uwe Rösler,&nbsp;Stefan Schwarz,&nbsp;Barbara Kohn","doi":"10.1111/vec.70143","DOIUrl":"10.1111/vec.70143","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate the clinical characteristics, underlying diseases, organ dysfunctions, and survival of dogs with systemic inflammatory response syndrome (SIRS) or sepsis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Design&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Prospective observational study from January to December, 2023.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Setting&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Single-center, veterinary university teaching hospital.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Animals&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;One hundred sixty-six dogs; six dogs with distinct cases of SIRS were included twice (172 cases).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Interventions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;None.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Measurements and Main Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Dogs were included if they met two or more of the four SIRS criteria (hypothermia or fever; tachycardia; tachypnea; leukocytosis, leukopenia, or left shift) and had a disease causing systemic inflammation. Cases were categorized into groups (G) “nonseptic SIRS” (G1: &lt;i&gt;n&lt;/i&gt; = 73), “sepsis” (G2: &lt;i&gt;n&lt;/i&gt; = 92), “sepsis without organ dysfunction” (G2a: &lt;i&gt;n&lt;/i&gt; = 25), “severe sepsis” (G2b: &lt;i&gt;n&lt;/i&gt; = 59; dysfunction of one or more organ systems), “septic shock” (G2c: &lt;i&gt;n&lt;/i&gt; = 8; hypotension despite adequate fluid resuscitation), and “SIRS of unclear origin” (G3: &lt;i&gt;n&lt;/i&gt; = 7). The most common causes of SIRS/sepsis were gastrointestinal diseases (&lt;i&gt;n&lt;/i&gt; = 61 [35.5%]), vector-borne diseases (&lt;i&gt;n&lt;/i&gt; = 28 [16.3%]), and neoplasia (&lt;i&gt;n&lt;/i&gt; = 22 [12.8%]). There was dysfunction of one or more organs in 114 cases (66.3%). The coagulation system was most frequently affected (&lt;i&gt;n&lt;/i&gt; = 78 [45.3%]), followed by the cardiovascular system (&lt;i&gt;n&lt;/i&gt; = 47 [27.3%]), respiratory tract (&lt;i&gt;n&lt;/i&gt; = 14 [8.1%]), kidney (&lt;i&gt;n&lt;/i&gt; = 13 [7.6%]), and liver (&lt;i&gt;n&lt;/i&gt; = 6 [3.5%]). Overall, 128 of 165 cases (77.6%) survived until discharge (short-term), and 116 of 159 (73%) survived ≥4 weeks after discharge (long-term). Differences in outcome were found between G1 and G2 (short-term: &lt;i&gt;p&lt;/i&gt; = 0.046, long-term: &lt;i&gt;p&lt;/i&gt; = 0.015), with dogs in G2 having better survival. Short-term mortality was higher in cases with one or more organ dysfunctions than in cases without (&lt;i&gt;p&lt;/i&gt; = 0.031).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;SIRS can be triggered by a variety of diseases in dogs. Stric","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 5","pages":"619-631"},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.70143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Baclofen Concentrations in Four Dogs With Baclofen Toxicosis Treated With In-Series Carbon Hemoperfusion and Hemodialysis","authors":"Amanda Spillane,&nbsp;Jiwoong Her,&nbsp;Nahvid Etedali,&nbsp;Joanna Finstad,&nbsp;Catherine Langston","doi":"10.1111/vec.70160","DOIUrl":"10.1111/vec.70160","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To report serum baclofen concentrations before, during, and after in-series carbon hemoperfusion (cHP) and hemodialysis (HD) in four dogs with severe baclofen toxicosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Series Summary</h3>\u0000 \u0000 <p>This series involves four dogs with serum samples collected before, during, and after in-series cHP/HD. The extraction ratio (ER, %) of cHP and HD, half-life during cHP/HD, and total extracorporeal elimination constant were calculated. Posttreatment samples were collected to determine endogenous half-life and intrinsic elimination constant. Two dogs received both cHP/HD and mechanical ventilation, while the other two received cHP/HD alone. The range of ingested dosages was 4–24 mg/kg. The median time from suspected ingestion to cHP/HD initiation was 7 h (range: 5–15 h). Extracorporeal therapy was performed using an intermittent hemodialysis platform in two cases and a continuous renal replacement therapy platform in two cases. The median duration of cHP/HD was 3 h (range: 2.2–4 h), with a median total blood volume processed of 1.3 L/kg (range: 1–1.5 L/kg), equating to 15 times (range: 12–18.2 times) the estimated blood volume (80 mL/kg) in dogs. Serum baclofen concentration was reduced during cHP/HD by a median 69% (range: 46%–80%). The median ER for cHP was 61% (range: 60%–81%) and for HD was 4% (range: −0.5% to 11.5%). The calculated half-life during cHP/HD was 1.9 h (range: 1.1–2.5 h), compared with 5.8 h (range: 3.1–13.6 h) after cHP/HD. The median extracorporeal elimination constant was 0.34 (range: 0.08–0.37), which was 2.8 times faster than the intrinsic elimination constant of 0.12 (range: 0.05–0.23).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> New or Unique Information Provided</h3>\u0000 \u0000 <p>In-series cHP/HD reduced serum baclofen concentrations in this small series of dogs, highlighting its potential role in the treatment of severe baclofen intoxication.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 5","pages":"673-681"},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.70160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking the Fall in Prothrombin Time in Dogs With Anticoagulant Rodenticide Toxicosis Following an Intravenous Dose of Mixed Micelle Phytomenadione","authors":"Erin T. Mooney,&nbsp;Lisa Smart","doi":"10.1111/vec.70155","DOIUrl":"10.1111/vec.70155","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Anticoagulant rodenticide toxicosis causes distruption to vitamin K metabolism, leading to excessive bleeding. Mixed micelle phytomenadione (MMP), administered intravenously, is used to reverse the anticoagulant effects of the rodenticide. In dogs with anticoagulant rodenticide toxicosis, prothrombin time (PT) is measured before and after treatment with MMP to assess whether and when normalization of PT has occurred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Findings</h3>\u0000 \u0000 <p>Eleven patients were enrolled, and one dog twice, resulting in 12 patient events. In two cases, PT normalized within 30 min of administration of MMP, seven within 1 h, and one within 2 h; however, apparent adverse reactions were seen.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance</h3>\u0000 \u0000 <p>Although adverse effects have been reported, coagulopathy can be rapidly reversed in dogs with suspected anticoagulant rodenticide toxicosis with use of intravenous MMP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 5","pages":"713-717"},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Intralipid Therapy and Therapeutic Plasma Exchange in the Management of Cholecalciferol Rodenticide Exposure in a Dog: A Case Report","authors":"Tanvi A. Kamat,&nbsp;Kara D. Altman,&nbsp;Emma Donnelly,&nbsp;Neus Elias Santo-Domingo","doi":"10.1111/vec.70157","DOIUrl":"10.1111/vec.70157","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To describe the presentation and outcome of a case of suspected cholecalciferol rodenticide intoxication managed with both intralipid emulsion (ILE) and therapeutic plasma exchange (TPE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Summary</h3>\u0000 \u0000 <p>A 3-year-old, neutered female, crossbreed dog presented for acute-onset vomiting and lethargy after suspected exposure to cholecalciferol rodenticide. Severe hypercalcemia was observed without other identifiable causes found upon investigation. Standard therapy for hypercalcemia was initiated, but rebound hypercalcemia led to consideration of alternative management options. Although ILE therapy initially showed promise, rebound hypercalcemia persisted. Ultimately, TPE was performed as a novel therapy and successfully reduced serum concentrations of vitamin D metabolites. Normocalcemia was eventually maintained, though the dog developed endocarditis that progressed to congestive heart failure and death. Blood cultures revealed the growth of <i>Serratia marcescens</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> New or Unique Information Provided</h3>\u0000 \u0000 <p>To the authors’ knowledge, this is the first report describing the use of both ILE and TPE in the management of cholecalciferol rodenticide intoxication in a dog. It is also the second reported case of <i>S. marcescens</i> causing endocarditis in a dog.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 5","pages":"696-702"},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.70157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts From the International Veterinary Emergency and Critical Care Symposium, the ACVECC-VetCOT Veterinary Trauma & Critical Care Conference, and the European Veterinary Emergency and Critical Care Annual Congress–2026","authors":"","doi":"10.1111/vec.70162","DOIUrl":"https://doi.org/10.1111/vec.70162","url":null,"abstract":"","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"36 S2","pages":"S3-S51"},"PeriodicalIF":1.6,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}